Catheter Tract Metastasis Often Overlooked in Mesothelioma Patients

catheter tract metastasis

A Canadian study says radiologists often overlook catheter tract metastasis in people with pleural mesothelioma, even though as many as a quarter of patients with pleural catheters develop the problem.  Mesothelioma patients can develop excess fluid around the lungs that makes it hard to breathe. Doctors can treat the problem with pleural catheters that stay in place and drain to the outside.  But tiny tumors that spring up along the tract where the catheter was inserted are a risk with this treatment. These tiny tumors are called metastatic tumors. They are easy to miss on CT scans. But the new report says there are other tell-tale signs of catheter tract metastasis. Pleural Catheters for Effusion in Mesothelioma Pleural effusion is … Continue reading Catheter Tract Metastasis Often Overlooked in Mesothelioma Patients »

Long-Term Mesothelioma Survival With Immunotherapy Combination

immunotherapy combination

An immunotherapy combination of tremelimumab and durvalumab has resulted in long-term survival for some mesothelioma patients in a new follow-up Italian study.  Tremelimumab and durvalumab (Imfinzi) received orphan drug designation from the FDA last year for liver cancer. Now, it looks like this immunotherapy combination could help some people with the rare asbestos cancer, too.  Mesothelioma patients who had the best results in the new study were those with a high number of mutated genes. Mesothelioma is often fatal within a year. But the longest-living patient in the study survived for more than 41 months.  Immunotherapy Combination Blocks Key Proteins White blood cells have the power to help combat mesothelioma. But a protein called CTLA-4 can block that ability. Tremelimumab … Continue reading Long-Term Mesothelioma Survival With Immunotherapy Combination »

Canadian Study Highlights Occupational Mesothelioma Risk

occupational mesothelioma risk

A new study of more than 2 million Canadian workers is shining a spotlight on the occupational mesothelioma risk from asbestos exposure in several industries. The study included data on 2.18 million workers in the Occupational Disease Surveillance System (ODSS). These workers were employed from 1983 to 2014. The researchers followed the workers for years to see how many of them developed mesothelioma or a chronic lung disease called asbestosis.  They compiled the data on which industries had the most diagnoses. The results paint a sobering picture of the occupational mesothelioma risk to thousands of industrial workers. Asbestos and the Link to Mesothelioma Asbestos is a fibrous mineral that occurs naturally in the soil in many parts of the world. … Continue reading Canadian Study Highlights Occupational Mesothelioma Risk »

Genetic Links to Mesothelioma Illustrated in New Interactive Model

genetic links to mesothelioma

An interactive model of protein interactions could reveal new genetic links to mesothelioma and even lead to new treatments.  The model is the brainchild of researchers in the US and India. It is a map of the thousands of protein-to-protein interactions that govern how mesothelioma cells develop, thrive, and spread.  Understanding the genetic links to mesothelioma is key to understanding who gets the disease and who does not. It is also crucial for developing new therapies aimed at manipulating the way mesothelioma cells use certain proteins.  Proteins Govern Cellular Functions Mesothelioma is a cancer of the membranes around organs. Asbestos is the main cause of mesothelioma worldwide. But only a small percentage of people who are exposed to asbestos go … Continue reading Genetic Links to Mesothelioma Illustrated in New Interactive Model »

Could an Inhaled Vaccine Help Prevent Mesothelioma?

inhaled vaccine

Research at MIT suggests that an inhaled vaccine may trigger a strong immune response against infections and even cancer in the lungs. The findings could be good news for people at risk for the rare lung-related cancer, pleural mesothelioma.  Lung infections often start on mucosal membranes. So researchers developed a vaccine that binds to a protein in mucus. When they immunized mice in a way that mimics an inhaled vaccine, their lungs produced many T-cells. T-cells are immune system cells that can help fight infections and cancer.  Pleural mesothelioma is caused by exposure to asbestos. Right now, there is no way to vaccinate against it and no cure. If an inhaled vaccine could bring more T-cells to the lungs of … Continue reading Could an Inhaled Vaccine Help Prevent Mesothelioma? »

CRS/HIPEC Procedure Has Improved Over Time, Study Finds

CRS/HIPEC Procedure

A new French study contains some good news for people considering the CRS/HIPEC procedure for peritoneal mesothelioma.  The CRS/HIPEC procedure combines surgical resection with localized chemotherapy. Its aim is to remove or destroy as many mesothelioma cells as possible in the abdomen.  French researchers studied the evolution of the procedure over time. They discovered that it has improved. As a result, people with peritoneal cancers like malignant mesothelioma are living longer.  Cytoreductive Surgery for Mesothelioma Peritoneal mesothelioma causes tumors on the peritoneal membrane that lines the abdomen. Like other forms of mesothelioma, the cause is usually asbestos exposure.  Cytoreductive surgery (CRS) is an operation to remove tumors from the abdomen. Mesothelioma tumors may be confined to the peritoneal membrane, or … Continue reading CRS/HIPEC Procedure Has Improved Over Time, Study Finds »

Waiting for Medicare Coverage Could Impact Mesothelioma Survival

medicare coverage

People who suspect they may have cancer but wait to get a diagnosis until they are eligible for Medicare coverage could negatively impact their ability to survive mesothelioma.  That is the message from a new Stanford study. The study suggests that many people wait until they are 65 to seek cancer care.  For people with a fast-growing cancer like mesothelioma, delaying diagnosis by waiting for Medicare coverage could have devastating consequences.  Early Mesothelioma Diagnosis Key to Survival Malignant pleural mesothelioma is a form of lung cancer caused by exposure to asbestos. It is one of the most deadly types of cancer. Like most cancers, the chances of surviving mesothelioma are higher the earlier it is diagnosed.  But mesothelioma is not … Continue reading Waiting for Medicare Coverage Could Impact Mesothelioma Survival »

Minimally Invasive Surgery for Mesothelioma is “Viable Alternative” to Standard Approaches

minimally invasive surgery for mesothelioma

A new study from the Icahn School of Medicine at Mount Sinai in New York suggests that minimally invasive surgery for mesothelioma is a “viable alternative” to open-chest procedures.  Both of the two main surgical procedures for pleural mesothelioma are usually done through a large incision in the chest. Both procedures also carry a high risk of post-surgical complications.  But the New York researchers found that minimally invasive surgery for mesothelioma may produce fewer serious problems in the short-term. It may also give mesothelioma patients a better quality of life after surgery. Surgical Treatment of Pleural Mesothelioma Pleural mesothelioma tumors occur on tissue that surrounds the lungs. These tumors tend to spread out across the tissue in irregular shapes. Their … Continue reading Minimally Invasive Surgery for Mesothelioma is “Viable Alternative” to Standard Approaches »

Prognostic Value of PET/CT in Pleural Mesothelioma Patients

prognostic value of PET/CT

New data highlights the prognostic value of PET/CT scans for patients with malignant pleural mesothelioma. Pleural mesothelioma is a rare malignancy with a poor prognosis. But some patients tend to do better than others. Scientists are always looking for better ways to predict which patients will respond best to which treatment. A new Turkish study focused on the prognostic value of scans that measure tumor volume and metabolic activity. They conclude that PET/CT is a valuable way to predict mesothelioma outcomes. Doctors can use the information to help plan for chemotherapy or surgical treatment.  How PET/CT Scans Work Doctors have been aware of malignant mesothelioma since the 1930s. That is when it first started appearing among asbestos workers. But there … Continue reading Prognostic Value of PET/CT in Pleural Mesothelioma Patients »

Real-World Mesothelioma Patients Need New Systemic Treatments

real-world mesothelioma patients

The newest study on real-world mesothelioma patients illustrates the need for more ways to treat this devastating cancer.  Many studies focus on a carefully-chosen subset of patients. Patients have to meet specific guidelines to qualify for a mesothelioma clinical trial.  But the authors of a new report in Future Oncology focused on real-world mesothelioma patients in community clinics. The goal was to see what kinds of treatments these patients got and how well they worked.  The results show most people do not have other treatments after first-line therapy. They also suggest that mesothelioma doctors and patients need new first-line alternatives.  First- and Second-Line Mesothelioma Therapies Malignant mesothelioma is the name for cancer on the membranes around internal organs. Pleural mesothelioma … Continue reading Real-World Mesothelioma Patients Need New Systemic Treatments »

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