Immune Systems Archives | Surviving Mesothelioma

Inflammation Marker May Predict Mesothelioma Prognosis

The ratio of neutrophils to lymphocytes – a way of measuring inflammation in the body of people with malignant pleural mesothelioma – may help doctors predict how well they will respond to treatment. That is the conclusion of mesothelioma researchers at China’s Sichuan University. In a new article in the journal Oncotarget, the team observed that NLR has been associated with survival in other types … Continue reading Inflammation Marker May Predict Mesothelioma Prognosis »

Using Immune Cells to Predict Mesothelioma Outcomes

Immune system cells may be some of the best predictors of mesothelioma outcomes, according to a group of British scientists. A new article in the British Journal of Cancer has found a close association between outcomes in people with different subtypes of malignant mesothelioma and the levels of different types of immune system cells in their bodies. Measuring Immune Response To create the experiment, researchers … Continue reading Using Immune Cells to Predict Mesothelioma Outcomes »

These Proteins Appear to Shorten Mesothelioma Survival

New evidence suggests that mesothelioma patients whose tumors express two particular proteins do not live as long as other mesothelioma patients. An international team of scientists including mesothelioma researchers at the National Cancer Institute say ALCAM (also called CD166) and PD-L1 (CD274) are both associated with “significantly decreased” survival in pleural mesothelioma. Understanding ALCAM and PD-L1 ALCAM is a type I transmembrane protein that regulates … Continue reading These Proteins Appear to Shorten Mesothelioma Survival »

Second-Line Immunotherapy Treatment Fails to Improve Mesothelioma Survival

A large international clinical trial of the immunotherapy drug tremelimumab as a second- or third-line treatment option for malignant mesothelioma has produced some disappointing news. Drug maker AstraZeneca has just released an update on the ongoing DETERMINE trial which suggests that the survival rates are roughly the same for previously-treated mesothelioma patients whether they later received treatment with tremelimumab or a placebo. What is Tremelimumab? … Continue reading Second-Line Immunotherapy Treatment Fails to Improve Mesothelioma Survival »

MicroRNAs May Be Key to Better Immunotherapy for Mesothelioma

Australian scientists say it may be possible to artificially reduce the levels of a protein that helps mesothelioma tumors hide from the immune system. The new research published in the Journal of Thoracic Oncology could open the door to more effective immunotherapy treatments for pleural mesothelioma. The Importance of PD-L1 Expression A cell surface protein called PD-L1 is key to the effectiveness of several new … Continue reading MicroRNAs May Be Key to Better Immunotherapy for Mesothelioma »

Altered Viruses May Help Boost Immunotherapy for Malignant Mesothelioma

Viruses may soon be playing a bigger role in the fight against malignant mesothelioma and other thoracic cancers. A pair of biologists from Minnesota say there is evidence that, in addition to killing mesothelioma cells directly, specific kinds of altered viruses might help make mesothelioma immunotherapy treatment more effective. How Does Immunotherapy Work? Like many other types of cancer, mesothelioma tumors are able to grow unchecked … Continue reading Altered Viruses May Help Boost Immunotherapy for Malignant Mesothelioma »

Immunotherapy and Radiation: A Powerful Mesothelioma Combo

New research suggests that, in the battle against malignant pleural mesothelioma, a treatment combining of immunotherapy drugs with radiotherapy may be a powerful new weapon. Researchers at the University of Pennsylvania reached that conclusion after reviewing the few existing studies on this emerging multimodal mesothelioma treatment for an article in Translational Lung Cancer Research.   Current available treatments for pleural mesothelioma, an aggressive lung-related cancer,  include surgical resection, … Continue reading Immunotherapy and Radiation: A Powerful Mesothelioma Combo »

MS Drug May Help Treat Malignant Mesothelioma, Too

Preliminary tests of a potential new mesothelioma treatment have yielded some exciting results at the University of Hawaii Cancer Center. Mesothelioma researchers there are evaluating an immune system modulator called FTY720 or fingolimod. Derived from a fungus called Iscaria sinclairii, FTY720 has been used to treat the relapsing form of multiple sclerosis. Although FTY720 has shown what the research team calls “therapeutic potential” in some … Continue reading MS Drug May Help Treat Malignant Mesothelioma, Too »

The Key to Mesothelioma Treatment Success with Immunotherapy

Researchers with a biotechnology company that makes antibody-drug conjugates (ADC) for hard-to-treat cancers like malignant mesothelioma say careful patient selection is the key to treatment success. Writing in the journal Advances in Therapy, John Lambert and Charles Morris of Massachusetts-based ImmunoGen call for the development of a “patient selection strategy” so that more mesothelioma patients and those with other cancers can take advantage of the … Continue reading The Key to Mesothelioma Treatment Success with Immunotherapy »

The Impact of Nutritional Status on Mesothelioma Survival

There is new evidence that a mesothelioma patient’s nutritional status could have an impact on their treatment outcomes. A group of Japanese surgeons, oncologists and pathologists compared the treatment responses of 83 patients with pleural mesothelioma and found that patients with the poorest nutritional status tended to have the poorest mesothelioma prognosis. Controlling Nutritional Status Score To reach their conclusion, the researchers used a tool … Continue reading The Impact of Nutritional Status on Mesothelioma Survival »

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