New evidence suggests that mesothelioma patients whose tumors express two particular proteins do not live as long as other mesothelioma patients. An international team of scientists including mesothelioma researchers at the National Cancer Institute say ALCAM (also called CD166) and PD-L1 (CD274) are both associated with “significantly decreased” survival in pleural mesothelioma. Understanding ALCAM and PD-L1 ALCAM is a type I transmembrane protein that regulates … Continue reading These Proteins Appear to Shorten Mesothelioma Survival
Pleural mesothelioma patients who are recommended for medical thoracoscopy can rest assured that the procedure is “a valuable and safe” diagnostic tool. That is the message from Chinese researchers after an analysis of nine years of medical thoracoscopies on more than 800 patients with malignant mesothelioma and other pleural cancers at a Beijing hospital. What is Medical Thoracoscopy? Medical thoracoscopy is a minimally invasive procedure … Continue reading Thoracoscopy Deemed “Valuable and Safe” for Mesothelioma Patients
The question of why some asbestos-exposed people develop malignant mesothelioma and others do not has been a key focus of mesothelioma research for more than a decade. We now know that a mutation in the BAP1 gene can predispose certain people to several types of cancer, including mesothelioma. This is known as BAP1 cancer syndrome. Without the BAP1 tumor-suppressing protein to keep it at bay, … Continue reading BAP1 May Not Be The Only Gene to Increase Mesothelioma RIsk
Mesothelioma has one of the longest latency periods of any disease. It is not unusual for patients to develop the asbestos cancer many decades after their last exposure to asbestos. Now, a new German study offers a more detailed explanation of why that is. Although the body is adept at ridding itself of many kinds of toxins, when asbestos fibers are inhaled or swallowed, their … Continue reading New Mesothelioma Study: Asbestos Fiber Burden Does Not Decline With Time
A mutation on the BAP1 tumor suppressor gene can influence the development of malignant mesothelioma but may have little bearing on survival. That conclusion comes from a new Chinese study of more than 2,400 people with cancers directly linked to the BAP1 genetic mutation, including pleural mesothelioma. BAP1 and Mesothelioma BRCA1-associated protein 1 (BAP1) is a tumor suppressing protein encoded by the BAP1 gene. Multiple studies … Continue reading The Influence of BAP1 on Mesothelioma Survival
Workers whose job it was to apply spray-on asbestos insulation may be at even higher risk for lung cancer and malignant mesothelioma than other types of asbestos workers. A Finnish study of four different groups of asbestos workers found that asbestos sprayers had a standardized incidence ratio (SIR) for malignant mesothelioma as much as 100 times that of the general population. The Danger of Spray-On … Continue reading Asbestos Sprayers Face Higher Lifetime Mesothelioma Risk
Researchers in Belgium say a breath analysis tool could provide the next big breakthrough in the effort to diagnose malignant mesothelioma earlier. The team, made up of scientists from Ghent and Antwerp Universities, says the technique looks “very promising” and fits well within the aims of the “National Cancer Moonshot” research initiative established by President Obama. The Challenge of Mesothelioma Diagnosis Malignant pleural mesothelioma (MPM) … Continue reading A Breath Test for Mesothelioma?
A calcium-binding protein called calretinin may provide the basis for a new kind of blood test for the asbestos-linked cancer, malignant mesothelioma. Right now, there is no reliable way to detect the presence of a mesothelioma tumor before symptoms develop. The Search for a Mesothelioma Blood Test But scientists around the world are searching for ways to use certain compounds produced by tumors to diagnose mesothelioma … Continue reading New Blood Test Could Mean Earlier Mesothelioma Diagnosis
New research suggests that a protein often used to help diagnose and track malignant mesothelioma may also be a valuable prognostic indicator. Soluble mesothelin-related protein (SMRP) is a biomarker for pleural mesothelioma, an aggressive asbestos-linked cancer that causes few symptoms until in its late stages. The presence of SMRP in the blood indicates that mesothelial cells on the lining around the lungs have been damaged. … Continue reading Predicting Mesothelioma Outcomes with Soluble Mesothelin
A new Italian study is a sobering reminder that living with someone who has worked around asbestos can have fatal consequences. Researchers examined the cases of 33 women and 2 men with malignant mesothelioma whose only known exposure to asbestos was through a family member – usually a husband or father – with a history of occupational asbestos exposure. Like asbestos-exposed workers, these family members were … Continue reading Mesothelioma Risk in the Families of Asbestos-Exposed Workers
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