These Proteins Appear to Shorten Mesothelioma Survival
New evidence suggests that mesothelioma patients whose tumors express two particular proteins do not live as long as other mesothelioma patients. An international team of scientists including mesothelioma researchers at the National Cancer Institute say ALCAM (also called CD166) and PD-L1 (CD274) are both associated with “significantly decreased” survival in pleural mesothelioma. Understanding ALCAM and PD-L1 ALCAM is a type I transmembrane protein that regulates … Continue reading These Proteins Appear to Shorten Mesothelioma Survival
MicroRNAs May Be Key to Better Immunotherapy for Mesothelioma
Australian scientists say it may be possible to artificially reduce the levels of a protein that helps mesothelioma tumors hide from the immune system. The new research published in the Journal of Thoracic Oncology could open the door to more effective immunotherapy treatments for pleural mesothelioma. The Importance of PD-L1 Expression A cell surface protein called PD-L1 is key to the effectiveness of several new … Continue reading MicroRNAs May Be Key to Better Immunotherapy for Mesothelioma
The Influence of BAP1 on Mesothelioma Survival
A mutation on the BAP1 tumor suppressor gene can influence the development of malignant mesothelioma but may have little bearing on survival. That conclusion comes from a new Chinese study of more than 2,400 people with cancers directly linked to the BAP1 genetic mutation, including pleural mesothelioma. BAP1 and Mesothelioma BRCA1-associated protein 1 (BAP1) is a tumor suppressing protein encoded by the BAP1 gene. Multiple studies … Continue reading The Influence of BAP1 on Mesothelioma Survival
Length of Time Between Surgeries a Marker for Mesothelioma Survival
Peritoneal mesothelioma patients who survive more than two years after surgery are the ones most likely to benefit from a second surgery if their cancer recurs. That is the conclusion of cancer researchers at the City of Hope Cancer Center and Wake Forest School of Medicine in an article newly published in the Journal of Surgical Oncology. Using a City of Hope database of 1,314 … Continue reading Length of Time Between Surgeries a Marker for Mesothelioma Survival
New Blood Test Could Mean Earlier Mesothelioma Diagnosis
A calcium-binding protein called calretinin may provide the basis for a new kind of blood test for the asbestos-linked cancer, malignant mesothelioma. Right now, there is no reliable way to detect the presence of a mesothelioma tumor before symptoms develop. The Search for a Mesothelioma Blood Test But scientists around the world are searching for ways to use certain compounds produced by tumors to diagnose mesothelioma … Continue reading New Blood Test Could Mean Earlier Mesothelioma Diagnosis
Altered Viruses May Help Boost Immunotherapy for Malignant Mesothelioma
Viruses may soon be playing a bigger role in the fight against malignant mesothelioma and other thoracic cancers. A pair of biologists from Minnesota say there is evidence that, in addition to killing mesothelioma cells directly, specific kinds of altered viruses might help make mesothelioma immunotherapy treatment more effective. How Does Immunotherapy Work? Like many other types of cancer, mesothelioma tumors are able to grow unchecked … Continue reading Altered Viruses May Help Boost Immunotherapy for Malignant Mesothelioma
Predicting Mesothelioma Outcomes with Soluble Mesothelin
New research suggests that a protein often used to help diagnose and track malignant mesothelioma may also be a valuable prognostic indicator. Soluble mesothelin-related protein (SMRP) is a biomarker for pleural mesothelioma, an aggressive asbestos-linked cancer that causes few symptoms until in its late stages. The presence of SMRP in the blood indicates that mesothelial cells on the lining around the lungs have been damaged. … Continue reading Predicting Mesothelioma Outcomes with Soluble Mesothelin
More Evidence for Inflammation Marker in Mesothelioma Prognosis
There is more evidence that a measure of how well the immune system is functioning may be an efficient prognostic tool for people with malignant pleural mesothelioma. Even though some recent studies have found the ratio of neutrophils to lymphocytes (NLR) in the blood to be a poor prognostic indicator for cancer, Chinese researchers say it may still be effective for planning mesothelioma treatment and qualifying … Continue reading More Evidence for Inflammation Marker in Mesothelioma Prognosis
Lung-Sparing Surgery and Mesothelioma Survival
When it comes to the mesothelioma surgery known as pleurectomy/decortication (P/D), not all techniques are created equal. A new report in the European Journal of Cardio-Thoracic Surgery finds that two of the three primary P/D approaches offer a significant mesothelioma survival advantage over the third. Setting up the Mesothelioma Surgery Study Thoracic surgeons from 11 Italian institutions reviewed the cases of 314 pleural mesothelioma patients … Continue reading Lung-Sparing Surgery and Mesothelioma Survival
Surgery May Impact Mesothelioma Survival More Than Stage
A study conducted in Belgium appears to support the idea that whether or not a malignant pleural mesothelioma patient undergoes surgery may be a better predictor of survival than the stage of their cancer. The study including 101 patients diagnosed with or treated for pleural mesothelioma between 2001 and 2015 at Antwerp University Hospital. The goal of the study was to determine how closely the … Continue reading Surgery May Impact Mesothelioma Survival More Than Stage
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