Personalized Exercise Program Improves Mesothelioma Quality of Life

exercise program

A new case study suggests that a personalized exercise program could improve the quality of life for people fighting malignant mesothelioma. An estimated 2,500 Americans receive a mesothelioma diagnosis every year. Most of them are over 65. This population is typically less active than younger people anyway. It can be even harder to get enough physical activity when they are depleted by cancer and treatment. Research shows that physical activity does more than make patients stronger. It can also help them fight cancers like malignant mesothelioma. But many patients still do not get enough. The new report shows how a custom exercise program can help mesothelioma patients feel and function better. Physical Activity and Mesothelioma Treatment Pleural mesothelioma is a … Continue reading Personalized Exercise Program Improves Mesothelioma Quality of Life »

CAR-T Cells + Keytruda: New Immunotherapy for Pleural Mesothelioma?

immunotherapy for pleural mesothelioma

Researchers at a top US cancer center are experimenting with a new approach to immunotherapy for pleural mesothelioma – with exciting results.  The research was done at Memorial Sloan Kettering Cancer Center in New York and published in a recent issue of Cancer Discovery.  The Phase I trial is the first to treat pleural mesothelioma patients with CAR-T cell therapy and the PD-1 blocker pembrolizumab (Keytruda). Although the trial was small, 83 percent of patients lived for more than a year. Some lived for nearly two.  Malignant Mesothelioma commonly claims the lives of patients within months. This new type of immunotherapy for pleural mesothelioma could be a breakthrough in improving survival. The Challenge of Malignant Mesothelioma Scientists have known about … Continue reading CAR-T Cells + Keytruda: New Immunotherapy for Pleural Mesothelioma? »

Mesothelioma Update: Drinking and Cancer Risk

drinking and cancer risk

A new study on the link between drinking and cancer risk may make people at risk for mesothelioma think twice about their alcohol consumption.  The new study is the latest to draw a direct line between drinking and cancer risk. According to the report released this week, more than 4 percent of new cancer cases last year were linked to alcohol use.  Asbestos exposure is the main cause of mesothelioma. But not everyone who is exposed to asbestos gets mesothelioma. Genetic factors play a role. But the new alcohol study suggests that drinking could also be a catalyst for cancer development.  The Link Between Drinking and Cancer Risk The new study was conducted by scientists from the International Agency for … Continue reading Mesothelioma Update: Drinking and Cancer Risk »

New Test May Help Doctors Choose the Best Mesothelioma Surgery

best mesothelioma surgery

A new predictive model may make it easier for cancer doctors to choose the best mesothelioma surgery for each pleural mesothelioma patient.  There are two major surgical approaches for pleural mesothelioma. One involves removal of a lung and the other does not.  Right now, the choice about which surgery to have is based on patient demographics, symptoms, and lab values. Which surgery is most common at the institution may also play a role. Many surgeons have strong opinions about which is the best mesothelioma surgery.   But Harvard researchers say the new predictive model they tested is a better way to stratify mesothelioma patients. Their study suggests that this approach may lead to better treatment outcomes and more accurate clinical trials.  … Continue reading New Test May Help Doctors Choose the Best Mesothelioma Surgery »

Annual Report on Cancer Death Rates: Good and Bad News for Mesothelioma Patients

cancer death rates

The latest report on cancer death rates in the US is both good and bad news for people with malignant mesothelioma.  The good news is that the rate of death from all types of cancer has declined in recent years. This is true for both men and women of all races. Better drugs and improved screening tools are some of the reasons.  The bad news for people with mesothelioma is that the likelihood of dying from it is not declining as rapidly as overall cancer death rates. Asbestos cancer continues to confound cancer researchers around the world.  Mesothelioma: A Rare Cancer with High Mortality Malignant mesothelioma is one of the rarest cancers in the US. That is fortunate because the … Continue reading Annual Report on Cancer Death Rates: Good and Bad News for Mesothelioma Patients »

Study May Lead to Safer Immunotherapy for Mesothelioma

immunotherapy for mesothelioma

New research conducted in Europe and at Harvard University may open the door to safer immunotherapy for mesothelioma patients.  Immunotherapy is one of the most promising approaches to fight malignant mesothelioma. But the potential side effects can be devastating.  Now, new data suggests there are ways to reduce the complications of immunotherapy for mesothelioma. The key is to target some of the white blood cells that trigger inflammation. Inflammation is the driver behind most of the serious side effects of immunotherapy.  Why Harness the Immune System? No one ever expects to contract mesothelioma. It is an extremely rare cancer. Most people who get it have spent time living or working around asbestos. Even among asbestos-exposed people, mesothelioma is rare. Scientists … Continue reading Study May Lead to Safer Immunotherapy for Mesothelioma »

Early Data Show Promise for Galinpepimut-S and Opdivo in Mesothelioma Patients

galinpepimut-s and opdivo

A combination of the immunotherapy drugs galinpepimut-S and Opdivo may give mesothelioma patients a few extra months, according to newly-released data.  The clinical data is part of an ongoing study of galinpepimut-S and Opdivo. SELLAS Life Sciences Group, the makers of galinpepimut-S, released the latest findings this week.  Although the early data is based on just four mesothelioma cases, it appears to be promising. All of the study subjects had either relapsed after chemotherapy or failed to respond at all.  These patients had a median overall survival of 35.4 weeks on the combination of galinpepimut-S and Opdivo. Typical overall survival in relapsed patients with standard care is just 7 months.  Immunotherapy with Galinpepimut-S and Opdivo Galinpepimut-S and Opdivo are both … Continue reading Early Data Show Promise for Galinpepimut-S and Opdivo in Mesothelioma Patients »

BAP1 Not the Only Gene to Raise Mesothelioma Risk

raise mesothelioma risk

A new study is further evidence that a mutation on the BAP1 gene is not the only genetic anomaly to raise mesothelioma risk. Scientists at Philadelphia’s Fox Chase Cancer Center along with a team of international researchers recently published a study of 13 malignant mesothelioma patients. All of these patients had close relatives who also had cancer. This suggested that something in their genetic makeup might raise mesothelioma risk.  Previous research suggests one gene that makes people more susceptible to mesothelioma is BAP1. People with a mutation on this gene are more likely to receive a mesothelioma diagnosis. They are also more susceptible to several other conditions.  But the people in the new study were chosen because none of them … Continue reading BAP1 Not the Only Gene to Raise Mesothelioma Risk »

Treatment with Vinorelbine for Relapsed Pleural Mesothelioma

treatment with vinorelbine

A new study suggests that treatment with vinorelbine may boost progression free survival for people with relapsed malignant mesothelioma. Mesothelioma is a virulent cancer caused by exposure to asbestos. Chemotherapy is the primary first-line treatment. But this cancer almost always comes back within a few months.  Now, researchers at the UK’s University of Leicester say treatment with vinorelbine might keep mesothelioma at bay for several months longer. They presented their research at this months’ annual meeting of the American Society of Clinical Oncology.  Second-Line Mesothelioma Treatments Needed Pleural mesothelioma is the most common form of mesothelioma. Tumors grow on the membrane around the lungs. The symptoms often mimic lung cancer but can be even more deadly.  Some of the healthiest … Continue reading Treatment with Vinorelbine for Relapsed Pleural Mesothelioma »

Does Pleural Fluid Exposure Affect Mesothelioma Survival?

pleural fluid

A recent study found no link between mesothelioma survival and exposure to pleural fluid. But that does not necessarily mean the link doesn’t exist.  Pleural fluid is also called pleural effusions or “water on the lungs”. It is extra fluid that builds up around the lungs. It is common in people with heart failure, kidney or liver disease, pleural mesothelioma and some other kinds of cancer.  Pleural effusions are usually treated as an uncomfortable mesothelioma symptom. Draining the fluid can help patients breathe easier.  But researchers at Oxford University wondered whether the pleural fluid itself could shorten mesothelioma survival. In this study, the answer appears to be no. But the researchers warn this may not be the final word on … Continue reading Does Pleural Fluid Exposure Affect Mesothelioma Survival? »

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