Diagnosing Pleural Mesothelioma with Lung Fluid: The Battle of the Biomarkers

Biologist Holding Flasks

A biomarker called soluble mesothelin related peptide (SMRP) may be a more reliable way to diagnose malignant pleural mesothelioma from lung fluid than the protein fibulin-3. That is the finding of Italian researchers who tested the diagnostic performance of the two markers in 120 patients, including 33 mesothelioma patients, in an effort to resolve what they call “conflicting data” on the two methods. SMRP and … Continue reading Diagnosing Pleural Mesothelioma with Lung Fluid: The Battle of the Biomarkers »

Radical Mesothelioma Surgery Deemed Not “Clinically Effective”

The heads of a European working group charged with advising cardio-thoracic surgeons on the best ways to treat malignant pleural mesothelioma say the most radical and risky type of surgery is not clinically effective. Dr. Giuseppe Cardillo of Carlo Forlanini Hospital in Rome and Dr. Tom Treasure with University College London (author of the MARS mesothelioma surgery study) detail their conclusion in a Letter to … Continue reading Radical Mesothelioma Surgery Deemed Not “Clinically Effective” »

Mesothelioma Risk in Older School Buildings

A new government report has some sobering news for teachers and students in England: Nearly 20 percent of schools may be failing to adequately protect them from asbestos, the primary cause of malignant pleural mesothelioma. The asbestos management report, issued by the Education Funding Agency, is based on data collected online from more than 5,500 schools in 2016. It offers a disturbing view of mesothelioma risk … Continue reading Mesothelioma Risk in Older School Buildings »

Immunotherapy for Pleural Mesothelioma: Does it Work?

Immunotherapy is an important emerging therapeutic strategy for several types of cancer, but the jury is still out on whether it will eventually be a viable approach for malignant pleural mesothelioma. In a newly-published special report on the immune checkpoint inhibitor tremelimumab, researchers at the University of Salford in the UK call the use of such drugs “largely questionable” for pleural mesothelioma treatment. Their concerns, … Continue reading Immunotherapy for Pleural Mesothelioma: Does it Work? »

Spice Compound Extends Mesothelioma Survival in Mice

The compound that gives the spice turmeric its yellow color and pungent flavor is once again attracting the attention of mesothelioma researchers. Curcumin has been the subject of numerous mesothelioma studies. The latest one, conducted by scientists at the Department of Experimental Medicine at the University of Rome, finds that the compound has the power to not only kill mesothelioma cells in the lab, but … Continue reading Spice Compound Extends Mesothelioma Survival in Mice »

Scoring Tool Helps Doctors Select Mesothelioma Patients for Clinical Trials

Researchers in London have developed a new way of categorizing patients with advanced malignant mesothelioma that allows them to predict who will benefit the most from participation in a Phase I clinical trial. The Drug Development Unit at the Royal Marsden Hospital already uses a prognostic scoring system for cancer patients to determine which patients would be good candidates for Phase 1 clinical trials of … Continue reading Scoring Tool Helps Doctors Select Mesothelioma Patients for Clinical Trials »

BAP1 May Be Valuable for Peritoneal Mesothelioma Prognosis

There is new evidence that the same genetic mutation that is common in people with pleural mesothelioma may be present in many cases of peritoneal mesothelioma, too. BAP1 is a tumor suppressing protein encoded by the BAP1 gene. People with a mutation in this gene are less likely to produce the protein and are more likely to develop certain kinds of cancer, including pleural mesothelioma. … Continue reading BAP1 May Be Valuable for Peritoneal Mesothelioma Prognosis »

Asbestos Found in the Gallbladders of Pleural Mesothelioma Patients

There is new evidence that asbestos fibers can make their way into the gallbladders of patients with the lung-related cancer malignant pleural mesothelioma. The finding may help explain why some of these patients also suffer from gallbladder disorders. A new study conducted in Italy and published in the Journal of Microscopy discovered microscopic fibers of the mineral asbestos when they analyzed thin sections of gallbladders … Continue reading Asbestos Found in the Gallbladders of Pleural Mesothelioma Patients »

The Role of Post-Surgical Radiation in Mesothelioma Survival

More research is needed before we will know whether radiotherapy after mesothelioma surgery can improve mesothelioma survival. That’s the conclusion of a newly-published assessment performed by an Egyptian doctor. The study, which tracked more than 2,000 mesothelioma patients over a ten-year period, found that, while some radiotherapy patients did live longer, the benefits did not extend to patients with a certain mesothelioma subtype. Radiotherapy and … Continue reading The Role of Post-Surgical Radiation in Mesothelioma Survival »

Diagnostic Accuracy of CT Limited for Pleural Mesothelioma

When it comes to diagnosing pleural mesothelioma, Scottish researchers say CT scanning is not accurate enough. Contrast-enhanced computed tomography (CT) can provide a cross-sectional image of the chest in people with suspected pleural mesothelioma. But researchers at Queen Elizabeth University Hospital in Glasgow say their tests show that CT is not sensitive enough to either confirm or rule out mesothelioma in most cases. CT Scans … Continue reading Diagnostic Accuracy of CT Limited for Pleural Mesothelioma »