Pharmaceutical researchers working on a way to make the most popular mesothelioma drug more effective have found more evidence that fat may be the answer. The team at Zagazig University in Egypt and Tokushima University in Japan have developed a fat-based coating for the antifolate drug pemetrexed (Alimta) that may help improve outcomes for patients. Pemetrexed is currently the only drug approved specifically to treat … Continue reading More Support for Novel Mesothelioma Drug Delivery System
The makers of the once-promising experimental mesothelioma drug defactinib have announced that they will stop a clinical trial of the drug early because, by itself, it does not appear to help. But this may not be the end of the road for defactinib in mesothelioma treatment. Defactinib (VS-6063) had been the leading compound for its manufacturer, Boston-based Verastem. While standard mesothelioma chemotherapy drugs like pemetrexed, … Continue reading Scrubbed Trial May Not Be the End for Mesothelioma Drug
A small group of Australian mesothelioma patients have reportedly lived more than twice as long as expected with a combination of standard chemotherapy and immune system manipulation with the CD40 protein. The CD40 protein plays a role in a broad range of immune and inflammatory responses in the body. Studies in mice have found that activating CD40 with an activating antibody may work “synergistically” with … Continue reading Long Term Mesothelioma Survival with Immune System Activation
The best second-line treatment for mesothelioma patients who fail to respond to standard chemotherapy is probably to enroll in a clinical trial. The authors of a newly-published paper on the subject reached that conclusion after reviewing the results of 29 studies on potential second- or third-line mesothelioma treatments. Most patients who are diagnosed with mesothelioma, an aggressive malignancy associated with asbestos exposure, will undergo chemotherapy, … Continue reading Clinical Trial May be Best Second-Line Approach for Mesothelioma
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