Metastatic Mesothelioma: Does Chemotherapy Work?

metastatic mesothelioma

New research out of Pennsylvania suggested that not all people with metastatic mesothelioma will live longer with chemotherapy. Although chemotherapy is the primary treatment for malignant pleural mesothelioma, some types of metastatic mesothelioma appear to be less responsive than others. In some cases, the researchers say best supportive care may be a better option for preserving a patient’s quality of life. Three Mesothelioma Subtypes There are three histological subtypes of malignant pleural mesothelioma. The categories are based on how the cells look under a microscope. Cell type appears to influence how aggressive they are as metastatic mesothelioma. Cell type also factors into mesothelioma prognosis. Epithelioid mesothelioma is the most common cell type. Epithelioid cells tend to lack uniformity and may … Continue reading Metastatic Mesothelioma: Does Chemotherapy Work? »

Study Highlights How Genes Impact Mesothelioma Survival

Genes impact mesothelioma survival

A new National Cancer Institute study shines a light on some of the ways genes impact mesothelioma survival. It could have important implications for mesothelioma treatment. The study was led by prominent mesothelioma researcher Raffit Hassan, MD. It focused on genetic mutations that may make certain mesothelioma patients more sensitive to chemotherapy. Genes, Genotype, and Mesothelioma Treatment A mesothelioma patient’s unique collection of genes, including genetic mutations, is known as their genotype. Genes impact mesothelioma survival in a variety of ways. Tumor suppressor genes are supposed to help keep tumors from forming. People with mutations on these genes may be more likely to get malignant mesothelioma. Other genes influence the cancer’s ability to “hide” from detection by the immune system. … Continue reading Study Highlights How Genes Impact Mesothelioma Survival »

Needle Procedure Could Prevent Unneeded Surgery for Malignant Mesothelioma

surgery for malignant mesothelioma

A minimally invasive method for cancer staging could prevent unnecessary surgery for malignant mesothelioma. The method involves putting a needle into the chest behind the breast bone. This area is called the mediastinum. The mediastinum contains critical lymph nodes. The presence or absence of cancer cells in these nodes can help determine whether a patient needs surgery for malignant mesothelioma. Now, a group of Canadian doctors say an ultrasound-guided needle biopsy procedure can provide as much information as more invasive options with less risk and pain. Staging Helps Direct Surgery for Malignant Mesothelioma Most mesothelioma patients receive chemotherapy. If the patient is healthy enough and the cancer has not spread, the patient may also have surgery for malignant mesothelioma. Some … Continue reading Needle Procedure Could Prevent Unneeded Surgery for Malignant Mesothelioma »

Combination Mesothelioma Therapy Begins Pivotal Trial

mesothelioma treatment combination

A combination mesothelioma therapy that showed promise in early trials is finally being studied on a larger scale. The power-packed chemo-immuno-gene therapy known as TR002 has the potential to change the outlook for thousands of malignant mesothelioma patients. A small trial of the combination mesothelioma therapy in 2016 produced “significantly higher” mesothelioma survival rates than most patients are told to expect. Drug company Trizell announced last month that the combination will now be tested on 300 patients at sites in the US, Europe, Australia and Russia. Combination Mesothelioma Therapy Starts with Gene Therapy TR002 is an investigational gene therapy for mesothelioma patients who have failed first-line chemotherapy. This combination mesothelioma therapy is based on the human interferon-alpha 2b gene. The … Continue reading Combination Mesothelioma Therapy Begins Pivotal Trial »

New Tool Could Replace TNM for Predicting Pleural Mesothelioma Survival

pleural mesothelioma survival

A new visual tool could offer a better way to predict pleural mesothelioma survival after surgery than the current TNM staging system. That is the message from cancer researchers at China’s Peking University. The group conducted a study using a large US government database of information on pleural mesothelioma survival and treatment. They used the data to create a visual representation of pleural mesothelioma survival called a nomogram. Testing of the nomogram showed it was more accurate at predicting survival in patients who have mesothelioma surgery than the tool doctors normally use. Pleural Mesothelioma Survival and TNM The most popular method for “staging” cancer is called the TNM staging system. TNM stands for tumor node metastasis. With TNM, the further … Continue reading New Tool Could Replace TNM for Predicting Pleural Mesothelioma Survival »

SMRP Still Among Best Diagnostic Biomarkers for Mesothelioma

biomarkers for mesothelioma

Chinese researchers say soluble mesothelin-related peptides (SMRP) in lung fluid is still one of the best biomarkers for mesothelioma, even if it sometimes produces false positives.. SMRP has been studied extensively as a way to help diagnose mesothelioma. The most popular test to check levels of SMRPs in the body is a blood test called MESOMARK. In recent years, other biomarkers for mesothelioma have also emerged. But SMRPs are not just in the blood. A new meta-analysis of SMRPs from pleural effusions finds that they have a valuable place among top biomarkers for mesothelioma. Biomarkers for Mesothelioma: SMRPs and Others Malignant mesothelioma is a type of cancer that starts on the membranes around the lungs, heart or abdomen. SMRPs are … Continue reading SMRP Still Among Best Diagnostic Biomarkers for Mesothelioma »

Study Reveals Mesothelioma Chemotherapy May Be Underused in Older Patients

mesothelioma chemotherapy treatment

The older a mesothelioma patient is, the less likely he or she may be to receive mesothelioma chemotherapy. A new study says many older mesothelioma sufferers may be paying the price in shorter lifespans. Chemotherapy with pemetrexed (Alimta) and cisplatin is the gold standard for mesothelioma treatment. Many studies have linked it with longer mesothelioma survival. But an Australian study suggests that not enough older people are receiving mesothelioma chemotherapy. In fact, the older they are, the less likely they are to have chemotherapy for their mesothelioma. As a result, their chances of dying from malignant mesothelioma are higher. Mesothelioma Chemotherapy is Standard of Care Malignant mesothelioma is a hard-to-treat cancer with a poor prognosis. Mesothelioma chemotherapy is the primary … Continue reading Study Reveals Mesothelioma Chemotherapy May Be Underused in Older Patients »

Prophylactic Radiation Will Not Prevent Pleural Mesothelioma Metastasis

mesothelioma metastasis prevention

A UK study says prophylactic radiation of the chest wall is unlikely to prevent pleural mesothelioma metastasis.   Pleural mesothelioma is an aggressive cancer caused by asbestos. Tumors start on the lining around the lungs and can spread to the lungs and other organs. Pleural mesothelioma is the most common type of asbestos cancer. Doctors sometimes use procedures that pierce the chest wall to help diagnose mesothelioma or to deal with mesothelioma side effects. Sometimes, new mesothelioma tumors can form along the instrument tracts or in the spot where the chest wall was pierced. When tumors spread it is known as mesothelioma metastasis. Some evidence suggests that radiating the chest wall after a procedure might prevent mesothelioma metastasis in that … Continue reading Prophylactic Radiation Will Not Prevent Pleural Mesothelioma Metastasis »

Longer Mesothelioma Survival Possible with Long-Term Local Chemotherapy

longer mesothelioma survival

There is evidence that repeatedly rinsing the abdomen with medicine might lead to longer mesothelioma survival after surgery. A rinse of heated chemotherapy drugs during surgery has become standard of care for peritoneal mesothelioma. Unfortunately, mesothelioma usually comes back. But a top mesothelioma doctor says longer mesothelioma survival might be possible if patients got regular chemotherapy “rinses” through a catheter. Studies show the drugs may not even have to be heated to work. Longer Mesothelioma Survival After Surgery Peritoneal mesothelioma is a type of asbestos cancer. It starts on the lining around the abdomen and can spread to other parts of the body. About a fifth of mesothelioma patients have this type. Heated intraperitoneal chemotherapy (HIPEC) has led to longer … Continue reading Longer Mesothelioma Survival Possible with Long-Term Local Chemotherapy »

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