Prognosis

A mesothelioma diagnosis comes with many important questions. Perhaps the most crucial question is – what is the prognosis? In fact, the prognosis of mesothelioma varies depending on a number of variables. These variables include:

1. The patient – their age, biology, and state of health
2. The cancer – has the mesothelioma spread or is it localized when it is diagnosed and what is the cell type
3. The treatment or treatments selected
4. The expertise of the treatment team (doctors and other clinicians)

The Patient’s Health

A patient’s general state of health is an important prognostic factor in fighting any disease and mesothelioma is no exception. In addition, a patient’s biology or physiology also plays a role. For example, will chemotherapy work or can it be tolerated? Does the patient have a heart condition so that surgery is not an option? How will the patient’s biology interact with the treatment? The answers to these questions can all play a role in the prognosis.

The Cancer

The spread or lack of spread of the cancer is also an important factor. If mesothelioma is localized it can be easier to treat. In fact, surgery is usually only an option if the cancer has not metastasized. If it has spread then treatment options may be more limited. In addition, there are three cell types of mesothelioma – epithelioid, biphasic, and sacramatoid. The first, epithelioid, often has the best prognosis of the three.

The Treatment

The treatment or therapies selected is also important. Patients can select from conventional therapies (radiation, chemo, and surgery), clinical trials or integrative or alternative modalities. Not every therapy works in every patient. There is an important connection between a person’s physiology, cancer and the treatments selected. The interchange or intersection of these three factors often dictate what the treatment outcome and prognosis will be. Unfortunately, it is often difficult to predict because how a tumor or a treatment acts in a patient’s body is often not known until after the fact.

The Doctors’ Expertise

The last factor is the expertise of your doctors or licensed care givers. How these people do their jobs can be a key factor in prognosis. Are the surgeons experienced with mesothelioma? For example, what is their mortality rate for surgery? The smallest rate bodes better than the highest rate. Also, what options can these treaters suggest? Do they only offer chemo or can they offer a wide range of different modalities and treatment options. All these factors play a role in the prognosis of mesothelioma.

Below are some more details about the prognosis for mesothelioma.

Prognosis of Pleural Mesothelioma

The prognosis of pleural mesothelioma with standard treatment is typically not great.   Median overall survival is a little over a year.  However, there are a number of factors that affect prognosis.

A number of studies have been performed over the years to determine what treatments are optimum for mesothelioma and what factors lead to a better prognosis. Below, we report on several of these.

In a September 2016 Austrian study, a total of 210 patients with malignant pleural mesothelioma were followed.

• 167 (79.5%) were men and 43 (20.5%) were women
• The average age was 67 at the time of diagnosis
• Asbestos exposure was confirmed in 109 (69.4%) patients
• The majority of patients had epithelioid cell type (67.2%)
• Sarcomatoid comprised 16 (7.6%)
• Biphasic was found in 28 patients (13.3%)
• In 25 patients, the cell type was not specified

Data about survival was available for 185 patients. The study found:

• Median overall survival was 19.1 months.
• Pleural mesothelioma patients with early-stage disease (stages I, II) had an overall survival of 26.4 months.
• Pleural mesothelioma patients with late-stage disease (stages III, IV) had an overall survival of 13.0 months .
• Patients with epithelioid cell type had overall survival of 25.1 months.
• Patients with sarcomatoid or biphasic cell type had overall survival of 10.2 months.
• There was no survival difference between males and females.
• There was no survival difference between patients below or above the age of 65 years.
• Survival was significantly better in patients undergoing surgery. However, these patients were significantly younger, had earlier-stage disease, better performance status, and more often had epithelioid subtype.

The study concluded that factors that indicated a better prognosis included: higher Karnofsky score, earlier stage disease, epithelioid cell type, and surgery within multimodality treatment.

• Management of malignant pleural mesothelioma – part 3 : Data from the Austrian Mesothelioma Interest Group (AMIG) database. Klikovits T, et al., Wien Klin Wochenschr. 2016 Sep;128(17-18):627-34.

Prognosis of Peritoneal Mesothelioma

The prognosis of peritoneal mesothelioma has become much better with the advent of surgery and HIPEC.  The following studies illustrate the improvements in prognosis over the last several years.

Peritoneal Mesothelioma Prognosis with Chemotherapy

In a 2011 Greek Study, chemotherapy was used to treat peritoneal mesothelioma patients.  Six patients with peritoneal mesothelioma were treated with 6 cycles of pemetrexed (500 mg/m2) and cisplatin (75 mg/m2). Chemotherapy was administered on an outpatient basis every 3 weeks. The estimated median overall survival was 24 months.

• Systemic chemotherapy with pemetrexed and cisplatin for malignant peritoneal mesothelioma: a single institution experience. Lainakis G, et al., Tumori. 2011 Jan-Feb;97(1):25-9.

Peritoneal Mesothelioma Prognosis with HIPEC

An April 2014 United States Study examined 65 patients with pleural mesothelioma who underwent surgery and HIPEC (hyperthermic intraperitoneal chemoperfusion) between 2001 and 2010.

What is HIPEC for Mesothelioma?

HIPEC is where heated chemotherapy is used to bath the surgical cavity putting the chemo in direct contact where the tumor cells remain.  The study found that overall mesothelioma survival was 46.2 months.  The study also found that although survival was better, there were side effects associated with this treatment approach that included:

• Six percent of the patients died within 60 days.
• Of the 65 patients, 91 % were admitted to the intensive care unit (ICU) postoperatively, with median hospital length of 12 days.
• A total of 12 patients (18 %) underwent reoperation: four patients (33 %) for enteric leak, 1 patient (8 %) for an intra-abdominal abscess, and seven patients (58%) for other reasons.

Factors that contributed to a poor prognosis included:

• Older patient
• More widespread tumors
• More aggressive cell type
• Incomplete surgery
• Post-operative infection

The study concluded that better prognosis is associated with patients who have the epithelioid cell type, lower volume of tumor, and more effective surgery (most tumor removed).

• Malignant peritoneal mesothelioma: prognostic factors and oncologic outcome analysis. Magge D., et al., Ann Surg Oncol. 2014 Apr;21(4):1159-65.

Next: Treatment

Related Posts

Mesothelioma Recurrence After PD Surgery - A new study finds that mesothelioma recurrence after PD surgery is common but most patients still live for more than a year afterwards. More than a third were still alive three years after recurrence. The study included 90 Japanese patients with malignant pleural mesothelioma.  Those who lived for at least a year without mesothelioma recurrence after PD surgery had the best chance of longer term survival. A good performance status and undergoing additional treatment were also key to better outcomes.  Understanding Pleurectomy with Decortication (PD) Surgery Pleural mesothelioma is a virulent cancer that occurs on the membrane around the lungs. There is no cure for mesothelioma. Even with the best treatment, the cancer usually comes back. The goal of most … Continue reading Mesothelioma Recurrence After PD Surgery »

It May Be Possible to Predict Recurrence of Mesothelioma with Help from AI - A newly-published report suggests that artificial intelligence (AI) might help pathologists predict recurrence of mesothelioma. The report focuses on technology developed by the RIKEN Center for Advanced Intelligence Project (AIP) in Japan. The Center claims the computer program taught itself to recognize key features in images of cancer.  Some of the features were ones that even pathologists did not know about. The findings suggest that AI and pathologists could predict recurrence of mesothelioma better than pathologists alone.  How AI Might Predict Recurrence of Mesothelioma  A computer program usually has to be “taught” to perform a certain task. But this limits how far the learning can go. Instead of “teaching” it about cancer, researchers let the RIKEN technology learn on its … Continue reading It May Be Possible to Predict Recurrence of Mesothelioma with Help from AI »

Antibiotic May Boost Response to Radiation Therapy for Mesothelioma - A common antibiotic may improve mesothelioma patients’ response to radiation therapy.  The concept is based on new research from the Perelman School of Medicine at the University of Pennsylvania.  Doctors there gave the antibiotic vancomycin to genetically modified mice. The mice had been modified to develop cancer. Mice that got the antibiotic had a better response to radiation therapy than untreated mice.  The effect applied not only to the treated tumor but also to tumors outside the treatment area. A heightened response to radiation therapy could be good news for patients with metastatic mesothelioma.  Understanding Cancer Response to Radiation Therapy Radiation therapy combats malignant mesothelioma by disrupting the DNA inside cancer cells. Mesothelioma tumors are irregularly-shaped which can make them … Continue reading Antibiotic May Boost Response to Radiation Therapy for Mesothelioma »

Is There a Risk for Depression Among Pleural Mesothelioma Patients? - Newly diagnosed pleural mesothelioma patients may be at higher risk for depression and that could be impacting their outcomes.   A new report finds that people diagnosed with advanced lung cancers are more likely to suffer from depression. Pleural mesothelioma is a form of lung cancer.  This risk for depression appears to have an impact on patients’ quality of life, their pain, and even the number of complications they experience.  Assessing the Risk for Depression in Cancer Patients Researchers at Ohio State University directed the study. It included 186 patients with Stage IV non-small-cell lung cancer. The patients had not yet started their cancer treatment.  Although pleural mesothelioma is not the same as non-small cell lung cancer, the two diseases share … Continue reading Is There a Risk for Depression Among Pleural Mesothelioma Patients? »

Mesothelioma Registry Could Improve Outcomes, Prevent Future Cases - A distinguished team of scientists are calling for a national mesothelioma registry they say could improve outcomes. If the registry collects and provides the right information, they say it could even help prevent future mesothelioma cases. Experts from the CDC, the National Institute for Occupational Safety and Health (NIOSH), and several top US cancer centers participated in a workshop on the topic. The Mesothelioma Applied Research Foundation convened the workshop. The group says existing tumor registries at some cancer centers are not as useful as a national mesothelioma registry. But coordinating a national registry will require government support. What is a Mesothelioma Registry? Malignant mesothelioma is a rare cancer which makes it hard to study. A national mesothelioma registry is … Continue reading Mesothelioma Registry Could Improve Outcomes, Prevent Future Cases »

Pleural Mesothelioma Staging: These Overlooked Lymph Nodes Might Help - An often-ignored set of lymph nodes behind the ribs could help make pleural mesothelioma staging more accurate and valuable.  Staging is the process of determining how advanced a patient’s cancer is. It involves looking at various different factors and assigning a rating between 0 and 4. A higher stage indicates more extensive cancer. A new report suggests that the posterior intercostal lymph nodes behind the ribs play a more important role in pleural mesothelioma staging than previously thought. Mesothelioma patients with cancer in these nodes lived half as long as other mesothelioma patients.  Researchers in Maryland and Pennsylvania say removing and examining these nodes may lead to more accurate staging, more informed treatment decisions, and better outcomes.   How Lymph Nodes … Continue reading Pleural Mesothelioma Staging: These Overlooked Lymph Nodes Might Help »

The Pathological Diagnosis of Mesothelioma: New Recommendations - An international team of researchers says it is time to refine the pathological diagnosis of mesothelioma. They are recommending a list of changes they say could make the process more effective. Mesothelioma is a deadly cancer caused by asbestos exposure. Under current pathology guidelines, it falls into just three categories. But the research team says those guidelines do not give doctors enough information. They recommend updates to make the pathological diagnosis of mesothelioma more specific.  Understanding Mesothelioma Pathology Pathologists study body tissue, fluids, and cells that are surgically removed. The pathological diagnosis of mesothelioma involves looking at cells under a microscope. Cells can then be put into a category.  About three quarters of mesothelioma cases are epithelioid. Epithelioid mesothelioma is … Continue reading The Pathological Diagnosis of Mesothelioma: New Recommendations »

Step Counts for Cancer Prognosis: Could it Work for Mesothelioma? - Cancer researchers in New York are exploring the concept of using step counts for cancer prognosis. If further studies back it up, the technique might help predict outcomes for people with mesothelioma. The new study involved people with non-small cell lung cancer. The patients wore commercial fitness trackers so doctors could see how much they walked.  The researchers compared step levels with treatment outcomes. They concluded that there is value to using step counts for cancer prognosis. It may even be more effective than some more traditional methods for predicting survival. Cancer Prognosis and Chemoradiotherapy Mesothelioma survival usually depends on how well patients respond to standard treatments. Healthier, more active cancer patients tend to have better outcomes.  Chemotherapy and radiation … Continue reading Step Counts for Cancer Prognosis: Could it Work for Mesothelioma? »

Risk for Malnutrition Among Older Mesothelioma Patients - A new study out of Brazil suggests that many older mesothelioma patients may be at risk for malnutrition and the problems that go with it.  The study included more than 4,500 Brazliian cancer patients from 45 hospitals. They were evaluated for their nutritional status, nutritional risk, and nutrition-related symptoms. Among the 25% of cancer patients over 65, more than half faced a moderate to severe risk for malnutrition. The findings suggest it is a problem hospitals should identify and address early for the best mesothelioma treatment outcomes.  Mesothelioma and Nutritional Status As with other types of cancer, nutrition has an affect on the treatment of people with mesothelioma.  An Australian study of pleural mesothelioma patients earlier this year found that … Continue reading Risk for Malnutrition Among Older Mesothelioma Patients »

Large Study Finds Treatment Combination Leads to Long-Term Mesothelioma Survival - There is more evidence that surgery and intraperitoneal chemotherapy can lead to long-term mesothelioma survival. The news comes from an Australian study of more than 1,200 cancer patients. The study finds that one in five peritoneal mesothelioma patients who had this treatment combination were still alive 10 years later.  Peritoneal Cancer Survival with Surgery  Peritoneal cancers occur on the lining of the abdomen. Peritoneal mesothelioma starts on this peritoneal membrane. Some other peritoneal cancers start elsewhere in the body and spread to the peritoneum. The new Australian study analyzed the cases of peritoneal cancer patients who had cytoreductive surgery between 1996 and 2018. Cytoreductive surgery aims to remove as much of the cancer as possible. Past studies have found that … Continue reading Large Study Finds Treatment Combination Leads to Long-Term Mesothelioma Survival »