Predicting the Risk of Death from Mesothelioma

risk of death from mesothelioma

New research suggests that the risk of death from mesothelioma does not always hinge on disease type or overall health. Researchers in Brazil and at Mayo Clinic have identified some subtle mesothelioma risk factors that only pathologists can see. These factors go beyond the characteristics of the mesothelioma cells themselves. The study shows the environment around the tumor, the number and type of immune system cells at the tumor site, and even how many cells are in the tumor can all impact the risk of death from mesothelioma.  Understanding the Risk Factors for Mesothelioma Asbestos exposure causes most cases of mesothelioma. But not everyone who encounters asbestos gets cancer. Genes and certain lifestyle factors may influence whether an exposed person … Continue reading Predicting the Risk of Death from Mesothelioma »

PD-L1 Expression and Mesothelioma Prognosis

PD-L1 expression and mesothelioma prognosis

The largest study yet on PD-L1 expression and mesothelioma prognosis shows that patients with more of this protein in their cells have poorer odds of survival. Programmed death ligand 1 (PD-L1) helps cancer cells evade immune system attack.  Other studies have suggested a link between PD-L1 expression and mesothelioma prognosis. But the new meta-analysis performed by two Chinese researchers appears to confirm it with an even bigger data set.  Understanding Mesothelioma Prognosis Malignant mesothelioma is an uncommon cancer that typically carries a poor prognosis. Many people diagnosed with mesothelioma lose their lives to the illness within a year.  But there are also many exceptions. Some mesothelioma survivors live for decades after a mesothelioma diagnosis. Australian Paul Kraus is an example. … Continue reading PD-L1 Expression and Mesothelioma Prognosis »

Mesothelioma and Lung Cancer: These Biomarkers Can Tell the Difference

mesothelioma and lung cancer

Researchers in Canada say when it comes to distinguishing between mesothelioma and lung cancer, some proteins are more valuable than others.  The team has identified an especially important protein biomarker for mesothelioma. A biomarker is a compound in body fluid or tissue that can act as a signpost for disease.  Understanding the value of this particular protein as compared to other biomarkers may improve the testing process for mesothelioma. Pleural mesothelioma and lung cancer share many of the same characteristics. Both affect the lungs and both cause similar symptoms. But they are treated differently.  It is not always easy to tell these two cancers apart, even with high-level diagnostic tools. But the biomarker testing completed in Canada may make it … Continue reading Mesothelioma and Lung Cancer: These Biomarkers Can Tell the Difference »

Personalized Immunotherapy for Mesothelioma: New Research Sheds Lights

personalized immunotherapy for mesothelioma

New research conducted by a team of German and Austrian scientists could help make personalized immunotherapy for mesothelioma possible.  Mesothelioma is an incurable cancer caused by exposure to asbestos. Immunotherapy is one of the most promising treatment approaches.  But immunotherapy drugs like Keytruda do not work for all patients. Scientists do not know exactly why this is. The new study suggests that understanding biomarkers could lead to better outcomes through personalized immunotherapy for mesothelioma.  How Does Immunotherapy Work? Immunotherapy is a broad term that means using the patient’s own immune system to fight their cancer. There are many different types of immunotherapy. Some involve stimulating an immune response. Others involve turning off the mechanism that lets mesothelioma cells hide from … Continue reading Personalized Immunotherapy for Mesothelioma: New Research Sheds Lights »

Recommendations for People with a Genetic Predisposition for Mesothelioma

genetic predisposition for mesothelioma

Cancer expects from Ohio State University have just released an updated version of their recommendations for people with a genetic predisposition for mesothelioma.  These people have an inherited mutation on their BAP1 tumor suppressor gene. This mutation puts them at risk for several different types of cancer, including malignant mesothelioma.  It is not possible to prevent cancer in people with this genetic risk factor. But the Ohio State doctors say awareness and screening may help extend the lives of people with a genetic predisposition for mesothelioma.  BAP1 Tumor Predisposition Syndrome BAP1 stands for BRCA association protein 1. The BAP1 gene encodes for the BAP1 protein. BAP1 is one of the proteins that helps keep normal cells from turning into cancer … Continue reading Recommendations for People with a Genetic Predisposition for Mesothelioma »

Diagnostic CT Scan for Mesothelioma: More is Better

diagnostic ct scan

A new report out of the UK suggests that a thorough diagnostic CT scan for pleural mesothelioma should include images of the abdomen and pelvis, as well as the chest.  When a person goes to the doctor with early signs of malignant pleural mesothelioma, a CT scan of the chest is often the next step in making a diagnosis. CT scans create a 3-dimensional image of internal organs, making it easier to spot mesothelioma tumors.  But a research team led by the University of Bristol says a diagnostic CT scan that shows only the chest might miss mesothelioma tumors in other areas. How a Diagnostic CT Scan Works CT stands for computerized tomography. CT scanning is an advanced type of … Continue reading Diagnostic CT Scan for Mesothelioma: More is Better »

Genetics Affect Accuracy of SMRP Test for Mesothelioma

SMRP test for mesothelioma

The SMRP test for mesothelioma is a tool doctors use to help diagnose asbestos cancer and plan treatment. But new research suggests that the test is not as useful as it could be due to genetic variability.  Slovenian doctors say a person’s genetics influence how much SMRP they produce.  Based on their research, they recommend combining the SMRP test for mesothelioma with genetic testing. Their findings suggest the combination method produces a more accurate and useful mesothelioma biomarker. What is the SMRP Test for Mesothelioma? SMRP stands for soluble mesothelin-related peptides. They are produced when proteins found in the mesothelial membranes start to break down. Malignant mesothelioma is one condition that can trigger this breakdown.  As a mesothelioma tumor grows … Continue reading Genetics Affect Accuracy of SMRP Test for Mesothelioma »

Immunotherapy for Pleural Mesothelioma: Biomarkers Urgently Needed

immunotherapy for pleural mesothelioma

A new report says biomarkers are urgently needed to determine which patients would benefit from immunotherapy for pleural mesothelioma.  Researchers made the statement in a review of immunotherapy drugs in testing for malignant mesothelioma.  They say some of these drugs have proven to be more effective than others for asbestos cancer. But a set of biomarkers would go a long way to funneling patients into the right immunotherapy for pleural mesothelioma.  The Status of Immunotherapy for Pleural Mesothelioma Immunotherapy is believed to be the most promising up-and-coming cancer treatment. Immunotherapy treatments harness the strength of the body’s own immune response to attack cancer or help other drugs do so.  Like other types of cancer, mesothelioma cells have ways of avoiding … Continue reading Immunotherapy for Pleural Mesothelioma: Biomarkers Urgently Needed »

Predicting Unresectable Mesothelioma Prior to Surgery

unresectable mesothelioma

Cancer researchers at Baylor have found an effective way to identify certain cases of unresectable mesothelioma without making an incision. They focused on a common reason a surgeon might decide not to operate, even after the patient is on the table. The condition, called DCWI, is hard to identify without opening the patient up.  But the Baylor team says there is a non-invasive way to identify DCWI and predict cases of unresectable mesothelioma. If it works, it could save patients the pain of surgery. It could also save lives by allowing doctors to start other mesothelioma treatments sooner.  Diffuse Chest Wall Invasion in Mesothelioma Diffuse chest wall invasion (DCWI) is a condition that can make it impossible to perform effective … Continue reading Predicting Unresectable Mesothelioma Prior to Surgery »

The Importance of Subtype in PET Scanning for Mesothelioma Prognosis

PET scanning for mesothelioma

A new study of PET scanning for mesothelioma prognosis shows how much radioactive tracer a tumor absorbs can predict survival. This is especially true in people with the epithelioid mesothelioma subtype.  The study comes from the Sungkyunkwan University School of Medicine in Seoul, South Korea. Researchers studied the medical records of dozens of mesothelioma patients diagnosed between 2009 and 2018. They found that SUVmax, a key factor in PET scanning for mesothelioma, is directly related to mesothelioma survival.  How PET Scanning Works Mesothelioma diagnosis is challenging. Pleural mesothelioma grows quickly on the membrane around the lungs. It is one of the rarest and deadliest cancers. Positron emission tomography (PET) combined with computed tomography (CT) can help with diagnosis.  During a … Continue reading The Importance of Subtype in PET Scanning for Mesothelioma Prognosis »

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