Biomarker for Pleural Mesothelioma: Transforming Growth Factor-Beta

biomarker for pleural mesothelioma

A protein called transforming growth factor-beta (TGF-β) might be an effective biomarker for pleural mesothelioma. New research shows it could help diagnose the asbestos cancer and distinguish it from other lung conditions.  The findings come from researchers at the West German Cancer Center in Essen, Germany.  They studied patients with malignant mesothelioma, non-malignant pleural diseases or lung cancer. TGF-β levels were different in mesothelioma patients than they were in people with other diseases.  They correlated with mesothelioma survival. This suggests that TGF-β could make a good biomarker for pleural mesothelioma. How Do Doctors Use a Biomarker for Pleural Mesothelioma? A biomarker for pleural mesothelioma is a substance whose presence indicates that a person has the disease. Some biomarkers occur in … Continue reading Biomarker for Pleural Mesothelioma: Transforming Growth Factor-Beta »

Study Evaluates Breath Test to Detect Early Mesothelioma

detect early mesothelioma with breath test?

Doctors in Michigan have launched a study to determine if volatile organic compounds (VOCs) in exhaled breath can detect early mesothelioma. They are also looking for a correlation between participants’ VOCs and biomarkers in the blood. VOCs can give doctors vital information about cellular metabolism. Previous studies of VOCs show that they can sometimes indicate the presence of mesothelioma.  But no one knows yet if VOCs can really detect early mesothelioma. None of the previous studies have been big enough for the technique to be universally recommended.  How VOCs Can Detect Early Mesothelioma Cancer causes biochemical changes in the body. These biochemical changes produce VOCs that a person exhales. Different types of cancer produce different combinations of VOCs. Breath testing … Continue reading Study Evaluates Breath Test to Detect Early Mesothelioma »

Mesothelioma Registry Could Improve Outcomes, Prevent Future Cases

mesothelioma registry

A distinguished team of scientists are calling for a national mesothelioma registry they say could improve outcomes. If the registry collects and provides the right information, they say it could even help prevent future mesothelioma cases. Experts from the CDC, the National Institute for Occupational Safety and Health (NIOSH), and several top US cancer centers participated in a workshop on the topic. The Mesothelioma Applied Research Foundation convened the workshop. The group says existing tumor registries at some cancer centers are not as useful as a national mesothelioma registry. But coordinating a national registry will require government support. What is a Mesothelioma Registry? Malignant mesothelioma is a rare cancer which makes it hard to study. A national mesothelioma registry is … Continue reading Mesothelioma Registry Could Improve Outcomes, Prevent Future Cases »

Accurate Diagnosis of Pleural Mesothelioma with History and Imaging Only

accurate diagnosis of mesothelioma

Medical history and CT imaging may be enough to make an accurate diagnosis of pleural mesothelioma, even without a biopsy. That finding comes from a team of French and Canadian researchers led by Universite Laval in Quebec.  Biopsy is usually considered critical for accurate diagnosis of pleural mesothelioma. But the French and Canadian team says imaging studies may provide enough information to make a diagnosis.  This could be especially good news for people who are not healthy enough to undergo thoracoscopy. Pleural Mesothelioma Diagnostic Procedure: First Steps Pleural mesothelioma is the most common type of mesothelioma. Mesothelioma is an aggressive cancer that grows on the membranes around internal organs.  This cancer is rare and notoriously difficult to diagnose, especially in … Continue reading Accurate Diagnosis of Pleural Mesothelioma with History and Imaging Only »

Pleural Mesothelioma Staging: These Overlooked Lymph Nodes Might Help

pleural mesothelioma staging

An often-ignored set of lymph nodes behind the ribs could help make pleural mesothelioma staging more accurate and valuable.  Staging is the process of determining how advanced a patient’s cancer is. It involves looking at various different factors and assigning a rating between 0 and 4. A higher stage indicates more extensive cancer. A new report suggests that the posterior intercostal lymph nodes behind the ribs play a more important role in pleural mesothelioma staging than previously thought. Mesothelioma patients with cancer in these nodes lived half as long as other mesothelioma patients.  Researchers in Maryland and Pennsylvania say removing and examining these nodes may lead to more accurate staging, more informed treatment decisions, and better outcomes.   How Lymph Nodes … Continue reading Pleural Mesothelioma Staging: These Overlooked Lymph Nodes Might Help »

Machine Learning Tool May Predict Mesothelioma Survival Better Than Pathologists

machine learning tool

The developers of a machine learning tool called MesoNet say the program can predict mesothelioma survival better than a pathologist. MesoNet is a deep convolutional neural network. It analyzes digitized images of mesothelioma cells to predict overall survival. In a new article in Nature Medicine, its creators compared the machine learning tool with pathologist-read slides. Then they validated MesoNet with two different sets of mesothelioma patients.  The result may offer a new, more accurate approach to mesothelioma treatment planning.  What is a Machine Learning Tool? A machine learning tool is a computer program that gets “smarter” the more it runs. A deep convolutional neural network is a type of machine learning tool that analyzes images. The more images it analyzes, … Continue reading Machine Learning Tool May Predict Mesothelioma Survival Better Than Pathologists »

The Pathological Diagnosis of Mesothelioma: New Recommendations

pathological diagnosis of mesothelioma

An international team of researchers says it is time to refine the pathological diagnosis of mesothelioma. They are recommending a list of changes they say could make the process more effective. Mesothelioma is a deadly cancer caused by asbestos exposure. Under current pathology guidelines, it falls into just three categories. But the research team says those guidelines do not give doctors enough information. They recommend updates to make the pathological diagnosis of mesothelioma more specific.  Understanding Mesothelioma Pathology Pathologists study body tissue, fluids, and cells that are surgically removed. The pathological diagnosis of mesothelioma involves looking at cells under a microscope. Cells can then be put into a category.  About three quarters of mesothelioma cases are epithelioid. Epithelioid mesothelioma is … Continue reading The Pathological Diagnosis of Mesothelioma: New Recommendations »

Signs of Peritoneal Mesothelioma After Radiotherapy

signs of peritoneal mesothelioma after radiotherapy

Japanese researchers are reminding doctors to watch for signs of peritoneal mesothelioma in people who have undergone past radiotherapy.  Many cancer patients undergo radiotherapy. Radiation disrupts the DNA inside cancer cells. This can help keep these malignant cells from replicating and spreading.  But radiation treatment also has a downside. It can cause cellular changes in healthy cells, too. This can cause side effects right away, or decades later.  As more people have radiation and survive, scientists at the Shinshu University School of Medicine say more of them could develop radiation-related mesothelioma later in life. But the signs of peritoneal mesothelioma years after radiation are easy to miss. Peritoneal Mesothelioma Case Study The new report is based on the case of … Continue reading Signs of Peritoneal Mesothelioma After Radiotherapy »

Lung Cancer Blood Test: Can it Find Early Mesothelioma?

lung cancer blood test for mesothelioma

Mesothelioma patients and their doctors may have reason to be optimistic about a new lung cancer blood test. A random trial of more than 12,000 high-risk people in Scotland shows the EarlyCDT test combined with CT imaging can detect cancer early. Earlier diagnosis is likely to lead to longer survival of lung cancers like pleural mesothelioma. Researchers presented their findings on the new lung cancer blood test at a global conference this week in Spain. Largest Lung Cancer Trial As in the US, lung cancer is the biggest cancer killer in Scotland. Pleural mesothelioma is a form of lung cancer. Although it is rare, mesothelioma is more common in the UK than in other parts of the world. This is … Continue reading Lung Cancer Blood Test: Can it Find Early Mesothelioma? »

MicroRNA Signature for Mesothelioma Could Lead to Earlier Diagnosis

microRNA signature for mesothelioma

Australian researchers believe they have identified what amounts to a microRNA signature for mesothelioma in pleural effusion.  Pleural effusion is the name for excess lung fluid. Up to 90 percent of pleural mesothelioma patients develop a pleural effusion. Researchers at the University of Western Australia say this fluid contains a wealth of information that could improve mesothelioma diagnosis. They have recently identified a trio of RNA molecules in fluid samples that could serve as a microRNA signature for mesothelioma. This “signature” could help doctors distinguish mesothelioma from other types of cancer. The Challenge of Mesothelioma Diagnosis Pleural mesothelioma is notoriously hard to diagnose. The early symptoms of mesothelioma are similar to the symptoms of many other lung conditions. They are … Continue reading MicroRNA Signature for Mesothelioma Could Lead to Earlier Diagnosis »

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