Comprehensive Genomic Profiling in Pediatric Peritoneal Mesothelioma
Mesothelioma is a serious cancer in the lining of body cavities. It affects people of all ages. Although rare in children, it shows how dangerous it is. A recent study looks at pediatric peritoneal mesothelioma. It highlights the need for detailed genetic testing. These insights could improve treatments for older patients. Case Report and Genomic Insights A case report followed a 5-year-old boy with a year of painless abdominal swelling. Doctors found a large cyst in his abdomen, which they removed. Tests confirmed peritoneal mesothelioma. Genetic profiling showed no typical mesothelioma mutations. But, there were gene amplifications in AURKA, AURKC, HLA-1B, ZNF-217, OR5F1, and MEN1. Three months after surgery, scans revealed the cancer had spread. Tragically, he died from pneumonia….