COVID-19 Pandemic Had Little Or No Impact On New Malignant Mesothelioma Diagnoses

COVID-19 Pandemic Had Little Or No Impact On New Malignant Mesothelioma Diagnoses

A new study published in Thoracic Cancer discussed the impact of COVID‐19 pandemic on new mesothelioma diagnoses in Italy. Malignant mesothelioma is a rare disease of great interest to the scientific community and to public health. This is due to its high lethality and its association with asbestos exposure. The timely diagnosis of mesothelioma is important. Although it may not change the prognosis of the disease, it can help in treatment strategies. It can also help in documenting previous exposure to asbestos. This can contribute to any request for compensation. New Study Shows Promising Results During the COVID-19 pandemic, there was a delay in the diagnosis of oncological diseases. This was because many departments were converted into COVID wards. And … Continue reading COVID-19 Pandemic Had Little Or No Impact On New Malignant Mesothelioma Diagnoses »

Hope for Mesothelioma Patients with Genetic Predisposition (Germline PVs) for Cancer

Mesothelioma Patients with Genetic Predisposition for Cancer are Candidates for Personalized Medicine

Malignant pleural mesothelioma is a tumor caused by asbestos exposure. Recently, the United States Food and Drug Administration approved immunotherapy treatment for mesothelioma. But the efficacy of available treatments is still limited. Researchers are still evaluating these new therapeutic approaches. They are also working to identify subgroups of patients who could benefit from precision medicine. Precision medicine uses information about a person’s tumor to find out how well a treatment is working. One of these groups could be represented by patients with an inherited cancer syndrome. These are caused by germline pathogenic variants (PVs) in DNA repair genes. A germline pathogenic variant is a gene variant (or mutation) that is passed from parent to child. These germline PVs are hereditary. … Continue reading Hope for Mesothelioma Patients with Genetic Predisposition (Germline PVs) for Cancer »

Understanding CAR T-Cell Therapy in Malignant Mesothelioma

Understanding CAR T-Cell Therapy in Malignant Pleural and Peritoneal Mesothelioma

One of the new therapies for mesothelioma is called antigen receptor T-cell therapy. It gives promise to malignant mesothelioma patients. This unique therapy has recently shown that it works in phase I clinical trials. A new report from French scientists details the current state of this therapy. This therapy has only been tested in a highly selected patient population. And it requires highly complex engineering. Yet, the treatment therapy shows promise. Adapting CAR T-Cell Therapy to Mesothelioma Malignant pleural and peritoneal mesothelioma are rare and aggressive cancers. They have had limited treatment options with moderate survival benefits. And all treatments have an impaired quality of life for a very long period. A chemotherapy drug combination known as cisplatin–pemetrexed has been … Continue reading Understanding CAR T-Cell Therapy in Malignant Mesothelioma »

Using CT Scans in Surgical Decision-Making in Peritoneal Mesothelioma

Using CT Scans in Surgical Decision-Making in Peritoneal Mesothelioma

Peritoneal mesothelioma is caused by asbestos. The peritoneum is the space in your abdomen that contains the intestines, the stomach, and the liver. The abdomen (peritoneum) is the second most common site of mesothelioma after the pleural (lungs and chest). Most doctors believe peritoneal mesothelioma is caused by the ingestion of asbestos fibers. Microscopic asbestos fibers become embedded in the abdomen (peritoneum). After about 20-50 years, these fibers can cause inflammation and mutations in the healthy mesothelial cells. These mutations may ultimately cause these cells to become cancerous. Thus, forming tumors in the peritoneum. Patients diagnosed with peritoneal mesothelioma may survive several or more years after diagnosis. There are long-term survivors, such as Paul Kraus. Using CT Scans to Avoid … Continue reading Using CT Scans in Surgical Decision-Making in Peritoneal Mesothelioma »

A New Prognostic Signature Discovered for Malignant Pleural Mesothelioma

New Prognostic Signature Discovered for Malignant Pleural Mesothelioma

Immune-related genes play an important role in malignant pleural mesothelioma prognosis. They can affect the tumor immune microenvironment and affect tumor prognosis. Immune-related genes can be used to predict the course of a disease or patient outcomes. These genes are often called a genetic prognostic signature. Chinese surgeons recently discovered a prognostic signature for malignant pleural mesothelioma patients. Constructing a Prognostic Signature with 5 Immune-Related Genes Genes play an important role in the development and progression of cancers like mesothelioma. The Chinese researchers started by searching for other studies on mesothelioma prognosis and genes. Researchers used data from the Cancer Genome Atlas to construct the prediction signature. Patients were divided into high-risk and low-risk groups. They also used this data … Continue reading A New Prognostic Signature Discovered for Malignant Pleural Mesothelioma »

MicroRNAs in Cancer Development and Mesothelioma Personalized Medicine

MicroRNAs in Cancer Development and Mesothelioma Personalized Medicine

A special issue was published in the Journal of Personalized Medicine. Dr. Alessandra Pulliero from the University of Genoa in Italy talks about microRNA. Specifically, the role of microRNA in cancer development and personalized medicine. A microRNA (miRNA) is a small part of an RNA molecule. MiRNAs play a key role in the regulation of gene expression in cells, including mesothelioma cells. Mesothelioma is a rare and aggressive cancer often caused by asbestos exposure. Asbestos also causes a progressive lung disease called asbestosis. Environmental exposure to asbestos often causes a higher incidence of malignant mesothelioma. Malignant mesothelioma is characterized by poor prognosis and short survival. Personalized Medicine and Mesothelioma Scientists now know that the role of miRNAs changes once they … Continue reading MicroRNAs in Cancer Development and Mesothelioma Personalized Medicine »

Mesothelioma and MRI Scans: Using an Old Tool in a New Way

Mesothelioma and MRI Scans: Using an Old Tool in a New Way

Imaging scans are an important tool in helping clinicians diagnose mesothelioma. These scans include X-rays, CT scans, MRI scans, and PET scans. These tools help clinicians to see tumors inside a patient’s body. The results of the scan cannot diagnose mesothelioma, but it is an important tool for arriving at the correct diagnosis. Unlike X-rays and CT’s, magnetic resonance imaging (MRI) scans use a completely different type of radiation. An MRI applies a very strong magnetic field to change the spin of protons. The scanner also produces a radio frequency. This process produces a signal that can be made into an image. Until now, the role of MRIs has been limited in mesothelioma. However, new evidence suggests MRIs can be … Continue reading Mesothelioma and MRI Scans: Using an Old Tool in a New Way »

Gender Differences in Men versus Women with Mesothelioma

Gender Differences in Men versus Women with Mesothelioma

Asbestos is toxic and cancer-causing for human beings. Asbestos causes mesothelioma and other asbestos related diseases. Asbestos-related diseases affect men and women differently. A recent study looked at Brazilian patients with asbestos-related diseases. These included mesothelioma, asbestosis, and lung and ovarian cancer. Introduction Mesothelioma, asbestosis, and pleural plaques are the main asbestos-related diseases. Many consider mesothelioma as the fingerprint of asbestos usage. Between 1961 and 2017, more 7 million tons of asbestos were consumed in Brazil. Mesothelioma from occupational exposure is most common in men. They were often exposed to asbestos at the job site. The number of non-occupational exposures is higher in women. Women are often exposed to asbestos from domestic and environmental sources. It has been difficult to … Continue reading Gender Differences in Men versus Women with Mesothelioma »

Body Swelling and Joint Pain in Malignant Pleural Mesothelioma

Body Swelling and Joint Pain in Malignant Pleural Mesothelioma

The diagnosis of malignant pleural mesothelioma often includes widespread body inflammation. Inflammation and body swelling occur when white blood cells try to protect against infection. Symptoms of inflammation are often redness, swelling, and joint pain or stiffness. Oncologists have studied the relationship between swelling and cancer for 150 years. New research was recently published in the scientific journal Lung Cancer. French medical oncologists believe that patients with more body swelling may have shorter survival. This suggests that body swelling may play a big role in malignant pleural mesothelioma. Body Swelling to Predict a Developing Mesothelioma Diagnosis Prediction of diagnosis is important for malignant pleural mesothelioma patients. The sooner a patient can be diagnosed, the better their outcomes. Oncologists suggest that … Continue reading Body Swelling and Joint Pain in Malignant Pleural Mesothelioma »

Living With Mesothelioma: Coping Strategies to Find Hope

Living With Mesothelioma: Coping Strategies to Find Hope

Mesothelioma is a cancer caused by exposure to asbestos. One key question remains unanswered. How do diagnosed patients experience living with mesothelioma? A new study in Health Psychology aimed to explore the mesothelioma patient experience. Data from 22 different research studies were analyzed. The coping strategies highlighted here provide hope for mesothelioma patients and caregivers. The results bring awareness of the patient experience, coping processes, and support pathways. Two Coping Strategies to Support a Mesothelioma Patient The best coping strategies help patients reclaim a sense of mental calm, individual autonomy, and meaning. These strategies can also reduce the trauma of living with mesothelioma. Patients who accepted the diagnosis fully were more optimistic than those in denial. Patients who accepted the … Continue reading Living With Mesothelioma: Coping Strategies to Find Hope »

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