Genetics | Surviving Mesothelioma

BAP1 May Not Be The Only Gene to Increase Mesothelioma RIsk

The question of why some asbestos-exposed people develop malignant mesothelioma and others do not has been a key focus of mesothelioma research for more than a decade. We now know that a mutation in the BAP1 gene can predispose certain people to several types of cancer, including mesothelioma. This is known as BAP1 cancer syndrome. Without the BAP1 tumor-suppressing protein to keep it at bay, … Continue reading BAP1 May Not Be The Only Gene to Increase Mesothelioma RIsk »

BAP1 May Be Valuable for Peritoneal Mesothelioma Prognosis

There is new evidence that the same genetic mutation that is common in people with pleural mesothelioma may be present in many cases of peritoneal mesothelioma, too. BAP1 is a tumor suppressing protein encoded by the BAP1 gene. People with a mutation in this gene are less likely to produce the protein and are more likely to develop certain kinds of cancer, including pleural mesothelioma. … Continue reading BAP1 May Be Valuable for Peritoneal Mesothelioma Prognosis »

Gene Test May Help Distinguish Pleural Mesothelioma from Lung Cancer

There is more evidence this week that the tumor suppressor gene known as BRCA1-associated protein 1 (BAP1) could help doctors distinguish pleural mesothelioma from other types of lung cancer – even cancers that commonly spread to the pleura. Pleural mesothelioma is unique among cancers in that it starts on the pleural membrane that surrounds the lungs. When other types of cancers metastasize to this region, … Continue reading Gene Test May Help Distinguish Pleural Mesothelioma from Lung Cancer »

Exome Sequencing Helps Reveal Origins of Mesothelioma Tumor

A type of genetic sequencing called whole exome sequencing (WES) may help scientists unlock the underlying causes of pleural mesothelioma and develop more targeted treatment plans. A new study conducted in Italy and published in the journal Medicine illustrates how WES – the process of sequencing all of an individual’s protein-coding genes – helped reveal the origins of three different types of lung tumors in … Continue reading Exome Sequencing Helps Reveal Origins of Mesothelioma Tumor »

Understanding the Underlying Causes of Peritoneal Mesothelioma

There is new evidence that alterations in the expression of certain genes, also known as epigenetics, may play an even bigger role in malignant peritoneal mesothelioma than in pleural mesothelioma. Both forms of malignant mesothelioma, an aggressive cancer that impacts internal membranes, are associated with exposure to asbestos, but the association is strongest with pleural mesothelioma. That led researchers in the Clinical Cancer Genomics Lab … Continue reading Understanding the Underlying Causes of Peritoneal Mesothelioma »

New Treatment Strategy Could Make Mesothelioma More Responsive to Chemotherapy

Researchers in Japan have taken another important step toward creating a novel therapeutic strategy for malignant pleural mesothelioma, a highly treatment-resistant and deadly form of lung cancer. Following up on research they conducted earlier this year, doctors at Tokushima University’s Institute of Health Biosciences successfully boosted the effectiveness of chemotherapy and prolonged mesothelioma survival in mice by manipulating their RNA. RNA and Malignant Mesothelioma Ribonucleic … Continue reading New Treatment Strategy Could Make Mesothelioma More Responsive to Chemotherapy »

DNA Screening May Enhance Mesothelioma Treatment

test tube

New research suggests that testing for evidence of DNA damage may make it possible for doctors to treat malignant pleural mesothelioma more effectively. Right now, there are few effective treatments for mesothelioma. Even the gold standard first-line treatment – pemetrexed-based chemotherapy – is only marginally helpful. For most patients who receive mesothelioma chemotherapy, their disease recurs within a few months. But a newly-released study conducted … Continue reading DNA Screening May Enhance Mesothelioma Treatment »

Tests Reveal Potential New Gene Target for Mesothelioma Therapy

A gene known as P2X7R (or P2RX7) and the protein that it encodes may offer a novel target for a new kind of mesothelioma therapy. A recent study of P2X7R at the University of Ferrara in Ferrara, Italy found that the protein was overexpressed in three different mesothelioma cell lines. Just as importantly, P2X7R was not expressed by healthy mesothelial membrane cells taken from healthy … Continue reading Tests Reveal Potential New Gene Target for Mesothelioma Therapy »

The Link Between Malignant Mesothelioma and Other Cancers

If you have malignant mesothelioma, evidence suggests that you have a higher-than-normal risk of also developing another type of cancer, either before or after your mesothelioma diagnosis. The research was carried out by a team of international scientists who examined the cases of more than 5,000 mesothelioma patients around the world. Second Primary Cancers After Mesothelioma In the first study of both secondary cancers after … Continue reading The Link Between Malignant Mesothelioma and Other Cancers »

Mesothelioma Patients With Gene Mutation May Live Longer

There is some good news and some bad news regarding the BAP1 gene and the asbestos-linked cancer, malignant mesothelioma. BAP1 is a tumor suppressor gene, that is often mutated in people with certain kinds of cancer, including both pleural and peritoneal mesothelioma. In fact, in recent years, scientists have identified what they call a BAP1 cancer syndrome in which individuals with missing or mutated BAP1 genes are … Continue reading Mesothelioma Patients With Gene Mutation May Live Longer »

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