Anti-Inflammatory Treatment for Mesothelioma Shows Long-Term Benefit

anti-inflammatory treatment for mesothelioma

Doctors in London are reporting a case of long-term mesothelioma survival with anti-inflammatory treatment for mesothelioma. The 64-year-old pleural mesothelioma patient had been a heating engineer. When he was diagnosed with pleural mesothelioma, he elected not to have standard cancer treatments.  His doctors advised him to start on a regimen of aspirin and other anti-inflammatory drugs. On just the anti-inflammatory treatment for mesothelioma, the man was still alive four years after his diagnosis.  Mesothelioma and Inflammation Pleural mesothelioma is an aggressive cancer of the membrane around the lungs. It is most common in people who have worked or lived around asbestos.  When asbestos fibers get into the lungs, they stay there permanently. Studies suggest that the inflammation caused by these … Continue reading Anti-Inflammatory Treatment for Mesothelioma Shows Long-Term Benefit »

Drug May Make Mesothelioma Cells More Sensitive to Radiation

sensitive to radiation

Scottish cancer researchers say they have found a way to make mesothelioma cells more sensitive to radiation.  Radiotherapy is one of the tools doctors can use to help slow progression of the asbestos cancer. It can also help alleviate mesothelioma symptoms.  But proteins expressed by mesothelioma cells can make them less sensitive to radiation. The Glasgow-based research team is getting around this protection with a sensitizing drug. The drug mimics a process that already happens in healthy people. Radiotherapy in the Treatment of Mesothelioma Radiotherapy is not usually the primary treatment for malignant mesothelioma. Most mesothelioma patients have chemotherapy as their first-line treatment.  But newer technology means that radiation can be more targeted than it used to be. This means … Continue reading Drug May Make Mesothelioma Cells More Sensitive to Radiation »

Biomarker for Pleural Mesothelioma: Transforming Growth Factor-Beta

biomarker for pleural mesothelioma

A protein called transforming growth factor-beta (TGF-β) might be an effective biomarker for pleural mesothelioma. New research shows it could help diagnose the asbestos cancer and distinguish it from other lung conditions.  The findings come from researchers at the West German Cancer Center in Essen, Germany.  They studied patients with malignant mesothelioma, non-malignant pleural diseases or lung cancer. TGF-β levels were different in mesothelioma patients than they were in people with other diseases.  They correlated with mesothelioma survival. This suggests that TGF-β could make a good biomarker for pleural mesothelioma. How Do Doctors Use a Biomarker for Pleural Mesothelioma? A biomarker for pleural mesothelioma is a substance whose presence indicates that a person has the disease. Some biomarkers occur in … Continue reading Biomarker for Pleural Mesothelioma: Transforming Growth Factor-Beta »

Second-Line Treatment for Mesothelioma with Lurbinectedin

second-line treatment for mesothelioma

Swiss researchers may have finally found an effective second-line treatment for mesothelioma.  Scientists with the Swiss Group for Clinical Cancer Research presented their findings at the recent European Society for Medical Oncology conference in Barcelona.  Mesothelioma patients who fail after first-line therapy have few options. The new study focused on lurbinectedin, a drug that impacts cancer cells at the DNA level. Early studies suggest lurbinectedin might make a good second-line treatment for small cell lung cancer.  According to the Swiss team, more than half of patients in their study responded to lurbinectedin as a second-line treatment for mesothelioma.  In Search of a Second-Line Mesothelioma Treatment Malignant mesothelioma is notoriously difficult to diagnose and even harder to treat. It is usually … Continue reading Second-Line Treatment for Mesothelioma with Lurbinectedin »

Mesothelioma Linked to Shipbuilding Finally Falling in the UK

mesothelioma linked to shipbuilding

After decades of higher-than-normal rates of mesothelioma near dockyards, cases of mesothelioma linked to shipbuilding appear to be falling in the UK. The UK has one of the highest per capita rates of malignant mesothelioma in the world. A big part of that comes from the shipbuilding industry where asbestos was used extensively. Now, a new report suggests the scourge of mesothelioma linked to shipbuilding is finally beginning to taper off, even though deaths from mesothelioma have not.  Why is Mesothelioma Linked to Shipbuilding? Asbestos is a naturally-occurring mineral that is strong and impervious to heat and corrosion. That made it a good insulator and a choice building material for many decades. Unfortunately, asbestos is also highly toxic.  Before scientists … Continue reading Mesothelioma Linked to Shipbuilding Finally Falling in the UK »

Supplement May Boost the Effectiveness of Mesothelioma Treatment

boost the effectiveness of mesothelioma treatment

A supplement that claims to increase oxygen in the tissues might boost the effectiveness of mesothelioma treatment.  That is the conclusion of researchers at Italy’s National Cancer Institute in Rome.  The group tested the supplement Cellfood (CF) on several types of cancer cells in the lab. They also gave the supplement to mice with implanted human mesothelioma tumors.  CF appeared to boost the effectiveness of mesothelioma treatment with radiation or chemoradiation.  What is Cellfood? Cellfood (Deutrosultazyme) is a nutraceutical produced by NuScience Corporation. A nutraceutical is a nutritional supplement that may function like a drug in some ways. According to NuScience, Cellfood contains colloidal minerals, amino acids, enzymes, and dissolved oxygen. Lab studies show that it has antioxidant effects and … Continue reading Supplement May Boost the Effectiveness of Mesothelioma Treatment »

Mesothelioma Clinical Trials: Study Highlights Challenges for Patients

mesothelioma clinical trials

A new UK study points to some of the potential challenges and benefits for patients involved in mesothelioma clinical trials.  Researchers at three teaching hospitals in England interviewed mesothelioma patients who took part in the Mesothelioma and Radical Surgery (MARS 2) trial.  The trial compared outcomes in people who had a combination of surgery and chemotherapy with those who only had chemotherapy. The findings show that not all aspects of mesothelioma clinical trials are positive for patients.  A Study Within a Study Pleural mesothelioma is a fast-growing cancer that starts on the lining around the lungs. Asbestos exposure is usually the cause. With standard cancer treatments, most mesothelioma patients face a poor prognosis. Mesothelioma often leads to death within a … Continue reading Mesothelioma Clinical Trials: Study Highlights Challenges for Patients »

Biphasic Mesothelioma Survival Possible in Select Patients

biphasic mesothelioma survival

A new report contains some hopeful news about biphasic mesothelioma survival.  Biphasic mesothelioma is the rarest subtype of a rare cancer. It is also the subtype that is hardest to treat.  Biphasic mesothelioma survival is typically shorter than other subtypes. But Italian researchers say, with the right combination of mesothelioma treatments, patients with this subtype can achieve long-term survival. Subtypes and their Impact on Biphasic Mesothelioma Survival All pleural mesothelioma tumors grow on the membrane that surrounds the lungs. When this membrane is healthy, it is flexible and expands naturally with each breath.  When a mesothelioma tumor grows on this membrane, it can restrict the lungs and make it hard to breathe. As tumors grow, mesothelioma can spread to other … Continue reading Biphasic Mesothelioma Survival Possible in Select Patients »

Machine Learning Tool May Predict Mesothelioma Survival Better Than Pathologists

machine learning tool

The developers of a machine learning tool called MesoNet say the program can predict mesothelioma survival better than a pathologist. MesoNet is a deep convolutional neural network. It analyzes digitized images of mesothelioma cells to predict overall survival. In a new article in Nature Medicine, its creators compared the machine learning tool with pathologist-read slides. Then they validated MesoNet with two different sets of mesothelioma patients.  The result may offer a new, more accurate approach to mesothelioma treatment planning.  What is a Machine Learning Tool? A machine learning tool is a computer program that gets “smarter” the more it runs. A deep convolutional neural network is a type of machine learning tool that analyzes images. The more images it analyzes, … Continue reading Machine Learning Tool May Predict Mesothelioma Survival Better Than Pathologists »

Mesothelioma Among Construction Workers in Southern Italy

mesothelioma among construction workers

New research in Southern Italy highlights the global problem of mesothelioma among construction workers.  The research comes from occupational medicine experts at the University of Bari.  Scientists studied 178 cases of mesothelioma among construction workers in the Apulia region of Italy. The data shows that heavy asbestos exposure raised the odds of contracting mesothelioma by more than two-and-a-half times.  Asbestos and the Risk for Mesothelioma Asbestos is the primary cause of mesothelioma, in Italy and around the world. But for decades, almost no one knew that.  Tens of thousands of people worked with asbestos before scientists recognized the risk for mesothelioma among construction workers.  Asbestos was in dozens of construction products including cement, wall board, insulation, floor and ceiling tiles … Continue reading Mesothelioma Among Construction Workers in Southern Italy »

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