Protein May Help Predict Complications After Peritoneal Mesothelioma Surgery

Researchers at MD Anderson Cancer Center say they may have found a way to help predict which peritoneal mesothelioma patients are most likely to develop complications after cytoreductive surgery and intraperitoneal chemotherapy. Cytoreductive surgery to remove as much of a mesothelioma tumor as possible, followed by a rinse of heated chemotherapy drugs in the abdomen is known as CRS + HIPEC. It has become a … Continue reading Protein May Help Predict Complications After Peritoneal Mesothelioma Surgery »

Immune System Changes Could Signal Mesothelioma Risk

The state of an asbestos-exposed person’s immune system might give doctors clues about how likely they are to develop malignant mesothelioma. It’s a fear for any person who has worked around asbestos – that one day they may develop the asbestos-linked cancer, mesothelioma. Pleural mesothelioma can take decades to develop, causes few symptoms at first, and is extremely hard to treat. Right now, there is … Continue reading Immune System Changes Could Signal Mesothelioma Risk »

Study Highlights Challenge of Selecting Patients for Mesothelioma Immunotherapy

A new study is casting some doubt on the value of a protein called PD-L1 as a way to select mesothelioma patients for targeted immunotherapy. Several of the most promising new treatments for malignant mesothelioma, including pembrolizumab (Keytruda) and avelumab (Avastin), are designed to inhibit PD-L1, a protein cells used to evade detection by the immune system. PD-L1 inhibitors like Keytruda have become an important … Continue reading Study Highlights Challenge of Selecting Patients for Mesothelioma Immunotherapy »

Better Nutrition Could Mean Longer Survival for Elderly Mesothelioma Patients

Could eating better improve elderly patient’s chances of surviving malignant pleural mesothelioma? Another new study suggests that it may. An article in the journal Surgical Oncology found that lung cancer patients who score low on a nutritional status assessment tool called the Geriatric Nutritional Risk Index (GNRI) have worse outcomes after surgery. The GNRI is a simple tool based on weight and levels of the … Continue reading Better Nutrition Could Mean Longer Survival for Elderly Mesothelioma Patients »

Immunotherapy for Mesothelioma: Who Are the Best Candidates?

Immunotherapy is emerging as one of the most promising new treatment approaches for a wide range of cancers, including malignant pleural mesothelioma, the treatment-resistant lung-related cancer caused by asbestos exposure. Every year, more than 2,500 Americans are diagnosed with pleural mesothelioma. Most will die of the illness within 18 months, even with the most advanced chemotherapeutic, radiotherapeutic, and surgical treatments. But immunotherapy, which recruits the … Continue reading Immunotherapy for Mesothelioma: Who Are the Best Candidates? »

FGFR Inhibitors May Offer New Way to Treat Malignant Pleural Mesothelioma

Drugs that inhibit a particular cell signaling pathway might offer a new way to help treat the intractable asbestos cancer, malignant mesothelioma. Fibroblast growth factor receptor (FGFR) is a tyrosine kinase signaling pathway that plays a fundamental role in the development of embryos, tissue regeneration, and the growth of new blood vessels (angiogenesis). Recent evidence suggests that it may also impact the development of cancers … Continue reading FGFR Inhibitors May Offer New Way to Treat Malignant Pleural Mesothelioma »

BAP1 Test Offers More Accurate Mesothelioma Diagnosis

asian doctor

A Chinese research study finds that adding a test for expression of the BAP1 tumor-suppressor protein to standard biomarker testing increases the diagnostic accuracy for malignant pleural mesothelioma to 93 percent. Pleural mesothelioma is especially challenging to diagnose and to distinguish from lung cancer. The distinction is important, however, because the two cancers respond differently to different types of drugs. In addition, the earlier malignant … Continue reading BAP1 Test Offers More Accurate Mesothelioma Diagnosis »

Mesothelioma Biomarker Test May Be Diagnostic Alternative for Frail Patients

A set of proteins found in the lung fluid of people with malignant pleural mesothelioma may offer a safer way to diagnose the asbestos cancer in frail or elderly patients. Mesothelioma is an extremely difficult cancer to diagnose. Accurate diagnosis usually requires a combination of tests including a physical exam, a thorough work history (including possible asbestos exposure), blood or lung fluid tests, imaging scans, … Continue reading Mesothelioma Biomarker Test May Be Diagnostic Alternative for Frail Patients »

New Biomarker Could Help Eradicate Mesothelioma Resistance to Chemotherapy

Researchers in the Netherlands have unveiled what may be a major breakthrough in the chemotherapeutic treatment of malignant mesothelioma. Malignant mesothelioma, a rare and virulent cancer caused by asbestos exposure, is notoriously resistant to standard cancer treatments, including chemotherapy. Even the only chemotherapy drug specifically approved for the treatment of mesothelioma, Alimta (pemetrexed), only works for some patients. Now, a new study published in the … Continue reading New Biomarker Could Help Eradicate Mesothelioma Resistance to Chemotherapy »

Inflammation Marker May Predict Mesothelioma Prognosis

The ratio of neutrophils to lymphocytes – a way of measuring inflammation in the body of people with malignant pleural mesothelioma – may help doctors predict how well they will respond to treatment. That is the conclusion of mesothelioma researchers at China’s Sichuan University. In a new article in the journal Oncotarget, the team observed that NLR has been associated with survival in other types … Continue reading Inflammation Marker May Predict Mesothelioma Prognosis »

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