New Cancer Vaccine Might Help Resistant Mesothelioma
Researchers at Harvard are developing a new cancer vaccine. Preliminary data suggest that it might work just as well as more complex and time-consuming personalized mesothelioma therapies. Mesothelioma immunotherapy is a focus for researchers around the world. But this kind of treatment can take a long time to develop. And there is no single therapy that works for every patient. The new cancer vaccine would combine chemotherapy and a more generic kind of immunotherapy. This approach has the potential to help mesothelioma patients who do not respond to standard treatments. How Does Mesothelioma Immunotherapy Work? Immunotherapy is one element of the proposed new cancer vaccine. Immunotherapy fights cancers like mesothelioma by manipulating the immune system. Some kinds of mesothelioma immunotherapy … Continue reading New Cancer Vaccine Might Help Resistant Mesothelioma
CAR T-Cell Therapy for Mesothelioma in New Phase I Trial
Researchers at Memorial Sloan Kettering in New York are about to try a new kind of CAR T-cell therapy for mesothelioma in human patients. This is the first Phase I trial of the new CAR T-cell approach. The therapy involves removing some of a patient’s T-cells, modifying them, and giving them back to fight cancer. The new CAR T-cell therapy for mesothelioma involves cells that have been modified in new ways. They still seek out cancer cells. But these CAR T-cells are made to last longer and to undermine a primary mesothelioma cell defense mechanism. The FDA approved the study in September. Memorial Sloan Kettering is recruiting mesothelioma patients for it now. T-Cells That Target Mesothelioma Cells CART T-cell therapy … Continue reading CAR T-Cell Therapy for Mesothelioma in New Phase I Trial
T-Cells Test May Predict Success of New Drug Combination for Mesothelioma
A month after the FDA approved a new drug combination for pleural mesothelioma, scientists are discovering more about who might benefit the most from this treatment. A new report in EBioMedicine suggests that the success of the new drug combination for mesothelioma depends on the presence and activation of special immune system cells. Researchers in the Netherlands found that patients with enough of the right kind of T-cells had the best results. The findings could help doctors screen out mesothelioma patients who are less likely to benefit. The Long-Awaited New Drug Combination for Mesothelioma The two medicines in the new drug combination for mesothelioma are nivolumab (Opdivo) and ipilimumab (Yervoy). The FDA approved a mix of the two immunotherapy drugs … Continue reading T-Cells Test May Predict Success of New Drug Combination for Mesothelioma
Study to Test Nivolumab and Chemotherapy for Mesothelioma
Researchers in Germany are recruiting patients for a trial of nivolumab and chemotherapy for pleural mesothelioma patients who have had surgery. Nivolumab (Opdivo) is an immunotherapy drug similar to pembrolizumab (Keytruda). It blocks a protein that helps mesothelioma cells hide from the immune system. Nivolumab is most often used for patients with non-small cell lung cancer. The multicenter German study will test if a combination of nivolumab and chemotherapy can help keep tumors from growing back after mesothelioma surgery. Previous studies suggest that it has the potential to do so. How Immune Checkpoint Inhibitors Work Immune checkpoint inhibitors like nivolumab, pembrolizumab, and ipilimumab (Yervoy) are a major focus for mesothelioma researchers. Mesothelioma cells are notoriously tenacious. They often fail to … Continue reading Study to Test Nivolumab and Chemotherapy for Mesothelioma
First Patient Dosed in New Trial for Relapsed Mesothelioma
Doctors in the UK have started treatment on the first patient in the trial of a new drug combination for relapsed mesothelioma. The drug is called bemcentinib. It blocks a protein encoded by the AXL gene. People with mesothelioma tend to overexpress this protein. Studies show that this extra AXL protein might help cancer cells hide from the immune system. It might also help them spread to other parts of the body. In the new trial, patients with relapsed mesothelioma will get a combination of bemcentinib and Keytruda (pembrolizumab). Keytruda is an immunotherapy drug. Like bemcentinib, it helps make mesothelioma cells vulnerable to immune system attack. Animal studies and tests in lung cancer patients show that bemcentinib may help immune … Continue reading First Patient Dosed in New Trial for Relapsed Mesothelioma
“Exceptional Survival” in Some Patients on Nivolumab for Mesothelioma
A real-world study of Dutch patients suggests that nivolumab for mesothelioma can dramatically extend survival in the right patients. Nivolumab is sold under the brand name Opdivo. It is a type of immunotherapy. It works by making cancer cells more vulnerable to attack. The FDA approved nivolumab to treat non-small cell lung cancer and some other cancers. It is still in the testing phase for malignant mesothelioma. The new report suggests that careful patient selection is the key to making nivolumab for mesothelioma work. Why Nivolumab for Mesothelioma? Malignant mesothelioma is an aggressive cancer caused by past exposure to asbestos. Like other types of cancer, it has ways of protecting itself from immune system attack. A protein called PD-L1 is … Continue reading “Exceptional Survival” in Some Patients on Nivolumab for Mesothelioma
Novel Strategy May Improve Immuno-radiotherapy for Mesothelioma
Canadian scientists say suppressing certain kinds of immune system cells could improve the effectiveness of immuno-radiotherapy for mesothelioma. Mesothelioma is a fast-growing membrane cancer caused by asbestos. Doctors have not found a single therapy that can beat it. For most patients, a combination of treatments offer the best survival odds. Immuno-radiotherapy for mesothelioma combines two types of treatments. Immunotherapy drugs activate the immune system while radiation attacks the tumor directly. Mesothelioma tumors fight back against both kinds of treatments. But researchers testing a combination of the two may have found a way to make it even more powerful. How Immuno-Radiotherapy for Mesothelioma Works Malignant mesothelioma is one of the most treatment-resistant cancers. Doctors have to attack it from many different … Continue reading Novel Strategy May Improve Immuno-radiotherapy for Mesothelioma
Manipulating “Fight or Flight” Could Impact Effectiveness of Immunotherapy for Mesothelioma
Doctors at the University of Connecticut may have found a way to influence the effectiveness of immunotherapy by manipulating the body’s fight or flight response. The finding could have a bearing on the treatment of advanced mesothelioma. Researchers used mice to confirm the connection between the sympathetic nervous system and the body’s ability to fight off cancer. The sympathetic nervous system regulates the “fight or flight” response to stress. The report shows that this response impacts the development of natural killer cells. Drugs that alter that response might change the effectiveness of immunotherapy. What is the Sympathetic Nervous System? When the body is under stress, the sympathetic nervous system (SNS) releases a cascade of hormones and chemicals. These hormones increase … Continue reading Manipulating “Fight or Flight” Could Impact Effectiveness of Immunotherapy for Mesothelioma
Immune Checkpoint Inhibitor May Change the Standard Treatment of Malignant Pleural Mesothelioma
The immune checkpoint inhibitor durvalumab could become a standard part of first-line mesothelioma treatment if the results of a new study hold true in a Phase 3 trial. Australian researchers have become the latest to show the benefit of adding durvalumab to first-line chemotherapy for pleural mesothelioma. Chemotherapy is usually the first thing doctors use to treat pleural mesothelioma. But as many as half of mesothelioma patients do not respond to it. Researchers around the world are hopeful that adding an immune checkpoint inhibitor like durvalumab will lead to better response rates. What is an Immune Checkpoint Inhibitor? Mesothelioma cells survive and thrive in part because they have ways of protecting themselves. Chemotherapy drugs are less likely to hurt them … Continue reading Immune Checkpoint Inhibitor May Change the Standard Treatment of Malignant Pleural Mesothelioma
T-Cell Immunotherapy Trial Could be Good News for Mesothelioma Patients
The first four mesothelioma patients treated with a new kind of T-cell immunotherapy have responded well with few side effects. That is the word from researchers working with the drug TC-210. TC-210 is a type of T cell therapy. It is made by TCR² Therapeutics. Malignant mesothelioma is one of several kinds of cancers that overproduce the protein mesothelin. In the Phase I trial, tumors regressed in all five cancer patients who received T-cell immunotherapy with TC-210. Targeting Cancer with T-Cells T-cells are immune system cells that help fight cancer and other invaders. Mesothelioma and other cancers have ways of avoiding the body’s natural killer T-cell response. T-cell immunotherapy helps to turn it back on. TC-210 is like a “living … Continue reading T-Cell Immunotherapy Trial Could be Good News for Mesothelioma Patients
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