Isolated Thoracic Perfusion for Mesothelioma Symptom Relief

isolated thoracic perfusion for mesothelioma

A new study suggests that a treatment called isolated thoracic perfusion could help alleviate some of the worst symptoms of malignant pleural mesothelioma. Isolated thoracic perfusion is a method for circulating medicine in just one area of the body. When doctors circulated chemotherapy drugs in the chests of people with pleural mesothelioma, their symptoms went away for several months.  Now, the team says it is time to test the technique in a bigger pool of mesothelioma patients.  The Theory Behind ITP Pleural mesothelioma is a membrane cancer that occurs in the chest. Chemotherapy drugs like Alimta can be powerful weapons against pleural mesothelioma. But they can also damage healthy tissues.  When healthy tissues are damaged by chemotherapy, mesothelioma patients can … Continue reading Isolated Thoracic Perfusion for Mesothelioma Symptom Relief »

Risk for Peritoneal Mesothelioma Keeps Rising Decades After Exposure

risk for peritoneal mesothelioma

Pleural mesothelioma risk may level off over several decades, but the risk for peritoneal mesothelioma never goes down. That is the conclusion of researchers at Italy’s University of Eastern Piedmont. It is based on data from more than 50,000 asbestos-exposed Italian workers.   More than 40 years after asbestos exposure, the workers’ risk for peritoneal mesothelioma continued to rise. Calculating Mesothelioma Rates Over Time Asbestos is the primary cause of all types of malignant mesothelioma. Even short-term asbestos exposure raises the risk for peritoneal mesothelioma and pleural mesothelioma. Peritoneal mesothelioma occurs in the lining of the abdomen. Pleural mesothelioma tumors start on the lining around the lungs.  If asbestos fibers are inhaled or swallowed, they embed themselves in these linings. This … Continue reading Risk for Peritoneal Mesothelioma Keeps Rising Decades After Exposure »

Unresectable Peritoneal Mesothelioma Becomes Operable After Bi-Directional Chemotherapy

French researchers have successfully operated on a man with unresectable peritoneal mesothelioma after treating him with bi-directional chemotherapy. Chemotherapy is the most common treatment for unresectable peritoneal mesothelioma. Most mesothelioma patients have chemotherapy by IV infusion. But some cancer centers now offer another chemotherapy delivery method. Intraperitoneal chemotherapy bypasses the bloodstream. It lets doctors put higher doses of cancer-killing medicine at the site of a tumor. The French team combined the two types of chemotherapy in one patient. It shrunk the patient’s unresectable peritoneal mesothelioma tumor enough to perform surgery.  Two Types of Mesothelioma Chemotherapy With IV chemotherapy, medicine travels to the tumor through the bloodstream. It is one way of treating unresectable peritoneal mesothelioma. One drawback of IV chemotherapy … Continue reading Unresectable Peritoneal Mesothelioma Becomes Operable After Bi-Directional Chemotherapy »

Keto Diet for Mesothelioma Not Advised Despite New Research

keto diet for mesothelioma

New research suggests a diet low in carbs and sugar may slow the growth of certain kinds of cancer cells. The news may have mesothelioma patients wondering about the value of the keto diet for mesothelioma, too.  The new study appears in the most recent issue of the journal Cell Reports. Researchers fed a restrictive ketogenic diet to mice with a certain kind of lung cancer. They also gave them a drug to keep the kidneys from absorbing extra glucose. The trial was not focused specifically on the keto diet for mesothelioma. But the findings do show that sugar and certain cancers do not mix.  What is the Ketogenic Diet? The ketogenic – or “keto” – diet is very low … Continue reading Keto Diet for Mesothelioma Not Advised Despite New Research »

New Mesothelioma Immunotherapy Trial Now Underway at Baylor

mesothelioma immunotherapy trial

Cancer researchers at Baylor College of Medicine have launched a new mesothelioma immunotherapy trial. The trial combines the cancer drug Opdivo (nivolumab) with injections of a modified virus called MTG201. Baylor scientists are hoping to recruit 12 pleural mesothelioma patients whose cancer has come back after chemotherapy.  The treatment combination appeared to work well in mice with mesothelioma. If it works as well in people, this new mesothelioma immunotherapy trial could change the outlook for many people with malignant mesothelioma.  How the New Mesothelioma Immunotherapy Trial Will Work Opdivo is the brand name for nivolumab. It blocks a protein called PD-1 in cancer cells. PD-1 is one of the ways that mesothelioma cells evade the immune system. Opdivo is often … Continue reading New Mesothelioma Immunotherapy Trial Now Underway at Baylor »

Mesothelioma Risk From Home Renovation in The Spotlight

mesothelioma risk from home renovation

The case of an Australian man is highlighting the mesothelioma risk from home renovation when asbestos is present.  Forty-two year old Matthew Werfel recently won a lawsuit against Amaca, the asbestos producer previously known as James Hardie. The company manufactured the asbestos-containing cement sheets that led to Werfel’s pleural mesothelioma. The record $3 million payout is an expensive warning to other DIY homeowners about the potential mesothelioma risk from home renovation. Asbestos in Construction Products Asbestos is a mineral that has to be mined from the ground. As early as the 1930’s, companies like James Hardie recognized its potential value as a construction material. Asbestos is strong, plentiful and resistant to heat and corrosion. It was used for decades to … Continue reading Mesothelioma Risk From Home Renovation in The Spotlight »

Cediranib for Mesothelioma: VEGF Inhibitor Fails Another Trial

cediranib for mesothelioma

Cediranib for mesothelioma appears to be ruled out by another failed clinical trial.  A new study led by MD Anderson researchers concludes that the VEGF inhibitor causes too many side effects for not enough survival benefit.  It is a blow to researchers hoping to use cediranib for mesothelioma patients on chemotherapy.  Cutting Off Tumor Blood Supply Cediranib is an oral drug made by AstraZeneca. It is part of a class of drugs called VEGF inhibitors. Vascular endothelial growth factor (VEGF) is a signal protein that stimulates blood vessel formation in tumors. Research shows that mesothelioma patients who have higher serum levels of VEGF have a lower chance of survival.  VEGF inhibitors like cediranib latch onto VEGF receptors inside mesothelioma cells. … Continue reading Cediranib for Mesothelioma: VEGF Inhibitor Fails Another Trial »

Minimally Invasive Lymph Node Staging May Prevent Unnecessary Mesothelioma Surgery

lymph node staging for mesothelioma

A minimally invasive procedure for lymph node staging may help some pleural mesothelioma patients avoid the pain and risk of surgery. That is the conclusion of a recent study on endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).  EBUS-TBNA is a minimally invasive method for testing the lymph nodes deep in the chest (mediastinal lymph nodes). If lymph node staging shows evidence of pleural mesothelioma, surgery is less likely to be effective.  Mediastinal Lymph Node Staging and Mesothelioma Pleural mesothelioma is a rare cancer that starts on the membrane around the lungs. It can spread to the lungs and other organs and is usually fatal.  The mediastinal lymph nodes are located in the area between the lungs. When the body is fighting … Continue reading Minimally Invasive Lymph Node Staging May Prevent Unnecessary Mesothelioma Surgery »

Dendritic Cell Therapy for Mesothelioma: Can it Help Other Treatments Work Better?

dendritic cell therapy for mesothelioma

A new kind of mesothelioma treatment called dendritic cell therapy might make other types of treatments even more effective.  Right now, chemotherapy with Alimta (pemetrexed) is the only approved therapy for malignant mesothelioma. Many others are in the works. But so far, none of them extend the lives of mesothelioma patients by more than a few months.  Dendritic cell therapy for mesothelioma may be different. This novel treatment uses the patient’s own cells to jumpstart the immune system.  A Dutch company developed and is testing the new treatment. The data so far suggests that it could boost chemotherapy and help new drugs like Keytruda work better.  How Dendritic Cell Therapy Works Dendritic cells are immune system cells that function as … Continue reading Dendritic Cell Therapy for Mesothelioma: Can it Help Other Treatments Work Better? »

New Cancer Blood Test Could Identify Early Mesothelioma

cancer blood test

Israeli researchers hope that a new kind of cancer blood test could help detect mesothelioma and other malignancies earlier. Earlier diagnosis could lead to longer mesothelioma survival. The blood test is based on the idea that immune system cells undergo metabolic changes when they fight a cancer like pleural mesothelioma. Different kinds of changes are associated with different kinds of cancers. The new cancer blood test detects these changes. Immune System Cells and Metabolism The immune system is the body’s primary way of defending itself against diseases like malignant mesothelioma. Metabolism refers to the way immune system cells expend energy to fight cancer.  An Israeli company is developing the new cancer blood test. It focuses on the metabolism of immune … Continue reading New Cancer Blood Test Could Identify Early Mesothelioma »

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