Tag Archives: chemotherapy

Treating Relapsed Malignant Pleural Mesothelioma

Treating Relapsed Malignant Pleural Mesothelioma

Researchers from China explored whether immunotherapy or chemotherapy was a better option as a second-line treatment for relapsed malignant pleural mesothelioma (MPM). There is currently no standard of care for malignant pleural mesothelioma (MPM) that comes back after initial treatment. Because of this, it can be hard for doctors to make good care decisions for MPM patients who relapse. Malignant Pleural Mesothelioma MPM is a rare but serious cancer that grows on the lining of the lungs. It is caused by exposure to a toxic substance called asbestos. A healthy pleura is thin and flexible and expands to accommodate the lungs during respiration. In a person with mesothelioma, this membrane becomes thick and stiff, constricting the lungs and causing shortness … Continue reading Treating Relapsed Malignant Pleural Mesothelioma »

Allergic Reaction to Chemotherapy

Allergic Reaction to Chemotherapy

Chemotherapy is one of the treatment options for mesothelioma. The only FDA approved chemotherapy for mesothelioma is a combination of pemetrexed and cisplatin. When patients receive the same chemotherapy treatment multiple times, their body can become allergic to it. This can cause dangerous allergic reactions when they receive the treatment again. However, doctors have developed a method called rapid drug desensitization which slowly introduces the treatment to the patient to avoid an allergic reaction. This method works well, but sometimes patients can still have an allergic reaction during the treatment. Researchers from Turkey looked at patients with lung cancer and mesothelioma who received chemotherapy. They wanted to identify what factors increase the risk of an allergic reaction during the treatment. … Continue reading Allergic Reaction to Chemotherapy »

Largest Study Shows HIPEC Treatment Effective for Mesothelioma

Largest Study Shows HIPEC Treatment Effective for Mesothelioma

Hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) could be an effective treatment for malignant peritoneal mesothelioma (MPM). This is the finding of one of the largest and longest studies on the use of CRS-HIPEC to treat MPM. Researchers from the Atrium Health Wake Forest Baptist Comprehensive Cancer Center looked at data from 111 patients over 28 years. Diagnosed with MPM MPM is an aggressive cancer caused by asbestos. Symptoms of MPM are usually noticed first in the abdomen or the gastrointestinal system. People might feel abdominal pain or swelling, fever, and night sweats. MPM occurs in less than 1,000 people in the United States every year and accounts for about 20-25% of all mesothelioma cases. Patients diagnosed with MPM have longer life expectancy … Continue reading Largest Study Shows HIPEC Treatment Effective for Mesothelioma »

Predicting Mesothelioma Treatment Response

Predicting Mesothelioma Treatment Response

Certain types of biomarkers can help doctors predict the best chemotherapy treatment for patients with malignant pleural mesothelioma. Researchers from Cairo University in Egypt looked at 91 mesothelioma patients. They tested two different chemotherapy drug combinations: pemetrexed plus cisplatin and gemcitabine plus cisplatin. FDA Approved Treatment Options Mesothelioma is a rare cancer caused by asbestos and standard therapies are limited. Most mesothelioma patients have chemotherapy as their first-line treatment. If they are healthy enough, they may also have surgery or radiation therapy. Chemotherapy is a group of toxic drugs that kill cells by damaging their DNA. As of this writing, the only FDA approved chemotherapy for malignant pleural mesothelioma is a combination of pemetrexed and cisplatin. Gemcitabine is not an … Continue reading Predicting Mesothelioma Treatment Response »

New Drug in the Pipeline for Mesothelioma

New Drug in the Pipeline for Mesothelioma

Researchers in Iran tested the safety of a new version of the drug pemetrexed in patients with non-small cell lung cancer and malignant pleural mesothelioma. This drug is used to treat these patients when they are not able to get surgery for their cancer. The researchers were able to determine that pemetrexed is safe in patients with non-squamous non-small cell lung cancer. Treatment Choices Malignant pleural mesothelioma is a lung-related cancer like non-small cell lung cancer. It is caused by exposure to asbestos. Treatment for mesothelioma usually involves chemotherapy, radiation therapy, and surgery. Patients may receive more than one type of treatment. This is called multimodal therapy. Pemetrexed is a chemotherapy drug that interrupts the cell replication process that helps … Continue reading New Drug in the Pipeline for Mesothelioma »

New Combination Chemotherapy Drug for Mesothelioma

Testing 527 Cancer Drugs on Mesothelioma

A recent study has found that a new drug for mesothelioma chemotherapy could improve treatment outcomes. The new drug is called abemaciclib. It works by blocking cancer cells from multiplying within the body. This helps to stop tumors from growing and spreading. The researchers in this study used cell samples from mesothelioma patients to test the drug. Their study found that adding abemaciclib to the standard chemotherapy treatment helped to stop the growth of mesothelioma cancer cells. Common Treatment Options Mesothelioma is an extremely rare cancer caused by exposure to asbestos. It affects the membranes around organs like the lungs and abdominal cavity. It takes a long time for symptoms to appear. By then, the cancer has usually become difficult … Continue reading New Combination Chemotherapy Drug for Mesothelioma »

Cost Comparison of Immunotherapy vs. Traditional Chemotherapy in Mesothelioma

Cost Comparison of Immunotherapy vs. Traditional Chemotherapy in Mesothelioma

A new study does a cost comparison of immunotherapy over traditional chemotherapy. Immunotherapy and chemotherapy are common in the first-line treatment of malignant pleural mesothelioma. The news came from Therapeutic Advances in Medical Oncology. Traditional Chemotherapy In 2004, the FDA approved pemetrexed for the treatment of malignant pleural mesothelioma. Pemetrexed is often taken together with cisplatin. It is for patients whose disease is either inoperable or who are not candidates for surgery. Pemetrexed + cisplatin/carboplatin are chemotherapy drugs. Chemotherapy is a group of toxic drugs that kill cells by damaging their DNA. They target both cancerous and healthy cells. Patients with this chemo regimen also take folic acid and vitamin B12 supplements. This helps to reduce side effects from the … Continue reading Cost Comparison of Immunotherapy vs. Traditional Chemotherapy in Mesothelioma »

Treatment Protocol of an 8-Year Survivor of Mesothelioma

Treatment Protocol of an 8-Year Survivor of Mesothelioma

A new article in Scholars Journal of Medical Case Reports outlines the treatment protocol of an 8-year survivor of mesothelioma. Malignant pleural mesothelioma is difficult to treat. This aggressive cancer is caused by asbestos exposure and is resistant to most standard cancer therapies, including radiotherapy. Many people diagnosed with mesothelioma die within a few months to a year. Paul Kraus is considered the longest documented survivor of mesothelioma in the world. He was diagnosed in 1997 and was given little hope of survival. Not willing to give up, he worked with a team of doctors to create his own tailored treatment protocol. This protocol included dramatic lifestyle changes, experimental therapies, dietary changes, mind-body medicine, and other modalities. Paul was fortunate. … Continue reading Treatment Protocol of an 8-Year Survivor of Mesothelioma »

Second Treatment Course May Increase Mesothelioma Patient Survival

New Drug in the Pipeline for Mesothelioma

Oncologists report that a second treatment course may be a good option for some mesothelioma patients. Almost all mesothelioma patients experience progression after the first treatment. Recommendations for a second treatment are still unclear. There is very limited information available on second and repeat treatments. Pemetrexed combined with platinum-based chemotherapy is a standard first treatment for mesothelioma. A report in BMC Cancer says that a repeat treatment may be good for eligible patients. In this study, patients who received a second treatment of chemotherapy survived longer. Understanding Second Treatments or Retreatments Malignant pleural mesothelioma is a rare, aggressive cancer linked to asbestos exposure. There have been several recent treatment advances. But the mesothelioma prognosis is still poor with an average … Continue reading Second Treatment Course May Increase Mesothelioma Patient Survival »

First-Line Chemotherapy versus Immunotherapy versus Maintenance Therapy

Chemotherapy versus Immunotherapy versus Maintenance Therapy

A recent study compared mesothelioma patients’ survival by physician’s choice of treatment. Is first-line chemotherapy the best choice? Malignant pleural mesothelioma is an aggressive cancer that affects older adults. Mesothelioma patients often have other comorbidities making real-world treatment decisions challenging. The first was by choice of first-line chemotherapy. The second was the physician’s choice of second-line chemotherapy versus immunotherapy. And the third was by the physician’s choice of use of maintenance therapy. Physician’s Choice of First-Line Chemotherapy Drugs This is the largest real-world study of U.S. patients diagnosed with mesothelioma. Scientists analyzed physicians’ choice of first-line chemotherapy, second-line therapy, and maintenance therapy. In the first-line chemotherapy analysis, there was no significant difference in patient survival. As of this writing, the only … Continue reading First-Line Chemotherapy versus Immunotherapy versus Maintenance Therapy »