Exposed to Asbestos? Lung Fluid Test May Waste Valuable Time

exposed to asbestos worker

If you have been exposed to asbestos and your doctor sees a mesothelioma tumor on your CT scan, it may be a waste of time to do a lung fluid test, too. Many different types of cancer cause excess lung fluid or pleural effusions. Looking for cancer cells in pleural effusions is one of the ways doctors test for cancers like pleural mesothelioma. This is called effusion cytology. But a new study says this test may not be very reliable for people with malignant mesothelioma. If other factors point to mesothelioma, they say it makes more sense to skip effusion cytology and go straight to a biopsy. Mesothelioma Develops in People Exposed to Asbestos Pleural mesothelioma is a type of … Continue reading Exposed to Asbestos? Lung Fluid Test May Waste Valuable Time »

Analysis of Three Top Mesothelioma Biomarkers

mesothelioma biomarkers testing

New research confirms that some mesothelioma biomarkers are much more effective than others for detecting asbestos cancer. The news comes from a study conducted at the Icahn School of Medicine at Mount Sinai in New York. Researchers ran an analysis of more than 50 studies on three popular mesothelioma biomarkers. They concluded that two of them make good mesothelioma screening tools but one of them does not.   The Challenge of Early Mesothelioma Diagnosis Mesothelioma is a highly aggressive cancer caused by exposure to asbestos. As with most cancers, the odds of surviving mesothelioma are higher if it is caught early. But mesothelioma does not cause many symptoms in the early stages. This can make it challenging to diagnose. Even … Continue reading Analysis of Three Top Mesothelioma Biomarkers »

Minimally Invasive Mesothelioma Diagnosis from Lung Fluid

minimally invasive mesothelioma diagnosis

Minimally invasive mesothelioma diagnosis with lung fluid may be just as effective as a tissue biopsy. That’s according to Australian mesothelioma researchers. Australia was once one of the biggest producers of asbestos and now has some of the highest mesothelioma rates in the world. It is also home to high-level mesothelioma research. In the latest study, scientists ran a meta-analysis comparing surgical biopsy with a minimally invasive mesothelioma diagnosis tool called cytology. Their conclusion is that surgery may not always be necessary to diagnose malignant mesothelioma. Tissue Versus Lung Fluid Malignant mesothelioma is a fatal cancer caused by exposure to asbestos. It is challenging to diagnose because the symptoms are often vague and similar to other less serious conditions. Doctors … Continue reading Minimally Invasive Mesothelioma Diagnosis from Lung Fluid »

Systemic Inflammation Linked to Shorter Mesothelioma Survival

systemic inflammation

Mesothelioma patients whose bodies respond to the illness with systemic inflammation are less likely to survive. Chinese researchers have linked a measure of systemic inflammation called SII to shorter survival in people with pleural mesothelioma. The new study involved 97 people with confirmed malignant mesothelioma. It suggests that SII could be a simple, non-invasive way to determine mesothelioma prognosis. What is SII? SII stands for “systemic immune-inflammation index”. When a body is under stress, such as when it is fighting mesothelioma, the innate immune system kicks into action. Certain kinds of white blood cells and proteins are released. The result is systemic inflammation. SII can be determined with a blood test. The test measures the levels of white blood cells … Continue reading Systemic Inflammation Linked to Shorter Mesothelioma Survival »

Mesothelioma Tumor Progression Can be Tracked With Blood Test

mesothelioma tumor progression

Italian researchers say it’s possible to monitor mesothelioma tumor progression with a simple blood test. They make their case in a Letter to the Editor in the latest edition of the Journal of Thoracic Oncology. The researchers say blood serum levels of the protein mesothelin correlate closely with tumor volume in malignant pleural mesothelioma patients. They are recommending that the blood test be used alongside CT to track mesothelioma tumor progression. The Importance of Monitoring Mesothelioma Tumor Progression Pleural mesothelioma is a rare cancer with a grim prognosis. Mesothelioma tumors tend to grow and spread quickly. Doctors have to carefully monitor mesothelioma tumor progression to tell if a treatment is working. Most mesothelioma patients have chemotherapy with Alimta (pemetrexed) and … Continue reading Mesothelioma Tumor Progression Can be Tracked With Blood Test »

SMRP Still Among Best Diagnostic Biomarkers for Mesothelioma

biomarkers for mesothelioma

Chinese researchers say soluble mesothelin-related peptides (SMRP) in lung fluid is still one of the best biomarkers for mesothelioma, even if it sometimes produces false positives.. SMRP has been studied extensively as a way to help diagnose mesothelioma. The most popular test to check levels of SMRPs in the body is a blood test called MESOMARK. In recent years, other biomarkers for mesothelioma have also emerged. But SMRPs are not just in the blood. A new meta-analysis of SMRPs from pleural effusions finds that they have a valuable place among top biomarkers for mesothelioma. Biomarkers for Mesothelioma: SMRPs and Others Malignant mesothelioma is a type of cancer that starts on the membranes around the lungs, heart or abdomen. SMRPs are … Continue reading SMRP Still Among Best Diagnostic Biomarkers for Mesothelioma »

New Research Reveals Gene Signature for Mesothelioma

gene signature for mesothelioma

Researchers in China say they have come up with a three-gene signature for mesothelioma. The gene signature may help doctors determine mesothelioma prognosis and plan treatment. Pleural mesothelioma is challenging to diagnose and even harder to treat. Many patients do not receive a diagnosis until the disease is in an advanced stage. The new study finds that the gene signature for mesothelioma is “significantly associated”  with overall survival in people with the pleural variety. Testing a Gene Signature for Mesothelioma Genes play an important role in the development and progression of cancers like mesothelioma. The Chinese researchers started by searching for other studies on  mesothelioma prognosis and genes. “The lack of relevant search results indicated that no gene prognostic signatures … Continue reading New Research Reveals Gene Signature for Mesothelioma »

Research Highlights Connection Between BDNF and Mesothelioma Survival

BDNF and mesothelioma survival

French scientists say there is a clear connection between a biomarker called BDNF and mesothelioma survival. The research may open the door to improved mesothelioma diagnosis, prognosis, and treatment. BDNF stands for brain-derived neurotrophic factor. It is a protein found in the brain and other tissues. In a new published study, researchers at the University of Nantes found that mesothelioma patients had higher BDNF levels than people with other cancers. Mesothelioma patients with the highest BDNF levels had the shortest mesothelioma survival. Linking BDNF and Mesothelioma Survival A biomarker is a substance that can be used to show the presence of disease. BDNF is a soluble mesothelioma biomarker. Soluble biomarkers are in body fluid and can be collected without a … Continue reading Research Highlights Connection Between BDNF and Mesothelioma Survival »

Early Detection of Mesothelioma with MicroRNAs

Testing for Early Detection of Mesothelioma

A new study appears to contradict some of what scientists thought they knew about early detection of mesothelioma. Malignant mesothelioma is a rare but highly aggressive cancer. It usually happens because of past asbestos exposure. Early detection of mesothelioma is key to improving survival. But it is notoriously hard to make a mesothelioma diagnosis. Many patients who have mesothelioma do not even know it until the cancer is in its advanced stage. As a result, most do not live more than a year. Some studies have suggested that tiny, non-coding bits of RNA could help doctors detect mesothelioma earlier. But new research in Germany brings that idea into question. Biomarkers for Early Detection of Mesothelioma MicroRNAs (miRNAs) play an important … Continue reading Early Detection of Mesothelioma with MicroRNAs »

BAP1 Can Distinguish Mesothelioma from Other Conditions

Scientist looking at mesothelioma cells

German scientists say a protein could help doctors distinguish mesothelioma from other conditions. Malignant mesothelioma is a cancer that grows on the membranes around organs. These membranes are called mesothelial membranes. But other conditions can also grow on mesothelial membranes. One of those conditions is adenomatoid tumors. Adenomatoid tumors are benign but, even under the microscope, their cells can look a lot like malignant mesothelioma. Now, a group of pathologists in Germany say the BAP1 protein can tell these two conditions apart. If doctors can distinguish mesothelioma from other conditions early enough, mesothelioma patients may have better outcomes. BAP1 Loss and Mesothelioma BAP1 is a protein encoded by the BAP1 gene. BAP1 is one of the proteins that helps keep … Continue reading BAP1 Can Distinguish Mesothelioma from Other Conditions »

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