Peritoneal Mesothelioma Surgery with HIPEC Can Trigger Blood Cell Problems

peritoneal mesothelioma surgery with HIPEC

More than half of patients who have peritoneal mesothelioma surgery with HIPEC develop problems with their blood cells afterward. That’s the finding of a team of cancer researchers from Singapore.  The group analyzed 15 years worth of data on peritoneal mesothelioma surgery outcomes. They found that, even though the procedure saves lives, it can be risky.  Older patients and those who had prior chemotherapy were most likely to develop hematological toxicities after peritoneal mesothelioma surgery.  Hematological Toxicities and Mesothelioma Treatment Hematological toxicities are problems with the cells that make up the blood. This can include white blood cells, red blood cells, platelets, and proteins involved in bleeding and clotting.  Several drugs that kill mesothelioma cells can cause blood cell problems. … Continue reading Peritoneal Mesothelioma Surgery with HIPEC Can Trigger Blood Cell Problems »

Repeated Mesothelioma Surgeries Credited with Japanese Man’s Survival

repeated mesothelioma surgeries

Can repeated mesothelioma surgeries extend peritoneal mesothelioma survival? A new case report out of Japan suggests the answer may be yes.  The article recounts the case of a patient with peritoneal mesothelioma. Each time surgeons removed a mesothelioma tumor, a new one would occur in a different location.  The man had four separate mesothelioma surgeries over the course of five years.  Repeated mesothelioma surgeries are not the norm. But this treatment approach may be the reason for the man’s unusually long mesothelioma survival.  Surgical Treatment of Peritoneal Mesothelioma Peritoneal mesothelioma accounts for about 20 percent of mesothelioma cases in the US each year. It occurs on the membrane that surrounds the abdominal organs. Because it sits so close to these … Continue reading Repeated Mesothelioma Surgeries Credited with Japanese Man’s Survival »

Signs of Peritoneal Mesothelioma After Radiotherapy

signs of peritoneal mesothelioma after radiotherapy

Japanese researchers are reminding doctors to watch for signs of peritoneal mesothelioma in people who have undergone past radiotherapy.  Many cancer patients undergo radiotherapy. Radiation disrupts the DNA inside cancer cells. This can help keep these malignant cells from replicating and spreading.  But radiation treatment also has a downside. It can cause cellular changes in healthy cells, too. This can cause side effects right away, or decades later.  As more people have radiation and survive, scientists at the Shinshu University School of Medicine say more of them could develop radiation-related mesothelioma later in life. But the signs of peritoneal mesothelioma years after radiation are easy to miss. Peritoneal Mesothelioma Case Study The new report is based on the case of … Continue reading Signs of Peritoneal Mesothelioma After Radiotherapy »

Mesothelioma Tumor Response to Nivolumab Detailed in New Case Study

mesothelioma tumor response to nivolumab

An Indian woman in still alive two years after a mesothelioma diagnosis thanks to a remarkable mesothelioma tumor response to nivolumab. Nivolumab is sold under the brand name Opdivo. It is a type of immunotherapy. Nivolumab is sometimes used for lung cancer that progresses after chemotherapy. A hospital in Mumbai tried nivolumab on a pleural mesothelioma patient after several types of chemotherapy did not work. Doctors say the mesothelioma tumor response to nivolumab was so great that the patient no longer needed supplemental oxygen.  Opdivo in Mesothelioma Treatment Opdivo is not FDA-approved for mesothelioma treatment. Only Alimta (pemetrexed) holds that designation. But pleural mesothelioma grows quickly and is hard to treat. Even the gold standard therapies often do not work … Continue reading Mesothelioma Tumor Response to Nivolumab Detailed in New Case Study »

First-Line Chemotherapy for Peritoneal Mesothelioma

chemotherapy for peritoneal mesothelioma

The same drugs doctors use to treat pleural mesothelioma can provide effective chemotherapy for peritoneal mesothelioma, too. Japanese researchers reviewed the cases of 29 peritoneal mesothelioma patients. These patients had first-line treatment with cisplatin and pemetrexed between 2001 and 2016. The results suggest these drugs are safe and potent chemotherapy for peritoneal mesothelioma. The finding may help doctors and patients make better treatment decisions. Treating Malignant Mesothelioma Malignant mesothelioma is a membrane cancer. It usually occurs in one of two places. About 80 percent of mesothelioma tumors arise on the membrane that surrounds the lungs (the pleura). This is called pleural mesothelioma.  About 20 percent of the 2,500 cases of mesothelioma diagnosed in the US each year are peritoneal. Peritoneal … Continue reading First-Line Chemotherapy for Peritoneal Mesothelioma »

Experimental Mesothelioma Treatment Targets Tumor Growth Compounds

Experimental mesothelioma treatment

Hong Kong researchers have released the first results of an experimental mesothelioma treatment they are working on. The treatment targets organic compounds believed to contribute to mesothelioma growth. The trial took place at the University of Hong Kong. Mice with mesothelioma received doses of an enzyme inhibitor called DFMO. The drug appears to stop the production of organic compounds called polyamines. In tests, mice with lower polyamine levels lived longer with pleural mesothelioma. Enzymes Contribute to Tumor Growth The growth and spread of pleural mesothelioma is a complex process. It involves many different proteins and enzymes working together. Scientists have not yet identified all of the compounds that contribute to cancer growth. But the experimental mesothelioma treatment in Hong Kong … Continue reading Experimental Mesothelioma Treatment Targets Tumor Growth Compounds »

New Study Suggests Music May Offer Relief from Mesothelioma Pain

relief from mesothelioma pain with music

There is new evidence that listening to music might offer some relief from mesothelioma pain and fatigue. A new study in the European Journal of Cancer Care details a 6-month experiment on the effects of music on cancer pain, anxiety, and fatigue.  Cancer patients listened to music at home five times a week. The results show that many of them started to feel better after just six weeks. Finding Relief from Mesothelioma Pain Pain is a common symptom of malignant mesothelioma, especially as the disease progresses. Patients with pleural mesothelioma have cancer on the lining around their lungs. These patients may experience symptoms such as shortness of breath, coughing, and chest pain. Patients with peritoneal mesothelioma have cancer on the … Continue reading New Study Suggests Music May Offer Relief from Mesothelioma Pain »

Systemic Inflammation Linked to Shorter Mesothelioma Survival

systemic inflammation

Mesothelioma patients whose bodies respond to the illness with systemic inflammation are less likely to survive. Chinese researchers have linked a measure of systemic inflammation called SII to shorter survival in people with pleural mesothelioma. The new study involved 97 people with confirmed malignant mesothelioma. It suggests that SII could be a simple, non-invasive way to determine mesothelioma prognosis. What is SII? SII stands for “systemic immune-inflammation index”. When a body is under stress, such as when it is fighting mesothelioma, the innate immune system kicks into action. Certain kinds of white blood cells and proteins are released. The result is systemic inflammation. SII can be determined with a blood test. The test measures the levels of white blood cells … Continue reading Systemic Inflammation Linked to Shorter Mesothelioma Survival »

Mesothelioma Doctors Urged to Sharpen Their Communication Skills

mesothelioma doctors need better communication

A Japanese study suggests that some mesothelioma doctors are falling short when it comes to communicating with their patients. The study was based on quality-of-life surveys of seventy-three pleural mesothelioma patients. Patients answered two open-ended questions about their care experience. The researchers say most concerns had to do with communication. Many patients said they wanted clearer explanations and more empathy from their mesothelioma doctors. Unique Challenges of Malignant Mesothelioma Coping with any type of cancer can be stressful and confusing. But mesothelioma presents some special challenges to both patients and mesothelioma doctors.   Pleural mesothelioma is a rare and complex malignancy with a poor prognosis. No single treatment is likely to help. On top of this, mesothelioma symptoms such as … Continue reading Mesothelioma Doctors Urged to Sharpen Their Communication Skills »

New Tool Could Replace TNM for Predicting Pleural Mesothelioma Survival

pleural mesothelioma survival

A new visual tool could offer a better way to predict pleural mesothelioma survival after surgery than the current TNM staging system. That is the message from cancer researchers at China’s Peking University. The group conducted a study using a large US government database of information on pleural mesothelioma survival and treatment. They used the data to create a visual representation of pleural mesothelioma survival called a nomogram. Testing of the nomogram showed it was more accurate at predicting survival in patients who have mesothelioma surgery than the tool doctors normally use. Pleural Mesothelioma Survival and TNM The most popular method for “staging” cancer is called the TNM staging system. TNM stands for tumor node metastasis. With TNM, the further … Continue reading New Tool Could Replace TNM for Predicting Pleural Mesothelioma Survival »

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