Prognosis Archives | Surviving Mesothelioma

Age May Have Little Impact on Mesothelioma Surgery Outcomes

Being older does not necessarily reduce a patient’s odds of benefiting from mesothelioma surgery. That is the good news from a study conducted by mesothelioma experts at Glenfield Hospital in Leicester, England. The bad news is that too many elderly mesothelioma patients are not being referred for adjuvant treatments that could improve their surgical outcomes. Adjuvant Therapy and Mesothelioma Survival Adjuvant therapy is a treatment … Continue reading Age May Have Little Impact on Mesothelioma Surgery Outcomes »

New Biomarker Could Help Eradicate Mesothelioma Resistance to Chemotherapy

Researchers in the Netherlands have unveiled what may be a major breakthrough in the chemotherapeutic treatment of malignant mesothelioma. Malignant mesothelioma, a rare and virulent cancer caused by asbestos exposure, is notoriously resistant to standard cancer treatments, including chemotherapy. Even the only chemotherapy drug specifically approved for the treatment of mesothelioma, Alimta (pemetrexed), only works for some patients. Now, a new study published in the … Continue reading New Biomarker Could Help Eradicate Mesothelioma Resistance to Chemotherapy »

Sickest Mesothelioma Patients May Benefit Most from P/D Surgery

Patients with the worst cases of malignant pleural mesothelioma may stand to gain the most from pleurectomy and decortication (P/D) surgery. That is the conclusion of researchers at the University of Chicago and Loyola University who subjected 114 mesothelioma patients to a quality of life and overall health scoring system both before and after P/D surgery.   Considering Mesothelioma Surgery The decision on whether or … Continue reading Sickest Mesothelioma Patients May Benefit Most from P/D Surgery »

Inflammation Marker May Predict Mesothelioma Prognosis

The ratio of neutrophils to lymphocytes – a way of measuring inflammation in the body of people with malignant pleural mesothelioma – may help doctors predict how well they will respond to treatment. That is the conclusion of mesothelioma researchers at China’s Sichuan University. In a new article in the journal Oncotarget, the team observed that NLR has been associated with survival in other types … Continue reading Inflammation Marker May Predict Mesothelioma Prognosis »

New Research Finds Little Survival Difference Between Mesothelioma Surgeries

The largest analysis of mesothelioma surgery ever done finds little survival difference between lung-sparing and lung-removing surgeries. A team of top mesothelioma oncologists and surgeons at three US Universities analyzed the cases of 1,307 malignant mesothelioma patients from the National Cancer Database (NCDB), a joint project of the American College of Surgeons and the American Cancer Society. After using a series of statistical tools to … Continue reading New Research Finds Little Survival Difference Between Mesothelioma Surgeries »

New Report Reveals Disparities in Mesothelioma Treatment

A new study of mesothelioma treatment and survival in the US contains some disturbing facts about treatment trends. Among them is the fact that people over 70 are much less likely to get any treatment for malignant mesothelioma, a rare but but fast-growing malignancy that can be quickly fatal. In fact, nearly a third of mesothelioma patients receive no therapy at all. The study was … Continue reading New Report Reveals Disparities in Mesothelioma Treatment »

Using Immune Cells to Predict Mesothelioma Outcomes

Immune system cells may be some of the best predictors of mesothelioma outcomes, according to a group of British scientists. A new article in the British Journal of Cancer has found a close association between outcomes in people with different subtypes of malignant mesothelioma and the levels of different types of immune system cells in their bodies. Measuring Immune Response To create the experiment, researchers … Continue reading Using Immune Cells to Predict Mesothelioma Outcomes »

These Proteins Appear to Shorten Mesothelioma Survival

New evidence suggests that mesothelioma patients whose tumors express two particular proteins do not live as long as other mesothelioma patients. An international team of scientists including mesothelioma researchers at the National Cancer Institute say ALCAM (also called CD166) and PD-L1 (CD274) are both associated with “significantly decreased” survival in pleural mesothelioma. Understanding ALCAM and PD-L1 ALCAM is a type I transmembrane protein that regulates … Continue reading These Proteins Appear to Shorten Mesothelioma Survival »

MicroRNAs May Be Key to Better Immunotherapy for Mesothelioma

Australian scientists say it may be possible to artificially reduce the levels of a protein that helps mesothelioma tumors hide from the immune system. The new research published in the Journal of Thoracic Oncology could open the door to more effective immunotherapy treatments for pleural mesothelioma. The Importance of PD-L1 Expression A cell surface protein called PD-L1 is key to the effectiveness of several new … Continue reading MicroRNAs May Be Key to Better Immunotherapy for Mesothelioma »

The Influence of BAP1 on Mesothelioma Survival

A mutation on the BAP1 tumor suppressor gene can influence the development of malignant mesothelioma but may have little bearing on survival. That conclusion comes from a new Chinese study of more than 2,400 people with cancers directly linked to the BAP1 genetic mutation, including pleural mesothelioma. BAP1 and Mesothelioma BRCA1-associated protein 1 (BAP1) is a tumor suppressing protein encoded by the BAP1 gene. Multiple studies … Continue reading The Influence of BAP1 on Mesothelioma Survival »

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