New Assessment Identifies People at High Risk for Malignant Mesothelioma
Scottish researchers say they have come up with a better way to decide which asbestos-exposed people might benefit from mesothelioma screening or even mesothelioma prevention measures. They have developed an assessment tool to gather detailed information from workers about the time, duration, and nature of their asbestos exposure in order to better quantify their mesothelioma risk. “The assessment is based on the tasks carried out … Continue reading New Assessment Identifies People at High Risk for Malignant Mesothelioma
Mesothelioma Biomarker Test May Be Diagnostic Alternative for Frail Patients
A set of proteins found in the lung fluid of people with malignant pleural mesothelioma may offer a safer way to diagnose the asbestos cancer in frail or elderly patients. Mesothelioma is an extremely difficult cancer to diagnose. Accurate diagnosis usually requires a combination of tests including a physical exam, a thorough work history (including possible asbestos exposure), blood or lung fluid tests, imaging scans, … Continue reading Mesothelioma Biomarker Test May Be Diagnostic Alternative for Frail Patients
New Biomarker Could Help Eradicate Mesothelioma Resistance to Chemotherapy
Researchers in the Netherlands have unveiled what may be a major breakthrough in the chemotherapeutic treatment of malignant mesothelioma. Malignant mesothelioma, a rare and virulent cancer caused by asbestos exposure, is notoriously resistant to standard cancer treatments, including chemotherapy. Even the only chemotherapy drug specifically approved for the treatment of mesothelioma, Alimta (pemetrexed), only works for some patients. Now, a new study published in the … Continue reading New Biomarker Could Help Eradicate Mesothelioma Resistance to Chemotherapy
Inflammation Marker May Predict Mesothelioma Prognosis
The ratio of neutrophils to lymphocytes – a way of measuring inflammation in the body of people with malignant pleural mesothelioma – may help doctors predict how well they will respond to treatment. That is the conclusion of mesothelioma researchers at China’s Sichuan University. In a new article in the journal Oncotarget, the team observed that NLR has been associated with survival in other types … Continue reading Inflammation Marker May Predict Mesothelioma Prognosis
Miner Study Finds Mesothelioma Often Undiagnosed
A new study of former South African mine workers suggests that too many asbestos-related diseases may be going undiagnosed. The study conducted by researchers at the University of the Witwatersrand and the National Institute for Occupational Health in Johannesburg found that, in a cohort of 149 workers, more than half of the cases of malignant mesothelioma were missed until after the patient had died. With … Continue reading Miner Study Finds Mesothelioma Often Undiagnosed
These Proteins Appear to Shorten Mesothelioma Survival
New evidence suggests that mesothelioma patients whose tumors express two particular proteins do not live as long as other mesothelioma patients. An international team of scientists including mesothelioma researchers at the National Cancer Institute say ALCAM (also called CD166) and PD-L1 (CD274) are both associated with “significantly decreased” survival in pleural mesothelioma. Understanding ALCAM and PD-L1 ALCAM is a type I transmembrane protein that regulates … Continue reading These Proteins Appear to Shorten Mesothelioma Survival
Thoracoscopy Deemed “Valuable and Safe” for Mesothelioma Patients
Pleural mesothelioma patients who are recommended for medical thoracoscopy can rest assured that the procedure is “a valuable and safe” diagnostic tool. That is the message from Chinese researchers after an analysis of nine years of medical thoracoscopies on more than 800 patients with malignant mesothelioma and other pleural cancers at a Beijing hospital. What is Medical Thoracoscopy? Medical thoracoscopy is a minimally invasive procedure … Continue reading Thoracoscopy Deemed “Valuable and Safe” for Mesothelioma Patients
BAP1 May Not Be The Only Gene to Increase Mesothelioma RIsk
The question of why some asbestos-exposed people develop malignant mesothelioma and others do not has been a key focus of mesothelioma research for more than a decade. We now know that a mutation in the BAP1 gene can predispose certain people to several types of cancer, including mesothelioma. This is known as BAP1 cancer syndrome. Without the BAP1 tumor-suppressing protein to keep it at bay, … Continue reading BAP1 May Not Be The Only Gene to Increase Mesothelioma RIsk
New Mesothelioma Study: Asbestos Fiber Burden Does Not Decline With Time
Mesothelioma has one of the longest latency periods of any disease. It is not unusual for patients to develop the asbestos cancer many decades after their last exposure to asbestos. Now, a new German study offers a more detailed explanation of why that is. Although the body is adept at ridding itself of many kinds of toxins, when asbestos fibers are inhaled or swallowed, their … Continue reading New Mesothelioma Study: Asbestos Fiber Burden Does Not Decline With Time
The Influence of BAP1 on Mesothelioma Survival
A mutation on the BAP1 tumor suppressor gene can influence the development of malignant mesothelioma but may have little bearing on survival. That conclusion comes from a new Chinese study of more than 2,400 people with cancers directly linked to the BAP1 genetic mutation, including pleural mesothelioma. BAP1 and Mesothelioma BRCA1-associated protein 1 (BAP1) is a tumor suppressing protein encoded by the BAP1 gene. Multiple studies … Continue reading The Influence of BAP1 on Mesothelioma Survival
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