Understanding CAR T-Cell Therapy in Malignant Mesothelioma

Understanding CAR T-Cell Therapy in Malignant Pleural and Peritoneal Mesothelioma

One of the new therapies for mesothelioma is called antigen receptor T-cell therapy. It gives promise to malignant mesothelioma patients. This unique therapy has recently shown that it works in phase I clinical trials. A new report from French scientists details the current state of this therapy. This therapy has only been tested in a highly selected patient population. And it requires highly complex engineering. Yet, the treatment therapy shows promise. Adapting CAR T-Cell Therapy to Mesothelioma Malignant pleural and peritoneal mesothelioma are rare and aggressive cancers. They have had limited treatment options with moderate survival benefits. And all treatments have an impaired quality of life for a very long period. A chemotherapy drug combination known as cisplatin–pemetrexed has been … Continue reading Understanding CAR T-Cell Therapy in Malignant Mesothelioma »

A New Prognostic Signature Discovered for Malignant Pleural Mesothelioma

New Prognostic Signature Discovered for Malignant Pleural Mesothelioma

Immune-related genes play an important role in malignant pleural mesothelioma prognosis. They can affect the tumor immune microenvironment and affect tumor prognosis. Immune-related genes can be used to predict the course of a disease or patient outcomes. These genes are often called a genetic prognostic signature. Chinese surgeons recently discovered a prognostic signature for malignant pleural mesothelioma patients. Constructing a Prognostic Signature with 5 Immune-Related Genes Genes play an important role in the development and progression of cancers like mesothelioma. The Chinese researchers started by searching for other studies on mesothelioma prognosis and genes. Researchers used data from the Cancer Genome Atlas to construct the prediction signature. Patients were divided into high-risk and low-risk groups. They also used this data … Continue reading A New Prognostic Signature Discovered for Malignant Pleural Mesothelioma »

Mesothelioma and MRI Scans: Using an Old Tool in a New Way

Mesothelioma and MRI Scans: Using an Old Tool in a New Way

Imaging scans are an important tool in helping clinicians diagnose mesothelioma. These scans include X-rays, CT scans, MRI scans, and PET scans. These tools help clinicians to see tumors inside a patient’s body. The results of the scan cannot diagnose mesothelioma, but it is an important tool for arriving at the correct diagnosis. Unlike X-rays and CT’s, magnetic resonance imaging (MRI) scans use a completely different type of radiation. An MRI applies a very strong magnetic field to change the spin of protons. The scanner also produces a radio frequency. This process produces a signal that can be made into an image. Until now, the role of MRIs has been limited in mesothelioma. However, new evidence suggests MRIs can be … Continue reading Mesothelioma and MRI Scans: Using an Old Tool in a New Way »

Body Swelling and Joint Pain in Malignant Pleural Mesothelioma

Body Swelling and Joint Pain in Malignant Pleural Mesothelioma

The diagnosis of malignant pleural mesothelioma often includes widespread body inflammation. Inflammation and body swelling occur when white blood cells try to protect against infection. Symptoms of inflammation are often redness, swelling, and joint pain or stiffness. Oncologists have studied the relationship between swelling and cancer for 150 years. New research was recently published in the scientific journal Lung Cancer. French medical oncologists believe that patients with more body swelling may have shorter survival. This suggests that body swelling may play a big role in malignant pleural mesothelioma. Body Swelling to Predict a Developing Mesothelioma Diagnosis Prediction of diagnosis is important for malignant pleural mesothelioma patients. The sooner a patient can be diagnosed, the better their outcomes. Oncologists suggest that … Continue reading Body Swelling and Joint Pain in Malignant Pleural Mesothelioma »

Precision Medicine Treatment: Gene-Targeting Mesothelioma

Precision Medicine Treatment: Gene-Targeting Mesothelioma

A new precision medicine treatment for mesothelioma comes from scientists in Italy. This form of mesothelioma occurs after asbestos exposure in people with a genetic mutation. The mutation is represented by patients with an inherited cancer syndrome. These patients typically have an even worse prognosis than other mesothelioma patients. But the Italian team came up with a way to target the mutated gene. This form of treatment is called precision medicine. Precision medicine treatment looks at the genetics of a patient to select a treatment that will work best for them. Discovery of a DNA Gene Mutation Malignant pleural mesothelioma is a rare and aggressive cancer caused by exposure to asbestos. Malignant mesothelioma is one of the most aggressive kinds … Continue reading Precision Medicine Treatment: Gene-Targeting Mesothelioma »

Two New Diagnostic Tissue Biomarkers Discovered for Mesothelioma

Identifying Two New Diagnostic Tissue Biomarkers for Mesothelioma

Scientists have now identified two new diagnostic tissue biomarkers for malignant pleural mesothelioma. Doctors identify mesothelioma using diagnostic tissue biomarkers. This is called immunohistochemistry. The use of immunohistochemistry improves the accuracy of mesothelioma diagnosis in clinical practice. Yet, new methods for discovering diagnostic markers are still needed. Following a Reverse Approach in a Rare Case Mesothelioma is usually diagnosed after a person experiencing symptoms goes to a doctor. One thing a doctor may do is perform a tissue biopsy. The doctor will remove a part of the tissue (suspected mesothelioma) for examination. Most tissue biopsies are done with a needle and then examined in a laboratory. The lab will look for specific biomarkers to find out if the tissue contains … Continue reading Two New Diagnostic Tissue Biomarkers Discovered for Mesothelioma »

New Artificial Intelligence Tool Measures Mesothelioma Tumors

New Artificial Intelligence Tool Measures Mesothelioma Tumors

A new artificial intelligence tool can measure mesothelioma tumors without any human input. Automated mesothelioma tumor measurement is now possible. The artificial intelligence algorithm performed well. There were 266 malignant pleural mesothelioma tumors analyzed. This is the largest study of its kind performed in mesothelioma. And this is the first description of an automated artificial intelligence tool. Inconsistent Mesothelioma Measurement During Clinical Assessment In malignant pleural mesothelioma, complex tumors result in inconsistent clinical assessment. Promising new methods need practical computer automation methods. A new publication showed an automated tool for this purpose. This study compared a new artificial intelligence tool with human standard clinical assessment. This study looked at mesothelioma patients treated with chemotherapy. Evaluating How Well the New Tool … Continue reading New Artificial Intelligence Tool Measures Mesothelioma Tumors »

Cells Talking in the Tumor Microenvironment: Cracking the Code

Tumor Microenvironment

The tumor microenvironment and stroma cells affect the progression and treatment of malignant pleural mesothelioma. A new study shows how cells support the malignancy of mesothelioma and potential therapies. Malignant pleural mesothelioma has a unique and complex tumor microenvironment. A new study recently showed that the tumor microenvironment plays a key role in cancer initiation and progression. Scientists are seeking to understand how cancer and non-cancer cells communicate. Cancer and Non-Cancer Cells Talk to Each Other When white blood cells do not filter out asbestos fibers, other cells in the body are able to begin growing cancerous mesothelial cells. Scientists are seeking to understand how cancer and non-cancer cells communicate in the body. Non-cancer cells include immune cells and stromal … Continue reading Cells Talking in the Tumor Microenvironment: Cracking the Code »

Detecting Mesothelioma by Smell: A Promising Future

Detecting Mesothelioma by Smell

Early cancer detection can be difficult, but there is a promising history of research on detecting mesothelioma by smell. A new study suggests that a change in a patient’s body odor may be used for early malignant pleural mesothelioma detection. This holds tremendous hope for early treatment. Right now, pleural mesothelioma detection relies heavily on various clinical tests. These tests often include radiography, CT, MRI, ultrasound, and biopsy. All of these technologies and methods are effective. However, several are invasive, expensive, time-consuming, or limited to large hospital settings. In an article in BBA – Reviews on Cancer, researchers explore how body odor can detect malignant pleural mesothelioma. The team says the research on detecting mesothelioma by smell is promising. Nevertheless, … Continue reading Detecting Mesothelioma by Smell: A Promising Future »

Cancer Biomarker Test Could Detect Mesothelioma Earlier

cancer biomarker test

A new cancer biomarker test that promises to identify cancer in patients with “non-specific symptoms” could be the key to detecting mesothelioma earlier.  Malignant mesothelioma is a deadly cancer caused by asbestos. The early symptoms of mesothelioma are usually vague and similar to other conditions. As a result, mesothelioma is frequently diagnosed in a late stage. But a cancer biomarker test developed in the UK could change that. The test looks for small molecules called metabolites in the blood. Its developers say it has the potential to find cancer earlier than other blood-based cancer tests.  Non-Specific Symptoms Make Mesothelioma a Diagnostic Challenge Mesothelioma is a rare cancer. It is most common in people who worked or lived around asbestos in … Continue reading Cancer Biomarker Test Could Detect Mesothelioma Earlier »

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