Earlier Mesothelioma Diagnosis with Machine Learning Model

Earlier Mesothelioma Diagnosis with Machine Learning Model

A new machine learning model can diagnose mesothelioma better than any current model. The model provides new hope for early diagnosis and better treatment of malignant mesothelioma. A machine learning tool is a computer program that gets “smarter” the more it runs. One challenge in predicting mesothelioma is that mesothelioma is very rare. With the exception of mesothelioma specialists, most doctors never even see a single case. The same is true for pathologists. If they do not see mesothelioma patients, they are less likely to see differences that may influence the diagnosis. Doctors trained the new machine learning tool to recognize and diagnose malignant mesothelioma. It works more quickly and accurately. Earlier mesothelioma diagnosis would allow for earlier intervention. This … Continue reading Earlier Mesothelioma Diagnosis with Machine Learning Model »

New Mesothelioma Blood Test Could Lead to Earlier Diagnosis

New Mesothelioma Blood Test Could Lead to Earlier Diagnosis

A new mesothelioma blood test promises an earlier diagnosis for patients. An article in BBA-Molecular Basis of Disease explains the new breakthrough. Malignant pleural mesothelioma is the asbestos-caused cancer. It is often diagnosed only in the advanced stage. This is because its early symptoms are also associated with other respiratory diseases. Finding a way to identify mesothelioma from other respiratory diseases is important. It helps doctors apply effective treatment strategies. And it increases the mesothelioma patient survival rate. Distinguishing Mesothelioma from Lung Cancer There is a well-known association between asbestos exposure and malignant mesothelioma. The most common type of asbestos-related cancer is malignant pleural mesothelioma. It accounts for approximately 80% of all mesothelioma cases. Malignant pleural mesothelioma is usually diagnosed … Continue reading New Mesothelioma Blood Test Could Lead to Earlier Diagnosis »

Cracking the Code: New Mathematical Model for Cancer Screening to Catch Some Mesotheliomas Sooner

Cracking the Code: New Mathematical Model for Cancer Screening to Catch Some Mesotheliomas Sooner

Cancers, such as malignant mesothelioma, are one of the leading causes of death. Yet mortality could be reduced by detecting malignant tumors earlier so that treatment is started earlier at a less aggressive stage. A team of American data scientists recently “cracked the code” of cancer screenings. Cancer screenings are expensive and it can be difficult to know who and when to give screening. The tradeoff between the cost and the benefit of cancer screening is an ongoing challenge. A new study in PLOS Computational Biology describes a new mathematical model to help clinicians decide whom to screen and when. This is a big step forward in catching some mesotheliomas earlier. Early Diagnosis for Mesothelioma is Key Exposure to asbestos … Continue reading Cracking the Code: New Mathematical Model for Cancer Screening to Catch Some Mesotheliomas Sooner »

New Mesothelioma Subtype Called Mesothelioma in Situ

A New Mesothelioma Subtype Called Mesothelioma in Situ

The 2015 WHO classification of pleural mesothelioma included three histological subtypes. The new fourth mesothelioma subtype is called mesothelioma in situ. It is a very early form of mesothelioma. Previous studies suggest that it may be a precursor to invasive mesothelioma. If patients know they have it, they may have years to try to keep mesothelioma from developing. Pathologists can tell the difference between the subtypes by looking at the cells under a microscope. Each subtype has a slightly different cell shape, growth pattern, and nuclear characteristics. Four Subtypes of Mesothelioma Pleural mesothelioma is a very rare type of cancer. Only about 2,500 people in the US receive a mesothelioma diagnosis every year. Asbestos inhalation is the primary cause of pleural mesothelioma. Most people with pleural … Continue reading New Mesothelioma Subtype Called Mesothelioma in Situ »

Understanding CAR T-Cell Therapy in Malignant Mesothelioma

Understanding CAR T-Cell Therapy in Malignant Pleural and Peritoneal Mesothelioma

One of the new therapies for mesothelioma is called antigen receptor T-cell therapy. It gives promise to malignant mesothelioma patients. This unique therapy has recently shown that it works in phase I clinical trials. A new report from French scientists details the current state of this therapy. This therapy has only been tested in a highly selected patient population. And it requires highly complex engineering. Yet, the treatment therapy shows promise. Adapting CAR T-Cell Therapy to Mesothelioma Malignant pleural and peritoneal mesothelioma are rare and aggressive cancers. They have had limited treatment options with moderate survival benefits. And all treatments have an impaired quality of life for a very long period. A chemotherapy drug combination known as cisplatin–pemetrexed has been … Continue reading Understanding CAR T-Cell Therapy in Malignant Mesothelioma »

A New Prognostic Signature Discovered for Malignant Pleural Mesothelioma

New Prognostic Signature Discovered for Malignant Pleural Mesothelioma

Immune-related genes play an important role in malignant pleural mesothelioma prognosis. They can affect the tumor immune microenvironment and affect tumor prognosis. Immune-related genes can be used to predict the course of a disease or patient outcomes. These genes are often called a genetic prognostic signature. Chinese surgeons recently discovered a prognostic signature for malignant pleural mesothelioma patients. Constructing a Prognostic Signature with 5 Immune-Related Genes Genes play an important role in the development and progression of cancers like mesothelioma. The Chinese researchers started by searching for other studies on mesothelioma prognosis and genes. Researchers used data from the Cancer Genome Atlas to construct the prediction signature. Patients were divided into high-risk and low-risk groups. They also used this data … Continue reading A New Prognostic Signature Discovered for Malignant Pleural Mesothelioma »

Mesothelioma and MRI Scans: Using an Old Tool in a New Way

Mesothelioma and MRI Scans: Using an Old Tool in a New Way

Imaging scans are an important tool in helping clinicians diagnose mesothelioma. These scans include X-rays, CT scans, MRI scans, and PET scans. These tools help clinicians to see tumors inside a patient’s body. The results of the scan cannot diagnose mesothelioma, but it is an important tool for arriving at the correct diagnosis. Unlike X-rays and CT’s, magnetic resonance imaging (MRI) scans use a completely different type of radiation. An MRI applies a very strong magnetic field to change the spin of protons. The scanner also produces a radio frequency. This process produces a signal that can be made into an image. Until now, the role of MRIs has been limited in mesothelioma. However, new evidence suggests MRIs can be … Continue reading Mesothelioma and MRI Scans: Using an Old Tool in a New Way »

Body Swelling and Joint Pain in Malignant Pleural Mesothelioma

Body Swelling and Joint Pain in Malignant Pleural Mesothelioma

The diagnosis of malignant pleural mesothelioma often includes widespread body inflammation. Inflammation and body swelling occur when white blood cells try to protect against infection. Symptoms of inflammation are often redness, swelling, and joint pain or stiffness. Oncologists have studied the relationship between swelling and cancer for 150 years. New research was recently published in the scientific journal Lung Cancer. French medical oncologists believe that patients with more body swelling may have shorter survival. This suggests that body swelling may play a big role in malignant pleural mesothelioma. Body Swelling to Predict a Developing Mesothelioma Diagnosis Prediction of diagnosis is important for malignant pleural mesothelioma patients. The sooner a patient can be diagnosed, the better their outcomes. Oncologists suggest that … Continue reading Body Swelling and Joint Pain in Malignant Pleural Mesothelioma »

Precision Medicine Treatment: Gene-Targeting Mesothelioma

Precision Medicine Treatment: Gene-Targeting Mesothelioma

A new precision medicine treatment for mesothelioma comes from scientists in Italy. This form of mesothelioma occurs after asbestos exposure in people with a genetic mutation. The mutation is represented by patients with an inherited cancer syndrome. These patients typically have an even worse prognosis than other mesothelioma patients. But the Italian team came up with a way to target the mutated gene. This form of treatment is called precision medicine. Precision medicine treatment looks at the genetics of a patient to select a treatment that will work best for them. Discovery of a DNA Gene Mutation Malignant pleural mesothelioma is a rare and aggressive cancer caused by exposure to asbestos. Malignant mesothelioma is one of the most aggressive kinds … Continue reading Precision Medicine Treatment: Gene-Targeting Mesothelioma »

Two New Diagnostic Tissue Biomarkers Discovered for Mesothelioma

Identifying Two New Diagnostic Tissue Biomarkers for Mesothelioma

Scientists have now identified two new diagnostic tissue biomarkers for malignant pleural mesothelioma. Doctors identify mesothelioma using diagnostic tissue biomarkers. This is called immunohistochemistry. The use of immunohistochemistry improves the accuracy of mesothelioma diagnosis in clinical practice. Yet, new methods for discovering diagnostic markers are still needed. Following a Reverse Approach in a Rare Case Mesothelioma is usually diagnosed after a person experiencing symptoms goes to a doctor. One thing a doctor may do is perform a tissue biopsy. The doctor will remove a part of the tissue (suspected mesothelioma) for examination. Most tissue biopsies are done with a needle and then examined in a laboratory. The lab will look for specific biomarkers to find out if the tissue contains … Continue reading Two New Diagnostic Tissue Biomarkers Discovered for Mesothelioma »

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