Treatment Details – 23.0 months

Survival: 23.0 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
Surgery
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: New York University School of Medicine
   
Journal: Link
   
Date: 8/2008

Description:
Patients: This phase II study involved 30 patients with malignant pleural mesothelioma. The average age was 66, ranging from 49 to 84 years of age. There were 25 men and 5 women.

Treatment: Patients had surgery and were treated with Tetrathiomolybdate. This is a biological therapy that affects copper levels and the development of new blood vessels (angiogenesis).

Toxicity: Many patients (53%) felt dizzy, but the dizziness was not related to any changes in blood pressure. Most (90%) of the patients reported grade 1 or 2 fatigue. Grade 3 granulocytopenia, anemia, and thrombocytopenia were also reported. The most common grade 3 toxicity was granulocytopenia, reported in 40% of the patients.

Results: The median overall survival was 23 months. For patients with stage I and II disease, the median survival time was 41 months, and for those with stage III disease, it was 15 months.

Support: This study was supported in part by funds from Attenuon LLC, a company which liscened the drug used in this study from the University of Michigan.

Correspondence: Dr. Harvey Pass
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