Misdiagnosis of Mesothelioma More Common with Cytology Alone
A new set of case reports illustrates how easily misdiagnosis of mesothelioma can happen when the diagnosis is based on cytology alone. Cytology tests look at the cells in body fluids. For peritoneal mesothelioma patients, this is often the fluid that collects in their abdomen called ascites. But doctors from India’s Dayanand Medical College and Hospital say using ascites samples alone to diagnose mesothelioma is a risky practice. Misdiagnosis of mesothelioma may delay proper treatment and negatively impact survival. The Difficulty of Diagnosing Peritoneal Mesothelioma Malignant mesothelioma only impacts about 2,500 people in the US every year. It is most common among people who have lived or worked around asbestos. Peritoneal mesothelioma is even rarer. About a fifth of patients … Continue reading Misdiagnosis of Mesothelioma More Common with Cytology Alone
PET/CT Scans May Be Less Accurate in Elderly Mesothelioma Patients
Researchers at Case Western Reserve are warning cancer doctors not to rely too heavily on PET/CT scans when diagnosing malignant mesothelioma – especially in older patients. PET/CT is an important tool for staging mesothelioma and can help with diagnosis. But a new case report highlights the problem of false-negative PET/CT scans. In this case involving a 77-year-old man, PET/CT showed no mesothelioma. Even the man’s lung fluid tests were negative for mesothelioma. The case is a potent reminder that biopsy is still the gold standard for diagnosing asbestos cancer. PET/CT Scans and Other Tools for Diagnosing Mesothelioma Pleural mesothelioma is a tricky cancer to diagnose. Most patients do not even have symptoms until the disease is in a later stage. … Continue reading PET/CT Scans May Be Less Accurate in Elderly Mesothelioma Patients
MRI Imaging May Be Superior to CT for Pleural Mesothelioma Diagnosis and Staging
When it comes to diagnosing and monitoring treatment response in people with pleural mesothelioma, MRI imaging may be better than CT. That is the message from a new Italian study published in the online medical journal Cancers. RIght now, CT (computed tomography) is the most popular form of imaging for pleural mesothelioma. Cancer doctors use CT images to help diagnose mesothelioma. They also use it to see how widespread the cancer is and to find out if treatment is making a difference. But radiology researchers at Pisa University Hospital say MRI imaging has advantages over CT for people with the rare asbestos cancer. Mesothelioma Diagnosis and Prognosis Malignant pleural mesothelioma is the most serious of several health conditions linked to … Continue reading MRI Imaging May Be Superior to CT for Pleural Mesothelioma Diagnosis and Staging
Biomarkers in Pleural Effusions Can Improve Mesothelioma Diagnosis
Italian scientists say some newly identified biomarkers in pleural effusions are very good at ruling out mesothelioma in patients who do not have the disease. Unfortunately, most of these biomarkers are not as good as positively identifying mesothelioma. But their accuracy can be improved by combining several of them. Pleural effusions are pockets of excess fluid that collect around the lungs of people with certain kinds of cancer and other conditions. Mesothelioma biomarkers in pleural effusions are proteins and other substances that are mostly found in mesothelioma patients. The new study suggests that using these biomarkers the right way can lead to more accurate diagnoses. The Importance of Biomarkers in Pleural Effusions Pleural mesothelioma is a rare cancer of the … Continue reading Biomarkers in Pleural Effusions Can Improve Mesothelioma Diagnosis
CT Evaluation Correlates with Actual Mesothelioma Tumor Volume, Subtype, and Survival
Two new studies highlight the value of CT evaluation for patients with either peritoneal or pleural mesothelioma. CT stands for computed tomography. The technology uses X-rays to create three dimensional images of internal structures. The studies show CT evaluation can give doctors an accurate idea of the size and extent of mesothelioma tumors. These scans can also help predict which patients have the best odds of survival. This helps doctors plan better, more effective treatment strategies. What is Malignant Mesothelioma? Malignant mesothelioma is a type of cancer that grows on the membranes around internal organs. The most common type of mesothelioma is pleural mesothelioma. This kind of tumor starts on the pleural membrane around the lungs. Peritoneal mesothelioma accounts for … Continue reading CT Evaluation Correlates with Actual Mesothelioma Tumor Volume, Subtype, and Survival
New Cancer Blood Test May Bolster Mesothelioma Diagnostic Tools
A new cancer blood test may make boost the accuracy of current screening tools and allow doctors to detect malignant mesothelioma and other hard-to-find cancers earlier. The test is called a multi-cancer early detection (MCED) test. The US company Grail developed it and researchers at the Cleveland Clinic tested it on more than 3,500 patients. They found that it correctly identified cancer in more than half of cases. The test was even more accurate in rare cancer types for which no screening test is available. Malignant mesothelioma was not specifically mentioned in the report. But it is an extremely rare cancer. The method used by the new cancer blood test suggests that it could be useful for finding mesothelioma, too. … Continue reading New Cancer Blood Test May Bolster Mesothelioma Diagnostic Tools
BAP1 Not the Only Gene to Raise Mesothelioma Risk
A new study is further evidence that a mutation on the BAP1 gene is not the only genetic anomaly to raise mesothelioma risk. Scientists at Philadelphia’s Fox Chase Cancer Center along with a team of international researchers recently published a study of 13 malignant mesothelioma patients. All of these patients had close relatives who also had cancer. This suggested that something in their genetic makeup might raise mesothelioma risk. Previous research suggests one gene that makes people more susceptible to mesothelioma is BAP1. People with a mutation on this gene are more likely to receive a mesothelioma diagnosis. They are also more susceptible to several other conditions. But the people in the new study were chosen because none of them … Continue reading BAP1 Not the Only Gene to Raise Mesothelioma Risk
Japanese Researchers Discover ‘Novel Diagnostic Marker’ for Mesothelioma
A protein called CDLN15 could be a novel diagnostic marker for malignant pleural mesothelioma, allowing doctors to pinpoint asbestos cancer earlier and boost the odds of survival. That is the message from a recently published Japanese study. Pleural mesothelioma is notoriously difficult to diagnose. It rarely causes any symptoms at all until it is in a late stage. When the symptoms do show up, they are easy to confuse with other illnesses. Earlier diagnosis of pleural mesothelioma depends on finding things that set it apart from other diseases. This novel diagnostic marker could serve as a red flag for this rare but deadly cancer. CDLN15 as a Novel Diagnostic Marker CDLN15 stands for claudin-15. Claudins are a family of proteins … Continue reading Japanese Researchers Discover ‘Novel Diagnostic Marker’ for Mesothelioma
Artificial Intelligence Improves Mesothelioma Diagnosis, Study Finds
There is more evidence that artificial intelligence may have a role to play in helping doctors diagnose deadly malignant mesothelioma earlier. A study conducted at Japan’s Hyogo College of Medicine used past patient records to test a deep convolutional neural network (CDNN). This is a complex computer program designed to evaluate diagnostic criteria. Pleural mesothelioma is a difficult cancer for doctors to diagnose. Artificial intelligence can help by quickly comparing diagnostic data to hundreds of past cases. In the Japanese study, the AI produced the most accurate mesothelioma diagnoses when combined with all of the available patient data. The Challenge of Diagnosing Mesothelioma Mesothelioma tumors grow on the membranes around internal organs. They usually come from past exposure to asbestos. … Continue reading Artificial Intelligence Improves Mesothelioma Diagnosis, Study Finds
Breath Test Could Predict Mesothelioma Immunotherapy Response
New research shows a breath test called an eNose might help doctors determine which mesothelioma patients are most likely to respond to immunotherapy. Immunotherapy is one of the most promising new approaches to malignant mesothelioma. But not every patient responds. A new Dutch study suggests that biomarkers in a patient’s exhaled breath may be indicators of immunotherapy response. The eNose breath test can identify those biomarkers quickly and easily. The technology might make it easier to decide on the best mesothelioma treatment. Immunotherapy for Malignant Mesothelioma Pleural mesothelioma is a rare but deadly cancer of the lung lining. Until last year, chemotherapy with Alimta (pemetrexed) was the only FDA-approved systemic treatment. In 2020, the FDA approved a combination of immunotherapy … Continue reading Breath Test Could Predict Mesothelioma Immunotherapy Response
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