Mesothelioma-Related Weight Loss: Synthetic Cannabinoid Might Help
The first patient has been treated in the trial of a new drug that might help people suffering from mesothelioma-related weight loss. The drug is a synthetic cannabinoid called ART27.13. A cannabinoid is a compound that acts on the CB1 and CB2 receptors of the endocannabinoid system. There are a number of cannabinoid drugs on the market. But several of them have significant side effects, including effects on the brain. Preclinical data on ART27.13 suggest that it may stimulate the appetite and counter mesothelioma-related weight loss with fewer unwanted side effects. The Cancer Appetite Recovery Study (CAReS) is a Phase I trial to test it in people. The Danger of Mesothelioma-Related Weight Loss Over 60 percent of late-stage cancer patients … Continue reading Mesothelioma-Related Weight Loss: Synthetic Cannabinoid Might Help
Triple-Modality Therapy May Improve Mesothelioma Outcomes, Study Suggests
A Canadian study suggests that triple-modality therapy with radiotherapy, immunotherapy, and surgery may extend the lives of people with malignant pleural mesothelioma. Pleural mesothelioma is an intractable cancer with a poor prognosis. It mainly affects people who have lived or worked around asbestos. There is no cure for mesothelioma. People who have the best mesothelioma outcomes usually have a combination of treatments. Now, scientists at Toronto General Hospital’s Research Institute say a triple-modality therapy they tested in mice might have the power to extend human lives, too. Multi-modal Mesothelioma Treatment Pleural mesothelioma is a fast-growing cancer that starts on the membrane around the lungs. Many mesothelioma patients die less than a year after diagnosis. There is no single accepted treatment … Continue reading Triple-Modality Therapy May Improve Mesothelioma Outcomes, Study Suggests
Canadian Study Highlights Occupational Mesothelioma Risk
A new study of more than 2 million Canadian workers is shining a spotlight on the occupational mesothelioma risk from asbestos exposure in several industries. The study included data on 2.18 million workers in the Occupational Disease Surveillance System (ODSS). These workers were employed from 1983 to 2014. The researchers followed the workers for years to see how many of them developed mesothelioma or a chronic lung disease called asbestosis. They compiled the data on which industries had the most diagnoses. The results paint a sobering picture of the occupational mesothelioma risk to thousands of industrial workers. Asbestos and the Link to Mesothelioma Asbestos is a fibrous mineral that occurs naturally in the soil in many parts of the world. … Continue reading Canadian Study Highlights Occupational Mesothelioma Risk
Chemotherapy Resistance in Mesothelioma Patients: New Insights
Canadian cancer researchers have discovered what may be a key cause of chemotherapy resistance in mesothelioma and other types of cancer. The news could lead to more effective ways of treating malignant mesothelioma. Chemotherapy resistance is a major problem for mesothelioma patients. The FDA has approved two different drug therapies for mesothelioma. But neither approach seems to hold asbestos cancer at bay long term. Scientists at Princess Margaret Cancer Centre in Toronto say it may be because cancer cells “hibernate” to escape attack. If doctors can understand this cancer cell defense mechanism, they might be able to undermine it. The Problem of Chemotherapy Resistance Malignant mesothelioma is the most serious of several illnesses caused by exposure to asbestos. Asbestos fibers … Continue reading Chemotherapy Resistance in Mesothelioma Patients: New Insights
Liquid Biopsy for Early Stage Mesothelioma Diagnosis
Canadian researchers are exploring a liquid biopsy test that could lead to early diagnosis of malignant mesothelioma. The test is based on mesothelial precursor cells (MPC). The researchers say these cells – in combination with mesothelin and some kinds of stem cells – “could be implicated” in the development of mesothelioma. A liquid biopsy detects cells in blood instead of tissue. The University of Toronto scientists think MPC in blood may be a new mesothelioma biomarker. If it proves to be true, this kind of biopsy might be able to identify mesothelioma patients even before they have symptoms. How Liquid Biopsy Works Patients with suspected mesothelioma may have many tests. Imaging scans and blood tests can help tell if a … Continue reading Liquid Biopsy for Early Stage Mesothelioma Diagnosis
Novel Strategy May Improve Immuno-radiotherapy for Mesothelioma
Canadian scientists say suppressing certain kinds of immune system cells could improve the effectiveness of immuno-radiotherapy for mesothelioma. Mesothelioma is a fast-growing membrane cancer caused by asbestos. Doctors have not found a single therapy that can beat it. For most patients, a combination of treatments offer the best survival odds. Immuno-radiotherapy for mesothelioma combines two types of treatments. Immunotherapy drugs activate the immune system while radiation attacks the tumor directly. Mesothelioma tumors fight back against both kinds of treatments. But researchers testing a combination of the two may have found a way to make it even more powerful. How Immuno-Radiotherapy for Mesothelioma Works Malignant mesothelioma is one of the most treatment-resistant cancers. Doctors have to attack it from many different … Continue reading Novel Strategy May Improve Immuno-radiotherapy for Mesothelioma
Pandemic-Related Mesothelioma Treatment Delays Could Impact Outcomes
Mesothelioma treatment delays that happened because of the COVID-19 pandemic will probably impact survival rates for some patients. A new study of Canadian lung cancer patients found that more than half of them stopped or delayed treatment because of concerns about the virus this spring. Pleural mesothelioma is a lung-related cancer. Like lung cancer patients, mesothelioma patients face a higher risk of virus-related complications because they already have breathing problems. But mesothelioma is also a fast-growing cancer. Most patients get several kinds of treatment at the same time. Mesothelioma treatment delays may give tumors a chance to grow unchecked. A Catch-22 for Mesothelioma Patients Mesothelioma patients and others with lung diseases have had to make some difficult decisions because of … Continue reading Pandemic-Related Mesothelioma Treatment Delays Could Impact Outcomes
Minimally Invasive Lymph Node Staging May Prevent Unnecessary Mesothelioma Surgery
A minimally invasive procedure for lymph node staging may help some pleural mesothelioma patients avoid the pain and risk of surgery. That is the conclusion of a recent study on endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). EBUS-TBNA is a minimally invasive method for testing the lymph nodes deep in the chest (mediastinal lymph nodes). If lymph node staging shows evidence of pleural mesothelioma, surgery is less likely to be effective. Mediastinal Lymph Node Staging and Mesothelioma Pleural mesothelioma is a rare cancer that starts on the membrane around the lungs. It can spread to the lungs and other organs and is usually fatal. The mediastinal lymph nodes are located in the area between the lungs. When the body is fighting … Continue reading Minimally Invasive Lymph Node Staging May Prevent Unnecessary Mesothelioma Surgery
Needle Procedure Could Prevent Unneeded Surgery for Malignant Mesothelioma
A minimally invasive method for cancer staging could prevent unnecessary surgery for malignant mesothelioma. The method involves putting a needle into the chest behind the breast bone. This area is called the mediastinum. The mediastinum contains critical lymph nodes. The presence or absence of cancer cells in these nodes can help determine whether a patient needs surgery for malignant mesothelioma. Now, a group of Canadian doctors say an ultrasound-guided needle biopsy procedure can provide as much information as more invasive options with less risk and pain. Staging Helps Direct Surgery for Malignant Mesothelioma Most mesothelioma patients receive chemotherapy. If the patient is healthy enough and the cancer has not spread, the patient may also have surgery for malignant mesothelioma. Some … Continue reading Needle Procedure Could Prevent Unneeded Surgery for Malignant Mesothelioma
Shortness of Breath Treatment Can ‘Seed’ New Mesothelioma Tumors
Mesothelioma patients who get pleural catheters to help with shortness of breath may pay a high price. New research shows about a quarter of them will develop new mesothelioma tumors at the spot where the catheter was placed. In a newly published paper, Canadian researchers say doctors need to consider the possibility of these catheter tract metastases (CTMs) when advising mesothelioma patients. Indwelling Pleural Catheters and Mesothelioma Many mesothelioma patients develop excess fluid around their lungs. This fluid puts pressure on the lungs and makes it hard for patients to get a deep breath. Shortness of breath is a common symptom of pleural mesothelioma. Indwelling pleural catheters (IPCs) can help. An IPC is a little tube inserted into the pleural … Continue reading Shortness of Breath Treatment Can ‘Seed’ New Mesothelioma Tumors
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