New Study Sheds Light on Genetic Origins of Malignant Mesothelioma
Scientists in Australia have made a big step forward in understanding how a genetic mutation appears to drive the development of cancers such as malignant mesothelioma. The gene in question is called p53. Also known as the “guardian of the genome” for its tumor-suppressing action, p53 has been found to be mutated in about half of all human cancers, including many cases of mesothelioma. Although the primary external cause of mesothelioma is exposure to asbestos, the mutated p53 gene helps explain why some asbestos-exposed cells suddenly become cancerous and are able to grow and spread, unchecked. It may also help scientists develop new, more effective mesothelioma treatments. Right now, the prognosis for mesothelioma is often very poor. The p53 Gene … Continue reading New Study Sheds Light on Genetic Origins of Malignant Mesothelioma
Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis
Australian researchers say proteins found in lung fluid could hold the key to diagnosing pleural mesothelioma months or even years before a tumor is visible on imaging scans. Proteins function as communication devices in the body, directing all sorts of critical cellular processes, including the processes that tell cancer cells to begin replicating at a higher rate than normal cells. Scientists at Flinders University, one of the world’s leaders in mesothelioma research, wondered if the proteins that help give rise to malignant pleural mesothelioma could be found in pleural effusions and used as biomarkers to identify the cancer earlier. Looking for Mesothelioma Biomarkers in Lung Fluid In a new study published in the Journal of Proteomics, the team notes that … Continue reading Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis
Mesothelioma Survival Odds Better for Women Than Men
Women diagnosed with malignant mesothelioma tend to live longer than men with the same disease. Australian researchers say understanding exactly why that is could open the door to improving mesothelioma treatment for both genders. Assessing Mesothelioma Survival Rates By Gender Researchers led by the Cancer Epidemiology and Intelligence Division of Cancer Council Victoria in Melbourne used cancer registry data to identify cases of malignant mesothelioma and 24 others types of cancer diagnosed in Victoria between 1982 and 2015. Then, they assessed the survival differences for each type of cancer between men and women, adjusting for each patient’s age and year of diagnosis. According to their report published this week in Cancer Causes & Control, the bad news for men is … Continue reading Mesothelioma Survival Odds Better for Women Than Men
Mesothelioma Risk May Differ Between Children and Adults
Australian researchers say it may take longer for asbestos-exposed children to develop malignant mesothelioma than it takes adults with the same level of exposure. Public health researchers with multiple Australian Universities and Utrecht University in The Netherlands say being younger may offer a short-term reprieve from the mesothelioma-inducing effects of asbestos. Unfortunately, that lower susceptibility is unlikely to last for a lifetime. Studying the People of Wittenoom Scientists determined that asbestos-exposed children are less likely to contract malignant mesothelioma, at least in the short term, by studying the records of Australians who lived around the notorious Wittenoom asbestos mine. The Wittenoom mine, which mined for crocidolite or “blue” asbestos from 1943 to 1966, has now been linked to hundreds of … Continue reading Mesothelioma Risk May Differ Between Children and Adults
Milk for Mesothelioma? Proteins in Cow’s Milk May Kill Mesothelioma Cells
There is new evidence that substances in cow’s milk may trigger a physiological process that leads to the death of chemotherapy-resistant mesothelioma cells. The substances are known as BAMLET and BLAGLET and they consist of either alpha- or beta-lactalbumin from cow’s milk and a lipid called oleic acid. The two protein-lipid complexes have been shown to have cytotoxic effects on eight other types of cancer. Now, researchers in Sydney, Australia have found that the same may be true for malignant mesothelioma, one of the hardest cancers to treat. BAMLET and BLAGLET Explained β-Lactoglobulin is the primary whey protein in the milk of cow’s and sheep (though not humans). α-Lactalbumin is the protein that regulates the production of lactose in … Continue reading Milk for Mesothelioma? Proteins in Cow’s Milk May Kill Mesothelioma Cells
Pleural Mesothelioma Patients Feel Better with This Symptom Management Regimen
For mesothelioma patients with indwelling pleural catheters, new research suggests that draining them daily can improve their quality of life and may even resolve the problem faster than waiting until symptoms arise. Pleural effusions, a buildup of fluid between the layers of the pleural membrane surrounding the lungs, is a fact of life for patients with several types of cancer, including pleural mesothelioma. If not addressed, this fluid accumulation often leads to life-limiting side effects like chest pain, coughing, and breathlessness. Managing Pleural Effusions from Malignant Mesothelioma There are surgical procedures aimed at preventing pleural effusions in mesothelioma patients and resolving symptoms by physically closing the spaces where fluid accumulates. Closing up the pleural space is known as pleurodesis. … Continue reading Pleural Mesothelioma Patients Feel Better with This Symptom Management Regimen
Mesothelioma Diagnosis: Lung Fluid Testing Has its Limits
Lung fluid tests for malignant mesothelioma are accurate less than half the time according to cancer researchers at Australia’s Royal Melbourne Hospital. The production of excess lung fluid (pleural effusions) is a common side effect of mesothelioma, as well as a number of other malignant and non-malignant conditions. In mesothelioma patients, this buildup of fluid often leads to breathlessness and chest pain. Because this fluid can contain cells from a growing tumor, doctors have used lung fluid testing, also known as cytologic analysis, to identify certain types of cancer, including pleural mesothelioma. But a new study published in the Internal Medicine Journal suggests that, especially with mesothelioma, lung fluid testing is only moderately effective and must be combined with other … Continue reading Mesothelioma Diagnosis: Lung Fluid Testing Has its Limits
Exercise Can Help Patients Manage Mesothelioma Symptoms
Fatigue, poor sleep, and reduced appetite are common complaints among people undergoing treatment for malignant mesothelioma. But new guidelines from Australia suggest that there is a powerful, natural way to address many of these problems: exercise. In an official position statement published in the Medical Journal of Australia, the country’s Clinical Oncology Society encourages cancer patients and their doctors to see physical exercise as a vital part of staying healthy and managing symptoms during treatment. In the COSA statement, the authors point to the significant amount of clinical research showing that exercise is “a safe and effective intervention to counteract the adverse physical and psychological effects of cancer and its treatment.” The authors say the intention of the statement is … Continue reading Exercise Can Help Patients Manage Mesothelioma Symptoms
CT Discovery May Lead to Earlier Mesothelioma Diagnosis
Researchers in Western Australia believe they may have found a way to overcome one of the biggest challenges in the management of malignant pleural mesothelioma—making the diagnosis earlier. Malignant mesothelioma is a fast-growing cancer that starts on the membrane, or pleura, that surrounds the lungs. Because the seeds for this disease can exist for decades before symptoms develop, and because the early symptoms of mesothelioma tend to be vague and similar to those of other conditions, the so-called “asbestos cancer” often goes undetected until it is in an advanced stage. As a result, the survivability of this disease is typically very low. But scientists at the University of Western Australia in Perth say there may be a simple way to … Continue reading CT Discovery May Lead to Earlier Mesothelioma Diagnosis
Mesothelioma Persists in Australia Despite Asbestos Ban
Australia’s legacy of asbestos mining and use continues to haunt it almost fifteen years after the country banned all forms of asbestos almost fifteen years ago. A new report published in the International Journal of Environmental Research and Public Health suggests that, although asbestos consumption peaked in Australia in the 1970s, malignant mesothelioma and other asbestos-related diseases continue to be a significant public health issue. Asbestos is a naturally-occurring mineral that was prized as a building product additive because of its high tensile strength and resistance to heat and corrosion. Australia is rich in the mineral and once operated several of the world’s largest mines. In the 1960s and 1970s, the country also had the highest per capita use of … Continue reading Mesothelioma Persists in Australia Despite Asbestos Ban
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