Long Term Peritoneal Mesothelioma Survival with NIPEC

Long Term Peritoneal Mesothelioma Survival

A new report suggests that long term peritoneal mesothelioma survival may be possible with a treatment called NIPEC and the drug paclitaxel.  NIPEC stands for normothermic intraperitoneal chemotherapy. It is similar to the heated chemotherapy that many peritoneal mesothelioma patients now get. But NIPEC is delivered through a catheter over time and at room temperature.  The new article details the long term peritoneal mesothelioma survival of six patients on NIPEC with paclitaxel. It comes from one the nation’s leading experts in this form of mesothelioma, Paul Sugarbaker, MD.  Even though the sample size is small, Dr. Sugarbaker says the results are impressive enough to warrant further study.  HIPEC and Mesothelioma Treatment Peritoneal mesothelioma accounts for about 20 percent of mesothelioma … Continue reading Long Term Peritoneal Mesothelioma Survival with NIPEC »

Immunotherapy with Durvalumab: Record Survival in Inoperable Mesothelioma

immunotherapy drug durvalumab

There is new evidence that the immunotherapy drug durvalumab may make chemotherapy more effective for people with inoperable pleural mesothelioma. Researchers recently achieved record mesothelioma survival times with this combination. Mesothelioma is a rare cancer with a poor prognosis. Surgery can sometimes help if it is caught early. But only a small percentage of patients are candidates for mesothelioma surgery. Most have chemotherapy, which is only moderately effective.  But new research presented to the nation’s largest gathering of cancer doctors shows the immunotherapy drug durvalumab may help.  Doctors at Johns Hopkins combined durvalumab with standard mesothelioma chemotherapy. Study participants lived an average of 8 months longer than is typical with this disease.  If further studies confirm the benefit, it could … Continue reading Immunotherapy with Durvalumab: Record Survival in Inoperable Mesothelioma »

Proton Therapy for Mesothelioma: New Consensus Statement

proton therapy for mesothelioma

A group of international experts in radiation oncology say proton therapy for mesothelioma may be a safer alternative to standard radiotherapy.  Proton therapy uses protons instead of photons to destroy mesothelioma tumor cells.  The group evaluated both types of radiation therapy. They conclude that proton therapy for mesothelioma is less likely to damage the opposite lung and other organs.  What is Proton Therapy? Conventional radiation therapy for mesothelioma uses photons. A radiation oncologist delivers photons into the tumor with a linear accelerator. The photons or X-rays permanently damage the DNA. Damaged mesothelioma cells cannot grow and divide normally and the cells die.  The downside of standard radiation therapy is that normal tissue absorbs some of the damaging photons, too. This … Continue reading Proton Therapy for Mesothelioma: New Consensus Statement »

Opdivo for Mesothelioma Recurrence is Safe and Effective, Study Finds

Opdivo for mesothelioma recurrence

A new Japanese study appears to show that Opdivo for mesothelioma recurrence after surgery is safe and effective.  Opdivo (nivolumab) is an immunotherapy drug similar to Keytruda (pembrolizumab). It blocks a protein called PD-L1. PD-L1 helps mesothelioma cells avoid detection by the immune system.  In the latest study, 35 patients received Opdivo for mesothelioma recurrence. More than three quarters of them experienced either stable or decreased disease. Understanding How Nivolumab Works Nivolumab is most often used to treat non-small cell lung cancer. It makes tumors more vulnerable to immune system attack. Pleural mesothelioma has many of the same characteristics as lung cancer. This is one reason researchers are hopeful about Opdivo for mesothelioma recurrence.  The primary treatment for mesothelioma is … Continue reading Opdivo for Mesothelioma Recurrence is Safe and Effective, Study Finds »

Best Practices for Pleural Mesothelioma: Updated Recommendations from Europe’s Top Doctors

best practices for pleural mesothelioma

Europe’s top mesothelioma experts have released new best practices for pleural mesothelioma. They include the latest recommendations on diagnosis, staging, monitoring, and treatment. The task force was made up of members from:  European Respiratory Society (ERS) European Society of Thoracic Surgeons (ESTS) European Association for Cardio-Thoracic Surgery (EACTS) European Society for Radiotherapy and Oncology (ESTRO) This is the first time the best practices for pleural mesothelioma were updated since 2009. The group based the new recommendations on mesothelioma data gathered in the last decade.  Mesothelioma Remains a Global Challenge Malignant mesothelioma is one of the world’s most challenging cancers. Doctors know that asbestos exposure causes mesothelioma. But many other things about this disease are a mystery.  Some people with a … Continue reading Best Practices for Pleural Mesothelioma: Updated Recommendations from Europe’s Top Doctors »

Photodynamic Therapy and Immunotherapy: A Powerful Mesothelioma Combo?

photodynamic therapy and immunotherapy

Swiss doctors have used a combination of photodynamic therapy and immunotherapy to dramatically shrink mesothelioma tumors in mice.  More than a third of mice treated with an immune checkpoint inhibitor and low-dose light therapy experienced complete regression of their cancer.  The new study explores how photodynamic therapy and immunotherapy can work together. The answers could have important implications for tens of thousands of people suffering from asbestos cancer.  Two Different Approaches to Mesothelioma Mesothelioma is a rare but deadly cancer caused by asbestos exposure. Pleural mesothelioma occurs on the membrane around the lungs. It is the most common type of mesothelioma. Around 2,500 Americans receive a mesothelioma diagnosis each year. There is no cure. Photodynamic therapy and immunotherapy both show … Continue reading Photodynamic Therapy and Immunotherapy: A Powerful Mesothelioma Combo? »

Radiotherapy Before Mesothelioma Surgery May Not Be Worth the Risk

Radiotherapy before mesothelioma surgery

Cancer doctors at Mayo Clinic say they do not plan to start routinely performing radiotherapy before mesothelioma surgery. The idea is based on a radiation protocol called SMART. The team monitored how well the SMART protocol worked among their pleural mesothelioma patients over a one year period.  The Mayo doctors acknowledged that radiotherapy before mesothelioma surgery can sometimes improve outcomes. But too many of their patients developed serious complications. In a recently-published article, the team concludes that SMART may not be worth the risk for most patients.  The SMART Way to Treat Mesothelioma? Pleural mesothelioma grows on the membrane that surrounds the lungs. Mesothelioma tumors lie close to the lungs and heart and may spread to one or both lungs. … Continue reading Radiotherapy Before Mesothelioma Surgery May Not Be Worth the Risk »

Researchers Argue Against Surgery for Mesothelioma

surgery for mesothelioma

A pair of California surgeons say surgery for mesothelioma is rarely worthwhile. They point to what they say are flawed studies on surgical treatment. One trial they believe was well-conducted seems to show reduced mesothelioma survival after surgery. Writing in the journal Translational Lung Cancer Research, the doctors argue that most patients should choose non-surgical treatment for mesothelioma.  Some Background on Surgery for Mesothelioma Pleural mesothelioma is a cancer of the lining around the lungs. It is an aggressive cancer with no known cure. There are two primary approaches to surgery for mesothelioma. Both types are controversial and the subject of much debate among surgeons.  Extrapleural pneumonectomy (EPP) is a surgical approach that involves removing the pleural membrane, one lung, … Continue reading Researchers Argue Against Surgery for Mesothelioma »

Targeted Radiotherapy for Mesothelioma May Extend Survival in the Right Patients

targeted radiotherapy for mesothelioma

A meta-analysis conducted by some of the country’s top cancer researchers says targeted radiotherapy for mesothelioma can help some people live longer. It is the first such analysis of targeted radiation after lung-sparing mesothelioma surgery. The team focused on intensity modulated radiation therapy (IMRT). IMRT is more precise than earlier forms of radiation treatment.  The new article appears in Practical Radiation Oncology. It is a meta-analysis of ten smaller studies. The researchers conclude that healthier surgery patients could safely consider targeted radiotherapy for mesothelioma. Making Radiotherapy Less Toxic In the past, radiation for mesothelioma has sometimes done more harm than good. Earlier types of radiation treatment were not as precise as IMRT. When radiation spills over into healthy tissue, it … Continue reading Targeted Radiotherapy for Mesothelioma May Extend Survival in the Right Patients »

Tumor Treating Fields for Mesothelioma Faces Criticism

tumor treating fields

Tumor Treating Fields for mesothelioma is coming under fire from some other researchers. The treatment uses electricity to interfere with division of cancer cells. The FDA approved it for mesothelioma last year under the Humanitarian Device Exemption. It is only the second treatment ever approved for asbestos cancer.  But scientists in Italy and the Netherlands are disputing some of the findings from the STELLAR trial of TTFields. They published separate articles in a recent issue of The Lancet Oncology. STELLAR tested Tumor Treating Fields along with chemotherapy as a novel mesothelioma treatment. The FDA based its approval on the STELLAR results.  But the newly published articles suggest that there were problems with the trial. Both say Tumor Treating Fields is … Continue reading Tumor Treating Fields for Mesothelioma Faces Criticism »

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