Early Detection of Mesothelioma with MicroRNAs
A new study appears to contradict some of what scientists thought they knew about early detection of mesothelioma. Malignant mesothelioma is a rare but highly aggressive cancer. It usually happens because of past asbestos exposure. Early detection of mesothelioma is key to improving survival. But it is notoriously hard to make a mesothelioma diagnosis. Many patients who have mesothelioma do not even know it until the cancer is in its advanced stage. As a result, most do not live more than a year. Some studies have suggested that tiny, non-coding bits of RNA could help doctors detect mesothelioma earlier. But new research in Germany brings that idea into question. Biomarkers for Early Detection of Mesothelioma MicroRNAs (miRNAs) play an important … Continue reading Early Detection of Mesothelioma with MicroRNAs
Talc Pleurodesis Patients Need Alternate PET/CT Scan for Mesothelioma
Certain patients may get more benefit out of an alternate type of PET/CT scan for mesothelioma. Positron emission tomography (PET) is a common tool for diagnosing mesothelioma. It is also used to monitor the effectiveness of mesothelioma treatments. Doctors often combine PET with computed tomography (CT) for an even clearer picture of mesothelioma progression. Typically, a PET/CT scan for mesothelioma involves injection of a tracer called FDG (fluorodeoxyglucose). But it turns out that PET/CT scans with this tracer do not work well for all mesothelioma patients. A new Japanese study suggests that mesothelioma patients who have had a procedure called talc pleurodesis should consider a different kind of PET/CT scan instead. How Does Talc Pleurodesis Impact PET/CT Scan for Mesothelioma? … Continue reading Talc Pleurodesis Patients Need Alternate PET/CT Scan for Mesothelioma
BAP1 Can Distinguish Mesothelioma from Other Conditions
German scientists say a protein could help doctors distinguish mesothelioma from other conditions. Malignant mesothelioma is a cancer that grows on the membranes around organs. These membranes are called mesothelial membranes. But other conditions can also grow on mesothelial membranes. One of those conditions is adenomatoid tumors. Adenomatoid tumors are benign but, even under the microscope, their cells can look a lot like malignant mesothelioma. Now, a group of pathologists in Germany say the BAP1 protein can tell these two conditions apart. If doctors can distinguish mesothelioma from other conditions early enough, mesothelioma patients may have better outcomes. BAP1 Loss and Mesothelioma BAP1 is a protein encoded by the BAP1 gene. BAP1 is one of the proteins that helps keep … Continue reading BAP1 Can Distinguish Mesothelioma from Other Conditions
Scientists Say Machine Learning Could Help Diagnose Mesothelioma Earlier
Researchers in Toronto say machine learning could help doctors diagnose mesothelioma earlier. Molecular geneticists at the University of Toronto teamed up with cancer and heart doctors to conduct the new research. The team collected data from hundreds of suspected mesothelioma cases and ran it through different statistical analysis programs. The goal was to see which one was best at determining who had pleural mesothelioma and who did not. The results revealed some important information – both about the machine learning tools and about how doctors might diagnose mesothelioma earlier, even without them. Why Doctors Need to Diagnose Mesothelioma Earlier Mesothelioma is almost always caused by asbestos exposure. In the first few years of the disease, there may be no mesothelioma … Continue reading Scientists Say Machine Learning Could Help Diagnose Mesothelioma Earlier
New Study Could Lead to a Mesothelioma Breath Test
A large new study now underway may eventually make it possible to create a mesothelioma breath test. Cancer Research UK has launched a two-year clinical trial of the Breath Biopsy. The Breath Biopsy is a device that detects molecules exhaled by people with cancer. The Need for Early Mesothelioma Detection Malignant mesothelioma is one of the deadliest types of cancer. Most people who get mesothelioma have been exposed to asbestos. By the time they receive a diagnosis, many mesothelioma patients have advanced disease. Late diagnosis is one of the main reasons people with mesothelioma often die within a year. When mesothelioma cancer is in an advanced stage, it is less likely to respond to treatment. Scientists around the world are … Continue reading New Study Could Lead to a Mesothelioma Breath Test
Japanese Discovery Could Lead to New Mesothelioma Blood Test
A discovery in Japan could lead to a more effective mesothelioma blood test for mesothelioma diagnosis. Japanese scientists say they have found a better way to detect mesothelioma cells in the blood. The scientists are experts in occupational health. Malignant mesothelioma is an occupational cancer because people can get it from working near asbestos. Mesothelioma diagnosis is challenging. But a powerful mesothelioma blood test could make it easier to find the asbestos cancer earlier. Treatment often works better when patients start it earlier. Circulating Tumor Cells in the Blood of Mesothelioma Patients No matter what kind of cancer a person has, their tumor releases some cells into the blood. Mesothelioma tumors are no exception. These circulating tumor cells (CTCs) are … Continue reading Japanese Discovery Could Lead to New Mesothelioma Blood Test
Genetics-Based Cancer Treatment Could Mean New Hope for Mesothelioma
The FDA has approved a new genetics-based cancer treatment that could open the door for more targeted mesothelioma therapy. The drug is called larotrectinib. The drug company Bayer sells it under the brand name Vitrakvi. Larotrectinib is unique because it is not specific to any one type of cancer. Instead, larotrectinib is based on a patient’s genetic biomarkers. It is the first drug of its kind to gain approval by the FDA. What is a Genetics-Based Cancer Treatment? A genetics-based cancer treatment is a drug that targets certain genetic mutations. Doctors find these mutations by testing for biomarkers. One mutation could cause breast cancer, colon cancer, or even pleural mesothelioma. Some kinds of mutations are connected to only one type … Continue reading Genetics-Based Cancer Treatment Could Mean New Hope for Mesothelioma
This Subset of Mesothelioma Patients May Live Longer
A group of mesothelioma experts from around the world has identified a set of criteria linked with longer mesothelioma survival. They are hopeful that their research will help doctors identify mesothelioma patients who fall into this longer-living group and direct them to the special care they may need to stay healthier, longer. In a new article in the Journal of Clinical Oncology, some of the world’s leading mesothelioma researchers, including scientists from Stanford University, New York University Langone Medical Center, The University of Hawaii, the Hyogo College of Medicine in Japan, and the Mesothelioma Applied Research Foundation, say mesothelioma patients who meet these criteria should consider genetic counseling and cancer screening. Criteria for Improved Mesothelioma Outcomes The report was based … Continue reading This Subset of Mesothelioma Patients May Live Longer
New Data Suggest a Mesothelioma Blood Test is Possible
A new technology that looks for genetic material from cancer cells in the blood could open the door to the fastest, easiest way yet to diagnose early malignant pleural mesothelioma. The test, which has already shown potential for early detection of lung cancer, was developed by a California-based life sciences company called GRAIL. GRAIL-funded researchers shared the data on the test at the American Society of Clinical Oncology annual meeting this summer in Chicago. The results are part of the preliminary data from the company’s ongoing Circulating Cell-Free Genome Atlas study, a huge study on cancer diagnosis that aims to enroll 15,000 people (70 percent with cancer and 30 percent without) from 141 sites in the US and Canada. “We’re … Continue reading New Data Suggest a Mesothelioma Blood Test is Possible
Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis
Australian researchers say proteins found in lung fluid could hold the key to diagnosing pleural mesothelioma months or even years before a tumor is visible on imaging scans. Proteins function as communication devices in the body, directing all sorts of critical cellular processes, including the processes that tell cancer cells to begin replicating at a higher rate than normal cells. Scientists at Flinders University, one of the world’s leaders in mesothelioma research, wondered if the proteins that help give rise to malignant pleural mesothelioma could be found in pleural effusions and used as biomarkers to identify the cancer earlier. Looking for Mesothelioma Biomarkers in Lung Fluid In a new study published in the Journal of Proteomics, the team notes that … Continue reading Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis
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