Chemoimmunotherapy Called “Next Frontier” for Mesothelioma Cancer
Mesothelioma researchers in Australia are calling the combination of chemotherapy and immunotherapy the “next frontier” in the treatment of mesothelioma cancer. In a study published in the journal Expert Opinions in Biological Therapy, the researchers reviewed past clinical trials on mesothelioma immunotherapy. They focused on studies published between 2016 and 2018. Their goal was to get a clearer picture of just how effective these drugs are and how they might be used in combination with other treatments. Chemotherapy for Mesothelioma Cancer Currently, immunotherapy is not the primary treatment for mesothelioma cancer. Instead, most patients have chemotherapy, which is considered the gold standard treatment. For the past 15 years, Alimta has been the main chemotherapy drug for people with malignant mesothelioma. … Continue reading Chemoimmunotherapy Called “Next Frontier” for Mesothelioma Cancer
Study Reveals Mesothelioma Chemotherapy May Be Underused in Older Patients
The older a mesothelioma patient is, the less likely he or she may be to receive mesothelioma chemotherapy. A new study says many older mesothelioma sufferers may be paying the price in shorter lifespans. Chemotherapy with pemetrexed (Alimta) and cisplatin is the gold standard for mesothelioma treatment. Many studies have linked it with longer mesothelioma survival. But an Australian study suggests that not enough older people are receiving mesothelioma chemotherapy. In fact, the older they are, the less likely they are to have chemotherapy for their mesothelioma. As a result, their chances of dying from malignant mesothelioma are higher. Mesothelioma Chemotherapy is Standard of Care Malignant mesothelioma is a hard-to-treat cancer with a poor prognosis. Mesothelioma chemotherapy is the primary … Continue reading Study Reveals Mesothelioma Chemotherapy May Be Underused in Older Patients
Quality of Life for Mesothelioma Patients Hinges on Activity and Nutrition
Muscle mass and nutrition can have a direct impact on quality of life for mesothelioma patients. That’s the finding of an Australian study of sixty-one men and women with malignant pleural mesothelioma. Researchers say the quality of life for mesothelioma patients was compromised by lower muscle mass or malnutrition. It is a wake-up call for mesothelioma patients to stay active and eat well for the best outcomes. Impacts on Quality of Life for Mesothelioma Patients Pleural mesothelioma is an incurable cancer. Even with the best mesothelioma treatments, most patients still face a grim prognosis. But there is evidence that good self-care may help. Previous studies have shown that patients with the best nutritional status often have longer mesothelioma survival. Nutritional … Continue reading Quality of Life for Mesothelioma Patients Hinges on Activity and Nutrition
Doctor Attitude Keeps Some Patient from Mesothelioma Chemotherapy
A new study suggests that some patients are missing out on chemotherapy for mesothelioma because their doctors do not believe it will work. Doctor “nihilism” – the idea that life is meaningless anyway – was the top reason that 20+ percent of pleural mesothelioma patients did not get the care that might have helped them. In other cases, patients were simply never referred to a cancer doctor who could prescribe chemotherapy for mesothelioma. Doctor Attitudes and Chemotherapy for Mesothelioma The Australian study is based on surveys with 107 doctors and 19 nurses. Most respondents were either lung specialists or cancer doctors. They completed the surveys in 2014. The surveys show that most of the doctors (90%) think at least one … Continue reading Doctor Attitude Keeps Some Patient from Mesothelioma Chemotherapy
New Study Sheds Light on Genetic Origins of Malignant Mesothelioma
Scientists in Australia have made a big step forward in understanding how a genetic mutation appears to drive the development of cancers such as malignant mesothelioma. The gene in question is called p53. Also known as the “guardian of the genome” for its tumor-suppressing action, p53 has been found to be mutated in about half of all human cancers, including many cases of mesothelioma. Although the primary external cause of mesothelioma is exposure to asbestos, the mutated p53 gene helps explain why some asbestos-exposed cells suddenly become cancerous and are able to grow and spread, unchecked. It may also help scientists develop new, more effective mesothelioma treatments. Right now, the prognosis for mesothelioma is often very poor. The p53 Gene … Continue reading New Study Sheds Light on Genetic Origins of Malignant Mesothelioma
Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis
Australian researchers say proteins found in lung fluid could hold the key to diagnosing pleural mesothelioma months or even years before a tumor is visible on imaging scans. Proteins function as communication devices in the body, directing all sorts of critical cellular processes, including the processes that tell cancer cells to begin replicating at a higher rate than normal cells. Scientists at Flinders University, one of the world’s leaders in mesothelioma research, wondered if the proteins that help give rise to malignant pleural mesothelioma could be found in pleural effusions and used as biomarkers to identify the cancer earlier. Looking for Mesothelioma Biomarkers in Lung Fluid In a new study published in the Journal of Proteomics, the team notes that … Continue reading Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis
Mesothelioma Survival Odds Better for Women Than Men
Women diagnosed with malignant mesothelioma tend to live longer than men with the same disease. Australian researchers say understanding exactly why that is could open the door to improving mesothelioma treatment for both genders. Assessing Mesothelioma Survival Rates By Gender Researchers led by the Cancer Epidemiology and Intelligence Division of Cancer Council Victoria in Melbourne used cancer registry data to identify cases of malignant mesothelioma and 24 others types of cancer diagnosed in Victoria between 1982 and 2015. Then, they assessed the survival differences for each type of cancer between men and women, adjusting for each patient’s age and year of diagnosis. According to their report published this week in Cancer Causes & Control, the bad news for men is … Continue reading Mesothelioma Survival Odds Better for Women Than Men
Mesothelioma Risk May Differ Between Children and Adults
Australian researchers say it may take longer for asbestos-exposed children to develop malignant mesothelioma than it takes adults with the same level of exposure. Public health researchers with multiple Australian Universities and Utrecht University in The Netherlands say being younger may offer a short-term reprieve from the mesothelioma-inducing effects of asbestos. Unfortunately, that lower susceptibility is unlikely to last for a lifetime. Studying the People of Wittenoom Scientists determined that asbestos-exposed children are less likely to contract malignant mesothelioma, at least in the short term, by studying the records of Australians who lived around the notorious Wittenoom asbestos mine. The Wittenoom mine, which mined for crocidolite or “blue” asbestos from 1943 to 1966, has now been linked to hundreds of … Continue reading Mesothelioma Risk May Differ Between Children and Adults
Milk for Mesothelioma? Proteins in Cow’s Milk May Kill Mesothelioma Cells
There is new evidence that substances in cow’s milk may trigger a physiological process that leads to the death of chemotherapy-resistant mesothelioma cells. The substances are known as BAMLET and BLAGLET and they consist of either alpha- or beta-lactalbumin from cow’s milk and a lipid called oleic acid. The two protein-lipid complexes have been shown to have cytotoxic effects on eight other types of cancer. Now, researchers in Sydney, Australia have found that the same may be true for malignant mesothelioma, one of the hardest cancers to treat. BAMLET and BLAGLET Explained β-Lactoglobulin is the primary whey protein in the milk of cow’s and sheep (though not humans). α-Lactalbumin is the protein that regulates the production of lactose in … Continue reading Milk for Mesothelioma? Proteins in Cow’s Milk May Kill Mesothelioma Cells
Pleural Mesothelioma Patients Feel Better with This Symptom Management Regimen
For mesothelioma patients with indwelling pleural catheters, new research suggests that draining them daily can improve their quality of life and may even resolve the problem faster than waiting until symptoms arise. Pleural effusions, a buildup of fluid between the layers of the pleural membrane surrounding the lungs, is a fact of life for patients with several types of cancer, including pleural mesothelioma. If not addressed, this fluid accumulation often leads to life-limiting side effects like chest pain, coughing, and breathlessness. Managing Pleural Effusions from Malignant Mesothelioma There are surgical procedures aimed at preventing pleural effusions in mesothelioma patients and resolving symptoms by physically closing the spaces where fluid accumulates. Closing up the pleural space is known as pleurodesis. … Continue reading Pleural Mesothelioma Patients Feel Better with This Symptom Management Regimen
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