Opdivo as Second-Line Treatment Option for Mesothelioma: Promising New Data

second-line treatment option

A new study suggests that the cancer drug Opdivo could be an effective second-line treatment option for people with relapsed mesothelioma. Right now, people whose mesothelioma comes back after treatment do not have an approved second-line treatment option.  The news on Opdivo comes from the first ever placebo-controlled phase 3 trial of patients with relapsed mesothelioma. It shows that the drug significantly improved overall survival for these patients. It also increased the time it took for patients’ cancer to get worse. Details of the CONFIRM Trial The trial of this proposed second-line treatment option for mesothelioma was called CONFIRM. It involved 332 mesothelioma patients from 24 UK cancer centers. The patients already had at least one treatment. Two thirds of … Continue reading Opdivo as Second-Line Treatment Option for Mesothelioma: Promising New Data »

Exercise and Nutrition Advice Could Help Some Mesothelioma Patients

exercise and nutrition

Most mesothelioma patients would welcome exercise and nutrition advice that might help them cope with their cancer and its symptoms better.  That news comes from a study in the Journal of Geriatric Oncology. Researchers wondered if seniors with lung cancer or mesothelioma would even be open to recommendations about their exercise and nutrition.  The study found that they would and that it would probably help them feel better. But there are barriers to getting this kind of information into the hands of people who need it.  Symptoms of Pleural Mesothelioma and Lung Cancer Pleural mesothelioma is an asbestos-related cancer that affects the lungs. Mesothelioma patients have many of the same symptoms as lung cancer patients. Among other things, they tend … Continue reading Exercise and Nutrition Advice Could Help Some Mesothelioma Patients »

High PD-L1 Levels Could Be Bad News for Mesothelioma Surgery Candidates

Yet another new study has found a link between PD-L1 levels and mesothelioma survival – this time in people slated to have surgery for malignant pleural mesothelioma.  PD-L1 stands for programmed cell death ligand 1. It is a protein expressed by some cancer cells that helps them avoid immune system attack.  Researchers at Baylor College of Medicine are the latest to show that higher PD-L1 levels may lead to a worse mesothelioma prognosis. Their study focused specifically on mesothelioma surgery candidates.  The results were published recently in the Annals of Thoracic Surgery.  PD-L1 Levels and Mesothelioma Prognosis Even healthy people express some amount of PD-L1. Its job is to suppress the part of the immune system that attacks foreign tissues. … Continue reading High PD-L1 Levels Could Be Bad News for Mesothelioma Surgery Candidates »

First Patient Dosed in New Trial for Relapsed Mesothelioma

relapsed mesothelioma

Doctors in the UK have started treatment on the first patient in the trial of a new drug combination for relapsed mesothelioma. The drug is called bemcentinib. It blocks a protein encoded by the AXL gene. People with mesothelioma tend to overexpress this protein. Studies show that this extra AXL protein might help cancer cells hide from the immune system. It might also help them spread to other parts of the body.  In the new trial, patients with relapsed mesothelioma will get a combination of bemcentinib and Keytruda (pembrolizumab). Keytruda is an immunotherapy drug. Like bemcentinib, it helps make mesothelioma cells vulnerable to immune system attack.  Animal studies and tests in lung cancer patients show that bemcentinib may help immune … Continue reading First Patient Dosed in New Trial for Relapsed Mesothelioma »

Pleural Mesothelioma Rates Expected to Decline Just as Lung Cancer Deaths Have

pleural mesothelioma rates

A new report suggests that pleural mesothelioma rates will continue to decline worldwide over the next decade as many countries get wise to the dangers of asbestos. The report comes on the heels of another study showing dramatic declines in US lung cancer deaths.  The report on mesothelioma rates comes from market research website, Research and Markets. The company evaluated malignant pleural mesothelioma incidence in seven countries to come up with an 11-year forecast. According to the research, the US, UK, Japan, and four European countries can expect declining rates of asbestos cancer through 2030. Those who do receive a pleural mesothelioma diagnosis may benefit from some of the same drugs that are helping lung cancer patients survive. Lung Cancer … Continue reading Pleural Mesothelioma Rates Expected to Decline Just as Lung Cancer Deaths Have »

COPD Drug Might Help with Drooling in Pleural Mesothelioma Patients

A UK doctor says a drug used to treat COPD can help with drooling in pleural mesothelioma patients on palliative care.  Dr. Claire Plunkett recently published the case report of a mesothelioma patient receiving palliative care. The patient developed a problem with drooling and swallowing. The medical term for drooling is sialorrhoea. It can happen in people with certain conditions or on certain drugs. Doctors at Farleigh Hospice in Chelmsford, UK treated the man with a glycopyrronium bromide inhaler. Glycopyrronium is normally used for patients with chronic obstructive pulmonary disorder (COPD).  The treatment cured the problem in just a few days. Plunkett says this is evidence that glycopyrronium is a good option to treat drooling in pleural mesothelioma patients. What … Continue reading COPD Drug Might Help with Drooling in Pleural Mesothelioma Patients »

Common Drugs May Impact Mesothelioma Survival After Immunotherapy

There is new evidence that taking certain common drugs could negatively impact mesothelioma survival after immunotherapy.  Drugs such as NSAIDs, antacids, corticosteroids, and antibiotics affect the microbiome. The microbiome is the collection of bacteria that live in a person’s gut.  The microbiome interacts with the immune system. Ohio State University researchers say some medicines disrupt the microbiome. This can threaten the effectiveness of cancer immunotherapy.  The Microbiome and Immunity The microbiome is the collection of bacteria that live in the intestinal tract. Every mesothelioma patient’s microbiome is unique. Scientists are just beginning to understand the importance of the microbiome in human health.  At first glance, there might not seem to be a direct correlation between the microbiome and mesothelioma survival … Continue reading Common Drugs May Impact Mesothelioma Survival After Immunotherapy »

Pleural Effusion in Mesothelioma: Comparing Solutions

pleural effusion in mesothelioma

A new study says, when it comes to pleural effusion in mesothelioma, the two main solutions are pretty equal – with one exception.  Pleural effusion is a buildup of fluid in the space around the lungs. Over time, this fluid restricts the lungs and makes it hard to breathe. The problem is common in several types of cancer, including malignant mesothelioma.  In a new report, Taiwanese and Hong Kong researchers compared the two primary ways of dealing with pleural effusion in mesothelioma. They conclude that the two methods work equally well. But one of them usually means a longer hospital stay. Understanding Pleural Effusion in Mesothelioma The pleura are layers of thin membranes that surround the lungs. Pleural mesothelioma tumors … Continue reading Pleural Effusion in Mesothelioma: Comparing Solutions »

Herb-like Compound May Be Alternative Treatment for Mesothelioma

alternative treatment for mesothelioma

A man-made version of a traditional Chinese herb could be an alternative treatment for mesothelioma.  Turkish researchers have published a new study on a drug called halofuginone. The study shows the drug has significant anticancer effects on mesothelioma cells.  In an article in Cell Biology International, they explore how halofuginone affects mesothelioma and lung cancer cells.  Mesothelioma Patients Need Another Treatment Option Mesothelioma is an asbestos-linked cancer that is hard to treat. Pleural mesothelioma is the most common type. Pleural mesothelioma grows quickly. It usually causes few symptoms until it is very advanced.  Chemotherapy is the main treatment. When that stops working, many patients look for an alternative treatment for mesothelioma.  Scientists are studying immunotherapy, new kinds of radiotherapy, and … Continue reading Herb-like Compound May Be Alternative Treatment for Mesothelioma »

Familial and Environmental Asbestos Exposure Raise Mesothelioma Risk in Women

environmental asbestos exposure

Italian researchers say women who live around an asbestos plant or with one of its workers may be at special risk for mesothelioma from the combination of familial and environmental asbestos exposure.  The research appears in a new issue of the Annals of Work Exposures and Health.  Scientists have long known about the link between asbestos on worker’s clothes and mesothelioma among the women who wash those clothes.  But the new report shows that some of these women face an even greater cumulative risk because of environmental asbestos exposure. Bringing the Mesothelioma Risk Home Traditionally, most jobs with the potential for asbestos exposure have been in male-dominated industries. These include industries like construction, shipbuilding, plumbing, electrical work, and asbestos mining … Continue reading Familial and Environmental Asbestos Exposure Raise Mesothelioma Risk in Women »

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