Treatment Details – 17.8 months

Survival: 17.8 months
  
Toxicity Grade:5
  
Treatments: Biologic therapy
Chemotherapy
  
Drugs: IFEX
Paraplatin
Vepesid
Country:Germany
  
City/State/Province:Lubeck
  
Hospital:Medical University of Lubeck
  
Journal:Link
  
Date: 3/2003

Description:
Patients: This Phase II study involved 27 patients with advanced malignant pleural mesothelioma.

Treatment: The treatment consisted of a combination of hyperthermia with three chemotherapy drugs – ifosfamide (IFEX), carboplatin (paraplatin), and etoposide (vepesid).

Toxicity: There was one death associated with progressive disease and sepsis. Other toxicities included hematologic (grades 1-4), gastrointestinal (grades 1-3), nausea and vomiting (grades 1-3), hepatic (grades 1-2), skin (grade 3), and renal (grades 1-2). In addition, there were two cardiac complications during hyperthermia.

Results: Median survival was 76.6 weeks (17.8 months).

Correspondence: A.Bakhshandeh, MD

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