Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis

Australian researchers say proteins found in lung fluid could hold the key to diagnosing pleural mesothelioma months or even years before a tumor is visible on imaging scans. Proteins function as communication devices in the body, directing all sorts of critical cellular processes, including the processes that tell cancer cells to begin replicating at a higher rate than normal cells. Scientists at Flinders University, one of the world’s leaders in mesothelioma research, wondered if the proteins that help give rise to malignant pleural mesothelioma could be found in pleural effusions and used as biomarkers to identify the cancer earlier. Looking for Mesothelioma Biomarkers in Lung Fluid In a new study published in the Journal of Proteomics, the team notes that … Continue reading Lung Fluid Proteins Could be Key to Earlier Mesothelioma Diagnosis »

Mesothelioma Genetic “Fingerprint” Could Impact Compensation

A new report suggests that it may be possible to verify that a case of lung cancer or malignant mesothelioma was caused by exposure to asbestos. The key may lie in tiny cellular structures called  microRNAs. If the microRNA asbestos profile can be verified, it could have a significant impact on work-related compensation for pleural mesothelioma and asbestos-related lung cancer. The Molecular “Fingerprint” of Mesothelioma? MicroRNAs (miRNAs) are small non-coding molecules of RNA that play a key role in the regulation of gene expression in cells. When these miRNAs are out of balance or “overexpressed”, the result can be cancer. By examining the miRNAs of mesothelioma patients, lung cancer patients, and healthy subjects, researchers at Marche Polytechnic University in Ancona, Italy … Continue reading Mesothelioma Genetic “Fingerprint” Could Impact Compensation »

Inhalable Formula May Be Key to Fighting Mesothelioma with Red Wine

grape wine

Scientists may finally have found a way to make a compound in red wine more effective against lung cancers like pleural mesothelioma. Resveratrol, a powerful antioxidant compound found in the skin and seeds of grapes and concentrated in red wine, has long been the focus of anti-cancer studies. Multiple laboratory tests have demonstrated that the molecule is damaging to cancer cells. Unfortunately, the effectiveness of resveratrol for people with cancers such as pleural mesothelioma or non-small cell lung cancer has been limited because the compound is eliminated from the body before it has the chance to reach the lungs. Now, researchers at the University of Geneva in Switzerland (UNIGE) believe they may have found a way around the problem. Their … Continue reading Inhalable Formula May Be Key to Fighting Mesothelioma with Red Wine »

Mesothelioma Surgery and the Threat of Opioid Addiction

A new study of opioid addiction among lung cancer patients may have implications for pleural mesothelioma patients who are considering surgery. The study, published this month in JAMA Oncology, finds that patients treated with more invasive surgical techniques are more likely to become chronic opioid users than those who have less invasive surgery. Opioids Are ‘Standard of Care’ for Lung Surgery Patients Researchers at Mount Sinai Medical Center in New York studied the cases of nearly 4,000  people from the SEER Medicare database who had some type of surgery for non-small cell lung cancer, a type of cancer that shares many commonalities with the lung-related asbestos cancer, pleural mesothelioma. Some of the lung cancer patients studied underwent open thoracic surgery while others … Continue reading Mesothelioma Surgery and the Threat of Opioid Addiction »

Heartland Teachers Face Mesothelioma Risk in the Classroom

Even though teaching is not a profession typically associated with asbestos exposure, a newly published report out of Wisconsin offers a disturbing reminder of the mesothelioma risk posed by asbestos, wherever it is found.   Researchers with the Wisconsin Department of Health Services and the University of Wisconsin analyzed mesothelioma incidence in the state between 1997 and 2013. They discovered that, not only are there higher numbers of malignant mesothelioma cases among people in construction and manufacturing — two areas that have often been linked to mesothelioma — but the incidence also appears to be elevated among teachers. Malignant Mesothelioma and Asbestos Exposure Malignant mesothelioma is the most deadly of a group of illnesses associated with exposure to asbestos, a fibrous … Continue reading Heartland Teachers Face Mesothelioma Risk in the Classroom »

Short Term Mesothelioma Survival Better with Conservative Surgery

Researchers at the Icahn School of Medicine at Mount Sinai have added their voices to the ongoing debate over the best type of surgery for malignant pleural mesothelioma. After a meta-analysis of 30-day mortality among 500 mesothelioma patients, the group has come down on the side of pleurectomy decortication (PD), the more conservative — and less risky — of the two major types of mesothelioma surgery. Mesothelioma Surgery: EPP vs. P/D Pleural mesothelioma, also referred to as asbestos cancer, is notoriously difficult to treat. Successful mesothelioma treatment usually involves a combination of therapies, such as Alimta (pemetrexed), radiotherapy, and curative surgery in patients who are healthy enough to undergo it. (Surgery is currently only recommended for patients with epithelioid mesothelioma, … Continue reading Short Term Mesothelioma Survival Better with Conservative Surgery »

New Study Points to Benefits of IMRT for Mesothelioma Treatment

There is more evidence that mesothelioma patients who have lung sparing surgery can live longer if it’s followed up with highly targeted radiation therapy. In the first study to come out of Israel on the subject, a team of oncologists, pulmonologists, radiation oncologists, and thoracic surgeons at Rabin Medicine Center in Petah Tikva say intensity modulated radiation therapy (IMRT) is safe and effective for slowing down the growth of pleural mesothelioma tumors. The Challenge of Radiotherapy for Mesothelioma The irregularity of malignant mesothelioma tumors makes them difficult to treat with standard external beam radiotherapy without damaging healthy tissue and causing serious side effects. This is particularly problematic in patients who still have both lungs, either because they were not good … Continue reading New Study Points to Benefits of IMRT for Mesothelioma Treatment »

Advanced Computer Program Might Pinpoint Mesothelioma Sooner

Scientists at New York University School of Medicine have successfully used a sophisticated computer program to distinguish between different types of lung cancer and identify the mutated genes behind them. The developers say the technology could open the door to faster diagnosis of other types of cancer, including malignant mesothelioma. Malignant Mesothelioma, the Asbestos Cancer Malignant pleural mesothelioma is a form of lung cancer caused by asbestos exposure. Instead of starting in the lung tissue like other types of lung cancer, it grows on the membrane that surrounds the lungs and can then spread to the lungs and other organs. There is no cure and the prognosis for mesothelioma is usually poor. As with most types of cancer, earlier diagnosis … Continue reading Advanced Computer Program Might Pinpoint Mesothelioma Sooner »

Radiofrequency Ablation for Recurrent Mesothelioma: A New Treatment Option?

A procedure normally used to help alleviate pain has been used to successfully stop a case of recurrent malignant pleural mesothelioma in Japan. Radiofrequency ablation (RFA) uses electrical energy delivered through a thin, hollow needle to heat and destroy cancer cells. Most of the time, this technology is used to destroy small tumors or a treat small area of cancer to alleviate symptoms such as pain or discomfort. But thoracic surgeons at the Hyogo College of Medicine in Hyogo, Japan say their new case study suggests that the procedure should also be considered as a definitive treatment — especially for mesothelioma patients for whom surgery is not a viable option. Complex Mesothelioma Case Drives RFA Decision In a new report … Continue reading Radiofrequency Ablation for Recurrent Mesothelioma: A New Treatment Option? »

Radiotherapy LIkely to Play a Bigger Role in Future Mesothelioma Therapy

New research suggests that radiotherapy is likely to play a larger role in the multi-modal treatment of malignant pleural mesothelioma in the future, supporting and enhancing treatments such as surgery and immunotherapy. Radiation scrambles the DNA inside cancer cells, interrupting their life cycle and making replication impossible. If it were possible to irradiate only mesothelioma cells without affecting the surrounding healthy tissue, radiotherapy might even be able to cure cancers like mesothelioma. But as the authors of a new study published in the Journal of Thoracic Disease point out, until recently, radiotherapy has been of limited use in the treatment of mesothelioma because it hasn’t been precise enough. Thanks to new technology, that is changing. Why Mesothelioma is Hard to … Continue reading Radiotherapy LIkely to Play a Bigger Role in Future Mesothelioma Therapy »

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