Biologic therapy – Netherlands Cancer Institute – Treatment Details

Survival: 7.6 months
Toxicity Grade: 3
Treatments: Biologic therapy
Country: Netherlands
City/State/Province: Amsterdam
Hospital: Netherlands Cancer Institute
Journal: Link
Date: 5/2005


Patients: This Phase II study involved 40 patients with malignant pleural mesothelioma. Thirty-four patients were men, and six were women. The median age was 62 years. All but one patient was exposed to asbestos. Twenty-five patients had stage 3 or 4 disease. Twenty patients had received prior chemotherapy, radiotherapy, or surgery.

Treatment: The treatment consisted of one biologic agent: thalidomide. Thalidomide is thought to be an anti-angiogenesis agent that helps stop new blood vessels from forming.

Toxicities: Grade 2-3 toxicities included an allergic reaction, neurotoxicity, and constipation.

Results: The median survival was 7.6 months (230 days).

Correspondence: Paul Baas, MD

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