Treatment Details – 17.8 months

Survival: 17.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs: IFEX
Paraplatin
Vepesid
Country: Germany
   
City/State/Province: Lubeck
   
Hospital: Medical University of Lubeck
   
Journal: Link
   
Date: 3/2003

Description:
Patients: This Phase II study involved 27 patients with advanced malignant pleural mesothelioma.

Treatment: The treatment consisted of a combination of hyperthermia with three chemotherapy drugs – ifosfamide (IFEX), carboplatin (paraplatin), and etoposide (vepesid).

Toxicity: There was one death associated with progressive disease and sepsis. Other toxicities included hematologic (grades 1-4), gastrointestinal (grades 1-3), nausea and vomiting (grades 1-3), hepatic (grades 1-2), skin (grade 3), and renal (grades 1-2). In addition, there were two cardiac complications during hyperthermia.

Results: Median survival was 76.6 weeks (17.8 months).

Correspondence: A.Bakhshandeh, MD
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