A new study suggests that a treatment called isolated thoracic perfusion could help alleviate some of the worst symptoms of malignant pleural mesothelioma. Isolated thoracic perfusion is a method for circulating medicine in just one area of the body. When doctors circulated chemotherapy drugs in the chests of people with pleural mesothelioma, their symptoms went away for several months. Now, the team says it is time to test the technique in a bigger pool of mesothelioma patients. The Theory Behind ITP Pleural mesothelioma is a membrane cancer that occurs in the chest. Chemotherapy drugs like Alimta can be powerful weapons against pleural mesothelioma. But they can also damage healthy tissues. When healthy tissues are damaged by chemotherapy, mesothelioma patients can … Continue reading Isolated Thoracic Perfusion for Mesothelioma Symptom Relief
Pleural mesothelioma risk may level off over several decades, but the risk for peritoneal mesothelioma never goes down. That is the conclusion of researchers at Italy’s University of Eastern Piedmont. It is based on data from more than 50,000 asbestos-exposed Italian workers. More than 40 years after asbestos exposure, the workers’ risk for peritoneal mesothelioma continued to rise. Calculating Mesothelioma Rates Over Time Asbestos is the primary cause of all types of malignant mesothelioma. Even short-term asbestos exposure raises the risk for peritoneal mesothelioma and pleural mesothelioma. Peritoneal mesothelioma occurs in the lining of the abdomen. Pleural mesothelioma tumors start on the lining around the lungs. If asbestos fibers are inhaled or swallowed, they embed themselves in these linings. This … Continue reading Risk for Peritoneal Mesothelioma Keeps Rising Decades After Exposure
French researchers have successfully operated on a man with unresectable peritoneal mesothelioma after treating him with bi-directional chemotherapy. Chemotherapy is the most common treatment for unresectable peritoneal mesothelioma. Most mesothelioma patients have chemotherapy by IV infusion. But some cancer centers now offer another chemotherapy delivery method. Intraperitoneal chemotherapy bypasses the bloodstream. It lets doctors put higher doses of cancer-killing medicine at the site of a tumor. The French team combined the two types of chemotherapy in one patient. It shrunk the patient’s unresectable peritoneal mesothelioma tumor enough to perform surgery. Two Types of Mesothelioma Chemotherapy With IV chemotherapy, medicine travels to the tumor through the bloodstream. It is one way of treating unresectable peritoneal mesothelioma. One drawback of IV chemotherapy … Continue reading Unresectable Peritoneal Mesothelioma Becomes Operable After Bi-Directional Chemotherapy
A new kind of mesothelioma treatment called dendritic cell therapy might make other types of treatments even more effective. Right now, chemotherapy with Alimta (pemetrexed) is the only approved therapy for malignant mesothelioma. Many others are in the works. But so far, none of them extend the lives of mesothelioma patients by more than a few months. Dendritic cell therapy for mesothelioma may be different. This novel treatment uses the patient’s own cells to jumpstart the immune system. A Dutch company developed and is testing the new treatment. The data so far suggests that it could boost chemotherapy and help new drugs like Keytruda work better. How Dendritic Cell Therapy Works Dendritic cells are immune system cells that function as … Continue reading Dendritic Cell Therapy for Mesothelioma: Can it Help Other Treatments Work Better?
Israeli researchers hope that a new kind of cancer blood test could help detect mesothelioma and other malignancies earlier. Earlier diagnosis could lead to longer mesothelioma survival. The blood test is based on the idea that immune system cells undergo metabolic changes when they fight a cancer like pleural mesothelioma. Different kinds of changes are associated with different kinds of cancers. The new cancer blood test detects these changes. Immune System Cells and Metabolism The immune system is the body’s primary way of defending itself against diseases like malignant mesothelioma. Metabolism refers to the way immune system cells expend energy to fight cancer. An Israeli company is developing the new cancer blood test. It focuses on the metabolism of immune … Continue reading New Cancer Blood Test Could Identify Early Mesothelioma
German doctors testing the HITHOC treatment for pleural mesothelioma say it is a “safe therapeutic option”. The key to success is careful patient selection. Pleural mesothelioma is a rare cancer linked to asbestos. Tumors grow on the membrane that surrounds the lungs. Doctors have not yet found a cure for mesothelioma. HITHOC treatment involves rinsing heated chemotherapy drugs through the chest after mesothelioma surgery. The new study suggests that this advanced approach may help certain mesothelioma patients live longer. Understanding Pleural Mesothelioma Tumors To understand how HITHOC treatment works, it is important to understand how and where mesothelioma tumors grow. Pleural mesothelioma tumors start on the lining around the lungs called the pleura. As tumors grow, the pleura thickens and … Continue reading HITHOC Treatment Deemed Safe for Some Pleural Mesothelioma Patients
Patients with the rarest mesothelioma subtypes tend to experience shorter mesothelioma survival. Now, new mesothelioma research suggests that may have something to do with a protein called PD-L1. French researchers studied the PD-L1 levels in the tumors of 214 mesothelioma patients. They compared the levels with each patient’s subtype and their treatment outcome. The results may help explain cases of shorter mesothelioma survival, especially among patients with sarcomatoid or biphasic mesothelioma subtypes. PD-L1 Levels and Shorter Mesothelioma Survival Programmed death ligand 1 (PD-L1) is one of the proteins that helps mesothelioma cells and other cancers “hide” from the immune system. Normally, the immune system finds and destroys renegade cells. But if a patient’s mesothelioma tumor expresses higher amount of PD-L1, … Continue reading Shorter Mesothelioma Survival Again Linked to Higher PD-L1 Levels
Researchers in France have come up with a way to turn some people with inoperable peritoneal mesothelioma into good candidates for mesothelioma surgery. They are using a new technique to spray chemotherapy drugs directly onto peritoneal tumors in order to shrink them. In some cases, the technique shrunk mesothelioma tumors enough that they could be surgically removed with the CRS/HIPEC procedure. What Makes a Good Candidate for Mesothelioma Surgery A number of factors influence whether patients are good candidates for mesothelioma surgery. Patients have to be in otherwise reasonably good health so that their body can handle the surgery. It is also critical that their mesothelioma not be so widespread in their abdomen that it would be impossible for surgeons … Continue reading PIPAC May Make More Patients Candidates for Mesothelioma Surgery
Two separate lung cancer studies suggest that antioxidant supplements for mesothelioma patients may not be advisable. The studies appear in the most recent issue of the medical journal Cell. Both focus on the role of antioxidants in the growth and spread of lung cancer. Although mesothelioma is not the same as lung cancer, it affects the same area of the body and shares many of the same characteristics. The new research suggests that, instead of fighting cancer, antioxidant supplements for mesothelioma patients, might actually help it grow. Supplements for Cancer Patients Antioxidant vitamins like A, C, and E are plentiful in fruits and vegetables. Many people take antioxidant supplements to make up for a poor diet. These vitamins can help … Continue reading Antioxidant Supplements for Mesothelioma Patients Might be Dangerous
Breath testing for mesothelioma may be a promising new way to catch asbestos cancer early. But Italian researchers are warning that there is not yet enough research to recommend widespread use of the technique. Malignant pleural mesothelioma is a virulent and hard-to-treat cancer. Researchers around the world continue to search for faster, easier ways to diagnose and treat it. Breath testing for mesothelioma is one proposed method. Special machines measure volatile organic compounds (VOCs) in patients’ exhaled breath. VOCs can give doctors important information about cellular metabolism and can indicate the presence of cancer. But researchers at Italy’s University of Bari analyzed all of the studies on breath testing for mesothelioma since 2000. They say none of the studies are … Continue reading Breath Testing for Mesothelioma: Not Yet Ready for Widespread Use?