Biomarkers Archives | Surviving Mesothelioma

Mesothelioma Biomarker Test May Be Diagnostic Alternative for Frail Patients

A set of proteins found in the lung fluid of people with malignant pleural mesothelioma may offer a safer way to diagnose the asbestos cancer in frail or elderly patients. Mesothelioma is an extremely difficult cancer to diagnose. Accurate diagnosis usually requires a combination of tests including a physical exam, a thorough work history (including possible asbestos exposure), blood or lung fluid tests, imaging scans, … Continue reading Mesothelioma Biomarker Test May Be Diagnostic Alternative for Frail Patients »

New Biomarker Could Help Eradicate Mesothelioma Resistance to Chemotherapy

Researchers in the Netherlands have unveiled what may be a major breakthrough in the chemotherapeutic treatment of malignant mesothelioma. Malignant mesothelioma, a rare and virulent cancer caused by asbestos exposure, is notoriously resistant to standard cancer treatments, including chemotherapy. Even the only chemotherapy drug specifically approved for the treatment of mesothelioma, Alimta (pemetrexed), only works for some patients. Now, a new study published in the … Continue reading New Biomarker Could Help Eradicate Mesothelioma Resistance to Chemotherapy »

Inflammation Marker May Predict Mesothelioma Prognosis

The ratio of neutrophils to lymphocytes – a way of measuring inflammation in the body of people with malignant pleural mesothelioma – may help doctors predict how well they will respond to treatment. That is the conclusion of mesothelioma researchers at China’s Sichuan University. In a new article in the journal Oncotarget, the team observed that NLR has been associated with survival in other types … Continue reading Inflammation Marker May Predict Mesothelioma Prognosis »

These Proteins Appear to Shorten Mesothelioma Survival

New evidence suggests that mesothelioma patients whose tumors express two particular proteins do not live as long as other mesothelioma patients. An international team of scientists including mesothelioma researchers at the National Cancer Institute say ALCAM (also called CD166) and PD-L1 (CD274) are both associated with “significantly decreased” survival in pleural mesothelioma. Understanding ALCAM and PD-L1 ALCAM is a type I transmembrane protein that regulates … Continue reading These Proteins Appear to Shorten Mesothelioma Survival »

The Influence of BAP1 on Mesothelioma Survival

A mutation on the BAP1 tumor suppressor gene can influence the development of malignant mesothelioma but may have little bearing on survival. That conclusion comes from a new Chinese study of more than 2,400 people with cancers directly linked to the BAP1 genetic mutation, including pleural mesothelioma. BAP1 and Mesothelioma BRCA1-associated protein 1 (BAP1) is a tumor suppressing protein encoded by the BAP1 gene. Multiple studies … Continue reading The Influence of BAP1 on Mesothelioma Survival »

A Breath Test for Mesothelioma?

Researchers in Belgium say a breath analysis tool could provide the next big breakthrough in the effort to diagnose malignant mesothelioma earlier. The team, made up of scientists from Ghent and Antwerp Universities, says the technique looks “very promising” and fits well within the aims of the “National Cancer Moonshot” research initiative established by President Obama. The Challenge of Mesothelioma Diagnosis Malignant pleural mesothelioma (MPM) … Continue reading A Breath Test for Mesothelioma? »

New Blood Test Could Mean Earlier Mesothelioma Diagnosis

A calcium-binding protein called calretinin may provide the basis for a new kind of blood test for the asbestos-linked cancer, malignant mesothelioma. Right now, there is no reliable way to detect the presence of a mesothelioma tumor before symptoms develop. The Search for a Mesothelioma Blood Test But scientists around the world are searching for ways to use certain compounds produced by tumors to diagnose mesothelioma … Continue reading New Blood Test Could Mean Earlier Mesothelioma Diagnosis »

Predicting Mesothelioma Outcomes with Soluble Mesothelin

New research suggests that a protein often used to help diagnose and track malignant mesothelioma may also be a valuable prognostic indicator. Soluble mesothelin-related protein (SMRP) is a biomarker for pleural mesothelioma, an aggressive asbestos-linked cancer that causes few symptoms until in its late stages. The presence of SMRP in the blood indicates that mesothelial cells on the lining around the lungs have been damaged. … Continue reading Predicting Mesothelioma Outcomes with Soluble Mesothelin »

More Evidence for Inflammation Marker in Mesothelioma Prognosis

There is more evidence that a measure of how well the immune system is functioning may be an efficient prognostic tool for people with malignant pleural mesothelioma. Even though some recent studies have found the ratio of neutrophils to lymphocytes (NLR) in the blood to be a poor prognostic indicator for cancer, Chinese researchers say it may still be effective for planning mesothelioma treatment and qualifying … Continue reading More Evidence for Inflammation Marker in Mesothelioma Prognosis »

Diagnosing Pleural Mesothelioma with Lung Fluid: The Battle of the Biomarkers

Biologist Holding Flasks

A biomarker called soluble mesothelin related peptide (SMRP) may be a more reliable way to diagnose malignant pleural mesothelioma from lung fluid than the protein fibulin-3. That is the finding of Italian researchers who tested the diagnostic performance of the two markers in 120 patients, including 33 mesothelioma patients, in an effort to resolve what they call “conflicting data” on the two methods. SMRP and … Continue reading Diagnosing Pleural Mesothelioma with Lung Fluid: The Battle of the Biomarkers »

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