Drug May help Mesothelioma Patients Overcome Resistance to Chemotherapy
A newly-identified compound might eventually help mesothelioma patients overcome resistance to chemotherapy. Chemotherapy resistance is one of the main reasons that mesothelioma treatments fail. But researchers at Duke University and the Massachusetts Institute of Technology have identified a compound that combats resistance to chemotherapy with cisplatin. Cisplatin is one of the primary drugs in first-line chemotherapy for mesothelioma. If mesothelioma cells can be sensitized to it, patients may have better outcomes. First-Line Treatment for Malignant Mesothelioma Pleural mesothelioma is a cancer that grows on the lining around the lungs. Peritoneal mesothelioma starts on the lining of the abdomen. Both types of mesothelioma are caused by asbestos exposure. Chemotherapy with cisplatin and pemetrexed (Alimta) is the treatment that doctors usually try … Continue reading Drug May help Mesothelioma Patients Overcome Resistance to Chemotherapy
Supplements During Chemotherapy May Work Against Mesothelioma Treatment
A new study suggests that it could be risky to take supplements during chemotherapy for mesothelioma and other cancers. The study took place at the Roswell Park Comprehensive Cancer Center in Buffalo, New York. It focused on more than 1,100 breast cancer patients. It found that patients who took certain antioxidant supplements during chemotherapy had worse outcomes than those who did not. The study’s authors say antioxidants undermine one of the main jobs of chemotherapy drugs – to create oxidative stress in cancer cells. Chemotherapy is the primary first-line treatment for malignant mesothelioma and many other cancers. Why Avoid Antioxidant Supplements During Chemotherapy? Antioxidants are compounds found in many fruits and vegetables. Vitamins A, C, E, and B12 are examples … Continue reading Supplements During Chemotherapy May Work Against Mesothelioma Treatment
Peritoneal Mesothelioma Surgery with HIPEC Can Trigger Blood Cell Problems
More than half of patients who have peritoneal mesothelioma surgery with HIPEC develop problems with their blood cells afterward. That’s the finding of a team of cancer researchers from Singapore. The group analyzed 15 years worth of data on peritoneal mesothelioma surgery outcomes. They found that, even though the procedure saves lives, it can be risky. Older patients and those who had prior chemotherapy were most likely to develop hematological toxicities after peritoneal mesothelioma surgery. Hematological Toxicities and Mesothelioma Treatment Hematological toxicities are problems with the cells that make up the blood. This can include white blood cells, red blood cells, platelets, and proteins involved in bleeding and clotting. Several drugs that kill mesothelioma cells can cause blood cell problems. … Continue reading Peritoneal Mesothelioma Surgery with HIPEC Can Trigger Blood Cell Problems
Mesothelioma Tumor Response to Nivolumab Detailed in New Case Study
An Indian woman in still alive two years after a mesothelioma diagnosis thanks to a remarkable mesothelioma tumor response to nivolumab. Nivolumab is sold under the brand name Opdivo. It is a type of immunotherapy. Nivolumab is sometimes used for lung cancer that progresses after chemotherapy. A hospital in Mumbai tried nivolumab on a pleural mesothelioma patient after several types of chemotherapy did not work. Doctors say the mesothelioma tumor response to nivolumab was so great that the patient no longer needed supplemental oxygen. Opdivo in Mesothelioma Treatment Opdivo is not FDA-approved for mesothelioma treatment. Only Alimta (pemetrexed) holds that designation. But pleural mesothelioma grows quickly and is hard to treat. Even the gold standard therapies often do not work … Continue reading Mesothelioma Tumor Response to Nivolumab Detailed in New Case Study
Effect of Chemotherapy on Immunotherapy for Mesothelioma
Belgian scientists say they are still not sure about the effect of chemotherapy on immunotherapy for mesothelioma. They reached that conclusion after testing several different chemotherapy drugs on mesothelioma cells in the lab. The combination of chemotherapy and immunotherapy is “chemoimmunotherapy”. It aims to harness the unique powers of each treatment approach. A meta-analysis last May called chemoimmunotherapy the “next frontier” in mesothelioma treatment. But the new Belgian study on the effect of chemotherapy on immunotherapy highlights how much doctors still do not know about the combo. Immune Checkpoints Are the Key When it is working properly, the immune system is supposed to find and kill cancer cells before they become mesothelioma tumors. But mesothelioma cells can hide from the … Continue reading Effect of Chemotherapy on Immunotherapy for Mesothelioma
Isolated Thoracic Perfusion for Mesothelioma Symptom Relief
A new study suggests that a treatment called isolated thoracic perfusion could help alleviate some of the worst symptoms of malignant pleural mesothelioma. Isolated thoracic perfusion is a method for circulating medicine in just one area of the body. When doctors circulated chemotherapy drugs in the chests of people with pleural mesothelioma, their symptoms went away for several months. Now, the team says it is time to test the technique in a bigger pool of mesothelioma patients. The Theory Behind ITP Pleural mesothelioma is a membrane cancer that occurs in the chest. Chemotherapy drugs like Alimta can be powerful weapons against pleural mesothelioma. But they can also damage healthy tissues. When healthy tissues are damaged by chemotherapy, mesothelioma patients can … Continue reading Isolated Thoracic Perfusion for Mesothelioma Symptom Relief
Unresectable Peritoneal Mesothelioma Becomes Operable After Bi-Directional Chemotherapy
French researchers have successfully operated on a man with unresectable peritoneal mesothelioma after treating him with bi-directional chemotherapy. Chemotherapy is the most common treatment for unresectable peritoneal mesothelioma. Most mesothelioma patients have chemotherapy by IV infusion. But some cancer centers now offer another chemotherapy delivery method. Intraperitoneal chemotherapy bypasses the bloodstream. It lets doctors put higher doses of cancer-killing medicine at the site of a tumor. The French team combined the two types of chemotherapy in one patient. It shrunk the patient’s unresectable peritoneal mesothelioma tumor enough to perform surgery. Two Types of Mesothelioma Chemotherapy With IV chemotherapy, medicine travels to the tumor through the bloodstream. It is one way of treating unresectable peritoneal mesothelioma. One drawback of IV chemotherapy … Continue reading Unresectable Peritoneal Mesothelioma Becomes Operable After Bi-Directional Chemotherapy
Cediranib for Mesothelioma: VEGF Inhibitor Fails Another Trial
Cediranib for mesothelioma appears to be ruled out by another failed clinical trial. A new study led by MD Anderson researchers concludes that the VEGF inhibitor causes too many side effects for not enough survival benefit. It is a blow to researchers hoping to use cediranib for mesothelioma patients on chemotherapy. Cutting Off Tumor Blood Supply Cediranib is an oral drug made by AstraZeneca. It is part of a class of drugs called VEGF inhibitors. Vascular endothelial growth factor (VEGF) is a signal protein that stimulates blood vessel formation in tumors. Research shows that mesothelioma patients who have higher serum levels of VEGF have a lower chance of survival. VEGF inhibitors like cediranib latch onto VEGF receptors inside mesothelioma cells. … Continue reading Cediranib for Mesothelioma: VEGF Inhibitor Fails Another Trial
First-Line Chemotherapy for Peritoneal Mesothelioma
The same drugs doctors use to treat pleural mesothelioma can provide effective chemotherapy for peritoneal mesothelioma, too. Japanese researchers reviewed the cases of 29 peritoneal mesothelioma patients. These patients had first-line treatment with cisplatin and pemetrexed between 2001 and 2016. The results suggest these drugs are safe and potent chemotherapy for peritoneal mesothelioma. The finding may help doctors and patients make better treatment decisions. Treating Malignant Mesothelioma Malignant mesothelioma is a membrane cancer. It usually occurs in one of two places. About 80 percent of mesothelioma tumors arise on the membrane that surrounds the lungs (the pleura). This is called pleural mesothelioma. About 20 percent of the 2,500 cases of mesothelioma diagnosed in the US each year are peritoneal. Peritoneal … Continue reading First-Line Chemotherapy for Peritoneal Mesothelioma
Immunotherapy Vaccine for Mesothelioma Shows Promise in Combination Treatment
A bacteria-based immunotherapy vaccine for mesothelioma may improve the odds of surviving the disease by boosting the effects of chemotherapy. That is the word from the latest clinical trial of CRS-207 headed by researchers at the National Cancer Institute. Thirty-five inoperable patients received the immunotherapy vaccine for mesothelioma along with standard mesothelioma chemotherapy. Eighty-nine percent of them experienced either a full or partial response to the treatment combination. CRS-207 Immunotherapy Vaccine for Mesothelioma CRS-207 is based on a modified version of Listeria monocytogenes. The bacterium is best known for causing the food borne illness Listeriosis. In CRS-207, the bacteria has been changed so it cannot make patients sick. The immunotherapy vaccine for mesothelioma uses the bacteria to trigger a powerful … Continue reading Immunotherapy Vaccine for Mesothelioma Shows Promise in Combination Treatment
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