Emerging Therapies Target Mesothelioma in New Ways


Targeted therapies may be the future of mesothelioma treatment. That word comes from a team of some of the world’s top mesothelioma researchers at the University of Hawaii and New York University. The group has just published a review detailing what is known about how mesothelioma develops – also called “pathogenesis” – and how that […]

Putting the Newest Mesothelioma “Orphan Drug” Into Perspective

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Last week, the FDA announced the approval of a new orphan drug for the treatment of malignant pleural mesothelioma. According to drug manufacturer MTG Biotherapeutics, MTG-201 is an “advanced biologic therapy” that targets a particular gene defect present in cancer cells. This defect prevents cells from producing a protein that is critical in apoptosis or programmed […]

Improving Mesothelioma Response to Chemotherapy


Most mesothelioma patients will undergo chemotherapy at some point, whether in preparation for surgery or as a treatment by itself. New research conducted in Italy suggests that it may be possible to make that chemotherapy more effective by manipulating proteins in the cancer cells. Researchers at Salento University in Milan focused on the role of […]

Making Mesothelioma Cells More Susceptible to Chemotherapy


A potential new mesothelioma drug may have moved a step closer to gaining mainstream acceptance for use in sick patients. Doctors studying the drug say they have found a way to make cells more susceptible to its damaging effects. GDC-0980, also known as Apitolisib, is a class I inhibitor of two cell signaling pathways – […]

Irish Physicians Frustrated by Inadequate Training for Mesothelioma Diagnosis

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Do general pulmonologists have the training they need to diagnose an illness as rare and challenging as mesothelioma? There is evidence that, at least in Northern Ireland, they do not. A survey conducted of general respiratory physicians in Northern Ireland found that just over a third of the 32 respondents indicated a “lack of confidence […]

Mesothelioma-Causing Power of Asbestos Lingers Long After Contaminating Industry Leaves


There is more evidence that exposure to asbestos can dramatically increase the lifetime odds of developing malignant mesothelioma, even after a contaminating industry has closed its doors. Researchers focused on Casale Monferrato in Northwest Italy, an area known for its high number of mesothelioma cases linked to the Eternit asbestos-cement plant. Although the plant was […]

Could a Virus-Delivered Gene Slow Mesothelioma Growth?


Researchers in Japan are enrolling mesothelioma patients into a trial to test whether blocking a growth signaling pathway inside mesothelioma cells could slow down this aggressive cancer or even stop its progression. The hepatocyte growth factor (HGF)/c-Met signal pathway is highly active in mesothelioma and many other types of cancer cells, telling them to grow and replicate […]

Kidney Cancer Drug Slows Mesothelioma Growth in Mice


A drug that has been shown to slow the growth of renal cell carcinoma may have moved a step closer to becoming a viable addition to the arsenal of patients fighting malignant mesothelioma. Temsirolimus is a kinase inhibitor that appears to work against mesothelioma, in part, by blocking the action of a protein that tells […]

A New Look at the Complex Process of Mesothelioma Diagnosis


Mesothelioma is not only a difficult cancer to treat. It’s also notoriously difficult to diagnose. Because there are no definitive biomarkers that can quickly reveal if a patient has this aggressive cancer, diagnosing mesothelioma typically involves a combination of different techniques. A new article in the Archives of Pathology and Laboratory Medicine highlights some of […]

European Group Issues Updated Treatment Guidelines for Mesothelioma

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A group of medical researchers has just released an updated set of clinical practice guidelines for treating patients with malignant pleural mesothelioma, one of the rarest and most treatment-resistant forms of cancer. The guidelines, released by the European Society for Medical Oncology and published in the newest issue of the Annals of Oncology, contain six […]