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Chemotherapy Treatment Details – The Netherlands Cancer Institute
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| Description: |
| Patients: This Phase II study involved 24 patients with malignant pleural mesothelioma; 19 men and 5 women. The median age was 63 years.
Treatment: The treatment consisted of the drug raltitrexed (tomudex). This agent inhibits the enzyme thymidylate synthase which is involved in the synthesis of DNA. Toxicity: Grade 3-4 toxicities included anorexia, shortness of breath/dyspnea, hematologic, febrile neutropenia, nausea/vomiting, neurological toxicity, chest pain, pleuritic pain, and cough. Results: The overall median survival was 7 months. Support: AstraZeneca provided the drug (Tomudex) free of charge. Correspondence: P. Baas, MD |
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