Chemotherapy – Scripps Clinic – Treatment Details

Survival: 4.8 months
Toxicity Grade: 5
Treatments: Chemotherapy
Drugs: Adriamycin
Country: United States
City/State/Province: La Jolla, California
Hospital: Scripps Clinic
Journal: Link
Date: 11/2001


Patients: This Phase II study involved 10 patients with malignant mesothelioma.

Treatment: The treatment consisted of the chemotherapy drug doxorubicin (adriamycin) (high-dose) with the drugs dexrazoxane (for cardio-protection), and GM-CSF (to lessen bone marrow toxicity).

Toxicity: One patient died of sepsis. In addition, grade 3-4 toxicities included hematologic, infection, esophagitis/dysphagia, and cardiac function. This study was terminated early due to excessive toxicity.

Results: No patient responded to treatment and the median overall survival was 4.8 months.

Correspondence: Michael P. Kosty, MD

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