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Biologic therapy – Chemotherapy – The Royal Marsden Hospital
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| Description: |
| Patients: This Phase I study involved 13 patients with malignant mesothelioma.
Treatment: The treatment consisted of a suspension of heat-killed Mycobacterium vaccae (SRL172), a fast growing avirulent mycobacterium, that may have non-specific immunomodulating properties in combination with standard chemotherapy (mitomycin-C (mitozytrex), vinblastine (velban) and cisplatin (platinol)). Toxicity: Grade 1-3 toxicities included infection, emesis, mucositis, diarrhea, constipation, alopecia, neuropathy, fatigue, and hematological. Results: The median overall survival was 10.5 months. Support: This study was supported by a research grant from SR Pharma. SR Pharma markets SRL172. Correspondence: MER O’Brien, MD |
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