New Study Examines Early Recurrence of Peritoneal Mesothelioma After Surgery

Symptoms of Peritoneal Mesothelioma

There is some good news and some bad news this week for patients with malignant peritoneal mesothelioma, an aggressive form of cancer that occurs on the lining of the abdomen. Both come from a new article on peritoneal cancer published in the International Journal of Clinical Oncology. The good news is that most patients with peritoneal mesothelioma and other forms of cancer on the peritoneal membrane respond well to the multi-modal treatment regimen that has become the standard-of-care for this form of the asbestos cancer. A combination of cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) allows most peritoneal cancer patients to “achieve long-term disease-free survival”, according to the study from the National Cancer Centre Singapore. But the more disturbing … Continue reading New Study Examines Early Recurrence of Peritoneal Mesothelioma After Surgery »

Life After Mesothelioma Can Still Be a Challenge

A new Japanese study has some sobering news for people hoping to survive malignant mesothelioma: Life after mesothelioma can still be challenging. The study was conducted by multiple centers across Japan. A total of 133 mesothelioma patients who had been free of disease for at least five years completed questionnaires about their experiences and their quality of life. Assessing the Lives of Mesothelioma Survivors To get a picture of what life is like for mesothelioma survivors, the study group sent a 64-question survey to hospitals and patient advocacy groups. Patients completed the questionnaire themselves and then returned it to the researchers by mail. The questions specifically about quality-of-life came from the European Organization for Research and Treatment of Cancer and the … Continue reading Life After Mesothelioma Can Still Be a Challenge »

Hard-to-Find Therapy Fights Mesothelioma Tumors with Carbon Ions

Carbon ion therapy—a cancer treatment developed in California but currently only available outside the US—may have the ability to significantly slow down the growth and spread of pleural mesothelioma tumors. Researchers at one of the world’s most experienced carbon ion therapy centers in Chiba, Japan shared that conclusion in a new article in the journal Oncotarget. According to the new research, carbon ion beams directed at two lines of malignant mesothelioma cells in the lab “suppressed cell viability”. The addition of cisplatin, one of two primary chemotherapy drugs used in the treatment of mesothelioma around the world, “significantly enhanced its action.” The news is likely to be both exciting and frustrating for American mesothelioma patients who do not yet have … Continue reading Hard-to-Find Therapy Fights Mesothelioma Tumors with Carbon Ions »

New Surgical Technique May Improve Mesothelioma Survival

A new study is asking the question, is it possible to remove a malignant mesothelioma tumor with pleurectomy-decortication (P/D) without risking the spread of new tumors? P/D, the lung-sparing pleural mesothelioma surgery, has become the preferred approach in many cases where mesothelioma has not spread to the lung tissue. Most studies have found that P/D has a lower complication rate, produces less pain, and allows for faster recovery than the more radical extrapleural pneumonectomy (EPP), in which surgeons remove a lung along with the diseased pleural membrane. But as a group of Japanese researchers note in a new article in the journal Surgery Today, the current method of performing P/D also poses significant risks for mesothelioma patients. One of these is the … Continue reading New Surgical Technique May Improve Mesothelioma Survival »

Blood Test May Not Predict Mesothelioma Survival as Well as Hoped

A new Japanese study is calling into question the value of a common prognostic test for people with malignant pleural mesothelioma. The test is called the neutrophil-to-lymphocyte ratio or NLR and it is used in many types of diseases, including mesothelioma, as a marker for inflammation. But in a new report published in the journal In Vivo, researchers with the Hyogo Prefectural Amagasaki General Medical Center say they found no relationship between NLR and overall survival in 143 mesothelioma patients. Instead, the scientists found that a different inflammation marker called C-reactive protein-to-albumin ratio (CAR) was a much better predictor of overall mesothelioma survival. How Does NLR Relate to Mesothelioma? Neutrophils are the most abundant type of white blood cells in … Continue reading Blood Test May Not Predict Mesothelioma Survival as Well as Hoped »

Bullfrog Eggs May Hold the Secret to Mesothelioma Survival

Researchers in Japan believe they may have discovered a new and more effective drug for the intractable asbestos cancer, malignant pleural mesothelioma – and it comes from an unlikely source. Sialic acid-binding lectin (cSBL) is a protein derived from the eggs of bullfrogs. It has the ability to bind to cell membranes and appears to exhibit antitumor activity through the degradation of RNA. Previous studies have shown cSBL to be involved in a variety of important biological processes. A New Kind of Mesothelioma Treatment? In a new report published in the open-access online medical journal PLoS One, researchers from the Tohoku Medical and Pharmaceutical University in Sendai, Japan say cSBL has the potential to extend mesothelioma survival. The team first tested … Continue reading Bullfrog Eggs May Hold the Secret to Mesothelioma Survival »

Predicting Mesothelioma Survival: A New Model

mesothelioma diagnosis

Could a geometric diagram hold the key to predicting the treatment outcomes of patients with malignant pleural mesothelioma? A team of thoracic surgery experts at China’s Fudan University believe the answer is yes. The team has developed such a diagram, called a nomogram, and used it to demonstrate the connection between a list of prognostic factors and actual mesothelioma survival. Predicting Mesothelioma Prognosis The new nomogram, recently published in the World Journal of Surgery, uses information on malignant mesothelioma treatments and outcomes from the Surveillance, Epidemiology, and End Results (SEER) database to offer a prediction model for overall mesothelioma survival. To build it, researchers analyzed the prognostic value of a long list of variables including age, gender, race, year of … Continue reading Predicting Mesothelioma Survival: A New Model »

A New Approach to Reducing Mesothelioma Risk in Asbestos-Exposed People

The Japanese researchers who first suggested that removing iron from the body could help prevent malignant mesothelioma have come up with a way to make the process even easier and safer. In their original 2016 study, scientists at Nagoya University Graduate School of Medicine induced a pre-mesothelioma state in lab rats by injecting their abdomens with deadly crocidolite asbestos. As predicted, the rats exhibited all the precursors to the development of peritoneal mesothelioma – inflammation, higher iron levels, and oxidative stress. The team then attempted to lower the risk and stave off mesothelioma by giving the rats an iron-removing agent called desferal. Excess Iron Can Lead to a Mesothelioma Diagnosis The good news from the original study is that removing … Continue reading A New Approach to Reducing Mesothelioma Risk in Asbestos-Exposed People »

Immune System Changes Could Signal Mesothelioma Risk

The state of an asbestos-exposed person’s immune system might give doctors clues about how likely they are to develop malignant mesothelioma. It’s a fear for any person who has worked around asbestos – that one day they may develop the asbestos-linked cancer, mesothelioma. Pleural mesothelioma can take decades to develop, causes few symptoms at first, and is extremely hard to treat. Right now, there is no definitive way to screen for it. Even making a mesothelioma diagnosis is a challenge. Now, a team of occupational medicine experts in Japan and China have released an article in Environmental Health and Preventive Medicine detailing a list of biomarkers they believe may indicate asbestos-induced immune changes that could result in mesothelioma. How Asbestos … Continue reading Immune System Changes Could Signal Mesothelioma Risk »

Fish and Sunlight May Lower Mesothelioma Risk

Want to lower your risk for malignant mesothelioma and other common cancers? Get more sunlight, eat more fish, and consider Vitamin D supplements. That advice comes from Michael Holick, MD, PhD, a long-time expert in Vitamin D at Boston University and is supported by a growing body of new research. In an article in the Journal of Clinical & Translational Endocrinology, Dr. Holick discusses the relationship between blood levels of Vitamin D and deadly cancers like malignant mesothelioma. “Although the exact mechanism by which enhanced vitamin D status reduces risk for cancer is not completely understood,” he writes, “there is evidence that by raising blood levels of 25-hydroxyvitamin D this metabolite can enter a wide variety of cells in the … Continue reading Fish and Sunlight May Lower Mesothelioma Risk »

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