T cell receptor fusion constructs (TRuCs)

Malignant mesothelioma is a challenging cancer to treat. New therapies like T cell receptor fusion constructs (TRuCs) show promise. Yet, identifying which patients will benefit from these treatments is important. Radiomics, a field that extracts data from medical images, offers a potential solution. Radiomics may predict treatment responses based on imaging features. Radiomics to Predict Tumor Response In a recent pilot study, researchers looked data from 23 clinical trial patients. They used radiomics to extract features from imaging scans of 85 target tumors. The goal was to predict how these tumors would respond to TRuC-T cell therapy. Most tumors (55.3%) were in the pleura (lining of the lungs), with others in lymph nodes, peritoneum, and soft tissues. This distribution influenced…