Chemotherapy During Mesothelioma Surgery: Is it Dangerous?

chemotherapy during mesothelioma surgery

A new study finds that chemotherapy during mesothelioma surgery does not raise the risk for complications. That could be good news for pleural mesothelioma patients who want to keep cancer at bay as long as possible. A group of Indian doctors compared the cases of thoracic cancer patients who had surgery with or without intraoperative chemotherapy. Only one of the “surgery + chemotherapy” patients developed a serious complication. Patients in this group also lived longer than those who did not receive intraoperative chemotherapy. When Do Doctors Use Chemotherapy During Mesothelioma Surgery? The two primary types of mesothelioma surgery are extrapleural pneumonectomy (EPP) or lung-sparing pleurectomy/decortication (P/D). Patients often have chemotherapy prior to surgery to shrink their mesothelioma tumor. Many have … Continue reading Chemotherapy During Mesothelioma Surgery: Is it Dangerous? »

Conservative Surgery Leads to Better Mesothelioma Survival After Recurrence

mesothelioma survival

Mesothelioma survival after recurrence may be better with lung-preserving P/D surgery than with more radical EPP. Japanese researchers recently analyzed the cases of 44 mesothelioma patients who underwent either EPP or P/D. It took about the same amount of time for mesothelioma tumors to start growing again, no matter what type of surgery the patient had. The difference was in survival. Both overall survival and mesothelioma survival after recurrence were longer in the P/D patients. EPP vs. P/D: The Ongoing Debate Mesothelioma surgeons around the world are still divided about which type of mesothelioma surgery is best. On one hand, extrapleural pneumonectomy (EPP) removes more diseased tissue, including a lung. Some say this improves the odds of long term mesothelioma … Continue reading Conservative Surgery Leads to Better Mesothelioma Survival After Recurrence »

Staging of Mesothelioma Could Change with Discovery of New Lymph Nodes

Staging of mesothelioma in surgery

A recent discovery at the University of Maryland could dramatically change how doctors handle the staging of malignant pleural mesothelioma. More accurate staging could lead to better mesothelioma treatment outcomes and longer survival. More than three quarters of people diagnosed with mesothelioma have the pleural variety. Pleural mesothelioma is the deadliest form of asbestos cancer. Most patients do not live longer than 18 months, even with aggressive treatment. Cancer staging is the process doctors use to determine how advanced the cancer is. Staging of mesothelioma is important because it directly impacts treatment decisions. But staging of mesothelioma – just like diagnosis and treatment – can be difficult. Lymph Nodes May Help in Staging of Mesothelioma The discovery was made by … Continue reading Staging of Mesothelioma Could Change with Discovery of New Lymph Nodes »

Researchers Name Six Top Mesothelioma Survival Factors

Certain factors lead to longer mesothelioma survival

Researchers at the University of Pittsburgh have named what they say are the top six mesothelioma survival factors. According to their new study, patients with one or more of these factors tend to have better mesothelioma treatment outcomes and live longer. Malignant mesothelioma – also called asbestos cancer – is one of the deadliest forms of cancer. It starts on internal membranes and spreads quickly. There is no cure and the disease is very hard to slow down. Many mesothelioma patients die within 12 to 18 months. But there are cases of much longer mesothelioma survival. Some patients have even lived for decades after mesothelioma treatment. The Pittsburgh researchers wanted to find the mesothelioma survival factors shared by the longest … Continue reading Researchers Name Six Top Mesothelioma Survival Factors »

Combination Therapy with Mesothelioma Surgery Leads to Longer Survival

Mesothelioma surgery patient with nurse

A new study finds almost a quarter of people who had combination therapy with mesothelioma surgery were still alive five years later. The study was published in the European Journal of Cardio-Thoracic Surgery. Researchers at University Hospitals KU Leuven in Belgium studied nearly 200 mesothelioma patients from 2003 to 2014. Many people do not live beyond about 18 months after a mesothelioma diagnosis. But the Belgian team says, for the right patients, there is a way to improve the odds. They say combination therapy with radical mesothelioma surgery offers a 1 in 4 chance of surviving for 5 years or more. Two Types of Mesothelioma Surgery There are two major schools of thought about mesothelioma surgery. Some surgeons say it … Continue reading Combination Therapy with Mesothelioma Surgery Leads to Longer Survival »

Survival After Mesothelioma Surgery Could Rise with Immunotherapy Spray

improving survival after mesothelioma surgery

A spray-on immune booster may one day improve survival after mesothelioma surgery. UCLA scientists tested the biodegradable spray gel in mice with advanced melanoma. They found that it stopped cancer recurrence after surgery in about half of the lab animals tested. “Around 90 percent of people with cancerous tumors end up dying because of tumor recurrence or metastasis,” says lead investigator Zhen Gu. “Being able to develop something that helps lower this risk for this to occur and has low toxicity is especially gratifying.” Gu is a professor of bioengineering and a member of the UCLA Jonsson Comprehensive Cancer Center where the spray was developed. Survival After Mesothelioma Surgery Survival after mesothelioma surgery or any other kind of cancer operation … Continue reading Survival After Mesothelioma Surgery Could Rise with Immunotherapy Spray »

Mesothelioma Surgery PD Comparison

operation for mesothelioma

Lung-sparing surgery is another name for pleurectomy/decortication (PD). In PD, surgeons take out as much mesothelioma cancer as they can without taking out one of the lungs. The other main type of mesothelioma surgery is called EPP (extrapleural pneumonectomy). In that surgery, doctors do take out a lung when they take out the mesothelioma tumor. Some studies say patients who have PD surgery live longer than people who have EPP. They may also have fewer problems after surgery. What is the New Clinical Trial? Researchers in Belgium and The Netherlands are running a test called EORTC 1205. EORTC 1205 is a clinical trial. Clinical trials test new drugs or treatments to see how well they work in people. Right now, … Continue reading Mesothelioma Surgery PD Comparison »

Meta-Analysis Finds Lung-Sparing Surgery the Best Option for Most Mesothelioma Patients

There is now more evidence to support the growing number of experts who favor lung-sparing P/D surgery over radical extrapleural pneumonectomy (EPP) for the treatment of malignant pleural mesothelioma. There has been an ongoing debate within the surgical community over which procedure carries the most benefit with the least risk. The late David Sugarbaker, MD, of Baylor St. Luke’s Medical Center in Houston was a pioneer of the EPP procedure, which involves removing not only the diseased pleural lining where mesothelioma tumors grow, but also the nearest lung, most of the diaphragm, the pericardium, and other at-risk tissues. But it turns out that, although Sugarbaker and his team were able to show a mesothelioma survival benefit with EPP, their results, … Continue reading Meta-Analysis Finds Lung-Sparing Surgery the Best Option for Most Mesothelioma Patients »

Mesothelioma Surgery and the Threat of Opioid Addiction

A new study of opioid addiction among lung cancer patients may have implications for pleural mesothelioma patients who are considering surgery. The study, published this month in JAMA Oncology, finds that patients treated with more invasive surgical techniques are more likely to become chronic opioid users than those who have less invasive surgery. Opioids Are ‘Standard of Care’ for Lung Surgery Patients Researchers at Mount Sinai Medical Center in New York studied the cases of nearly 4,000  people from the SEER Medicare database who had some type of surgery for non-small cell lung cancer, a type of cancer that shares many commonalities with the lung-related asbestos cancer, pleural mesothelioma. Some of the lung cancer patients studied underwent open thoracic surgery while others … Continue reading Mesothelioma Surgery and the Threat of Opioid Addiction »

Surgery May Offer Survival Advantage for Rare Mesothelioma Subtypes

People with the most dangerous subtypes of malignant pleural mesothelioma may live longer if they undergo surgery. In an article in the Annals of Thoracic Surgery, University of Arizona researchers say cancer-directed surgery can lengthen survival in people with sarcomatoid and biphasic mesothelioma, two of the hardest cancers to treat. Multiple studies have suggested that there is a survival benefit from surgery in people with epithelioid mesothelioma, the most common subtype. But, the evidence is much more scanty for people with either sarcomatoid or biphasic mesothelioma, both of which are associated with a worse mesothelioma prognosis  and shorter overall survival. Now, the Tucson-based research team says surgery aimed at removing the cancer (rather than just alleviating symptoms) can help these mesothelioma … Continue reading Surgery May Offer Survival Advantage for Rare Mesothelioma Subtypes »

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