Ofev Shelved as a Treatment for Pleural Mesothelioma

Treatment for pleural mesothelioma

It is official – the VEGF inhibitor Ofev is out of the running as a treatment for pleural mesothelioma. Hopes had been high for this drug after initial results showed a survival advantage. For the last two years, Ofev (nintedanib) was the subject of a large, international clinical trial. But now the leaders of that trial have published their Phase III trial results in The Lancet: Respiratory Medicine. They show that Ofev did not extend survival and is not an effective treatment for pleural mesothelioma. Why Hopes Were High for Ofev Ofev is an oral medication that stops cancer cells from producing a protein called VEGF. VEGF promotes the growth of blood vessels that help mesothelioma tumors grow. VEGF may … Continue reading Ofev Shelved as a Treatment for Pleural Mesothelioma »

Machine Learning Could Lead to Earlier Mesothelioma Diagnosis

earlier mesothelioma diagnosis

A machine learning tool being developed by Google could lead to earlier mesothelioma diagnosis and better survival rates. That word comes from Google artificial intelligence experts who recently presented their research at a developer conference in California. Machine learning specialist Lily Peng told the gathering that advanced A.I. can detect lung cancers like mesothelioma before doctors can even see them. Earlier mesothelioma diagnosis would allow for earlier intervention which could mean longer survival for victims of one of the world’s deadliest cancers. Diagnosis Often Comes Too Late Mesothelioma is a form of lung cancer caused by asbestos exposure. It can take decades to develop, but It is usually fatal within 18 months of diagnosis. One reason is that earlier mesothelioma … Continue reading Machine Learning Could Lead to Earlier Mesothelioma Diagnosis »

Mesothelioma Quality of Life Improves After Surgery

mesothelioma quality of life

New research confirms that surgery followed by HIPEC improves mesothelioma quality of life for people with peritoneal disease. Every mesothelioma surgery carries risks and can cause serious side effects. These problems often have a negative impact on mesothelioma quality of life in the short term. But researchers at Wake Forest University say cytoreductive surgery followed by intraperitoneal chemotherapy (HIPEC) boosts life quality for most mesothelioma patients over time. Evolving Management of Peritoneal Mesothelioma Malignant mesothelioma is a fast-growing cancer with a very low cure rate. Peritoneal mesothelioma accounts for about a fifth of all mesothelioma cases. With peritoneal mesothelioma, tumors start on the membrane that surrounds the abdominal organs and can spread to other parts of the body. Fatigue, pain, … Continue reading Mesothelioma Quality of Life Improves After Surgery »

Many Elderly Mesothelioma Patients Get No Treatment

elderly mesothelioma patients

The majority of elderly mesothelioma patients are observed rather than treated and this can have a negative impact on their survival. That is the finding of a new study published in the Annals of Surgical Oncology. The study included more than 4,500 mesothelioma patients. Less than a quarter of these patients received any treatment for their mesothelioma. As a result, most of these patients lived less than six months. Treatment Options for Elderly Mesothelioma Patients Exposure to asbestos causes pleural mesothelioma. It can take decades after exposure for mesothelioma symptoms to occur. The median age for a malignant pleural mesothelioma diagnosis is 72. The older a patient is at diagnosis, the more likely they are to have other health problems. … Continue reading Many Elderly Mesothelioma Patients Get No Treatment »

Lower-Volume Centers Less Likely to Follow Mesothelioma Treatment Guidelines

mesothelioma treatment guidelines

Mesothelioma patients need to beware of low-volume centers that are less likely to follow mesothelioma treatment guidelines. That is the message from a new study based on data from the National Cancer Institute. The study was run by doctors at Cedars-Sinai Medical Center in Los Angeles. It shows that treatment centers that do not see a lot of mesothelioma cases are less likely to follow the life-saving mesothelioma treatment guidelines. As a result, patients treated in these lower-volume facilities tend to have shorter mesothelioma survival. What are the Mesothelioma Treatment Guidelines? Malignant pleural mesothelioma is a cancer that occurs on the membrane that surrounds the lungs. It is extremely rare and difficult to treat. Many hospitals and doctors never see … Continue reading Lower-Volume Centers Less Likely to Follow Mesothelioma Treatment Guidelines »

Combination Mesothelioma Therapy Begins Pivotal Trial

mesothelioma treatment combination

A combination mesothelioma therapy that showed promise in early trials is finally being studied on a larger scale. The power-packed chemo-immuno-gene therapy known as TR002 has the potential to change the outlook for thousands of malignant mesothelioma patients. A small trial of the combination mesothelioma therapy in 2016 produced “significantly higher” mesothelioma survival rates than most patients are told to expect. Drug company Trizell announced last month that the combination will now be tested on 300 patients at sites in the US, Europe, Australia and Russia. Combination Mesothelioma Therapy Starts with Gene Therapy TR002 is an investigational gene therapy for mesothelioma patients who have failed first-line chemotherapy. This combination mesothelioma therapy is based on the human interferon-alpha 2b gene. The … Continue reading Combination Mesothelioma Therapy Begins Pivotal Trial »

Study Reveals Mesothelioma Chemotherapy May Be Underused in Older Patients

mesothelioma chemotherapy treatment

The older a mesothelioma patient is, the less likely he or she may be to receive mesothelioma chemotherapy. A new study says many older mesothelioma sufferers may be paying the price in shorter lifespans. Chemotherapy with pemetrexed (Alimta) and cisplatin is the gold standard for mesothelioma treatment. Many studies have linked it with longer mesothelioma survival. But an Australian study suggests that not enough older people are receiving mesothelioma chemotherapy. In fact, the older they are, the less likely they are to have chemotherapy for their mesothelioma. As a result, their chances of dying from malignant mesothelioma are higher. Mesothelioma Chemotherapy is Standard of Care Malignant mesothelioma is a hard-to-treat cancer with a poor prognosis. Mesothelioma chemotherapy is the primary … Continue reading Study Reveals Mesothelioma Chemotherapy May Be Underused in Older Patients »

Patients with Impaired Kidneys Could Still Take Alimta for Mesothelioma, Study Finds

Alimta for mesothelioma is kidney patients

New research in the Netherlands suggests that patients who would not normally be prescribed Alimta for mesothelioma could still benefit from the gold standard mesothelioma treatment. The key is an alternate dosing strategy. Alimta is a powerful drug that works by blocking a molecule needed for cell replication. Right now, doctors do not recommend Alimta for mesothelioma in people with poor kidney function. But Dutch pharmacology experts now say it is possible to adjust the dosing to make Alimta safer for these mesothelioma patients. Alimta for Mesothelioma: Proper Dosing is Key The FDA approved Alimta for mesothelioma in 2004. Alimta (pemetrexed) is still the only drug approved for the treatment of malignant mesothelioma. It has also been approved to treat … Continue reading Patients with Impaired Kidneys Could Still Take Alimta for Mesothelioma, Study Finds »

Quality of Life for Mesothelioma Patients Hinges on Activity and Nutrition

quality of life for mesothelioma

Muscle mass and nutrition can have a direct impact on quality of life for mesothelioma patients. That’s the finding of an Australian study of sixty-one men and women with malignant pleural mesothelioma. Researchers say the quality of life for mesothelioma patients was compromised by lower muscle mass or malnutrition. It is a wake-up call for mesothelioma patients to stay active and eat well for the best outcomes. Impacts on Quality of Life for Mesothelioma Patients Pleural mesothelioma is an incurable cancer. Even with the best mesothelioma treatments, most patients still face a grim prognosis. But there is evidence that good self-care may help. Previous studies have shown that patients with the best nutritional status often have longer mesothelioma survival. Nutritional … Continue reading Quality of Life for Mesothelioma Patients Hinges on Activity and Nutrition »

Chemotherapy During Mesothelioma Surgery: Is it Dangerous?

chemotherapy during mesothelioma surgery

A new study finds that chemotherapy during mesothelioma surgery does not raise the risk for complications. That could be good news for pleural mesothelioma patients who want to keep cancer at bay as long as possible. A group of Indian doctors compared the cases of thoracic cancer patients who had surgery with or without intraoperative chemotherapy. Only one of the “surgery + chemotherapy” patients developed a serious complication. Patients in this group also lived longer than those who did not receive intraoperative chemotherapy. When Do Doctors Use Chemotherapy During Mesothelioma Surgery? The two primary types of mesothelioma surgery are extrapleural pneumonectomy (EPP) or lung-sparing pleurectomy/decortication (P/D). Patients often have chemotherapy prior to surgery to shrink their mesothelioma tumor. Many have … Continue reading Chemotherapy During Mesothelioma Surgery: Is it Dangerous? »

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