Radiotherapy Outcomes in Mesothelioma Linked to Pembrolizumab

Radiotherapy Outcomes in Mesothelioma Linked to Pembrolizumab

Canadian researchers say radiotherapy may hold the key to improving outcomes in mesothelioma. Mesothelioma is a fast-growing membrane cancer caused by asbestos. Doctors have not found a single therapy that can beat it. For most patients, a combination of treatments offer the best survival odds. Pembrolizumab plus Radiotherapy Pleural mesothelioma is a rare lung-related cancer caused by asbestos exposure. There is no cure for mesothelioma. Most mesothelioma patients have a combination of therapies. Radiation is one of the methods doctors use to help slow its spread. Outcomes in mesothelioma vary widely with the use of radiotherapy. Pembrolizumab is used in combination with chemotherapy as a first-line treatment for mesothelioma. Radiotherapy uses beams of intense energy to kill cancer cells. One … Continue reading Radiotherapy Outcomes in Mesothelioma Linked to Pembrolizumab »

Radiation Therapy for Mesothelioma Patients: Value and Timing

Radiation Therapy for Mesothelioma Patients: Value and Timing

The value and safety of radiation therapy for mesothelioma patients are promising. Oncologists from the Fox Chase Cancer Center released new data on radiotherapy. What are the options for radiation therapy? What is the best timing? Who should receive it? This guide shows the role of radiotherapy in the treatment of mesothelioma. Mesothelioma Radiosensitivity and Treatment Combinations Mesothelioma tumors are radiosensitive. This means they are sensitive to X-rays and radiant energy forms. In other words, mesothelioma tumors are treatable with radiation therapy. The use of a multi-modality treatment has also shown potential for mesothelioma patients. A tri-modality treatment uses three different treatment types. The combination of surgery, chemotherapy, and radiotherapy is most common. Understanding Timing and Adverse Effects There are … Continue reading Radiation Therapy for Mesothelioma Patients: Value and Timing »

Sensitizer Could Improve Radiotherapy for Pleural Mesothelioma

radiotherapy for pleural mesothelioma

A chemical compound that sensitizes cancer cells to radiation could help improve radiotherapy for pleural mesothelioma. Radiotherapy uses ionizing radiation to scramble the DNA of cancer cells. This makes it harder for cells to replicate and form new tumors.  But mesothelioma cells and other hard-to-treat cancers have ways of protecting themselves against radiation-induced DNA damage. The possibility of damaging healthy cells is another limiting factor in radiotherapy for pleural mesothelioma.  Now, a Japanese study of mice shows a new compound called SQAP can enhance the damage to cancer cells from radiation. The researchers are hopeful it could help keep mesothelioma tumors in check. The Challenge of Radiotherapy for Pleural Mesothelioma Malignant pleural mesothelioma is difficult to treat. This aggressive membrane … Continue reading Sensitizer Could Improve Radiotherapy for Pleural Mesothelioma »

New Mesothelioma Trial to Test Tri-Modal Approach

new mesothelioma trial

Enrollment is open for a new mesothelioma trial run by Memorial Sloan Kettering Cancer Center to test a three-prong approach to treatment.  Pleural mesothelioma is a lung-related cancer caused by asbestos. It is notoriously difficult to treat and highly aggressive.  The new mesothelioma trial aims to recruit 150 pleural mesothelioma patients. Patients will receive lung-sparing surgery and chemotherapy. Some will also receive intensity modulated radiation therapy (IMRT).  Researchers will test which group does better – those who only have surgery and chemotherapy or those who also have targeted radiation therapy. They plan to measure not only survival but also complications, quality of life, and how long it takes for the cancer to come back.  Tri-Modal Treatment to Fight Mesothelioma The … Continue reading New Mesothelioma Trial to Test Tri-Modal Approach »

Adjuvant Radiotherapy May Not Lengthen Mesothelioma Survival, Study Shows

adjuvant radiotherapy

Having adjuvant radiotherapy after surgery may not help mesothelioma patients live any longer according to researchers at Duke and Stanford Universities. Researchers used a database of pleural mesothelioma patients from Duke and a national registry to conduct the analysis.  They compared the outcomes of patients who had radiation after surgery (adjuvant radiotherapy) with the outcomes of those who did not.  While radiotherapy may help reduce mesothelioma symptoms for some patients, the results of the study suggest that it is unlikely to extend survival. Radiation for Mesothelioma and Its Symptoms Radiotherapy is a mainstay of cancer therapy for certain kinds of cancer. But the irregular shape and aggressive nature of mesothelioma tumors makes them less than ideal for radiation treatment.  Pleural … Continue reading Adjuvant Radiotherapy May Not Lengthen Mesothelioma Survival, Study Shows »

Triple-Modality Therapy May Improve Mesothelioma Outcomes, Study Suggests

triple-modality therapy

A Canadian study suggests that triple-modality therapy with radiotherapy, immunotherapy, and surgery may extend the lives of people with malignant pleural mesothelioma.  Pleural mesothelioma is an intractable cancer with a poor prognosis. It mainly affects people who have lived or worked around asbestos.  There is no cure for mesothelioma. People who have the best mesothelioma outcomes usually have a combination of treatments.  Now, scientists at Toronto General Hospital’s Research Institute say a triple-modality therapy they tested in mice might have the power to extend human lives, too. Multi-modal Mesothelioma Treatment Pleural mesothelioma is a fast-growing cancer that starts on the membrane around the lungs. Many mesothelioma patients die less than a year after diagnosis.  There is no single accepted treatment … Continue reading Triple-Modality Therapy May Improve Mesothelioma Outcomes, Study Suggests »

Still No Clear Answer on SMART Protocol for Pleural Mesothelioma

SMART protocol for mesothelioma

Another study is out and there is still no clear answer about the value of the SMART protocol for mesothelioma.  SMART stands for surgery for mesothelioma after radiotherapy. After studying nearly a hundred patients, doctors in Toronto say radical surgery after RT can be effective. But they also say it is still very hard to prevent serious complications, even in an experienced center like theirs.  The team at Princess Margaret Cancer Center tested the SMART protocol on previously-untreated pleural mesothelioma patients.  As with previous studies of the SMART protocol for mesothelioma, some of the patients did very well. Many lived longer than they would normally expect to live. But there was also a high incidence of serious surgery-related complications.  The … Continue reading Still No Clear Answer on SMART Protocol for Pleural Mesothelioma »

Focused Radiation After Chemotherapy May Improve Mesothelioma Survival

focused radiation after chemotherapy

New research suggests that mesothelioma patients who have focused radiation after chemotherapy may live longer with slower disease progression than those who have other therapy combinations. Researchers used two kinds of focused radiotherapy (FRT) in the study. One was stereotactic body radiotherapy (SBRT) and the other was hypo-fractionated radiotherapy. Both treatments deliver a deadly dose of radiation into tumors while sparing normal tissue.  Italian researchers say giving focused radiation after chemotherapy makes it even more effective against mesothelioma that is not yet widespread.  Radiotherapy for Pleural Mesothelioma Radiotherapy is one of several possible treatments for mesothelioma. Most patients start with chemotherapy. But chemotherapy has limited effectiveness. Increasingly, researchers are looking for other approaches to combat mesothelioma.  Most patients get the … Continue reading Focused Radiation After Chemotherapy May Improve Mesothelioma Survival »

Novel Strategy May Improve Immuno-radiotherapy for Mesothelioma

Immuno-radiotherapy for Mesothelioma

Canadian scientists say suppressing certain kinds of immune system cells could improve the effectiveness of immuno-radiotherapy for mesothelioma. Mesothelioma is a fast-growing membrane cancer caused by asbestos. Doctors have not found a single therapy that can beat it. For most patients, a combination of treatments offer the best survival odds. Immuno-radiotherapy for mesothelioma combines two types of treatments. Immunotherapy drugs activate the immune system while radiation attacks the tumor directly.  Mesothelioma tumors fight back against both kinds of treatments. But researchers testing a combination of the two may have found a way to make it even more powerful. How Immuno-Radiotherapy for Mesothelioma Works Malignant mesothelioma is one of the most treatment-resistant cancers. Doctors have to attack it from many different … Continue reading Novel Strategy May Improve Immuno-radiotherapy for Mesothelioma »

Palliative Radiotherapy for Mesothelioma Faster with New Technology

Palliative Radiotherapy for Mesothelioma

A new type of linear accelerator could make palliative radiotherapy for mesothelioma faster and safer.  That news comes from researchers in the Perelman School of Medicine at the University of Pennsylvania. Perelman is the site of some of the world’s foremost mesothelioma research.  Their new report on palliative radiotherapy for mesothelioma focuses on the Halcyon multileaf collimator. This machine delivers radiotherapy to relieve mesothelioma symptoms.  The report shows patients were in and out of treatment within minutes. This could make Halcyon an option for fragile mesothelioma patients who could not tolerate a longer treatment. What is Palliative Radiotherapy for Mesothelioma? Palliative medicine is a branch of medicine focused on symptom management. Many mesothelioma patients have no symptoms for many years. … Continue reading Palliative Radiotherapy for Mesothelioma Faster with New Technology »

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