Sarcomatoid Mesothelioma Treatment Focuses on Two-Drug Combo

sarcomatoid mesothelioma treatment

Researchers in Spain are developing what they hope will be a more effective sarcomatoid mesothelioma treatment. The new treatment focuses on a pair of drugs that are already being tested in humans.  Mesothelioma impacts about 2,500 Americans each year. Sarcomatoid mesothelioma is a rare form of this rare cancer. About a quarter of the annual cases are sarcomatoid.  This form of cancer is even more aggressive than epithelioid mesothelioma. But sarcomatoid mesothelioma treatment is not significantly different. Neither are the results.  But the new study could change the prognosis for people with asbestos cancer. It appears in the journal Cancer Research. Chemotherapy is the Primary Sarcomatoid Mesothelioma Treatment Most people with malignant mesothelioma receive chemotherapy with cisplatin and Alimta. This … Continue reading Sarcomatoid Mesothelioma Treatment Focuses on Two-Drug Combo »

Mesothelioma and Tile Production Linked by New Case Studies

mesothelioma and tile production

Two newly published case studies have drawn a link between malignant mesothelioma and tile production.  The authors of the new report analyzed the cases of two people who contracted mesothelioma after working for a tile manufacturer.  Both people were exposed to talc in their work. This is likely where they encountered the asbestos that may have triggered mesothelioma. Understanding the Different Types of Tile Malignant mesothelioma is caused by exposure to asbestos. Before the 1990s, many homes and businesses were built with asphalt or vinyl ‘tiles’ made with asbestos. These types of tiles are still in many older buildings. Disturbing or removing them can pose a risk for mesothelioma.  But the current report focuses on ceramic tile workers. Mesothelioma and … Continue reading Mesothelioma and Tile Production Linked by New Case Studies »

Drug May help Mesothelioma Patients Overcome Resistance to Chemotherapy

resistance to chemotherapy

A newly-identified compound might eventually help mesothelioma patients overcome resistance to chemotherapy.  Chemotherapy resistance is one of the main reasons that mesothelioma treatments fail.  But researchers at Duke University and the Massachusetts Institute of Technology have identified a compound that combats resistance to chemotherapy with cisplatin.  Cisplatin is one of the primary drugs in first-line chemotherapy for mesothelioma. If mesothelioma cells can be sensitized to it, patients may have better outcomes.   First-Line Treatment for Malignant Mesothelioma Pleural mesothelioma is a cancer that grows on the lining around the lungs. Peritoneal mesothelioma starts on the lining of the abdomen. Both types of mesothelioma are caused by asbestos exposure.  Chemotherapy with cisplatin and pemetrexed (Alimta) is the treatment that doctors usually try … Continue reading Drug May help Mesothelioma Patients Overcome Resistance to Chemotherapy »

Uncertainly, Worry, and Hope Characterize the Experience of Mesothelioma

experience of mesothelioma

The experience of mesothelioma is characterized by uncertainty and worry for some patients. But the same patients say they are also optimistic and hopeful.  These findings come from in-depth interviews with seven people with pleural mesothelioma. They were all patients at Penn-Presbyterian Medical Center in Philadelphia.  This is not the first study on the lived experience of mesothelioma. But the authors say American mesothelioma patients are underrepresented in the medical literature. The US has a higher number of mesothelioma deaths each year than any other country.  The new study shows the experience of these patients is much like that of mesothelioma patients elsewhere in the world.  Fostering Understanding, Identifying Needs Mesothelioma is an extremely rare cancer with a poor prognosis. … Continue reading Uncertainly, Worry, and Hope Characterize the Experience of Mesothelioma »

Protein Biomarker for Mesothelioma Linked to Shorter Survival

protein biomarker for mesothelioma

An international team of scientists has identified a protein biomarker for mesothelioma that appears to shorten survival. The biomarker is CD70. It belongs to the tumor necrosis factor (TNF) family of proteins. New research suggests that patients who express more of this protein biomarker for mesothelioma have faster-growing tumors that are less likely to respond to treatment. High CD70 levels have been linked with tumor aggression in some other types of cancer. This is the first time they have been linked to malignant pleural mesothelioma survival.  CD70 and Mesothelioma Prognosis Pleural mesothelioma is a highly aggressive type of tumor. It grows on the membranes around internal organs. Mesothelioma rarely responds to standard cancer treatments. People diagnosed with pleural mesothelioma are … Continue reading Protein Biomarker for Mesothelioma Linked to Shorter Survival »

Pesticide Inhibits Mesothelioma Cell Growth in Lab Animals

mesothelioma cell growth

Researchers in Switzerland say a pesticide designed to make grapes and kiwifruit bigger can also slow mesothelioma cell growth.  The EPA approved forchlorfenuron (FCF) in 2004. Farmers use it to help grapes and kiwifruit grow bigger, break less easily, and last longer in cold storage. But new research at the University of Fribourg suggests that the chemical has the opposite effect on mesothelioma cell growth. Mesothelioma cells exposed to FCF are less likely to live and spread. The researchers say this could be a promising step toward a new kind of mesothelioma treatment.  Forchlorfenuron and Mesothelioma Cell Growth The EPA classifies FCF as a plant growth regulator. According to the EPA fact sheet, FCF is a cytokinin which “improves fruit … Continue reading Pesticide Inhibits Mesothelioma Cell Growth in Lab Animals »

Pain a Sign of Successful Pleurodesis for Mesothelioma, Study Says

pleurodesis for mesothelioma

A temporary increase in pain may be a sign of success when undergoing pleurodesis for mesothelioma-related lung fluid. An uncomfortable build-up of lung fluid is one of the most common and life-limiting mesothelioma symptoms.  Chemical pleurodesis is one way doctors treat the problem. About three out of four patients have good luck with pleurodesis for mesothelioma. Now, a new study from the UK suggests that those who have the best results with the procedure also tend to have the most pain afterward.  What is Pleurodesis for Mesothelioma? Pleural mesothelioma is a malignancy that starts in the layers of the pleura. The pleura is a membrane that surrounds the lungs.  When tumors grow in the pleural membrane, they can trigger a … Continue reading Pain a Sign of Successful Pleurodesis for Mesothelioma, Study Says »

Drinking and Mesothelioma Risk: How Much is Too Much?

drinking and mesothelioma risk

The findings of a major new study on cancer and alcohol suggest there may be an even stronger link between drinking and mesothelioma risk than previously thought. The Japanese study included more than 120,000 drinkers and non-drinkers. It tracked which participants got any type of cancer over a 15 year period. Cancer diagnoses were correlated with participants’ drinking habits.  The report found that even light drinkers faced a higher incidence of cancers like malignant mesothelioma. It is one of the largest studies to connect cancer incidence, drinking and mesothelioma risk.  Even Light to Moderate Drinkers Face Risk Scientists have known about the connection between drinking and mesothelioma risk for some time. But the problem of alcohol consumption and cancer had … Continue reading Drinking and Mesothelioma Risk: How Much is Too Much? »

Second-Line Treatment for Mesothelioma with Lurbinectedin

second-line treatment for mesothelioma

Swiss researchers may have finally found an effective second-line treatment for mesothelioma.  Scientists with the Swiss Group for Clinical Cancer Research presented their findings at the recent European Society for Medical Oncology conference in Barcelona.  Mesothelioma patients who fail after first-line therapy have few options. The new study focused on lurbinectedin, a drug that impacts cancer cells at the DNA level. Early studies suggest lurbinectedin might make a good second-line treatment for small cell lung cancer.  According to the Swiss team, more than half of patients in their study responded to lurbinectedin as a second-line treatment for mesothelioma.  In Search of a Second-Line Mesothelioma Treatment Malignant mesothelioma is notoriously difficult to diagnose and even harder to treat. It is usually … Continue reading Second-Line Treatment for Mesothelioma with Lurbinectedin »

CRISPR Gene Editing Technique and the Future of Mesothelioma Treatment

CRISPR gene editing tehcnique

The powerful CRISPR gene editing technique might have a role to play in the future of mesothelioma treatment. CRISPR is a method for altering certain genes to help fight disease. This week, scientists at the University of Pennsylvania released data from the first study of CRISPR in US cancer patients.  It was only a safety study, but the results are promising. They could have wide-ranging implications for patients fighting aggressive cancers like malignant mesothelioma.  Modifying Genes To Help Fight Cancer The CRISPR gene editing technique is a simplified version of the method bacteria cells use to defend themselves against viruses. This antiviral defense system is called CRISPR-Cas9. The new Penn Medicine study involved just three cancer patients. Two of the … Continue reading CRISPR Gene Editing Technique and the Future of Mesothelioma Treatment »

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