P/D Surgery for Mesothelioma Improves Quality of Life Regardless of Lung Function

P/D Surgery for Mesothelioma

Japanese researchers say P/D surgery for mesothelioma improves quality of life for most patients, even if their lung function gets worse.  Doctors at the Hyogo College of Medicine tracked the cases of forty-five patients who had P/D surgery for mesothelioma between 2014 and 2018.  Lung function tests showed most pleural mesothelioma patients could not breathe as well after surgery as they did before. Their energy, vitality, and social functioning also decreased. But patients reported better mental health after surgery and significantly less pain.  The researchers conclude that quality of life after P/D surgery for mesothelioma may have less to do with breathing than previously thought.  What is P/D Surgery for Mesothelioma? Pleural mesothelioma tumors grow on the pleura, a thin … Continue reading P/D Surgery for Mesothelioma Improves Quality of Life Regardless of Lung Function »

NIPEC Treatment: Is This the Key to Long-Term Mesothelioma Survival?

nipec treatment

A mesothelioma treatment called NIPEC may help people with peritoneal mesothelioma live longer than expected. In some cases, much longer. A recent study of 74 peritoneal mesothelioma patients showed a combination of cytoreductive surgery (CRS), HIPEC, and NIPEC works better than CRS/HIPEC alone. The study comes from one of the country’s foremost medical authorities on peritoneal mesothelioma. Dr. Paul Sugarbaker runs the Peritoneal Surface Malignancy Program at Washington Cancer Institute in Washington, DC.  Last year, Dr. Sugarbaker released results of a small study on NIPEC treatment for mesothelioma. Although that study included only six patients, the results were impressive enough to warrant further study.  This year’s larger NIPEC study is even more promising for people fighting mesothelioma. Similarities and DIfferences … Continue reading NIPEC Treatment: Is This the Key to Long-Term Mesothelioma Survival? »

Mesothelioma Surgeries Carry Similar Mortality Risk, Study Finds

mesothelioma surgeries

The two major types of mesothelioma surgeries carry similar risk of death, according to a new study from cancer researchers in Japan.  One surgery involves removing the diseased pleural lining and one of the lungs. The other surgery removes many of the same tissues but leaves the lungs intact.  Surgeons around the world are divided as to which of these mesothelioma surgeries is best. Mesothelioma patients have more complications with lung-removing surgery. But some studies suggest it could lead to longer survival.  The 4-year Japanese study included more than 600 patients. It suggests that the likelihood of dying is similar with either of these mesothelioma surgeries.  Surgical Treatment of Pleural Mesothelioma Pleural mesothelioma is the most common type of asbestos … Continue reading Mesothelioma Surgeries Carry Similar Mortality Risk, Study Finds »

CRS/HIPEC Procedure Has Improved Over Time, Study Finds

CRS/HIPEC Procedure

A new French study contains some good news for people considering the CRS/HIPEC procedure for peritoneal mesothelioma.  The CRS/HIPEC procedure combines surgical resection with localized chemotherapy. Its aim is to remove or destroy as many mesothelioma cells as possible in the abdomen.  French researchers studied the evolution of the procedure over time. They discovered that it has improved. As a result, people with peritoneal cancers like malignant mesothelioma are living longer.  Cytoreductive Surgery for Mesothelioma Peritoneal mesothelioma causes tumors on the peritoneal membrane that lines the abdomen. Like other forms of mesothelioma, the cause is usually asbestos exposure.  Cytoreductive surgery (CRS) is an operation to remove tumors from the abdomen. Mesothelioma tumors may be confined to the peritoneal membrane, or … Continue reading CRS/HIPEC Procedure Has Improved Over Time, Study Finds »

Minimally Invasive Surgery for Mesothelioma is “Viable Alternative” to Standard Approaches

minimally invasive surgery for mesothelioma

A new study from the Icahn School of Medicine at Mount Sinai in New York suggests that minimally invasive surgery for mesothelioma is a “viable alternative” to open-chest procedures.  Both of the two main surgical procedures for pleural mesothelioma are usually done through a large incision in the chest. Both procedures also carry a high risk of post-surgical complications.  But the New York researchers found that minimally invasive surgery for mesothelioma may produce fewer serious problems in the short-term. It may also give mesothelioma patients a better quality of life after surgery. Surgical Treatment of Pleural Mesothelioma Pleural mesothelioma tumors occur on tissue that surrounds the lungs. These tumors tend to spread out across the tissue in irregular shapes. Their … Continue reading Minimally Invasive Surgery for Mesothelioma is “Viable Alternative” to Standard Approaches »

Mesothelioma Subtypes Often Misclassified by Biopsy

mesothelioma subtypes

Pleural biopsy is not perfect when it comes to telling the difference between the three mesothelioma subtypes. But misclassification could lead to shorter survival.  That is the conclusion reached by top mesothelioma researchers in Brescia, Italy.  They compared autopsy records from 134 Italian mesothelioma patients. The patients were either shipyard workers or their spouses. The researchers found that the mesothelioma subtypes identified from biopsy tissue were incorrect a large percent of the time. Misclassification matters because it impacts which mesothelioma treatments doctors choose.  The Three Mesothelioma Subtypes Pleural mesothelioma is an aggressive malignancy on the lung lining. It is caused by exposure to asbestos. Mesothelioma cells fall into three mesothelioma subtypes based on certain cellular characteristics. Pleural mesothelioma is notoriously … Continue reading Mesothelioma Subtypes Often Misclassified by Biopsy »

Some Mesothelioma Surgery Complications May be Predictable

mesothelioma surgery complications

It is not always possible to predict which patients will suffer from mesothelioma surgery complications. But a new study suggests there is way to make an educated guess about one particular kind of complication. A lung-removing operation called EPP used to be the preferred surgery for pleural mesothelioma. Most surgeons now favor a more conservative procedure called P/D.  But surgeries do not always work out the way patients and surgeons hope they will. In some cases, mesothelioma surgery complications require the surgeon to convert a planned P/D procedure into an EPP operation instead.  A team of Japanese researchers recently analyzed which patients had the highest risk for these mesothelioma surgery complications and what kinds of outcomes they experienced.  Converting P/D … Continue reading Some Mesothelioma Surgery Complications May be Predictable »

Still No Clear Answer on SMART Protocol for Pleural Mesothelioma

SMART protocol for mesothelioma

Another study is out and there is still no clear answer about the value of the SMART protocol for mesothelioma.  SMART stands for surgery for mesothelioma after radiotherapy. After studying nearly a hundred patients, doctors in Toronto say radical surgery after RT can be effective. But they also say it is still very hard to prevent serious complications, even in an experienced center like theirs.  The team at Princess Margaret Cancer Center tested the SMART protocol on previously-untreated pleural mesothelioma patients.  As with previous studies of the SMART protocol for mesothelioma, some of the patients did very well. Many lived longer than they would normally expect to live. But there was also a high incidence of serious surgery-related complications.  The … Continue reading Still No Clear Answer on SMART Protocol for Pleural Mesothelioma »

CT Scans Fail To Identify Metastatic Mesothelioma Prior to Surgery

CT scans

CT scans are not a reliable way to detect the spread of mesothelioma into certain lymph nodes between the ribs. This is important because people with mesothelioma cells in their posterior intercostal lymph nodes (PILN) do not tend to get good results from P/D surgery. Surgeons need a good way to find mesothelioma cells in these lymph nodes before they decide to perform this risky operation. But University of Pennsylvania researchers say CT scans are not the best method.  CT Scans in Mesothelioma Diagnosis and Prognosis CT stands for computerized tomography. A CT machine uses a series of X-ray images from different angles to create a 3D picture of a mesothelioma tumor. Most hospitals have a CT scanner. They are … Continue reading CT Scans Fail To Identify Metastatic Mesothelioma Prior to Surgery »

High PD-L1 Levels Could Be Bad News for Mesothelioma Surgery Candidates

Yet another new study has found a link between PD-L1 levels and mesothelioma survival – this time in people slated to have surgery for malignant pleural mesothelioma.  PD-L1 stands for programmed cell death ligand 1. It is a protein expressed by some cancer cells that helps them avoid immune system attack.  Researchers at Baylor College of Medicine are the latest to show that higher PD-L1 levels may lead to a worse mesothelioma prognosis. Their study focused specifically on mesothelioma surgery candidates.  The results were published recently in the Annals of Thoracic Surgery.  PD-L1 Levels and Mesothelioma Prognosis Even healthy people express some amount of PD-L1. Its job is to suppress the part of the immune system that attacks foreign tissues. … Continue reading High PD-L1 Levels Could Be Bad News for Mesothelioma Surgery Candidates »

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