When Chemotherapy Fails: Apatinib May Offer Third-Line Option for Mesothelioma Patients

An investigational drug being developed in China may offer a third lifeline to mesothelioma patients whose cancer does not respond to other chemotherapy drugs. Apatinib, also called YN968D1, is a tyrosine kinase inhibitor that is thought to help prevent the formation of blood vessels that mesothelioma tumors need to grow and spread. Right now, there is no approved second-line treatment for pleural mesothelioma, let alone a third-line treatment. Chinese researchers at 363 Hospital in Cheng Du — along with mesothelioma patients around the world — are hoping that apatinib will change that. Mesothelioma Case Study The researchers are hanging their hopes on the case of a 58-year old woman who showed up at their hospital complaining that she had had … Continue reading When Chemotherapy Fails: Apatinib May Offer Third-Line Option for Mesothelioma Patients »

Is it Time for a Curcumin-Based Mesothelioma Treatment?

Yet another scientific study appears to confirm the power of the spice-derived compound curcumin as a weapon against malignant pleural mesothelioma. The Chinese researchers who conducted the latest study say the substance has the potential to be the basis of a whole new way of treating this aggressive asbestos cancer. This team tested curcumin on a line of mouse mesothelioma cells, both in the lab and in live animals, and published their promising results in the prestigious International Journal of Oncology. Curcumin’s Impact on Mesothelioma Cells Curumin is a primary chemical in turmeric, responsible for the root’s spicy flavor and characteristic yellow hue. If turmeric does, in fact, help fight cancer, as so many health food stores and supplement makers … Continue reading Is it Time for a Curcumin-Based Mesothelioma Treatment? »

Radiofrequency Ablation for Recurrent Mesothelioma: A New Treatment Option?

A procedure normally used to help alleviate pain has been used to successfully stop a case of recurrent malignant pleural mesothelioma in Japan. Radiofrequency ablation (RFA) uses electrical energy delivered through a thin, hollow needle to heat and destroy cancer cells. Most of the time, this technology is used to destroy small tumors or a treat small area of cancer to alleviate symptoms such as pain or discomfort. But thoracic surgeons at the Hyogo College of Medicine in Hyogo, Japan say their new case study suggests that the procedure should also be considered as a definitive treatment — especially for mesothelioma patients for whom surgery is not a viable option. Complex Mesothelioma Case Drives RFA Decision In a new report … Continue reading Radiofrequency Ablation for Recurrent Mesothelioma: A New Treatment Option? »

Mobile App Could Help Mesothelioma Patients Find New Treatments

Mesothelioma patients now have a high-tech new way to connect with cutting edge mesothelioma treatments around the world – for a price. A pair of Harvard-trained oncologists have just rolled out a new app that promises to connect people who have cancers like pleural mesothelioma with treatments and clinical trials that even their physicians may not be aware of. The app, called Driver, is being rolled out this week in the US and China in the wake of a trial run with a hundred people over the past year. How Might Driver Help Mesothelioma Patients? One of the biggest obstacles faced by patients diagnosed with rare cancers like pleural or peritoneal mesothelioma is getting the most up-tp-date information about potential … Continue reading Mobile App Could Help Mesothelioma Patients Find New Treatments »

Mesothelioma Tumors Thrive in Low Oxygen Environment

Epithelioid cells

South Korean researchers have uncovered a clue that might help explain why mesothelioma tumors are so aggressive — and what can be done to counter that aggression. The new study centers on hypoxia, a deficiency in the amount of oxygen reaching the tissues. It is a hallmark of many types of solid tumors and it turns out that malignant mesothelioma tumors are no exception. Patients with these hypoxic tumors tend to worsen quickly, be less responsive to treatment, and end up with poor outcomes. The Effect of Oxygen on Malignant Mesothelioma Scientists in the Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University are trying to better understand how hypoxia effects human malignant mesothelioma cells and exactly what … Continue reading Mesothelioma Tumors Thrive in Low Oxygen Environment »

Telomere Length May Be Key to Earlier Detection of Pleural Mesothelioma

Japanese pathologists have a new theory that may lead to earlier detection and better outcomes for people with malignant pleural mesothelioma. Researchers led by the International University of Health and Welfare in Tokyo say exposure to asbestos appears to shorten the telomeres that protect the ends of DNA strands. The discovery could give doctors another way to diagnose malignant mesothelioma in time to implement more effective treatments. What are Telomeres? Telomeres are the caps on the end of each strand of DNA. According to Telomere Activation Sciences, telomeres function like the plastic tips on the ends of shoelaces. Like those tips, telomeres help protect chromosomes from becoming frayed and damaged. When DNA is damaged, normal cellular processes are disrupted and … Continue reading Telomere Length May Be Key to Earlier Detection of Pleural Mesothelioma »

Opdivo for Malignant Mesothelioma: Could a Lower Dose Work?

There is new evidence that low doses of the drug Opdivo (nivolumab) may extend lung cancer survival as well as the standard dose—at a much lower cost. The news may have implications for people with the lung-related asbestos cancer, malignant mesothelioma, who are also sometimes treated with Opdivo. Pleural mesothelioma is a hard-to-treat cancer that grows on the lining around the lungs and causes many of the same symptoms as lung cancer. Some evidence has suggested that Opdivo, an immunotherapy drug already approved for the treatment of recurrent lung cancer, may soon become the first drug approved for recurrent mesothelioma, too. Now, a newly-published Korean study finds that patients may not need as much of the drug as originally thought … Continue reading Opdivo for Malignant Mesothelioma: Could a Lower Dose Work? »

Hundreds of Mesothelioma Deaths Predicted for Taiwan

Taiwanese cancer researchers say a total asbestos ban is “urgently needed” to help stem the tide of pleural mesothelioma cases predicted in the next 30 years. While the incidence of malignant mesothelioma has finally begun to level off in some countries, its incidence worldwide continues to grow. Taiwan is just one example of a country where mesothelioma rates, as well as the rates of other asbestos-related diseases (ARDs), are expected to keep climbing for at least another couple of years. Even after 2020, the authors of a new mesothelioma study say the disease will continue to be a problem for decades, highlighting the need for Taiwan to implement a total asbestos ban and devote more resources to mesothelioma screening, diagnosis, … Continue reading Hundreds of Mesothelioma Deaths Predicted for Taiwan »

Nurse Compassion May Improve Mesothelioma Outcomes

counseling

Recent research suggests that how people with lung cancers like pleural mesothelioma are treated by their oncology nurses can have a direct bearing on their treatment outcomes. The news is based on a groundbreaking study conducted at two Chinese universities and published in Psychology Research and Behavior Management. Empathy and Lung Cancer Survival The study focused on 365 lung cancer patients who were cared for by 30 different nurses at a Beijing hospital between October 2016 and May 2017. Researchers used a test called flow cytometry to measure the activity of cancer fighting immune system cells including T-cells, B-cells and natural killer (NK) cells. These cells are also activated in patients battling malignant mesothelioma and other cancers. This “cellular immunity” … Continue reading Nurse Compassion May Improve Mesothelioma Outcomes »

New Study Examines Early Recurrence of Peritoneal Mesothelioma After Surgery

Symptoms of Peritoneal Mesothelioma

There is some good news and some bad news this week for patients with malignant peritoneal mesothelioma, an aggressive form of cancer that occurs on the lining of the abdomen. Both come from a new article on peritoneal cancer published in the International Journal of Clinical Oncology. The good news is that most patients with peritoneal mesothelioma and other forms of cancer on the peritoneal membrane respond well to the multi-modal treatment regimen that has become the standard-of-care for this form of the asbestos cancer. A combination of cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) allows most peritoneal cancer patients to “achieve long-term disease-free survival”, according to the study from the National Cancer Centre Singapore. But the more disturbing … Continue reading New Study Examines Early Recurrence of Peritoneal Mesothelioma After Surgery »

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