SMRP Still Among Best Diagnostic Biomarkers for Mesothelioma

biomarkers for mesothelioma

Chinese researchers say soluble mesothelin-related peptides (SMRP) in lung fluid is still one of the best biomarkers for mesothelioma, even if it sometimes produces false positives.. SMRP has been studied extensively as a way to help diagnose mesothelioma. The most popular test to check levels of SMRPs in the body is a blood test called MESOMARK. In recent years, other biomarkers for mesothelioma have also emerged. But SMRPs are not just in the blood. A new meta-analysis of SMRPs from pleural effusions finds that they have a valuable place among top biomarkers for mesothelioma. Biomarkers for Mesothelioma: SMRPs and Others Malignant mesothelioma is a type of cancer that starts on the membranes around the lungs, heart or abdomen. SMRPs are … Continue reading SMRP Still Among Best Diagnostic Biomarkers for Mesothelioma »

New Research Reveals Gene Signature for Mesothelioma

gene signature for mesothelioma

Researchers in China say they have come up with a three-gene signature for mesothelioma. The gene signature may help doctors determine mesothelioma prognosis and plan treatment. Pleural mesothelioma is challenging to diagnose and even harder to treat. Many patients do not receive a diagnosis until the disease is in an advanced stage. The new study finds that the gene signature for mesothelioma is “significantly associated”  with overall survival in people with the pleural variety. Testing a Gene Signature for Mesothelioma Genes play an important role in the development and progression of cancers like mesothelioma. The Chinese researchers started by searching for other studies on  mesothelioma prognosis and genes. “The lack of relevant search results indicated that no gene prognostic signatures … Continue reading New Research Reveals Gene Signature for Mesothelioma »

Research Highlights Connection Between BDNF and Mesothelioma Survival

BDNF and mesothelioma survival

French scientists say there is a clear connection between a biomarker called BDNF and mesothelioma survival. The research may open the door to improved mesothelioma diagnosis, prognosis, and treatment. BDNF stands for brain-derived neurotrophic factor. It is a protein found in the brain and other tissues. In a new published study, researchers at the University of Nantes found that mesothelioma patients had higher BDNF levels than people with other cancers. Mesothelioma patients with the highest BDNF levels had the shortest mesothelioma survival. Linking BDNF and Mesothelioma Survival A biomarker is a substance that can be used to show the presence of disease. BDNF is a soluble mesothelioma biomarker. Soluble biomarkers are in body fluid and can be collected without a … Continue reading Research Highlights Connection Between BDNF and Mesothelioma Survival »

Early Detection of Mesothelioma with MicroRNAs

Testing for Early Detection of Mesothelioma

A new study appears to contradict some of what scientists thought they knew about early detection of mesothelioma. Malignant mesothelioma is a rare but highly aggressive cancer. It usually happens because of past asbestos exposure. Early detection of mesothelioma is key to improving survival. But it is notoriously hard to make a mesothelioma diagnosis. Many patients who have mesothelioma do not even know it until the cancer is in its advanced stage. As a result, most do not live more than a year. Some studies have suggested that tiny, non-coding bits of RNA could help doctors detect mesothelioma earlier. But new research in Germany brings that idea into question. Biomarkers for Early Detection of Mesothelioma MicroRNAs (miRNAs) play an important … Continue reading Early Detection of Mesothelioma with MicroRNAs »

BAP1 Can Distinguish Mesothelioma from Other Conditions

Scientist looking at mesothelioma cells

German scientists say a protein could help doctors distinguish mesothelioma from other conditions. Malignant mesothelioma is a cancer that grows on the membranes around organs. These membranes are called mesothelial membranes. But other conditions can also grow on mesothelial membranes. One of those conditions is adenomatoid tumors. Adenomatoid tumors are benign but, even under the microscope, their cells can look a lot like malignant mesothelioma. Now, a group of pathologists in Germany say the BAP1 protein can tell these two conditions apart. If doctors can distinguish mesothelioma from other conditions early enough, mesothelioma patients may have better outcomes. BAP1 Loss and Mesothelioma BAP1 is a protein encoded by the BAP1 gene. BAP1 is one of the proteins that helps keep … Continue reading BAP1 Can Distinguish Mesothelioma from Other Conditions »

Genetics-Based Cancer Treatment Could Mean New Hope for Mesothelioma

genetic-based cancer treatment for targeted mesothelioma therapy

The FDA has approved a new genetics-based cancer treatment that could open the door for more targeted mesothelioma therapy. The drug is called larotrectinib. The drug company Bayer sells it under the brand name Vitrakvi. Larotrectinib is unique because it is not specific to any one type of cancer. Instead, larotrectinib is based on a patient’s genetic biomarkers. It is the first drug of its kind to gain approval by the FDA. What is a Genetics-Based Cancer Treatment? A genetics-based cancer treatment is a drug that targets certain genetic mutations. Doctors find these mutations by testing for biomarkers. One mutation could cause breast cancer, colon cancer, or even pleural mesothelioma. Some kinds of mutations are connected to only one type … Continue reading Genetics-Based Cancer Treatment Could Mean New Hope for Mesothelioma »

Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis

Australian researchers say proteins found in lung fluid could hold the key to diagnosing pleural mesothelioma months or even years before a tumor is visible on imaging scans. Proteins function as communication devices in the body, directing all sorts of critical cellular processes, including the processes that tell cancer cells to begin replicating at a higher rate than normal cells. Scientists at Flinders University, one of the world’s leaders in mesothelioma research, wondered if the proteins that help give rise to malignant pleural mesothelioma could be found in pleural effusions and used as biomarkers to identify the cancer earlier. Looking for Mesothelioma Biomarkers in Lung Fluid In a new study published in the Journal of Proteomics, the team notes that … Continue reading Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis »

Lung Fluid Tests May Lead to Earlier Mesothelioma Diagnosis

Using the free-floating cancer cells present in lung-fluid to diagnose malignant mesothelioma may lead to earlier detection and better outcomes. That is the conclusion of cancer researchers at Stockholm’s Karolinska University Hospital. The team’s goal was to evaluate the established criteria for cytopathological diagnosis of mesothelioma, i.e. diagnosis using cells found in fluid (effusions) instead of cells from a tissue biopsy. In a newly published article in the Archives of Pathological and Laboratory Medicine, the researchers observe, “Despite the difficulties in recognizing malignant cells present in those early effusions, they are often the first available biologic material for diagnosis.” Diagnosing Pleural  Mesothelioma Malignant pleural mesothelioma, a rare but fast-growing cancer associated with asbestos exposure, is notoriously difficult to diagnose. Diagnosis … Continue reading Lung Fluid Tests May Lead to Earlier Mesothelioma Diagnosis »

Peritoneal Mesothelioma Case Highlights Importance of Genetic Testing

The case of a peritoneal mesothelioma patient who was diagnosed at just 45-years-old is drawing attention to the role of genetics in this aggressive asbestos-linked malignancy. Sometimes referred to as “asbestos cancer”, malignant mesothelioma is almost always connected with known exposure to the fibrous mineral—often in a work environment. But even though most mesothelioma cases can be traced back to asbestos, not all asbestos-exposed people go on to develop malignant mesothelioma. Because of this, scientists began to believe that, in mesothelioma as in so many other types of cancer, there were likely other factors at play. Early Mesothelioma, Genes, and Asbestos Exposure In most cases, mesothelioma takes decades to develop, meaning that most patients are not diagnosed with mesothelioma until they … Continue reading Peritoneal Mesothelioma Case Highlights Importance of Genetic Testing »

Mesothelioma Diagnosis: Lung Fluid Testing Has its Limits

mesothelioma diagnosis

Lung fluid tests for malignant mesothelioma are accurate less than half the time according to cancer researchers at Australia’s Royal Melbourne Hospital. The production of excess lung fluid (pleural effusions) is a common side effect of mesothelioma, as well as a number of other malignant and non-malignant conditions. In mesothelioma patients, this buildup of fluid often leads to breathlessness and chest pain. Because this fluid can contain cells from a growing tumor, doctors have used lung fluid testing, also known as cytologic analysis, to identify certain types of cancer, including pleural mesothelioma. But a new study published in the Internal Medicine Journal suggests that, especially with mesothelioma, lung fluid testing is only moderately effective and must be combined with other … Continue reading Mesothelioma Diagnosis: Lung Fluid Testing Has its Limits »

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