Evening Primrose Extract Acts on Invasive Mesothelioma Cells, Study Shows

evening primrose

There is new evidence that compounds found in the seeds of the evening primrose plant have the potential to slow the growth and spread of mesothelioma.  Researchers in Poland extracted key compounds from the seeds using alcohol. They applied the extract (EPE) to malignant pleural mesothelioma cells in the lab.  Evening primrose extract seemed to have the biggest effect on the most invasive mesothelioma cells. The more EPE the researchers used, the greater the impact. The study suggests there may be a future role for evening primrose in mesothelioma therapy. What is Evening Primrose? The evening primrose is a plant with yellow flowers. Its seeds contain a range of polyphenols including ellagic acid, gallic acid, and catechin.  Oil extracted from … Continue reading Evening Primrose Extract Acts on Invasive Mesothelioma Cells, Study Shows »

Gene Editing Technology May Hold the Key to Curing Mesothelioma

gene editing technology

New research on gene editing technology for cancer suggests that it could be the key to one day curing intractable cancers like malignant mesothelioma. Researchers at Tel Aviv University have used a technology called CRISPR to dramatically extend the lives of mice with some of the most serious kinds of cancer.  Gene editing technology alters the genes of cancer cells so they cannot replicate. The Israeli team found a way to make it target cancer cells.   It could be the breakthrough that many mesothelioma doctors have been hoping for.  Genes and Mesothelioma The genetic material inside a person’s cells determines how those cells will behave. Genes encode for proteins which give signals to cells. Gene editing technology aims to change … Continue reading Gene Editing Technology May Hold the Key to Curing Mesothelioma »

P16 Test May Improve Diagnostic Accuracy for Mesothelioma

diagnostic accuracy for mesothelioma

Scientists in the UK say testing for a tumor suppressor protein called p16 can improve diagnostic accuracy for mesothelioma. It may also help predict which patients are likely to have the best treatment response. The p16 protein is encoded by the CDKN2A gene. Many people with mesothelioma are missing this gene.  Previous studies show a lack of p16 may be linked to lower cancer survival. Now, researchers in Manchester say it should be added to routine tests to improve prognostic and diagnostic accuracy for mesothelioma. The Challenge of Diagnostic Accuracy for Mesothelioma It is not easy to diagnose mesothelioma. There is no single test that can show if a person has this cancer. Diagnosis usually involves blood tests, imaging studies, … Continue reading P16 Test May Improve Diagnostic Accuracy for Mesothelioma »

Smartphone Monitoring System Helps Manage Mesothelioma Symptoms

Manage Mesothelioma Symptoms

A new study shows a system that connects doctors and patients via smartphone may make it easier to manage mesothelioma symptoms.  Mesothelioma tumors grow quickly on the membrane around the lungs. Mesothelioma patients tend to have many physical symptoms.  Researchers in the UK tested a mesothelioma-specific version of a symptom management system. Their study shows patients felt better with easier access to a doctor to help them manage mesothelioma symptoms.  Symptoms of Malignant Pleural Mesothelioma Pleural mesothelioma is the most common form of asbestos cancer. As tumors grow, the pleural membrane becomes less pliable. This makes it harder for the lungs to expand. The space around the lungs can also fill up with fluid (pleural effusions) as the body tries … Continue reading Smartphone Monitoring System Helps Manage Mesothelioma Symptoms »

T-Cells Test May Predict Success of New Drug Combination for Mesothelioma

new drug combination for mesothelioma

A month after the FDA approved a new drug combination for pleural mesothelioma, scientists are discovering more about who might benefit the most from this treatment.  A new report in EBioMedicine suggests that the success of the new drug combination for mesothelioma depends on the presence and activation of special immune system cells. Researchers in the Netherlands found that patients with enough of the right kind of T-cells had the best results. The findings could help doctors screen out mesothelioma patients who are less likely to benefit.  The Long-Awaited New Drug Combination for Mesothelioma  The two medicines in the new drug combination for mesothelioma are nivolumab (Opdivo) and ipilimumab (Yervoy).  The FDA approved a mix of the two immunotherapy drugs … Continue reading T-Cells Test May Predict Success of New Drug Combination for Mesothelioma »

Altered Herpes Virus Halts Mesothelioma Growth in New Study

altered herpes virus

An altered herpes virus has been shown to stabilize the growth of mesothelioma tumors in half of patients who participated in a new UK study.  Researchers at the University of Sheffield injected thirteen mesothelioma patients with a cancer cell-seeking version of HSV, the virus that causes herpes.  The altered herpes virus is not able to replicate in non-dividing cells. This also makes it most destructive inside cancer cells. It is also attenuated or weakened so it does not cause herpes. Other studies show the virus (HSV1716) can stimulate the immune system against cancer. The new report suggests that it may be a safe new way to fight mesothelioma, too. The Need for a New Mesothelioma Drug The FDA has only approved … Continue reading Altered Herpes Virus Halts Mesothelioma Growth in New Study »

Study to Test Nivolumab and Chemotherapy for Mesothelioma

Nivolumab and Chemotherapy

Researchers in Germany are recruiting patients for a trial of nivolumab and chemotherapy for pleural mesothelioma patients who have had surgery. Nivolumab (Opdivo) is an immunotherapy drug similar to pembrolizumab (Keytruda). It blocks a protein that helps mesothelioma cells hide from the immune system. Nivolumab is most often used for patients with non-small cell lung cancer. The multicenter German study will test if a combination of nivolumab and chemotherapy can help keep tumors from growing back after mesothelioma surgery. Previous studies suggest that it has the potential to do so. How Immune Checkpoint Inhibitors Work Immune checkpoint inhibitors like nivolumab, pembrolizumab, and ipilimumab (Yervoy) are a major focus for mesothelioma researchers. Mesothelioma cells are notoriously tenacious. They often fail to … Continue reading Study to Test Nivolumab and Chemotherapy for Mesothelioma »

Asbestos-Based Clutches and Brakes Linked to Cancer in Italian Workers

asbestos-based clutches and brakes

Italian researchers say cases of lung cancer among people who work with asbestos-based clutches and brakes in the country have probably been underestimated. And it remains to be seen how many of these workers end up contracting malignant mesothelioma. The study was led by occupational medicine experts from the province of Brescia. They focused on an Italian company that produced asbestos-based clutches and brakes for more than 20 years.  The team conducted an analysis of the workers’ likely asbestos exposure levels. These levels were compared to the incidence of asbestos-related diseases like lung cancer, asbestosis, and pleural mesothelioma.  The conclusion? The risk is bigger than anyone realized.  Mesothelioma Risk from Asbestos-Based Clutches and Brakes Asbestos is a fibrous mineral that … Continue reading Asbestos-Based Clutches and Brakes Linked to Cancer in Italian Workers »

Vitamin D3 May Slow the Spread of Pleural Mesothelioma, Study Shows

Vitamin D

A study conducted in Italy suggests that Vitamin D3 might help keep mesothelioma cells from growing and spreading. The biologically active form of Vitamin D is calcitriol or D3. Other studies suggest it might have anticancer properties. But no one has studied its effect on mesothelioma cells until now.  The researchers applied Vitamin D3 to pleural mesothelioma cells in the lab. Not only did it weaken the cells, but it also blocked their ability to divide into new cells. The study suggests that Vitamin D may even boost the effectiveness of mesothelioma chemotherapy. The Cancer-Fighting Role of Calcitriol The body naturally produces calcitriol. It plays a role in regulating the cell cycle, including apoptosis or natural cell death. Vitamin D3 … Continue reading Vitamin D3 May Slow the Spread of Pleural Mesothelioma, Study Shows »

First Patient Dosed in New Trial for Relapsed Mesothelioma

relapsed mesothelioma

Doctors in the UK have started treatment on the first patient in the trial of a new drug combination for relapsed mesothelioma. The drug is called bemcentinib. It blocks a protein encoded by the AXL gene. People with mesothelioma tend to overexpress this protein. Studies show that this extra AXL protein might help cancer cells hide from the immune system. It might also help them spread to other parts of the body.  In the new trial, patients with relapsed mesothelioma will get a combination of bemcentinib and Keytruda (pembrolizumab). Keytruda is an immunotherapy drug. Like bemcentinib, it helps make mesothelioma cells vulnerable to immune system attack.  Animal studies and tests in lung cancer patients show that bemcentinib may help immune … Continue reading First Patient Dosed in New Trial for Relapsed Mesothelioma »

Get your free copy of
“Surviving Mesothelioma” Today!