New Mesothelioma Immunotherapy Treatment Reduces Tregs with Immunotoxin

mesothelioma immunotherapy treatment

There is a new mesothelioma immunotherapy treatment in the works. This one is based on reducing the number of Tregs or regulatory T-cells around a mesothelioma tumor. Tregs are an important part of maintaining balance in the immune system. They help protect people against autoimmune diseases like MS and lupus. But in people with malignant mesothelioma and other types of cancer, too many Tregs can be a problem. Tregs respond to distress signals sent out by a tumor. They surround the tumor and protect it against attack from the immune system. The goal of mesothelioma immunotherapy treatment is to reactivate the immune system to fight the cancer. Developing a Mesothelioma Immunotherapy Treatment Molecular biologists at the National Cancer Institute and … Continue reading New Mesothelioma Immunotherapy Treatment Reduces Tregs with Immunotoxin »

Early Detection of Mesothelioma with MicroRNAs

Testing for Early Detection of Mesothelioma

A new study appears to contradict some of what scientists thought they knew about early detection of mesothelioma. Malignant mesothelioma is a rare but highly aggressive cancer. It usually happens because of past asbestos exposure. Early detection of mesothelioma is key to improving survival. But it is notoriously hard to make a mesothelioma diagnosis. Many patients who have mesothelioma do not even know it until the cancer is in its advanced stage. As a result, most do not live more than a year. Some studies have suggested that tiny, non-coding bits of RNA could help doctors detect mesothelioma earlier. But new research in Germany brings that idea into question. Biomarkers for Early Detection of Mesothelioma MicroRNAs (miRNAs) play an important … Continue reading Early Detection of Mesothelioma with MicroRNAs »

Talc Pleurodesis Patients Need Alternate PET/CT Scan for Mesothelioma

PET/CT scan for mesothelioma

Certain patients may get more benefit out of an alternate type of PET/CT scan for mesothelioma. Positron emission tomography (PET) is a common tool for diagnosing mesothelioma. It is also used to monitor the effectiveness of mesothelioma treatments. Doctors often combine PET with computed tomography (CT) for an even clearer picture of mesothelioma progression. Typically, a PET/CT scan for mesothelioma involves injection of a tracer called FDG (fluorodeoxyglucose). But it turns out that PET/CT scans with this tracer do not work well for all mesothelioma patients. A new Japanese study suggests that mesothelioma patients who have had a procedure called talc pleurodesis should consider a different kind of PET/CT scan instead. How Does Talc Pleurodesis Impact PET/CT Scan for Mesothelioma? … Continue reading Talc Pleurodesis Patients Need Alternate PET/CT Scan for Mesothelioma »

Mesothelioma Patient Alert: Study Questions Safety of B12 Supplements

Safety of B12 Supplements Questioned

New research about the safety of Vitamin B12 supplements is raising red flags for mesothelioma patients and those at risk for mesothelioma. A major international study published in the International Journal of Cancer suggests that too much Vitamin B12 in the body may be a cause of lung cancer. The study included researchers from top institutions like Brigham and Women’s Hospital, Harvard Medical School, the University of Pittsburgh, the American Cancer Society, and the National Cancer Institute. Pleural Mesothelioma and Lung Cancer Pleural mesothelioma has a lot in common with lung cancer. It develops in the cells of the membrane around the lungs. As mesothelioma spreads, the membrane becomes less pliable, making it hard for the lungs to expand normally. … Continue reading Mesothelioma Patient Alert: Study Questions Safety of B12 Supplements »

Asbestos in Mesothelioma Development: No Amount is Safe

asbestos in mesothelioma development

A new study contains some sobering news about the role of asbestos in mesothelioma development. Public health officials in Italy analyzed the medical records of people who died of pleural mesothelioma in the Broni, Italy area. Broni was the site of an asbestos cement plant from 1932 until 1993. They discovered that even some people who did not work with asbestos had a high risk of dying from this rare cancer. In fact, their risk for mesothelioma was higher even though their asbestos exposure was smaller. It suggests that no amount of asbestos exposure is “safe” — especially for people who are extra sensitive because of their genetics. Small Amounts of Asbestos in Mesothelioma Development Scientists began to suspect the … Continue reading Asbestos in Mesothelioma Development: No Amount is Safe »

Doctor Attitude Keeps Some Patient from Mesothelioma Chemotherapy

chemotherapy for mesothelioma

A new study suggests that some patients are missing out on chemotherapy for mesothelioma because their doctors do not believe it will work. Doctor “nihilism” – the idea that life is meaningless anyway – was the top reason that 20+ percent of pleural mesothelioma patients did not get the care that might have helped them. In other cases, patients were simply never referred to a cancer doctor who could prescribe chemotherapy for mesothelioma. Doctor Attitudes and Chemotherapy for Mesothelioma The Australian study is based on surveys with 107 doctors and 19 nurses. Most respondents were either lung specialists or cancer doctors. They completed the surveys in 2014. The surveys show that most of the doctors (90%) think at least one … Continue reading Doctor Attitude Keeps Some Patient from Mesothelioma Chemotherapy »

Nutritional Status of Mesothelioma Patients and Prognosis

nutritional status of mesothelioma patients

The nutritional status of mesothelioma patients could impact their treatment outcomes. That is the conclusion of a new Chinese study. The study focused on patients with peritoneal mesothelioma. Peritoneal mesothelioma is a cancer that grows on the abdominal lining. About a fifth of mesothelioma patients have this type. Researchers at Cangzhou Central Hospital measured the nutritional status of mesothelioma patients with a tool called the Controlling Nutritional Status (CONUT) score. When they compared the scores with patients’ survival rates, they found that those with worse scores did not live as long. Measuring Nutritional Status of Mesothelioma Patients with CONUT CONUT is a computer-based tool. It calculates the nutritional status of mesothelioma patients based on laboratory information. Lab values considered by … Continue reading Nutritional Status of Mesothelioma Patients and Prognosis »

Palliative Care for Mesothelioma: Earlier is Not Necessarily Better

palliative care for mesothelioma

New research suggests that palliative care for mesothelioma may be most helpful in later stages of the disease. Scientists in the UK and Australia say there is no reason for most mesothelioma patients to be referred to a palliative care specialist when they are diagnosed. As long as patients have access to palliative care when they need it, early referral does not seem to make much difference in quality of life. What is Palliative Care for Mesothelioma? Palliative care for mesothelioma aims to manage the symptoms of the disease and the treatment. Chest pain and shortness of breath are common symptoms of mesothelioma. Mesothelioma treatment can cause fatigue, nausea, and weight loss. Physical symptoms can cause depression or anxiety, which … Continue reading Palliative Care for Mesothelioma: Earlier is Not Necessarily Better »

BAP1 Can Distinguish Mesothelioma from Other Conditions

Scientist looking at mesothelioma cells

German scientists say a protein could help doctors distinguish mesothelioma from other conditions. Malignant mesothelioma is a cancer that grows on the membranes around organs. These membranes are called mesothelial membranes. But other conditions can also grow on mesothelial membranes. One of those conditions is adenomatoid tumors. Adenomatoid tumors are benign but, even under the microscope, their cells can look a lot like malignant mesothelioma. Now, a group of pathologists in Germany say the BAP1 protein can tell these two conditions apart. If doctors can distinguish mesothelioma from other conditions early enough, mesothelioma patients may have better outcomes. BAP1 Loss and Mesothelioma BAP1 is a protein encoded by the BAP1 gene. BAP1 is one of the proteins that helps keep … Continue reading BAP1 Can Distinguish Mesothelioma from Other Conditions »

Scientists Say Machine Learning Could Help Diagnose Mesothelioma Earlier

machine leaning might help diagnose mesothelioma earlier

Researchers in Toronto say machine learning could help doctors diagnose mesothelioma earlier. Molecular geneticists at the University of Toronto teamed up with cancer and heart doctors to conduct the new research. The team collected data from hundreds of suspected mesothelioma cases and ran it through different statistical analysis programs. The goal was to see which one was best at determining who had pleural mesothelioma and who did not. The results revealed some important information – both about the machine learning tools and about how doctors might diagnose mesothelioma earlier, even without them. Why Doctors Need to Diagnose Mesothelioma Earlier Mesothelioma is almost always caused by asbestos exposure. In the first few years of the disease, there may be no mesothelioma … Continue reading Scientists Say Machine Learning Could Help Diagnose Mesothelioma Earlier »

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