A Multimodality Treatment Plan may be Best for Pleural Mesothelioma

A Multimodality Treatment Plan may be Best for Pleural Mesothelioma

A multimodality treatment plan may improve mesothelioma patient outcomes. Malignant pleural mesothelioma is an invasive, locally aggressive tumor related to asbestos exposure. A new study shows that the best treatment plan for pleural mesothelioma may be when different types of therapy work together. The ideal combination of treatment therapies is still unknown. But a recent study encourages further studies on a multimodality treatment plan. This may include chemotherapy, surgery, and adjuvant radiotherapy. Current Clinical Guidelines: A History of Single or Multimodality Treatment Plans Despite a long history of clinical research, there is still no cure or any evidence of the best treatment. Many single-treatment plans, single-modality plans, have had disappointing results. Researchers have begun to evaluate different multi-modal treatment approaches. … Continue reading A Multimodality Treatment Plan may be Best for Pleural Mesothelioma »

Could Phlebotomy Delay Development of Mesothelioma?

development of mesothelioma

New research from Japan suggests that removing some blood from the body might offer a way to delay the development of mesothelioma in people exposed to asbestos.  Nearly all cases of malignant mesothelioma occur in people with a history of asbestos exposure. Scientists know that asbestos causes mesothelioma. But they still do not know exactly how.  What is clear is that both iron and byproducts of metabolism called reactive oxygen species (ROS) appear to play a role. Blood removal or phlebotomy can temporarily reduce iron and ROS levels.  The new report from Yasumasa Okazaki, a pathologist with Japan’s Nagoya University Graduate School of Medicine, details how phlebotomy in asbestos-exposed mice delayed the development of mesothelioma. It offers hope that this … Continue reading Could Phlebotomy Delay Development of Mesothelioma? »

Improve Mesothelioma Outcomes with a Fast-Mimicking Diet: Is it Possible?

Improve mesothelioma outcomes

New science from Italy suggests that it might eventually be possible to improve mesothelioma outcomes by severely restricting calories during cancer treatment.  The study appears in a recent version of the journal Cancer Discovery. Researchers with Italy’s FIRC Institute of Molecular Oncology (IFOM) in Milan tested a fast-mimicking diet in 101 cancer patients.  They concluded that restricting calories is a safe and feasible method for “reshaping metabolism” to impact tumor growth. If further studies confirm their findings, it could improve mesothelioma outcomes for thousands of patients. The Need for Better Mesothelioma Treatments Mesothelioma is a fast-growing and deadly type of cancer. Most people who receive a mesothelioma diagnosis do not live out the year. Malignant mesothelioma grows on the membranes … Continue reading Improve Mesothelioma Outcomes with a Fast-Mimicking Diet: Is it Possible? »

Expert Says Malignant Mesothelioma Research ‘Turned a Corner’ in 2021

mesothelioma research

An internationally-known mesothelioma specialist says 2021 has been one of the best years yet for malignant mesothelioma research, giving patients and their families more reason than ever to be hopeful.  Hedy Lee Kindler, MD, is Director of the University of Chicago Medical Center’s Mesothelioma Program. In a commentary in JCO Oncology Practice, Dr. Kindler says the outlook for mesothelioma sufferers this year is “far brighter than it has been for a very long time.” Dr. Kindler points to several recent advances in malignant mesothelioma research and treatment as reasons for optimism. The FDA approved the second systemic therapy for mesothelioma in late 2020. This year saw five positive mesothelioma clinical trials.  Kindler says these advances suggest that the future may … Continue reading Expert Says Malignant Mesothelioma Research ‘Turned a Corner’ in 2021 »

New Treatment for Malignant Mesothelioma Kills Cancer ‘From the Inside Out’

new treatment for malignant mesothelioma

The University of Vermont is about to start a first-in-human trial of a new kind of treatment for malignant mesothelioma.  The new approach involves a drug called RSO-021. The drug works differently from other cancer therapies. It blocks the ability of cancer cells to manage their own waste products. It’s developers say the new treatment for malignant mesothelioma aims to kill cancer cells from the inside out.  The concept for RSO-021 was first developed at the University of Vermont. Scientists at Wake Forest University School of Medicine and the UK biotech company RS Oncology have tested the drug in mice with promising results.  Human trials of RSO-021 will start soon in the UK. US patients will be recruited in 2022.  … Continue reading New Treatment for Malignant Mesothelioma Kills Cancer ‘From the Inside Out’ »

Mesothelioma Clinical Trials: Are Minorities Underrepresented?

mesothelioma clinical trials

The results of a new study from Harvard and Dana Farber Cancer Institute raise the question of whether ethnic minorities are being fairly represented in mesothelioma clinical trials. The study focused on four of the most common types of cancer in the US: breast, prostate, lung, and colorectal cancer.  It looked at demographic data for close to 6,000 people enrolled in precision oncology trials for these cancers. Researchers found that clinical trials tend to favor white and Asian patients over Hispanic and black patients.  The study could have implications for mesothelioma clinical trials of new, tailored treatments.  Precision Oncology and Mesothelioma Clinical Trials Malignant mesothelioma is a challenging cancer to treat. Mesothelioma cells are good at protecting themselves from damaging … Continue reading Mesothelioma Clinical Trials: Are Minorities Underrepresented? »

Follow-Up Care for Mesothelioma: What Happens After Treatment?

follow-up care for mesothelioma

A new UK study on follow-up care for mesothelioma finds that patients need more continuity, timely information, and more input from their caregivers.  The study focused on three National Health Service facilities in the South of England. Two were secondary care hospitals and the third was a tertiary care center. A tertiary care center has special, high-level expertise in mesothelioma care.  Researchers talked to patients, nurses, caregivers, and members of practice groups called clinical commissioning groups. They used the feedback to develop the UK’s first set of best practices for follow-up care for mesothelioma. They now plan to share these best practices with clinicians across the country to improve after-care for all mesothelioma patients.  The Importance of Follow-Up Care for … Continue reading Follow-Up Care for Mesothelioma: What Happens After Treatment? »

New Mesothelioma Trial to Test Tri-Modal Approach

new mesothelioma trial

Enrollment is open for a new mesothelioma trial run by Memorial Sloan Kettering Cancer Center to test a three-prong approach to treatment.  Pleural mesothelioma is a lung-related cancer caused by asbestos. It is notoriously difficult to treat and highly aggressive.  The new mesothelioma trial aims to recruit 150 pleural mesothelioma patients. Patients will receive lung-sparing surgery and chemotherapy. Some will also receive intensity modulated radiation therapy (IMRT).  Researchers will test which group does better – those who only have surgery and chemotherapy or those who also have targeted radiation therapy. They plan to measure not only survival but also complications, quality of life, and how long it takes for the cancer to come back.  Tri-Modal Treatment to Fight Mesothelioma The … Continue reading New Mesothelioma Trial to Test Tri-Modal Approach »

Mesothelioma Risk to War Survivors Highlighted by Journalist’s Case

mesothelioma risk to war survivors

A new Italian case study highlights the mesothelioma risk to war survivors, including journalists and bystanders.  In an article in BMJ Case Reports, researchers from Rome detail the case of a war journalist who contracted mesothelioma after more than ten years in the field.  The male journalist worked in war zones in the Far and Near East. He inhaled a range of toxic substances including asbestos in the dust and smoke from destroyed buildings.  The new case report is a sobering reminder that bombs and bullets are not the only deadly threats in war-torn regions. Asbestos dust poses an often-overlooked mesothelioma risk to war survivors. Asbestos and its Link to Mesothelioma Asbestos is a naturally-occurring mineral. It is inexpensive, plentiful, … Continue reading Mesothelioma Risk to War Survivors Highlighted by Journalist’s Case »

Targeting Nerve Cells Might Offer New Way to Fight Mesothelioma, Other Cancers

targeting nerve cells

Israeli scientists may have found a new way to fight mesothelioma and other cancers from the inside out by targeting nerve cells.  Researchers at Technion – Israel Institute of Technology conducted the new study. It appears in the journal Science Advances.  Nerve cells called neurons help promote tumor growth. The team reasoned that targeting these tumor nerve cells with a damaging drug might slow cancer progression.  They tested the theory on triple-negative breast cancer tumors in mice. The tumors still grew but they grew much slower than the untreated tumors. The findings could have implications for other hard-to-treat cancers like malignant mesothelioma.  New Options Needed for Malignant Mesothelioma Malignant mesothelioma is one of the rarest and most treatment-resistant cancers. Many … Continue reading Targeting Nerve Cells Might Offer New Way to Fight Mesothelioma, Other Cancers »

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