Prophylactic Radiation Will Not Prevent Pleural Mesothelioma Metastasis

mesothelioma metastasis prevention

A UK study says prophylactic radiation of the chest wall is unlikely to prevent pleural mesothelioma metastasis.   Pleural mesothelioma is an aggressive cancer caused by asbestos. Tumors start on the lining around the lungs and can spread to the lungs and other organs. Pleural mesothelioma is the most common type of asbestos cancer. Doctors sometimes use procedures that pierce the chest wall to help diagnose mesothelioma or to deal with mesothelioma side effects. Sometimes, new mesothelioma tumors can form along the instrument tracts or in the spot where the chest wall was pierced. When tumors spread it is known as mesothelioma metastasis. Some evidence suggests that radiating the chest wall after a procedure might prevent mesothelioma metastasis in that … Continue reading Prophylactic Radiation Will Not Prevent Pleural Mesothelioma Metastasis »

Adjuvant Radiotherapy for Mesothelioma Extends Survival

radiotherapy mesothelioma patient

The largest study ever conducted on adjuvant radiotherapy for mesothelioma shows that it can help patients live longer. Pleural mesothelioma is a rare cancer that tends to be highly resistant to standard treatments. Doctors usually have to use a combination of treatments to attack it. These may include chemotherapy, radiotherapy, surgery, and/or immunotherapy. But there are still many questions about what combination of therapies to use and in what order. Adjuvant radiotherapy for mesothelioma is radiation delivered prior to surgery. Now, radiation oncology researchers in Texas say this approach can extend mesothelioma survival. Killing Mesothelioma Cells with Radiation Mesothelioma cells are hard to kill. Chemotherapy with Alimta (pemetrexed) and cisplatin is the most common treatment. But mesothelioma tumors usually start … Continue reading Adjuvant Radiotherapy for Mesothelioma Extends Survival »

Combination Therapy with Mesothelioma Surgery Leads to Longer Survival

Mesothelioma surgery patient with nurse

A new study finds almost a quarter of people who had combination therapy with mesothelioma surgery were still alive five years later. The study was published in the European Journal of Cardio-Thoracic Surgery. Researchers at University Hospitals KU Leuven in Belgium studied nearly 200 mesothelioma patients from 2003 to 2014. Many people do not live beyond about 18 months after a mesothelioma diagnosis. But the Belgian team says, for the right patients, there is a way to improve the odds. They say combination therapy with radical mesothelioma surgery offers a 1 in 4 chance of surviving for 5 years or more. Two Types of Mesothelioma Surgery There are two major schools of thought about mesothelioma surgery. Some surgeons say it … Continue reading Combination Therapy with Mesothelioma Surgery Leads to Longer Survival »

Radiation May Help Mesothelioma Immunotherapy Treatment Work Better

mesothelioma radiation treatment

Hypofractionated radiation for mesothelioma could change how doctors treat this rare cancer.  Researchers in Toronto, Canada have been testing hypofractionated radiation in mesothelioma surgery patients. They have used it to shrink tumors before lung-removing EPP surgery. Hypofractionated radiation is faster than than standard radiation. It may also cause fewer side effects. Now, doctors want to know what else this type of radiation might be good for. They plan to test how well hypofractionated radiation works with less radical mesothelioma surgery. There is also evidence that hypofractionated radiation may strengthen mesothelioma immunotherapy treatment. Radiation Before Mesothelioma Surgery Doctors at the Princess Margaret Cancer Center in Toronto ran a clinical trial called SMART. SMART stands for Surgery for Mesothelioma After Radiation Therapy. … Continue reading Radiation May Help Mesothelioma Immunotherapy Treatment Work Better »

Old Drug May Breath New Life Into Mesothelioma Radiotherapy

Researchers at the University of Ohio may have found a way to make radiation therapy more effective for people with mesothelioma and other types of solid tumors. They’re using a muscle relaxant approved in the 1800s to increase the level of oxygen in cancer cells and make them more susceptible to the damaging effects of radiation. The research could have wide-ranging implications, especially for patients fighting treatment-resistant malignancies like pleural mesothelioma. The Limitations of Radiation for Pleural Mesothelioma Mesothelioma is a fast-growing cancer associated with asbestos exposure that occurs on the membranes around internal organs. Although the irregular shape and tricky location of mesothelioma tumors can make them difficult to treat with radiotherapy, advanced targeting techniques are making it more … Continue reading Old Drug May Breath New Life Into Mesothelioma Radiotherapy »

New Study Points to Benefits of IMRT for Mesothelioma Treatment

There is more evidence that mesothelioma patients who have lung sparing surgery can live longer if it’s followed up with highly targeted radiation therapy. In the first study to come out of Israel on the subject, a team of oncologists, pulmonologists, radiation oncologists, and thoracic surgeons at Rabin Medicine Center in Petah Tikva say intensity modulated radiation therapy (IMRT) is safe and effective for slowing down the growth of pleural mesothelioma tumors. The Challenge of Radiotherapy for Mesothelioma The irregularity of malignant mesothelioma tumors makes them difficult to treat with standard external beam radiotherapy without damaging healthy tissue and causing serious side effects. This is particularly problematic in patients who still have both lungs, either because they were not good … Continue reading New Study Points to Benefits of IMRT for Mesothelioma Treatment »

Radiotherapy LIkely to Play a Bigger Role in Future Mesothelioma Therapy

New research suggests that radiotherapy is likely to play a larger role in the multi-modal treatment of malignant pleural mesothelioma in the future, supporting and enhancing treatments such as surgery and immunotherapy. Radiation scrambles the DNA inside cancer cells, interrupting their life cycle and making replication impossible. If it were possible to irradiate only mesothelioma cells without affecting the surrounding healthy tissue, radiotherapy might even be able to cure cancers like mesothelioma. But as the authors of a new study published in the Journal of Thoracic Disease point out, until recently, radiotherapy has been of limited use in the treatment of mesothelioma because it hasn’t been precise enough. Thanks to new technology, that is changing. Why Mesothelioma is Hard to … Continue reading Radiotherapy LIkely to Play a Bigger Role in Future Mesothelioma Therapy »

Mesothelioma Survival Improves with Post-Surgery Radiation

Pleural mesothelioma patients who undergo radiotherapy after their surgery tend to live longer than those whose treatment plan does not include radiation. Unfortunately, only a small percentage of patients who could stand to benefit from this treatment actually get it. Researchers at Houston Methodist Hospital, Baylor, and The University of Texas have come to that conclusion after analyzing data from the National Cancer Database on nearly 25,000 patients with malignant pleural mesothelioma from 2004 to 2013. It was the largest study of adjuvant radiotherapy for mesothelioma ever conducted. Radiotherapy in Mesothelioma Treatment Although radiotherapy is not routinely used in mesothelioma treatment, when it is used, it is typically either palliative as a way to relieve symptoms, or as an add-on … Continue reading Mesothelioma Survival Improves with Post-Surgery Radiation »

Radiation for Mesothelioma: Could Proton Therapy Be the Answer?

Researchers at the Maryland Proton Therapy Treatment Center say a highly-targeted version of proton beam radiation could be the future of radiotherapy for malignant pleural mesothelioma. In a new journal article, doctors at the center detail the evolution of radiation treatment for pleural mesothelioma, from standard photon-based therapy to targeted proton therapy. “Radiation therapy has historically been used [for mesothelioma] only in the palliative setting or as adjuvant therapy after extrapleural pneumonectomy,” notes the report. But the researchers go on to say that radiotherapy advances such as intensity-modulated radiation therapy (IMRT) and a more precise form of proton beam therapy called pencil-beam scanning, are changing the value of radiotherapy for mesothelioma patients. Radiation’s Role in Pleural Mesothelioma Treatment Radiation works … Continue reading Radiation for Mesothelioma: Could Proton Therapy Be the Answer? »

Experimental Mesothelioma Therapy Shrinks Mouse Tumors by 80 Percent

An innovative approach to mesothelioma treatment being developed in Italy has produced results researchers call “very promising”. The treatment reduced the size of mesothelioma tumors in  mice by 80 to 85 percent in just over a month. Noninvasive image-guided Boron Neutron Capture Therapy (BNCT) utilizes the unique properties of boron to destroy mesothelioma cells from the inside out. It has been used as an alternative to conventional radiation therapy for the treatment of malignant brain tumors and recurrent head and neck cancers. The new Italian study is the latest to evaluate this approach for patients with malignant mesothelioma, a hard-to-treat membrane cancer caused by exposure to asbestos. Boron Neutron Capture Therapy for Mesothelioma BNCT is a two-step cancer treatment approach. … Continue reading Experimental Mesothelioma Therapy Shrinks Mouse Tumors by 80 Percent »

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