Serum IgG4: A New Biomarker for Mesothelioma Pleural Effusion

Serum IgG4: A New Biomarker for Mesothelioma Pleural Effusion

Egyptian scientists say a new biomarker is very good at identifying mesothelioma. Pleural effusions are pockets of excess fluid. They collect around the lungs of people with certain kinds of cancer and other conditions. Biomarkers in pleural effusions are proteins and other substances found in mesothelioma patients. The new study suggests that using this biomarker the right way can lead to more accurate diagnoses. The Importance of Biomarkers in Pleural Effusions Pleural mesothelioma is a rare cancer of the lung lining. It is a challenge to diagnose. The early symptoms can be as vague as cough and fatigue. But an accurate diagnosis is often the difference between life and death. As tumors grow, mesothelioma patients produce pleural effusions or ‘water … Continue reading Serum IgG4: A New Biomarker for Mesothelioma Pleural Effusion »

New Tips for Diagnosing Malignant Peritoneal Mesothelioma

New Tips for Diagnosing Malignant Peritoneal Mesothelioma

Malignant peritoneal mesothelioma is an aggressive cancer that often mimics other conditions. This can make it difficult to get a definitive diagnosis. But a new report in Pathology Case Reviews provides tips for identifying peritoneal mesothelioma. Diagnosing Malignant Peritoneal Mesothelioma Mesothelioma is usually diagnosed after a person experiencing symptoms goes to a doctor. Patients often complain of vague abdominal symptoms, such as pain, nausea, bloating, weight loss. Distinguishing peritoneal mesothelioma from other cancers is important to ensure appropriate treatment. One thing a doctor may do is perform a tissue biopsy. The doctor will remove a part of the tissue (suspected mesothelioma) for examination. A biopsy is the “gold standard” and the single most important procedure for an accurate diagnosis. Doctors … Continue reading New Tips for Diagnosing Malignant Peritoneal Mesothelioma »

Combining Cytology and Immunology for a Less Invasive Mesothelioma Diagnosis

Combining Cytology and Immunology for a Less Invasive Mesothelioma Diagnosis

An invasive surgical or tissue biopsy is often required to get a definitive mesothelioma diagnosis. But a new hybrid exam might offer an alternative for mesothelioma patients. It involves the combination of cytology and immunology. Cytology tests look at the cells in body fluids. It is the analysis of a patient’s cells under a microscope. And immunology is the study of the immune system. Together, these two areas of science provide new hope for mesothelioma patients. The Tokyo Medical University in Japan has been looking into advanced diagnostic options. They believe that a combination of cytology and immunology methods can lead to a definitive diagnosis. This is good news for mesothelioma patients. It will mean a quicker mesothelioma diagnosis without … Continue reading Combining Cytology and Immunology for a Less Invasive Mesothelioma Diagnosis »

Mesothelioma Mimics Ovarian Cancer: Lessons from a Case Report

Mesothelioma Mimics Ovarian Cancer: Lessons from a Recent Case Report

Mesothelioma mimics ovarian cancer in a new report by Radiology Case Reports. Mesothelioma is a rare and very aggressive tumor of the peritoneum. Similar clinical and imaging presentations mean mesothelioma mimics ovarian cancer at times. Yet, a history of asbestosis exposure is key as the main risk factor for mesothelioma. Imaging plays a key role in getting the diagnosis correct. It narrows down the diagnosis possibilities. Ultrasound-guided biopsy with histological study can confirm a mesothelioma diagnosis. Case Report Misdiagnosis The Bangladesh National Institute of Oncology recently published a case report. A 42-year-old woman reported pelvic pain and progressive abdominal distension. An abdominal ultrasound revealed a high volume anechoic peritoneal effusion. Further investigation showed extensive peritoneal disease and bilateral ovarian tissue … Continue reading Mesothelioma Mimics Ovarian Cancer: Lessons from a Case Report »

Diagnostic Accuracy of Lung Fluid Tests for Mesothelioma

diagnostic accuracy

Researchers in Germany say the diagnostic accuracy of lung fluid tests for mesothelioma is high enough that they can be routinely used for diagnosis.  Right now, if mesothelioma is suspected, doctors may order a fluid test first. If the fluid test (cytology) is positive, the doctor usually orders a tissue biopsy (histology) to confirm.  But the German team says their study shows that the diagnostic accuracy of cytology is almost as good as histology for mesothelioma – especially when doctors consider the patient’s hyaluronic acid level, too. Scientists from several German institutions analyzed cytology tests from more than 4,500 suspected cases of pleural mesothelioma. They conclude that cytology is accurate enough to be used routinely for diagnosis.  The Importance of … Continue reading Diagnostic Accuracy of Lung Fluid Tests for Mesothelioma »

Misdiagnosis of Mesothelioma More Common with Cytology Alone

misdiagnosis of mesothelioma

A new set of case reports illustrates how easily misdiagnosis of mesothelioma can happen when the diagnosis is based on cytology alone.  Cytology tests look at the cells in body fluids. For peritoneal mesothelioma patients, this is often the fluid that collects in their abdomen called ascites.  But doctors from India’s Dayanand Medical College and Hospital say using ascites samples alone to diagnose mesothelioma is a risky practice. Misdiagnosis of mesothelioma may delay proper treatment and negatively impact survival. The Difficulty of Diagnosing Peritoneal Mesothelioma Malignant mesothelioma only impacts about 2,500 people in the US every year. It is most common among people who have lived or worked around asbestos. Peritoneal mesothelioma is even rarer. About a fifth of patients … Continue reading Misdiagnosis of Mesothelioma More Common with Cytology Alone »

Immunohistochemical Staining and Sarcomatoid Mesothelioma: Beyond the Lab

immunohistochemical staining

When it comes to understanding individual cases of sarcomatoid mesothelioma, doctors should not rely too heavily on immunohistochemical staining.  That conclusion comes from mesothelioma researchers at MD Anderson Cancer Center in Texas.  The researchers just released a new study focused on this rare mesothelioma subtype. A patient’s subtype has an impact on what kind of treatment could work best for them. Sarcomatoid mesothelioma is usually less responsive to chemotherapy. Immunohistochemical staining is a pathology technique. It is the main way that doctors tell the difference between mesothelioma subtypes.  But the MD Anderson report suggests that not all cases of sarcomatoid mesothelioma are created equal. The researchers say it is important to look beyond the lab findings to understand individual cases. … Continue reading Immunohistochemical Staining and Sarcomatoid Mesothelioma: Beyond the Lab »

Mesothelioma Subtypes Often Misclassified by Biopsy

mesothelioma subtypes

Pleural biopsy is not perfect when it comes to telling the difference between the three mesothelioma subtypes. But misclassification could lead to shorter survival.  That is the conclusion reached by top mesothelioma researchers in Brescia, Italy.  They compared autopsy records from 134 Italian mesothelioma patients. The patients were either shipyard workers or their spouses. The researchers found that the mesothelioma subtypes identified from biopsy tissue were incorrect a large percent of the time. Misclassification matters because it impacts which mesothelioma treatments doctors choose.  The Three Mesothelioma Subtypes Pleural mesothelioma is an aggressive malignancy on the lung lining. It is caused by exposure to asbestos. Mesothelioma cells fall into three mesothelioma subtypes based on certain cellular characteristics. Pleural mesothelioma is notoriously … Continue reading Mesothelioma Subtypes Often Misclassified by Biopsy »

Irradiating Procedure Tracts Reduces Metastatic Mesothelioma in New Study

metastatic pleural mesothelioma

Irradiating the tracts through which certain interventions are performed can reduce the risk of metastatic pleural mesothelioma. That word comes from a new study in Singapore.  The pleural form of malignant mesothelioma occurs on the lining around the lungs. Doctors often have to insert tools through the chest wall for diagnosis or treatment. The paths or tracts along which they insert those tools can be the site of new mesothelioma tumors.  But the study shows that timely radiation treatment of those paths may prevent metastatic pleural mesothelioma. Metastatic Pleural Mesothelioma Metastasis is when cancer cells move from their original site to another place in the body. A tumor that is contained in one spot is easier to treat or remove. … Continue reading Irradiating Procedure Tracts Reduces Metastatic Mesothelioma in New Study »

Visualizing the Immune Profile of Mesothelioma Patients

immune profile

Researchers at MD Anderson Cancer Center in Houston have come up with a better way to analyze the immune profile of people with malignant mesothelioma.  A person’s immune profile is the unique set of immune system cells and how they are working at any given time. The functionality of immune system cells in the area right around the tumor – the tumor microenvironment or TME – is especially telling.  The system developed at MD Anderson assigns different colors to key immune system markers. They applied the color system to a sample from the microenvironment of mesothelioma tumors. The result was an image of each tmor’s immune profile. These images could help doctors determine new targets for mesothelioma treatment.  What is … Continue reading Visualizing the Immune Profile of Mesothelioma Patients »

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