Tumor Treating Fields for Mesothelioma Faces Criticism

tumor treating fields

Tumor Treating Fields for mesothelioma is coming under fire from some other researchers. The treatment uses electricity to interfere with division of cancer cells. The FDA approved it for mesothelioma last year under the Humanitarian Device Exemption. It is only the second treatment ever approved for asbestos cancer.  But scientists in Italy and the Netherlands are disputing some of the findings from the STELLAR trial of TTFields. They published separate articles in a recent issue of The Lancet Oncology. STELLAR tested Tumor Treating Fields along with chemotherapy as a novel mesothelioma treatment. The FDA based its approval on the STELLAR results.  But the newly published articles suggest that there were problems with the trial. Both say Tumor Treating Fields is … Continue reading Tumor Treating Fields for Mesothelioma Faces Criticism »

Study Supports Curative Radiation Therapy for Pleural Mesothelioma

radiation therapy for pleural mesothelioma

A new study out of Turkey supports the idea of using highly targeted radiation therapy for pleural mesothelioma that can’t be treated surgically. Pleural mesothelioma is a cancer that grows on the membrane around the lungs. The membrane is called the pleura. Like all forms of mesothelioma, it carries a grim prognosis. But the Turkish researchers say new radiotherapy techniques offer the promise of better outcomes. They compared two types of radiation therapy for pleural mesothelioma. They found that both could be delivered safely and with limited damage to nearby organs.  Unrectable Pleural Mesothelioma The first-line treatment for pleural mesothelioma is chemotherapy. Ideally, chemotherapy will help to shrink the pleural mesothelioma. Then doctors can remove most of it surgically. They … Continue reading Study Supports Curative Radiation Therapy for Pleural Mesothelioma »

Sarcomatoid Mesothelioma Treatment Focuses on Two-Drug Combo

sarcomatoid mesothelioma treatment

Researchers in Spain are developing what they hope will be a more effective sarcomatoid mesothelioma treatment. The new treatment focuses on a pair of drugs that are already being tested in humans.  Mesothelioma impacts about 2,500 Americans each year. Sarcomatoid mesothelioma is a rare form of this rare cancer. About a quarter of the annual cases are sarcomatoid.  This form of cancer is even more aggressive than epithelioid mesothelioma. But sarcomatoid mesothelioma treatment is not significantly different. Neither are the results.  But the new study could change the prognosis for people with asbestos cancer. It appears in the journal Cancer Research. Chemotherapy is the Primary Sarcomatoid Mesothelioma Treatment Most people with malignant mesothelioma receive chemotherapy with cisplatin and Alimta. This … Continue reading Sarcomatoid Mesothelioma Treatment Focuses on Two-Drug Combo »

Mesothelioma in Seafarers: Cancer Risk at Sea

mesothelioma in seafarers

New research has revealed a higher risk for mesothelioma in seafarers and fisherman in Nordic countries. A seafarer is someone who makes their living at sea. The study conducted by the Danish Cancer Society found an elevated risk in most types of cancer among Nordic seafarers. Mesothelioma was one of just three cancers whose cause was not difficult to guess. The research included tens of thousands of seamen and fisherman and spanned more than 40 years. The authors say malignant mesothelioma in seafarers is the result of on-the-job asbestos exposure. Asbestos at Sea Asbestos is a toxic mineral. It causes malignant mesothelioma and several other types of cancer. Before scientists made the connection between asbestos and cancer, it was a … Continue reading Mesothelioma in Seafarers: Cancer Risk at Sea »

Pesticide Inhibits Mesothelioma Cell Growth in Lab Animals

mesothelioma cell growth

Researchers in Switzerland say a pesticide designed to make grapes and kiwifruit bigger can also slow mesothelioma cell growth.  The EPA approved forchlorfenuron (FCF) in 2004. Farmers use it to help grapes and kiwifruit grow bigger, break less easily, and last longer in cold storage. But new research at the University of Fribourg suggests that the chemical has the opposite effect on mesothelioma cell growth. Mesothelioma cells exposed to FCF are less likely to live and spread. The researchers say this could be a promising step toward a new kind of mesothelioma treatment.  Forchlorfenuron and Mesothelioma Cell Growth The EPA classifies FCF as a plant growth regulator. According to the EPA fact sheet, FCF is a cytokinin which “improves fruit … Continue reading Pesticide Inhibits Mesothelioma Cell Growth in Lab Animals »

Pain a Sign of Successful Pleurodesis for Mesothelioma, Study Says

pleurodesis for mesothelioma

A temporary increase in pain may be a sign of success when undergoing pleurodesis for mesothelioma-related lung fluid. An uncomfortable build-up of lung fluid is one of the most common and life-limiting mesothelioma symptoms.  Chemical pleurodesis is one way doctors treat the problem. About three out of four patients have good luck with pleurodesis for mesothelioma. Now, a new study from the UK suggests that those who have the best results with the procedure also tend to have the most pain afterward.  What is Pleurodesis for Mesothelioma? Pleural mesothelioma is a malignancy that starts in the layers of the pleura. The pleura is a membrane that surrounds the lungs.  When tumors grow in the pleural membrane, they can trigger a … Continue reading Pain a Sign of Successful Pleurodesis for Mesothelioma, Study Says »

Anti-Inflammatory Treatment for Mesothelioma Shows Long-Term Benefit

anti-inflammatory treatment for mesothelioma

Doctors in London are reporting a case of long-term mesothelioma survival with anti-inflammatory treatment for mesothelioma. The 64-year-old pleural mesothelioma patient had been a heating engineer. When he was diagnosed with pleural mesothelioma, he elected not to have standard cancer treatments.  His doctors advised him to start on a regimen of aspirin and other anti-inflammatory drugs. On just the anti-inflammatory treatment for mesothelioma, the man was still alive four years after his diagnosis.  Mesothelioma and Inflammation Pleural mesothelioma is an aggressive cancer of the membrane around the lungs. It is most common in people who have worked or lived around asbestos.  When asbestos fibers get into the lungs, they stay there permanently. Studies suggest that the inflammation caused by these … Continue reading Anti-Inflammatory Treatment for Mesothelioma Shows Long-Term Benefit »

Drug May Make Mesothelioma Cells More Sensitive to Radiation

sensitive to radiation

Scottish cancer researchers say they have found a way to make mesothelioma cells more sensitive to radiation.  Radiotherapy is one of the tools doctors can use to help slow progression of the asbestos cancer. It can also help alleviate mesothelioma symptoms.  But proteins expressed by mesothelioma cells can make them less sensitive to radiation. The Glasgow-based research team is getting around this protection with a sensitizing drug. The drug mimics a process that already happens in healthy people. Radiotherapy in the Treatment of Mesothelioma Radiotherapy is not usually the primary treatment for malignant mesothelioma. Most mesothelioma patients have chemotherapy as their first-line treatment.  But newer technology means that radiation can be more targeted than it used to be. This means … Continue reading Drug May Make Mesothelioma Cells More Sensitive to Radiation »

Biomarker for Pleural Mesothelioma: Transforming Growth Factor-Beta

biomarker for pleural mesothelioma

A protein called transforming growth factor-beta (TGF-β) might be an effective biomarker for pleural mesothelioma. New research shows it could help diagnose the asbestos cancer and distinguish it from other lung conditions.  The findings come from researchers at the West German Cancer Center in Essen, Germany.  They studied patients with malignant mesothelioma, non-malignant pleural diseases or lung cancer. TGF-β levels were different in mesothelioma patients than they were in people with other diseases.  They correlated with mesothelioma survival. This suggests that TGF-β could make a good biomarker for pleural mesothelioma. How Do Doctors Use a Biomarker for Pleural Mesothelioma? A biomarker for pleural mesothelioma is a substance whose presence indicates that a person has the disease. Some biomarkers occur in … Continue reading Biomarker for Pleural Mesothelioma: Transforming Growth Factor-Beta »

Second-Line Treatment for Mesothelioma with Lurbinectedin

second-line treatment for mesothelioma

Swiss researchers may have finally found an effective second-line treatment for mesothelioma.  Scientists with the Swiss Group for Clinical Cancer Research presented their findings at the recent European Society for Medical Oncology conference in Barcelona.  Mesothelioma patients who fail after first-line therapy have few options. The new study focused on lurbinectedin, a drug that impacts cancer cells at the DNA level. Early studies suggest lurbinectedin might make a good second-line treatment for small cell lung cancer.  According to the Swiss team, more than half of patients in their study responded to lurbinectedin as a second-line treatment for mesothelioma.  In Search of a Second-Line Mesothelioma Treatment Malignant mesothelioma is notoriously difficult to diagnose and even harder to treat. It is usually … Continue reading Second-Line Treatment for Mesothelioma with Lurbinectedin »

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