Mesothelioma Genetic “Fingerprint” Could Impact Compensation

A new report suggests that it may be possible to verify that a case of lung cancer or malignant mesothelioma was caused by exposure to asbestos. The key may lie in tiny cellular structures called  microRNAs. If the microRNA asbestos profile can be verified, it could have a significant impact on work-related compensation for pleural mesothelioma and asbestos-related lung cancer. The Molecular “Fingerprint” of Mesothelioma? MicroRNAs (miRNAs) are small non-coding molecules of RNA that play a key role in the regulation of gene expression in cells. When these miRNAs are out of balance or “overexpressed”, the result can be cancer. By examining the miRNAs of mesothelioma patients, lung cancer patients, and healthy subjects, researchers at Marche Polytechnic University in Ancona, Italy … Continue reading Mesothelioma Genetic “Fingerprint” Could Impact Compensation »

Inhalable Formula May Be Key to Fighting Mesothelioma with Red Wine

grape wine

Scientists may finally have found a way to make a compound in red wine more effective against lung cancers like pleural mesothelioma. Resveratrol, a powerful antioxidant compound found in the skin and seeds of grapes and concentrated in red wine, has long been the focus of anti-cancer studies. Multiple laboratory tests have demonstrated that the molecule is damaging to cancer cells. Unfortunately, the effectiveness of resveratrol for people with cancers such as pleural mesothelioma or non-small cell lung cancer has been limited because the compound is eliminated from the body before it has the chance to reach the lungs. Now, researchers at the University of Geneva in Switzerland (UNIGE) believe they may have found a way around the problem. Their … Continue reading Inhalable Formula May Be Key to Fighting Mesothelioma with Red Wine »

New Study Points to Benefits of IMRT for Mesothelioma Treatment

There is more evidence that mesothelioma patients who have lung sparing surgery can live longer if it’s followed up with highly targeted radiation therapy. In the first study to come out of Israel on the subject, a team of oncologists, pulmonologists, radiation oncologists, and thoracic surgeons at Rabin Medicine Center in Petah Tikva say intensity modulated radiation therapy (IMRT) is safe and effective for slowing down the growth of pleural mesothelioma tumors. The Challenge of Radiotherapy for Mesothelioma The irregularity of malignant mesothelioma tumors makes them difficult to treat with standard external beam radiotherapy without damaging healthy tissue and causing serious side effects. This is particularly problematic in patients who still have both lungs, either because they were not good … Continue reading New Study Points to Benefits of IMRT for Mesothelioma Treatment »

Pleural Mesothelioma Risk: Genes and Exposure Both Play a Role

When it comes to the development of malignant pleural mesothelioma, your job and your relatives both appear to play critical roles. A new study in the European Journal of Cancer points to the interplay between environment and genetics in the development of the asbestos cancer. The study shows, once again, just how destructive asbestos can be to human health. Analyzing Mesothelioma Incidence Among Swedes The new research used data from the Swedish Family-Cancer Database, which includes all Swedes born after 1931 and their biological parents – a total of 16.1 million people, including 2.3 million cancer patients. After analyzing the data on all people with pleural mesothelioma, the researchers determined that those who worked around asbestos were more than three … Continue reading Pleural Mesothelioma Risk: Genes and Exposure Both Play a Role »

New Report Highlights Mesothelioma Danger in British Classrooms

A new report suggests that teaching is a surprisingly dangerous — and, in some cases, even deadly — profession in Great Britain. That is because more than 86 percent of the country’s 24,000 schools were built with products that contain asbestos — the primary cause of malignant mesothelioma. As these schools age, there is an increasing likelihood that some of that asbestos will turn into dust and that teachers, staffers, and even students may be inadvertently exposed to it. Asbestos in Schools Asbestos is a fibrous mineral that was once routinely used to add strength and fire-resistance to everything from concrete to floor and ceiling tiles, roof shingles, wallboard, and insulation. It has also been definitively linked to lung cancer, … Continue reading New Report Highlights Mesothelioma Danger in British Classrooms »

Muscle Loss May Predict Peritoneal Mesothelioma Survival

Age-related muscle loss appears to be an independent predictor of peritoneal mesothelioma survival after surgery. The news might help patients and doctors make better treatment decisions. Researchers at the Lyon-Sud Hospital Center in Lyon say they have found a connection between sarcopenia—muscle loss associated with aging—and how long people with peritoneal mesothelioma (or another abdominal condition called pseudomyxoma peritonei) survive after cytoreductive surgery. The bottom line: The less muscle loss, the longer a mesothelioma patient is likely to survive. CRS/HIPEC Surgery for Mesothelioma Cancer Both peritoneal mesothelioma and pseudomyxoma peritonei (PMP) are cancers that grow in the abdomen. Like other types of malignant mesothelioma, peritoneal mesothelioma is associated with exposure to asbestos. It is typically a fast-growing cancer for which … Continue reading Muscle Loss May Predict Peritoneal Mesothelioma Survival »

Study Predicts New Mesothelioma Therapies on the Horizon

mesothelioma survivor

A new article published by a pair of UK scientists predicts a brighter future for mesothelioma patients thanks to a growing understanding of the disease and how to treat it. Malignant mesothelioma is the cancer most closely associated with asbestos. Although only a small percentage of asbestos-exposed people go on to develop mesothelioma, those who do face a grim prognosis. Doctors learned early on that standard cancer treatments rarely work for patients with mesothelioma. But Anna Bibby and Nick Maskell with Bristol Medical School and the North Bristol Lung Centre say the large amount of high-quality mesothelioma research conducted in the last decade has moved medicine closer to finding a cure for this intractable cancer. Important Mesothelioma Research Findings In … Continue reading Study Predicts New Mesothelioma Therapies on the Horizon »

Unravelling the Mystery Behind Mesothelioma Tumors

In what could be a step closer to a mesothelioma cure, French cancer researchers say they have identified two of the key genetic pathways responsible for triggering mesothelioma in asbestos-exposed people. Led by Inserm (The French National Institute of Health and Medical Research), the study focused on mice that had been genetically engineered with mutations on certain tumor-suppressor genes known to play a role in malignant mesothelioma in people. Learning About Human Mesothelioma from Mice In the experiment, published in the International Journal of Molecular Sciences, some of the genetically engineered mice, as well as some normal (wild type) mice, were exposed to asbestos while others were not. The goal was to understand exactly what is happening at the molecular … Continue reading Unravelling the Mystery Behind Mesothelioma Tumors »

Lung Fluid Tests May Lead to Earlier Mesothelioma Diagnosis

Using the free-floating cancer cells present in lung-fluid to diagnose malignant mesothelioma may lead to earlier detection and better outcomes. That is the conclusion of cancer researchers at Stockholm’s Karolinska University Hospital. The team’s goal was to evaluate the established criteria for cytopathological diagnosis of mesothelioma, i.e. diagnosis using cells found in fluid (effusions) instead of cells from a tissue biopsy. In a newly published article in the Archives of Pathological and Laboratory Medicine, the researchers observe, “Despite the difficulties in recognizing malignant cells present in those early effusions, they are often the first available biologic material for diagnosis.” Diagnosing Pleural  Mesothelioma Malignant pleural mesothelioma, a rare but fast-growing cancer associated with asbestos exposure, is notoriously difficult to diagnose. Diagnosis … Continue reading Lung Fluid Tests May Lead to Earlier Mesothelioma Diagnosis »

Drug-Coated Film May Prevent Mesothelioma Recurrence

Mesothelioma researchers in Italy have developed a new surgical technique with the potential to dramatically increase the odds of surviving malignant pleural mesothelioma. Pleural mesothelioma is a rare and aggressive cancer that grows on the membranous tissue (pleura) surrounding the lungs. It is most common in people who have ever lived or worked in the presence of deadly asbestos dust.                       The new technique involves placing a drug-coated polymer film directly on the mesothelial surface after tumor-removal surgery as a way to prevent recurrent pleural mesothelioma. In a new article in the European Journal of Pharmaceutical Science, researchers at the University of Parma say the film “almost completely prevented tumor recurrence” in treated mice. Battling Recurrent Mesothelioma The typical treatment … Continue reading Drug-Coated Film May Prevent Mesothelioma Recurrence »

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