Study Predicts New Mesothelioma Therapies on the Horizon

mesothelioma survivor

A new article published by a pair of UK scientists predicts a brighter future for mesothelioma patients thanks to a growing understanding of the disease and how to treat it. Malignant mesothelioma is the cancer most closely associated with asbestos. Although only a small percentage of asbestos-exposed people go on to develop mesothelioma, those who do face a grim prognosis. Doctors learned early on that standard cancer treatments rarely work for patients with mesothelioma. But Anna Bibby and Nick Maskell with Bristol Medical School and the North Bristol Lung Centre say the large amount of high-quality mesothelioma research conducted in the last decade has moved medicine closer to finding a cure for this intractable cancer. Important Mesothelioma Research Findings In … Continue reading Study Predicts New Mesothelioma Therapies on the Horizon »

Mesothelioma Tumors Thrive in Low Oxygen Environment

Epithelioid cells

South Korean researchers have uncovered a clue that might help explain why mesothelioma tumors are so aggressive — and what can be done to counter that aggression. The new study centers on hypoxia, a deficiency in the amount of oxygen reaching the tissues. It is a hallmark of many types of solid tumors and it turns out that malignant mesothelioma tumors are no exception. Patients with these hypoxic tumors tend to worsen quickly, be less responsive to treatment, and end up with poor outcomes. The Effect of Oxygen on Malignant Mesothelioma Scientists in the Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University are trying to better understand how hypoxia effects human malignant mesothelioma cells and exactly what … Continue reading Mesothelioma Tumors Thrive in Low Oxygen Environment »

Drug-Coated Film May Prevent Mesothelioma Recurrence

Mesothelioma researchers in Italy have developed a new surgical technique with the potential to dramatically increase the odds of surviving malignant pleural mesothelioma. Pleural mesothelioma is a rare and aggressive cancer that grows on the membranous tissue (pleura) surrounding the lungs. It is most common in people who have ever lived or worked in the presence of deadly asbestos dust.                       The new technique involves placing a drug-coated polymer film directly on the mesothelial surface after tumor-removal surgery as a way to prevent recurrent pleural mesothelioma. In a new article in the European Journal of Pharmaceutical Science, researchers at the University of Parma say the film “almost completely prevented tumor recurrence” in treated mice. Battling Recurrent Mesothelioma The typical treatment … Continue reading Drug-Coated Film May Prevent Mesothelioma Recurrence »

Compound Makes Mesothelioma Tumors More Susceptible to Chemo

Swiss cancer researchers may have found a way to get around malignant mesothelioma’s notorious resistance to chemotherapy with an investigational metal-based compound called RAPTA-T. Malignant pleural mesothelioma is an incurable and highly aggressive cancer. One of the reasons it is so deadly is that it rarely responds to standard cancer treatments. Even the treatment combination that is considered the standard of care for pleural mesothelioma—pemetrexed (Alimta) and cisplatin—is only effective in about 4 out of 10 patients. But scientists with Centre Hospitalier Universitaire Vaudois and the Swiss Federal Institute of Technology in Lausanne, Switzerland have discovered a counterintuitive way to ramp up the cancer-killing power of mesothelioma chemotherapy. Creating a “Healthier” Tumor The element on which the RAPTA-T compound is … Continue reading Compound Makes Mesothelioma Tumors More Susceptible to Chemo »

Immunotherapy Drug Produces ‘Exceptional and Sustained Response’ in Mesothelioma Patient

As part of what they call the “new era” of mesothelioma immunotherapy research, doctors in Ohio and Florida have just published the case report of a man whose pleural mesothelioma was stopped in its tracks with the drug nivolumab. The case is detailed in the latest issue of the American Journal of Case Reports by researchers at the University of Florida and The Christ Hospital in Cincinnati. Details of the Mesothelioma Case Report The patient in question had been diagnosed with malignant pleural mesothelioma, a deadly cancer that typically carries a poor prognosis, even with aggressive treatment. In fact, even though chemotherapy with a combination of cisplatin and pemetrexed (Alimta) is considered the standard-of-care for malignant mesothelioma, fewer than 4 … Continue reading Immunotherapy Drug Produces ‘Exceptional and Sustained Response’ in Mesothelioma Patient »

Extending Mesothelioma Survival with Chemotherapy

In the continued quest to improve the effectiveness of chemotherapy treatment for malignant pleural mesothelioma, two new studies have been published this week on the effectiveness of adding additional drugs to the standard combination. The majority of patients who receive a mesothelioma diagnosis will have treatment that includes chemotherapy. According to data from the National Cancer Institute’s SEER database, the chemotherapy regimen prescribed most often for mesothelioma is a combination of pemetrexed (Alimta) and cisplatin or carboplatin. Approximately 67 percent of mesothelioma patients who receive chemotherapy have this combination. Unfortunately, even the standard chemotherapy combination has not been shown to extend mesothelioma survival by more that a few months. Scientists are continually looking for ways to make it more effective. … Continue reading Extending Mesothelioma Survival with Chemotherapy »

New Immunotherapy Drug Stops Mesothelioma in Half of Patients Tested

The results are in on the Phase I/II trial of the mesothelioma drug ONCOS-102 and researchers say there is reason to be excited. As Surviving Mesothelioma first reported in the fall of 2016, ONCOS-102 and standard chemotherapy significantly slowed the growth of malignant mesothelioma tumors in preclinical studies of infected mice. Now, the first human trial suggests that it can do the same thing in some human mesothelioma patients, boosting the effectiveness of standard chemotherapy and improving mesothelioma survival. Mesothelioma Study Results According to news released by Norway-based drug maker Targovax this week, three out of six patients with unresectable mesothelioma responded to a combination of ONCOS-102 and standard chemotherapy. In two patients, their mesothelioma tumors stopped growing and in … Continue reading New Immunotherapy Drug Stops Mesothelioma in Half of Patients Tested »

“Spray On” Drugs May Be New Option for Peritoneal Mesothelioma Patients

Surgery for Peritoneal Mesothelioma

A new, minimally-invasive way of delivering drugs right to the site of a tumor is being called “safe and feasible” for people with recurrent malignant mesothelioma. Right now, mesothelioma patients whose cancer comes back after surgery and systemic chemotherapy have few viable treatment options. The new procedure, called Pressurized Inraperitoneal Aerosol Chemotherapy (PIPAC), may change that. During PIPAC, chemotherapy drugs are essentially “sprayed” as gas directly onto the site of the cancer. PIPAC is performed through a small incision using a laparoscope for guidance. Testing PIPAC in Mesothelioma Treatment Right now, PIPAC is still in clinical trials, but it has already been used on thousands of patients in Germany and several other European locations. In a new malignant mesothelioma study, … Continue reading “Spray On” Drugs May Be New Option for Peritoneal Mesothelioma Patients »

Study Finds Chemotherapy Unlikely to Improve Peritoneal Mesothelioma Survival

A new study from the University of Illinois suggests that patients with peritoneal mesothelioma who undergo  surgery may not get any benefit from having chemotherapy, too. Mesothelioma patients who have cytoreductive surgery, which is also called debulking surgery, tend to live more than four times as long as those who do not have the surgery. Rinsing the abdominal cavity with a heated solution of cancer-killing drugs may improve survival even more. But, according to the new study, the same cannot be said of chemotherapy drugs that are delivered orally or by injection or infusion so that they circulate through the whole body (systemic chemotherapy). Peritoneal Mesothelioma and Cytoreductive Surgery Peritoneal mesothelioma is a fast-growing malignancy that occurs on the membrane … Continue reading Study Finds Chemotherapy Unlikely to Improve Peritoneal Mesothelioma Survival »

Home-Based Rehab Helps Mesothelioma Patients Bounce Back After Chemotherapy

New evidence suggests that a pulmonary rehabilitation program that comes to them might help patients recover after pleural mesothelioma treatment. Experts in pulmonary cancers at several French institutions recently published what they called a “real-life feasibility study” of home-based rehab in patients who had received chemotherapy for either lung cancer or malignant pleural mesothelioma. Previous research has shown that these patients are typically less physically active and experience a lower quality of life as a result of the cancer and/or the treatment. Managing Mesothelioma Rehabilitation at Home In the new French study, patients who had undergone chemotherapy for lung cancer or pleural mesothelioma were screened to see if they would be good candidates for a rehabilitation program offered in their … Continue reading Home-Based Rehab Helps Mesothelioma Patients Bounce Back After Chemotherapy »

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