Vitamin D3 May Slow the Spread of Pleural Mesothelioma, Study Shows

Vitamin D

A study conducted in Italy suggests that Vitamin D3 might help keep mesothelioma cells from growing and spreading. The biologically active form of Vitamin D is calcitriol or D3. Other studies suggest it might have anticancer properties. But no one has studied its effect on mesothelioma cells until now.  The researchers applied Vitamin D3 to pleural mesothelioma cells in the lab. Not only did it weaken the cells, but it also blocked their ability to divide into new cells. The study suggests that Vitamin D may even boost the effectiveness of mesothelioma chemotherapy. The Cancer-Fighting Role of Calcitriol The body naturally produces calcitriol. It plays a role in regulating the cell cycle, including apoptosis or natural cell death. Vitamin D3 … Continue reading Vitamin D3 May Slow the Spread of Pleural Mesothelioma, Study Shows »

High-Dose Vitamin C and a Fast-Like Diet Might Help Fight Mesothelioma

Vitamin C

A combination of a low-calorie, plant-based diet and high levels of Vitamin C might offer a new and less-toxic way to combat malignant mesothelioma. A report published in the journal Nature Communications says the combination delayed tumor progression in mouse models of colorectal cancer. In some mice, it even caused their tumors to shrink. The most-affected tumors had a genetic mutation found in about a quarter of human cancers, including some cases of mesothelioma. Mutations in the KRAS gene help mesothelioma resist standard cancer treatments.  The study indicates that adding Vitamin C to a diet that mimics fasting might help doctors get around this mesothelioma defence mechanism.  The Anti-Cancer Effects of Ascorbic Acid Vitamin C is also known as ascorbic … Continue reading High-Dose Vitamin C and a Fast-Like Diet Might Help Fight Mesothelioma »

Leukemia Drug for Mesothelioma? Lab Tests Show It’s Possible

leukemia drug

New data suggests that doctors might have good luck using a leukemia drug to treat pleural mesothelioma. The drug in question is ponatinib. It sells under the brand name Iclusig. Ponatinib is a pill that inhibits certain enzymes that may lead to mesothelioma tumor growth.  A study carried out at the University of California showed that the leukemia drug kept mesothelioma cells from growing and spreading in the lab. It could give doctors a new treatment option for patients who do not respond to standard therapies.  How the Leukemia Drug Works Ponatinib is a tyrosine kinase inhibitor. Tyrosine kinases are enzymes that interact with certain proteins inside cells. Tyrosine kinases act as on/off switches for many cellular functions.  In some … Continue reading Leukemia Drug for Mesothelioma? Lab Tests Show It’s Possible »

Could This Protein Play a Role in Survival of Pleural Mesothelioma?

survival of pleural mesothelioma

Research funded by the National Cancer Institute has identified a protein that might play a key role in survival of pleural mesothelioma.  The protein is called UHRF1. It is encoded by a gene of the same name. Researchers believe it may be a driver of growth and spread in malignant mesothelioma.  The research will have to be confirmed on a larger scale. But if it turns out to be true, it could give doctors a new way to extend survival of pleural mesothelioma.  Finding Drivers of Mesothelioma Growth Pleural mesothelioma is a membrane (mesothelium) cancer caused by asbestos exposure. Although some people do survive mesothelioma, it is rare. Average survival of pleural mesothelioma is right around 18 months.  It can … Continue reading Could This Protein Play a Role in Survival of Pleural Mesothelioma? »

Multimodal Mesothelioma Treatment Doubles Survival in Mexican Study

multimodal mesothelioma treatment

Researchers at Mexico’s National Cancer Institute say multimodal mesothelioma treatment with chemotherapy, surgery, and radiation can slow tumor growth and improve survival. Their new study of patients with advanced pleural mesothelioma produced a median survival of nearly two years. That is almost twice as long as average for pleural mesothelioma.  The researchers say the key is a multimodal mesothelioma treatment approach that attacks tumors from three different angles. Chemotherapy Alone is Rarely Enough Chemotherapy is still the main treatment for most patients with pleural mesothelioma. The FDA approved pemetrexed (Alimta) in 2004. Until the recent approval of a combination of Opdivo and Yervoy, Alimta was the only drug for mesothelioma. It is still the main component in mesothelioma chemotherapy. But … Continue reading Multimodal Mesothelioma Treatment Doubles Survival in Mexican Study »

Asbestos Causes Mesothelioma Through Release of This Protein, Study Finds

asbestos causes mesothelioma

Some of the world’s top mesothelioma experts believe they now have a better understanding of how asbestos causes mesothelioma. The finding could help lead to more effective ways of treating it.  Malignant mesothelioma is a deadly cancer caused by exposure to asbestos. There is no cure. Once symptoms develop, many patients do not live beyond a year.  Scientists have known since the early 1900s that asbestos causes mesothelioma. But they are still trying to figure out exactly how. A new international study led by the University of Hawaii may help answer the question. Membrane Cells Under Attack Mesothelioma is a cancer of a mesothelial membrane. The most common mesothelial membrane where mesothelioma occurs is the pleura. The pleura is a … Continue reading Asbestos Causes Mesothelioma Through Release of This Protein, Study Finds »

COVID-19 in Mesothelioma Patients: Case Highlights Unusual Symptoms

COVID-19 in Mesothelioma Patients

There’s evidence that the symptoms of COVID-19 in mesothelioma patients may sometimes be different than in other people.  Pakistani doctors say one of their mesothelioma patients developed stomach distension as a result of the coronavirus. The man also complained of severe abdominal pain. The case highlights the need for doctors and patients to watch for unusual symptoms of COVID-19 in mesothelioma patients. The Danger of Coronavirus for Asbestos Cancer Patients SARS-CoV2 is the coronavirus that causes COVID-19. In most symptomatic people, COVID-19 causes respiratory symptoms. Some people just get the sniffles while others develop severe breathing problems.  People with pleural mesothelioma may be at special risk from the virus. Their lungs are already compromised by the cancer. Breathing problems are … Continue reading COVID-19 in Mesothelioma Patients: Case Highlights Unusual Symptoms »

Pandemic-Related Mesothelioma Treatment Delays Could Impact Outcomes

mesothelioma treatment delays

Mesothelioma treatment delays that happened because of the COVID-19 pandemic will probably impact survival rates for some patients.  A new study of Canadian lung cancer patients found that more than half of them stopped or delayed treatment because of concerns about the virus this spring. Pleural mesothelioma is a lung-related cancer. Like lung cancer patients, mesothelioma patients face a higher risk of virus-related complications because they already have breathing problems.  But mesothelioma is also a fast-growing cancer. Most patients get several kinds of treatment at the same time. Mesothelioma treatment delays may give tumors a chance to grow unchecked.  A Catch-22 for Mesothelioma Patients Mesothelioma patients and others with lung diseases have had to make some difficult decisions because of … Continue reading Pandemic-Related Mesothelioma Treatment Delays Could Impact Outcomes »

Medical Appointments for Advanced Mesothelioma Patients: How Much is Too Much?

medical appointments

A pair of researchers in New Zealand say the typical number of in-person medical appointments for people with untreatable pleural mesothelioma may be more stressful than helpful. Their study focused on lung cancer and pleural mesothelioma patients with no active treatment options. They found that what most of these patients really want is reliable information, hope, and a positive relationship with their medical team.  The report suggests that doctors could meet many of these with fewer visits or virtual medical appointments. Coping with Advanced Mesothelioma Malignant pleural mesothelioma is a rare but highly aggressive lung-related cancer. Mesothelioma starts on the lining around the lungs. It can quickly spread into the lungs and to other organs in the chest.  Most patients … Continue reading Medical Appointments for Advanced Mesothelioma Patients: How Much is Too Much? »

Keytruda and Tumor Treating Fields: New Hope for Mesothelioma?

Keytruda and Tumor Treating Fields

There is hope that a new lung cancer trial combining Keytruda and Tumor Treating Fields could lead to a new treatment for pleural mesothelioma.  Recent studies show Keytruda (pembrolizumab) is one of the most promising immunotherapy drugs against malignant mesothelioma. Electrical device Tumor Treating Fields is only the second treatment to receive FDA approval for mesothelioma.  This summer, the manufacturers of these two treatments announced they would team up. They will test Keytruda and Tumor Treating Fields in patients with non-small cell lung cancer. The results could impact the future of mesothelioma treatment, too. Two Promising Therapies: Keytruda Keytruda is an immunotherapy drug. It blocks a protein called PD-1. Many types of cancer cells overproduce PD-1 to evade the immune … Continue reading Keytruda and Tumor Treating Fields: New Hope for Mesothelioma? »

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