Unlocking Cancer’s Weakness: How Scientists Are Targeting Mesothelin

Unlocking Cancer’s Weakness: How Scientists Are Targeting Mesothelin

When it comes to fighting cancer, scientists have been working hard to find better ways to help patients. One exciting area they’re exploring is something called CAR-T therapy, which targets specific proteins found on cancer cells. One of these proteins, called mesothelin, is found in different kinds of cancer like mesothelioma, ovarian, lung cancer, and some types of leukemia. But using CAR-T therapy against mesothelin has been tricky. The treatment sometimes gets tired out, and other proteins in the body can stop it from working well. To fix these problems, scientists have come up with a new way to make CAR-T therapy work better against mesothelin in cancer. Game-Changing Journey to Success First off, they made a special kind of…

Breakthrough in Mesothelioma Treatment: Cellectis’ Promising CAR-T Therapy
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Breakthrough in Mesothelioma Treatment: Cellectis’ Promising CAR-T Therapy

Mesothelioma is a challenging cancer with limited treatment options. Yet, recent advancements in CAR-T therapy are bringing new hope to the table. There is a breakthrough that holds the potential for improving mesothelioma treatment outcomes. Data comes from Journal for ImmunoTherapy of Cancer. CAR-T Therapy: A New Frontier for Mesothelioma CART T-cell therapy for mesothelioma is a type of immunotherapy. It starts with T-cells from the patient’s blood. Scientists alter the cells to recognize certain antigens on the surface of cancer cells. Then they give them back to the patient. In the case of mesothelioma, the main targeted antigen is mesothelin. Mesothelioma patients tend to produce extra mesothelin. This protein helps drive the growth and spread of their cancer. People with high levels…