Treatment Advances Fail to Improve Mesothelioma Survival Trends

mesothelioma survival trends

A new report shows mesothelioma survival trends have remained steady for decades, despite new drugs, new surgery techniques, and the introduction of pleural catheters.  The report comes from cancer researchers at Ottawa Hospital Cancer Centre in Canada. Canada has one of the world’s highest rates of malignant pleural mesothelioma. This is likely related to the country’s long history of asbestos production. To compile the new report, researchers compared mesothelioma outcomes in three different decades between 1991 and 2019. There were surprisingly few differences in mesothelioma survival trends in the three decades.  Mesothelioma’s Destructive History Pleural mesothelioma is a virulent cancer of the pleural membrane. This is the tissue or mesothelium that surrounds the lungs. It is thin but flexible and … Continue reading Treatment Advances Fail to Improve Mesothelioma Survival Trends »

Concerning CT Findings and Mesothelioma Prognosis

Concerning CT Findings

One of the nation’s top mesothelioma doctors says concerning CT findings may be one of the best ways to predict peritoneal mesothelioma outcomes.  Dr. Paul Sugarbaker is with MedStar Washington Hospital Center in Washington, DC. His newly published study compares 11 different concerning CT findings with outcomes in 100 mesothelioma patients.  Sugarbaker and his team found that the prognostic value of these 11 CT features is on a par with peritoneal cancer index (PCI) and cytoreduction (CC) score. It means that CT findings could become even more important for mesothelioma treatment planning.  CT Scans Reveal Information About Peritoneal Mesothelioma Peritoneal mesothelioma occurs on the lining around the abdomen. It is an aggressive and hard-to-treat cancer caused by exposure to asbestos. … Continue reading Concerning CT Findings and Mesothelioma Prognosis »

Prognostic Value of PET/CT in Pleural Mesothelioma Patients

prognostic value of PET/CT

New data highlights the prognostic value of PET/CT scans for patients with malignant pleural mesothelioma. Pleural mesothelioma is a rare malignancy with a poor prognosis. But some patients tend to do better than others. Scientists are always looking for better ways to predict which patients will respond best to which treatment. A new Turkish study focused on the prognostic value of scans that measure tumor volume and metabolic activity. They conclude that PET/CT is a valuable way to predict mesothelioma outcomes. Doctors can use the information to help plan for chemotherapy or surgical treatment.  How PET/CT Scans Work Doctors have been aware of malignant mesothelioma since the 1930s. That is when it first started appearing among asbestos workers. But there … Continue reading Prognostic Value of PET/CT in Pleural Mesothelioma Patients »

Age and Smoking Less Important Than Other Factors for Mesothelioma Outcomes

age and smoking

A newly published study suggests that a mesothelioma patient’s age and smoking history is less important to prognosis than certain biomarkers or what treatment they choose. The study comes from scientists at the National Institute of Respiratory Diseases in Mexico City.  They performed a retrospective analysis of 136 patients with pleural mesothelioma. The goal was to see which factors played the biggest role in outcomes. Age and smoking were among seven factors evaluated. It turns out they were not the most important ones.  Who Gets Pleural Mesothelioma? Malignant mesothelioma is the cancer most closely associated with asbestos exposure. Most people who get it have lived or worked around asbestos. Mesothelioma can take decades to develop. Most patients are over 65.  … Continue reading Age and Smoking Less Important Than Other Factors for Mesothelioma Outcomes »

Estrogen Signaling Genes May be Secret to Survival for Women with Mesothelioma

women with mesothelioma

Scientists think they now have a better understanding of why most women with mesothelioma live longer than men.  Malignant mesothelioma is four times more common in men than in women. But many studies show that women with mesothelioma do better than men after treatment.  Researchers with The International Mesothelioma Program at Brigham and Women’s Hospital in Boston say the difference is in the genes. Their new study focused on the potentially protective role of estrogen signaling genes in female patients. The RERG Gene and Mesothelioma Survival In the latest study, researchers analyzed genetic data and survival in groups of mesothelioma patients. The groups included both men and women with mesothelioma. The goal was to determine what aspect of the women’s … Continue reading Estrogen Signaling Genes May be Secret to Survival for Women with Mesothelioma »

Radiotherapy Outcomes in Mesothelioma Linked to Metabolism

radiotherapy outcomes

Italian researchers say metabolic markers may hold the key to predicting radiotherapy outcomes in people with mesothelioma. Metabolism is the process by which cells produce energy. Metabolism is necessary for cancer cells to live. Mesothelioma cells metabolize faster than healthy cells.  Radiotherapy affects cancer cell metabolism. A new study shows that compounds produced during metabolism may impact radiotherapy outcomes. It suggests that a patient’s metabolic profile – or metabolome – could help doctors choose good candidates for radiation. Radical Hemithoracic Radiotherapy and Mesothelioma  Pleural mesothelioma is a rare lung-related cancer caused by asbestos exposure. There is no cure for mesothelioma. Most mesothelioma patients have a combination of therapies. Radiation is one of the methods doctors use to help slow its … Continue reading Radiotherapy Outcomes in Mesothelioma Linked to Metabolism »

Standard Biomarkers for Pleural Mesothelioma “Not Useful” for Immunotherapy

Biomarkers for pleural mesothelioma

Two of the most important biomarkers for pleural mesothelioma are not much help when it comes to tracking response to immunotherapy. Top mesothelioma researchers at the University of Pennsylvania drew that conclusion based on data from a cohort of 58 patients.  They focused on two primary biomarkers for pleural mesothelioma: SMRP and fibulin-3. Doctors use both of these markers to diagnose and plan treatment for mesothelioma.  The study confirms the correlation between these markers and mesothelioma tumor volume. But the Penn Medicine researchers say these biomarkers of pleural mesothelioma were “not useful” for measuring immunotherapy response. Understanding Biomarkers for Pleural Mesothelioma A biomarker is a substance produced by the body that indicates a biological process or condition. Most mesothelioma biomarkers … Continue reading Standard Biomarkers for Pleural Mesothelioma “Not Useful” for Immunotherapy »

Epithelioid Subtype Leads to Longer Survival Regardless of Treatment

epithelioid subtype

Danish researchers say people with the epithelioid subtype of pleural mesothelioma tend to live longer than those with other subtypes, even if they don’t receive treatment.  The study is the latest to confirm what prior research suggests: that epithelial mesothelioma is more survivable than other subtypes.  In the newest report, mesothelioma patients with the epithelioid subtype lived longer, even when they were not good candidates for curative treatment. Mesothelioma Subtypes and Symptoms Pleural mesothelioma is a fast-growing cancer on the membrane around the lungs. Exposure to asbestos is the primary cause of mesothelioma.  There are three main mesothelioma subtypes. They are the epithelioid subtype, the sarcomatoid subtype, and the biphasic subtype. Epithelioid mesothelioma is the most common subtype. Sarcomatoid is … Continue reading Epithelioid Subtype Leads to Longer Survival Regardless of Treatment »

Autoimmune Disease and Mesothelioma: Will it Impact Survival?

autoimmune disease

A new lung cancer study suggests that having an autoimmune disease will not necessarily lead to shorter cancer survival. This could be good news for pleural mesothelioma patients suffering from autoimmune disorders. Pleural mesothelioma is a lung-related disease that has many characteristics in common with lung cancer.  The new study comes from Northwestern University Feinberg School of Medicine in Chicago. It included 177 lung cancer patients who also had immune diseases. Doctors compared their survival with a control group of lung cancer patients.   They determined that having an autoimmune disease did not negatively impact lung cancer survival. In fact, some of those patients lived longer than those with healthy immune systems.  What is an Autoimmune Disease? An autoimmune disease is … Continue reading Autoimmune Disease and Mesothelioma: Will it Impact Survival? »

Predicting Mesothelioma Survival with Routine Clinical Tests

predicting mesothelioma survival

UK researchers say predicting mesothelioma survival does not have to be complicated. Their new study shows routine doctor’s office tests may be just as accurate as more complex metrics. The study appears in the new issue of the BMJ Open Respiratory Research journal. It involved 100 patients with malignant mesothelioma over a four-year period.  The team compared treatment outcomes among these patients with their results on basic health tests. More often than not, these tests correctly predicted their prognosis. The researchers say simplifying the process of predicting mesothelioma survival could help doctors and patients make better treatment decisions.  Prognostic Indicators in Asbestos Cancer Malignant pleural mesothelioma is an uncommon but lethal form of membrane cancer. Patients who get it usually … Continue reading Predicting Mesothelioma Survival with Routine Clinical Tests »

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