Australian researchers say proteins found in lung fluid could hold the key to diagnosing pleural mesothelioma months or even years before a tumor is visible on imaging scans. Proteins function as communication devices in the body, directing all sorts of critical cellular processes, including the processes that tell cancer cells to begin replicating at a higher rate than normal cells. Scientists at Flinders University, one of the world’s leaders in mesothelioma research, wondered if the proteins that help give rise to malignant pleural mesothelioma could be found in pleural effusions and used as biomarkers to identify the cancer earlier. Looking for Mesothelioma Biomarkers in Lung Fluid In a new study published in the Journal of Proteomics, the team notes that … Continue reading Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis
A new report suggests that it may be possible to verify that a case of lung cancer or malignant mesothelioma was caused by exposure to asbestos. The key may lie in tiny cellular structures called microRNAs. If the microRNA asbestos profile can be verified, it could have a significant impact on work-related compensation for pleural mesothelioma and asbestos-related lung cancer. The Molecular “Fingerprint” of Mesothelioma? MicroRNAs (miRNAs) are small non-coding molecules of RNA that play a key role in the regulation of gene expression in cells. When these miRNAs are out of balance or “overexpressed”, the result can be cancer. By examining the miRNAs of mesothelioma patients, lung cancer patients, and healthy subjects, researchers at Marche Polytechnic University in Ancona, Italy … Continue reading Mesothelioma Genetic “Fingerprint” Could Impact Compensation
Scientists may finally have found a way to make a compound in red wine more effective against lung cancers like pleural mesothelioma. Resveratrol, a powerful antioxidant compound found in the skin and seeds of grapes and concentrated in red wine, has long been the focus of anti-cancer studies. Multiple laboratory tests have demonstrated that the molecule is damaging to cancer cells. Unfortunately, the effectiveness of resveratrol for people with cancers such as pleural mesothelioma or non-small cell lung cancer has been limited because the compound is eliminated from the body before it has the chance to reach the lungs. Now, researchers at the University of Geneva in Switzerland (UNIGE) believe they may have found a way around the problem. Their … Continue reading Inhalable Formula May Be Key to Fighting Mesothelioma with Red Wine
Yet another scientific study appears to confirm the power of the spice-derived compound curcumin as a weapon against malignant pleural mesothelioma. The Chinese researchers who conducted the latest study say the substance has the potential to be the basis of a whole new way of treating this aggressive asbestos cancer. This team tested curcumin on a line of mouse mesothelioma cells, both in the lab and in live animals, and published their promising results in the prestigious International Journal of Oncology. Curcumin’s Impact on Mesothelioma Cells Curumin is a primary chemical in turmeric, responsible for the root’s spicy flavor and characteristic yellow hue. If turmeric does, in fact, help fight cancer, as so many health food stores and supplement makers … Continue reading Is it Time for a Curcumin-Based Mesothelioma Treatment?
There is more evidence that mesothelioma patients who have lung sparing surgery can live longer if it’s followed up with highly targeted radiation therapy. In the first study to come out of Israel on the subject, a team of oncologists, pulmonologists, radiation oncologists, and thoracic surgeons at Rabin Medicine Center in Petah Tikva say intensity modulated radiation therapy (IMRT) is safe and effective for slowing down the growth of pleural mesothelioma tumors. The Challenge of Radiotherapy for Mesothelioma The irregularity of malignant mesothelioma tumors makes them difficult to treat with standard external beam radiotherapy without damaging healthy tissue and causing serious side effects. This is particularly problematic in patients who still have both lungs, either because they were not good … Continue reading New Study Points to Benefits of IMRT for Mesothelioma Treatment
There was some sobering news out of Canada this week that gives even more urgency to the need to find a cure for malignant mesothelioma. According to data compiled by Statistics Canada, while the net survival of several types of cancer has increased since the early 1990s, there has been little change in mesothelioma survival. Analysis of Cancer Net Survival The report, published in the journal Health Reports, calculated changes in net survival (where cancer is hypothetically the only possible cause of death) of patients with 30 different types of cancer during two 2-year time periods — 1992 to 1994 and 2012 to 2014. After factoring for age-related changes, the report analyzes differences in the five-year survival rates of patients … Continue reading Mesothelioma Survival Has Changed Little in Two Decades in Canada
A procedure normally used to help alleviate pain has been used to successfully stop a case of recurrent malignant pleural mesothelioma in Japan. Radiofrequency ablation (RFA) uses electrical energy delivered through a thin, hollow needle to heat and destroy cancer cells. Most of the time, this technology is used to destroy small tumors or a treat small area of cancer to alleviate symptoms such as pain or discomfort. But thoracic surgeons at the Hyogo College of Medicine in Hyogo, Japan say their new case study suggests that the procedure should also be considered as a definitive treatment — especially for mesothelioma patients for whom surgery is not a viable option. Complex Mesothelioma Case Drives RFA Decision In a new report … Continue reading Radiofrequency Ablation for Recurrent Mesothelioma: A New Treatment Option?
Women diagnosed with malignant mesothelioma tend to live longer than men with the same disease. Australian researchers say understanding exactly why that is could open the door to improving mesothelioma treatment for both genders. Assessing Mesothelioma Survival Rates By Gender Researchers led by the Cancer Epidemiology and Intelligence Division of Cancer Council Victoria in Melbourne used cancer registry data to identify cases of malignant mesothelioma and 24 others types of cancer diagnosed in Victoria between 1982 and 2015. Then, they assessed the survival differences for each type of cancer between men and women, adjusting for each patient’s age and year of diagnosis. According to their report published this week in Cancer Causes & Control, the bad news for men is … Continue reading Mesothelioma Survival Odds Better for Women Than Men
When it comes to the development of malignant pleural mesothelioma, your job and your relatives both appear to play critical roles. A new study in the European Journal of Cancer points to the interplay between environment and genetics in the development of the asbestos cancer. The study shows, once again, just how destructive asbestos can be to human health. Analyzing Mesothelioma Incidence Among Swedes The new research used data from the Swedish Family-Cancer Database, which includes all Swedes born after 1931 and their biological parents – a total of 16.1 million people, including 2.3 million cancer patients. After analyzing the data on all people with pleural mesothelioma, the researchers determined that those who worked around asbestos were more than three … Continue reading Pleural Mesothelioma Risk: Genes and Exposure Both Play a Role
Calling it an “extremely promising therapeutic option” that demonstrates “an impressive extension of median overall survival”, researchers testing a new type of pleural mesothelioma treatment announced the final results of their phase II clinical trial this week. Tumor Treating Fields, a creation of Jersey-based Novocare, are alternating electric fields that destabilize critical proteins, disrupting mesothelioma tumor cell division and killing them. As Surviving Mesothelioma first reported in April, early tests of the technology looked promising. But the final results of the STELLAR phase 2 mesothelioma clinical trial, released this week, are even better than expected. Researchers say Tumor Treating Fields may even become part of the new standard of care for pleural mesothelioma. Tumor Treating Fields Gain Momentum in … Continue reading Electricity-based Mesothelioma Treatment Moves a Step Closer to FDA Approval