How Asbestos Turns Healthy Cells into Mesothelioma Tumors

Scientists are a step closer to understanding how malignant mesothelioma may take hold in the body thanks to new research from the University of Vermont. A team of pathologists, biologists, and geneticists have released a report suggesting that exosomes, tiny vesicles secreted by cells, undergo dangerous changes when the cells encounter asbestos fibers. According to the researchers, exosomes from asbestos-exposed cells can carry gene-altering cargo … Continue reading How Asbestos Turns Healthy Cells into Mesothelioma Tumors »

New Technology Could Change How Mesothelioma Treatment is Monitored

New technology could eventually make it easier, less painful, and less expensive to track the progress of patients undergoing treatment for malignant mesothelioma and other cancers. A research team led by University of Wisconsin-Madison pharmacy professor Seungpyo Hong has developed what they say is a more efficient method for capturing free-floating cancer cells in the blood. The developers say the system is far more effective … Continue reading New Technology Could Change How Mesothelioma Treatment is Monitored »

Simple Blood Test Detects Mesothelioma Progression

Malignant mesothelioma patients may not need multiple CT scans to tell whether their cancer has progressed in the months after  chemotherapy treatment. UK researchers say a simple blood test to check their levels of the protein mesothelin costs less, requires fewer hospital visits, and is 96 percent accurate in most mesothelioma patients.   Measuring Mesothelioma Progression The study was conducted by scientists at the University … Continue reading Simple Blood Test Detects Mesothelioma Progression »

Protein May Help Predict Complications After Peritoneal Mesothelioma Surgery

Researchers at MD Anderson Cancer Center say they may have found a way to help predict which peritoneal mesothelioma patients are most likely to develop complications after cytoreductive surgery and intraperitoneal chemotherapy. Cytoreductive surgery to remove as much of a mesothelioma tumor as possible, followed by a rinse of heated chemotherapy drugs in the abdomen is known as CRS + HIPEC. It has become a … Continue reading Protein May Help Predict Complications After Peritoneal Mesothelioma Surgery »

Immune System Changes Could Signal Mesothelioma Risk

The state of an asbestos-exposed person’s immune system might give doctors clues about how likely they are to develop malignant mesothelioma. It’s a fear for any person who has worked around asbestos – that one day they may develop the asbestos-linked cancer, mesothelioma. Pleural mesothelioma can take decades to develop, causes few symptoms at first, and is extremely hard to treat. Right now, there is … Continue reading Immune System Changes Could Signal Mesothelioma Risk »

Study Highlights Challenge of Selecting Patients for Mesothelioma Immunotherapy

A new study is casting some doubt on the value of a protein called PD-L1 as a way to select mesothelioma patients for targeted immunotherapy. Several of the most promising new treatments for malignant mesothelioma, including pembrolizumab (Keytruda) and avelumab (Avastin), are designed to inhibit PD-L1, a protein cells used to evade detection by the immune system. PD-L1 inhibitors like Keytruda have become an important … Continue reading Study Highlights Challenge of Selecting Patients for Mesothelioma Immunotherapy »

Better Nutrition Could Mean Longer Survival for Elderly Mesothelioma Patients

Could eating better improve elderly patient’s chances of surviving malignant pleural mesothelioma? Another new study suggests that it may. An article in the journal Surgical Oncology found that lung cancer patients who score low on a nutritional status assessment tool called the Geriatric Nutritional Risk Index (GNRI) have worse outcomes after surgery. The GNRI is a simple tool based on weight and levels of the … Continue reading Better Nutrition Could Mean Longer Survival for Elderly Mesothelioma Patients »

Immunotherapy for Mesothelioma: Who Are the Best Candidates?

Immunotherapy is emerging as one of the most promising new treatment approaches for a wide range of cancers, including malignant pleural mesothelioma, the treatment-resistant lung-related cancer caused by asbestos exposure. Every year, more than 2,500 Americans are diagnosed with pleural mesothelioma. Most will die of the illness within 18 months, even with the most advanced chemotherapeutic, radiotherapeutic, and surgical treatments. But immunotherapy, which recruits the … Continue reading Immunotherapy for Mesothelioma: Who Are the Best Candidates? »

FGFR Inhibitors May Offer New Way to Treat Malignant Pleural Mesothelioma

Drugs that inhibit a particular cell signaling pathway might offer a new way to help treat the intractable asbestos cancer, malignant mesothelioma. Fibroblast growth factor receptor (FGFR) is a tyrosine kinase signaling pathway that plays a fundamental role in the development of embryos, tissue regeneration, and the growth of new blood vessels (angiogenesis). Recent evidence suggests that it may also impact the development of cancers … Continue reading FGFR Inhibitors May Offer New Way to Treat Malignant Pleural Mesothelioma »

BAP1 Test Offers More Accurate Mesothelioma Diagnosis

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A Chinese research study finds that adding a test for expression of the BAP1 tumor-suppressor protein to standard biomarker testing increases the diagnostic accuracy for malignant pleural mesothelioma to 93 percent. Pleural mesothelioma is especially challenging to diagnose and to distinguish from lung cancer. The distinction is important, however, because the two cancers respond differently to different types of drugs. In addition, the earlier malignant … Continue reading BAP1 Test Offers More Accurate Mesothelioma Diagnosis »

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