COVID-19 Pandemic Had Little Or No Impact On New Malignant Mesothelioma Diagnoses

COVID-19 Pandemic Had Little Or No Impact On New Malignant Mesothelioma Diagnoses

A new study published in Thoracic Cancer discussed the impact of COVID‐19 pandemic on new mesothelioma diagnoses in Italy. Malignant mesothelioma is a rare disease of great interest to the scientific community and to public health. This is due to its high lethality and its association with asbestos exposure. The timely diagnosis of mesothelioma is important. Although it may not change the prognosis of the disease, it can help in treatment strategies. It can also help in documenting previous exposure to asbestos. This can contribute to any request for compensation. New Study Shows Promising Results During the COVID-19 pandemic, there was a delay in the diagnosis of oncological diseases. This was because many departments were converted into COVID wards. And … Continue reading COVID-19 Pandemic Had Little Or No Impact On New Malignant Mesothelioma Diagnoses »

New Cancer Guidelines to Manage and Treat Mesothelioma

Updating Mesothelioma Cancer Guidelines from a Global Perspective

Malignant pleural mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the body’s internal organs. Mesothelioma is a difficult disease to study on a global scale for many reasons. Yet, there has been tremendous progress in mesothelioma research over the last decade. However, current cancer guidelines are fragmented. An editorial in the Annals of Oncology recommends that new guidelines need to focus on both global and gender perspectives. Shifting Timeframes Make it Difficult to Study Mesothelioma Cases of mesothelioma are rising in some countries and falling in others. This makes it difficult to study the disease on a global level. There are a few different reasons for this global variation. First, … Continue reading New Cancer Guidelines to Manage and Treat Mesothelioma »

Quality of Life Similar Regardless of Pleural Mesothelioma Surgery Type

pleural mesothelioma surgery

New research suggests that the two major types of pleural mesothelioma surgery have about the same impact on patients’ quality of life afterward.  Thoracic surgeons at Switzerland’s University Hospital Zurich compared the results of 42 mesothelioma patients. Patients had either extrapleural pneumonectomy (EPP) or lung-sparing PD surgery between 2013 and 2017.  Patients answered questions about their health in the weeks and months after pleural mesothelioma surgery. Their answers show that, where post-surgical quality of life is concerned, it may not matter which procedure a person has.  Two Approaches to Pleural Mesothelioma Surgery Pleural mesothelioma tumors start on the membranous tissue (pleura) that surrounds the lungs. A healthy pleura is thin and flexible and expands to accommodate the lungs during respiration. … Continue reading Quality of Life Similar Regardless of Pleural Mesothelioma Surgery Type »

Celiac Disease May Be a Little-Known Complication of Mesothelioma Immunotherapy

mesothelioma immunotherapy

A new French case report shines a spotlight on a little-known potential complication of mesothelioma immunotherapy: celiac disease.  Celiac disease is a chronic digestive and immune disorder brought on by sensitivity to gluten. Over time, celiac disease damages the small intestine causing long-lasting digestive problems. It can prevent patients from getting the nutrients they need to stay healthy.  The new case report appears in Frontiers in Immunology. It details the case of a 70-year-old man who developed celiac disease after treatment with nivolumab. The case suggests that celiac disease may be an underrecognized side effect of mesothelioma immunotherapy. It is a reminder for mesothelioma patients and doctors to pay close attention to digestive problems after treatment.  Stimulating the Immune System … Continue reading Celiac Disease May Be a Little-Known Complication of Mesothelioma Immunotherapy »

Goat Virus Proves Lethal to Mesothelioma Cells in Italian Study

mesothelioma cells

Researchers in Italy say a virus normally found in goats could offer a new, safer way to kill malignant mesothelioma cells and improve patient outcomes.  The virus is caprine herpesvirus 1 (CpHV-1). It has been blamed for bouts of spontaneous abortions in goat herds. But it does not appear to cause any disease in humans. In fact, previous studies show CpHV-1 can kill several types of human cancer cells.  The newest study of CpHV-1 was conducted at the National Cancer Institute IRCCS G. Pascale Foundation in Naples. Scientists there made two important discoveries. They found that not only can CpHV-1 kill mesothelioma cells without harming normal cells, but it might also have the potential to make chemotherapy work better.  Mesothelioma … Continue reading Goat Virus Proves Lethal to Mesothelioma Cells in Italian Study »

“Remodeling” Mesothelioma Cells May Improve Responsiveness to Immunotherapy

Responsiveness to immunotherapy

Italian researchers are experimenting with the idea of remodeling mesothelioma cells from the inside out to improve their responsiveness to immunotherapy. Malignant mesothelioma is highly resistant to standard cancer treatments. Immunotherapy is widely considered to be one of the most hopeful new approaches to this cancer. But this approach works better for some people than it does for others.  The difference may lie in the genes. Scientists at University Hospital of Siena believe that manipulating the gene expression of mesothelioma cells could be the key to bolstering responsiveness to immunotherapy.  Mesothelioma, Genetics, and Responsiveness to Immunotherapy Immunotherapy is a method of treating disease by using the body’s natural immune response. This can mean trying to attract more immune cells to … Continue reading “Remodeling” Mesothelioma Cells May Improve Responsiveness to Immunotherapy »

Cancer Biomarker Test Could Detect Mesothelioma Earlier

cancer biomarker test

A new cancer biomarker test that promises to identify cancer in patients with “non-specific symptoms” could be the key to detecting mesothelioma earlier.  Malignant mesothelioma is a deadly cancer caused by asbestos. The early symptoms of mesothelioma are usually vague and similar to other conditions. As a result, mesothelioma is frequently diagnosed in a late stage. But a cancer biomarker test developed in the UK could change that. The test looks for small molecules called metabolites in the blood. Its developers say it has the potential to find cancer earlier than other blood-based cancer tests.  Non-Specific Symptoms Make Mesothelioma a Diagnostic Challenge Mesothelioma is a rare cancer. It is most common in people who worked or lived around asbestos in … Continue reading Cancer Biomarker Test Could Detect Mesothelioma Earlier »

Improve Mesothelioma Outcomes with a Fast-Mimicking Diet: Is it Possible?

Improve mesothelioma outcomes

New science from Italy suggests that it might eventually be possible to improve mesothelioma outcomes by severely restricting calories during cancer treatment.  The study appears in a recent version of the journal Cancer Discovery. Researchers with Italy’s FIRC Institute of Molecular Oncology (IFOM) in Milan tested a fast-mimicking diet in 101 cancer patients.  They concluded that restricting calories is a safe and feasible method for “reshaping metabolism” to impact tumor growth. If further studies confirm their findings, it could improve mesothelioma outcomes for thousands of patients. The Need for Better Mesothelioma Treatments Mesothelioma is a fast-growing and deadly type of cancer. Most people who receive a mesothelioma diagnosis do not live out the year. Malignant mesothelioma grows on the membranes … Continue reading Improve Mesothelioma Outcomes with a Fast-Mimicking Diet: Is it Possible? »

Glucose Solution May Prevent Complication After Pleural Mesothelioma Surgery

pleural mesothelioma surgery

There is new evidence that a solution of hypertonic glucose can help correct persistent air leak –  a complication that sometimes occurs after major pleural mesothelioma surgery. Pleural mesothelioma affects the membrane that surrounds the lungs. Efforts to surgically separate a mesothelioma tumor from the surface of the lungs can damage the lungs.  When this damage causes air to seep out of the lungs into the chest cavity, it is an air leak. Some air leaks fix themselves within a few days. But when an air leak persists for more than 5 days, it can cause further complications and slow recovery after pleural mesothelioma surgery.  A team of thoracic oncologists in Milan, Italy say hypertonic glucose can help clear up … Continue reading Glucose Solution May Prevent Complication After Pleural Mesothelioma Surgery »

Chemotherapy Still Good First-Line Option for Unresectable Epithelioid Mesothelioma

unresectable epithelioid mesothelioma

A top mesothelioma expert says chemotherapy may still be the best first-line treatment for unresectable epithelioid mesothelioma, even though immunotherapy is an increasingly popular option. Chemotherapy has been the primary way to treat mesothelioma since 2004. This is when the FDA approved the drug Alimta (pemetrexed). Alimta remained the only systemic treatment for asbestos cancer until 2020. In 2020, the FDA approved a combination of the immunotherapy drugs ipilimumab (Yervoy) and nivolumab (Opdivo). But Dean Fennell, PhD, of the UK’s University of Leicester says chemotherapy is still a good choice for many unresectable epithelioid mesothelioma cases. A Better Version of Chemotherapy? Epithelioid mesothelioma is the most common subtype. It is also the most responsive to treatment. For the healthiest patients, … Continue reading Chemotherapy Still Good First-Line Option for Unresectable Epithelioid Mesothelioma »

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