Chemotherapy – Scripps Clinic – Treatment Details

Survival:4.8 months
Toxicity Grade:5
Treatments:Chemotherapy
Drugs:Adriamycin
Country:United States
City/State/Province:La Jolla, California
Hospital:Scripps Clinic
Journal:Link
Date:11/2001

 

Description:
Patients: This Phase II study involved 10 patients with malignant mesothelioma.

Treatment: The treatment consisted of the chemotherapy drug doxorubicin (adriamycin) (high-dose) with the drugs dexrazoxane (for cardio-protection), and GM-CSF (to lessen bone marrow toxicity).

Toxicity: One patient died of sepsis. In addition, grade 3-4 toxicities included hematologic, infection, esophagitis/dysphagia, and cardiac function. This study was terminated early due to excessive toxicity.

Results: No patient responded to treatment and the median overall survival was 4.8 months.

Correspondence: Michael P. Kosty, MD

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