|

Saving Lives and Lung Tissue: The Ideal Surgical Approach for Mesothelioma

Saving Lives and Lung Tissue: The Ideal Surgical Approach for Mesothelioma

New research has outlined the ideal approach to surgery for treating mesothelioma. The news comes from Hyogo Medical University in Japan.

Since surgery is just one part of the treatment plan, it is important to focus on saving the lung tissue as much as possible. After the surgery, the patient’s quality of life should be the top priority, especially when they need other treatments.

Improving Mesothelioma Treatment Outcomes

Mesothelioma is a type of cancer that is caused by exposure to asbestos. When asbestos fibers get into the lining of the lungs, it can cause the tissue to become inflamed and grow tumors.

The usual treatment strategy for mesothelioma includes multiple types of therapies. The treatment plans usually include surgery, chemotherapy, and radiation therapy. Since mesothelioma can be difficult to treat, doctors will use more than type of treatment to get rid of as many cancer cells as possible.

There are two types of surgery for mesothelioma. One of these is called extra-pleural pneumonectomy (EPP). The other is called pleurectomy/decortication (P/D).

There is currently no accepted standard among doctors for which type of surgery to perform on patients with mesothelioma. Yet, most doctors prefer to use P/D because it does a better job of sparing lung tissue, reducing side effects, and improving quality of life.

Choosing the Right Surgical Procedure for Mesothelioma

This new study points out important factors when choosing surgery for mesothelioma. Doctors should think about the size of the tumor, its location, and the health of the patient.

One concern is the biggest when performing surgery to remove mesothelioma tumors. That is to make sure the patient is still healthy enough after the surgery to receive other types of treatments. Surgery doesn’t usually remove all the cancer cells, so follow-up treatments are important. Chemotherapy, radiation, and immunotherapy usually follow a surgical procedure.

A multi-modal approach to treating mesothelioma gives the patient the best chance at long-term survival. This is because it kills as many cancer cells as possible.

The study reveals that lung-sparing surgery is an important part of mesothelioma treatment plans.

Source

Kondo N, Hasegawa S. Optimal surgery for resectable malignant pleural mesothelioma in the setting of multimodality treatment [published online ahead of print, 2023 Jul 20]. Surg Today. 2023;10.1007/s00595-023-02723-8. doi:10.1007/s00595-023-02723-8. https://link.springer.com/content/pdf/10.1007/s00595-023-02723-8.pdf

 

Similar Posts

  • | |

    Doctors Describe "Concrete Therapeutic Approach" for Mesothelioma

    A team of medical researchers in Italy have achieved what they are calling “excellent” tumor control and survival results in malignant pleural mesothelioma patients using a combination of surgery, chemotherapy, and radiotherapy. Caused by exposure to asbestos, mesothelioma typically spreads quickly across the lung-encasing membrane called the pleura. There is no known cure but treatments are improving. In the current prospective study, 20 malignant pleural mesothelioma patients underwent radical pleurectomy/decortication followed by high doses of radiation. After surgeons removed as much of the visible mesothelioma tumor and surrounding tissue as possible, patients received 50Gy of radiation to the effected side of their chest, delivered in 25 fractions. Regions of particular concern for mesothelioma regrowth got an extra radiation “boost” to…

  • | |

    Does Radiotherapy Reduce Mesothelioma Pain?

    A new study says there is not enough evidence to support the use of radiotherapy for the treatment of pain associated with malignant pleural mesothelioma. Researchers at the University of Edinburgh in Scotland reviewed a range of past studies on mesothelioma pain and radiotherapy by searching databases that date back as far as 1974. To be eligible to be included in their review, the study had to focus on malignant pleural mesothelioma and radiotherapy given “with the intent of improving pain”. The study also had to report doses and fractionation of the radiotherapy and how the pain responded. In all, the researchers found eight studies on mesothelioma pain and radiotherapy that met the criteria. Two of the studies were prospective…

  • | |

    Radiotherapy for Mesothelioma: Better But Still Limited

    A form of highly-targeted radiation therapy for mesothelioma is better than it used to be, but is still risky. That is the message of a recent article on intensity-modulated radiation therapy (IMRT) in Seminars in Thoracic and Cardiovascular Surgery. Author Kenneth E. Rosenzweig, MD, a Radiation Oncologist with Mount Sinai Hospital in New York, reviewed recent studies on IMRT and mesothelioma. He concludes that, while the “troubling toxicity” associated with IMRT when it was first introduced has not been entirely eliminated, the fact that clinicians now have more experience with it is making a positive difference for mesothelioma patients. Before targeted therapies like IMRT were available, high-dose radiation was not usually a feasible option for mesothelioma since the irregular shape…

  • | |

    A Second-Line Option for Mesothelioma?

    Although survival was not significantly extended, the chemotherapy drug vinorelbine might be a treatment option for mesothelioma patients whose cancer has returned after first-line chemotherapy with pemetrexed. A new study on vinorelbine as a second-line treatment finds that the drug is “moderately active” in mesothelioma patients who were initially treated with pemetrexed-based chemotherapy. Pemetrexed (Alimta), along with a platinum-based drug like cisplatin, is the primary first-line drug therapy for mesothelioma. But vinorelbine is gaining attention as a possible option for mesothelioma, in part because it is available in a less expensive generic form. In “Vinorelbine in pemetrexed-pretreated patients with malignant pleural mesothelioma”, the Italian authors detail the results of their study on 59 patients with unresectable pleural mesothelioma.  These patients…

  • | |

    Repeat HIPEC Improves Mesothelioma Survival

    If one cytoreductive surgery and HIPEC procedure for mesothelioma is good, subsequent treatments may be even better. That is the central message of research conducted at the Moffitt Cancer Center in Florida. The study’s aim was to assess overall survival among peritoneal mesothelioma patients who had not just one, but two or more rounds of heated intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery. The cytoreduction/HIPEC approach has become popular for peritoneal mesothelioma, a treatment-resistant cancer of abdominal membranes caused by asbestos. Cytoreductive surgery involves removing as much of the mesothelioma tumor as possible from the abdomen. Because the shape and spreading pattern of mesothelioma tumors make complete cytoreduction difficult, the surgery is often followed by a rinse with a heated solution…

  • | |

    Value of Mesothelioma Surgery Challenged for Healthy Patients

    New research conducted in Italy and presented at the 15th World Conference on Lung Cancer in Sydney, Australia suggests that mesothelioma surgery – no matter what kind – may not offer a survival advantage over medical management for the healthiest of patients. Mesothelioma is a rare but aggressive malignancy that is highly resistant to standard cancer treatments. The two types of mesothelioma surgery considered to be options for people with resectable cancer are pleurectomy decortication (P/D) or extrapleural pneumonectomy (EPP). While EPP is more radical than P/D because it involves removing a lung, both carry a heavy risk of complications and, according to the Italian researchers, may not be of value for certain patients. The study reviewed data from 1,365…