Catheter Tract Metastasis Often Overlooked in Mesothelioma Patients

catheter tract metastasis

A Canadian study says radiologists often overlook catheter tract metastasis in people with pleural mesothelioma, even though as many as a quarter of patients with pleural catheters develop the problem.  Mesothelioma patients can develop excess fluid around the lungs that makes it hard to breathe. Doctors can treat the problem with pleural catheters that stay in place and drain to the outside.  But tiny tumors that spring up along the tract where the catheter was inserted are a risk with this treatment. These tiny tumors are called metastatic tumors. They are easy to miss on CT scans. But the new report says there are other tell-tale signs of catheter tract metastasis. Pleural Catheters for Effusion in Mesothelioma Pleural effusion is … Continue reading Catheter Tract Metastasis Often Overlooked in Mesothelioma Patients »

Mesothelioma Case Study: Keytruda Side Effect Treated with Plasma Exchange

Keytruda side effect

German mesothelioma doctors say a Keytruda side effect that causes the heart to swell can be treated by “cleaning” the blood plasma.  The team shared the details of a recent mesothelioma case in Translational Lung Cancer Research. The mesothelioma patient developed a condition called myocarditis after treatment with pembrolizumab (Keytruda).  The Keytruda side effect is rare but serious. The good news is that cleaning the blood through a process called plasmapheresis restored the patient’s heart function. The article could help other doctors if any of their mesothelioma patients have similar problems.   Myocarditis as a Keytruda Side Effect Keytruda is a type of immunotherapy drug called an immune checkpoint inhibitor. It is approved to treat patients who have already tried other … Continue reading Mesothelioma Case Study: Keytruda Side Effect Treated with Plasma Exchange »

Irradiating Procedure Tracts Reduces Metastatic Mesothelioma in New Study

metastatic pleural mesothelioma

Irradiating the tracts through which certain interventions are performed can reduce the risk of metastatic pleural mesothelioma. That word comes from a new study in Singapore.  The pleural form of malignant mesothelioma occurs on the lining around the lungs. Doctors often have to insert tools through the chest wall for diagnosis or treatment. The paths or tracts along which they insert those tools can be the site of new mesothelioma tumors.  But the study shows that timely radiation treatment of those paths may prevent metastatic pleural mesothelioma. Metastatic Pleural Mesothelioma Metastasis is when cancer cells move from their original site to another place in the body. A tumor that is contained in one spot is easier to treat or remove. … Continue reading Irradiating Procedure Tracts Reduces Metastatic Mesothelioma in New Study »

Long-Term Mesothelioma Survival with ONCOS-102

long-term mesothelioma survival

The makers of the immunotherapy treatment ONCOS-102 have released promising new data on its ability to promote long-term mesothelioma survival. The report came less than two weeks after ONCOS-102 got FDA approval to fast-track its development.  ONCOS-102 is an investigational treatment made from a modified virus. The virus helps the treatment target mesothelioma cells while leaving healthy cells alone.  The new long-term mesothelioma survival data shows half of people on ONCOS-102 and chemotherapy have lived for 21 months. And the study is not over yet. Typical survival with standard mesothelioma chemotherapy is about a year.  Targovax says the data shows how valuable ONCOS-102 could be for patients with this rare but aggressive malignancy. Standard of Care for Pleural Mesothelioma Pleural … Continue reading Long-Term Mesothelioma Survival with ONCOS-102 »

Some Mesothelioma Patients Have Unrealistic View of Palliative Chemotherapy

palliative chemotherapy

A new Danish study suggests that, when it comes to palliative chemotherapy for mesothelioma, patients, families, and doctors may have very different expectations.  Malignant mesothelioma is an aggressive cancer caused by asbestos. It is not curable but chemotherapy can sometimes slow it down. Palliative chemotherapy is chemotherapy aimed at relieving mesothelioma symptoms.  But researchers at Odense University and University of Southern Denmark say nearly a third of families expect palliative chemotherapy to cure their cancer. This was especially true of patients younger than 70.  Palliative Chemotherapy for Mesothelioma Chemotherapy has been the main treatment for mesothelioma since the early 2000s. Pemetrexed (Alimta) and a platinum drug like cisplatin is the standard drug combination. But this treatment is rarely a cure. … Continue reading Some Mesothelioma Patients Have Unrealistic View of Palliative Chemotherapy »

Opdivo as Second-Line Treatment Option for Mesothelioma: Promising New Data

second-line treatment option

A new study suggests that the cancer drug Opdivo could be an effective second-line treatment option for people with relapsed mesothelioma. Right now, people whose mesothelioma comes back after treatment do not have an approved second-line treatment option.  The news on Opdivo comes from the first ever placebo-controlled phase 3 trial of patients with relapsed mesothelioma. It shows that the drug significantly improved overall survival for these patients. It also increased the time it took for patients’ cancer to get worse. Details of the CONFIRM Trial The trial of this proposed second-line treatment option for mesothelioma was called CONFIRM. It involved 332 mesothelioma patients from 24 UK cancer centers. The patients already had at least one treatment. Two thirds of … Continue reading Opdivo as Second-Line Treatment Option for Mesothelioma: Promising New Data »

Exercise and Nutrition Advice Could Help Some Mesothelioma Patients

exercise and nutrition

Most mesothelioma patients would welcome exercise and nutrition advice that might help them cope with their cancer and its symptoms better.  That news comes from a study in the Journal of Geriatric Oncology. Researchers wondered if seniors with lung cancer or mesothelioma would even be open to recommendations about their exercise and nutrition.  The study found that they would and that it would probably help them feel better. But there are barriers to getting this kind of information into the hands of people who need it.  Symptoms of Pleural Mesothelioma and Lung Cancer Pleural mesothelioma is an asbestos-related cancer that affects the lungs. Mesothelioma patients have many of the same symptoms as lung cancer patients. Among other things, they tend … Continue reading Exercise and Nutrition Advice Could Help Some Mesothelioma Patients »

High PD-L1 Levels Could Be Bad News for Mesothelioma Surgery Candidates

Yet another new study has found a link between PD-L1 levels and mesothelioma survival – this time in people slated to have surgery for malignant pleural mesothelioma.  PD-L1 stands for programmed cell death ligand 1. It is a protein expressed by some cancer cells that helps them avoid immune system attack.  Researchers at Baylor College of Medicine are the latest to show that higher PD-L1 levels may lead to a worse mesothelioma prognosis. Their study focused specifically on mesothelioma surgery candidates.  The results were published recently in the Annals of Thoracic Surgery.  PD-L1 Levels and Mesothelioma Prognosis Even healthy people express some amount of PD-L1. Its job is to suppress the part of the immune system that attacks foreign tissues. … Continue reading High PD-L1 Levels Could Be Bad News for Mesothelioma Surgery Candidates »

First Patient Dosed in New Trial for Relapsed Mesothelioma

relapsed mesothelioma

Doctors in the UK have started treatment on the first patient in the trial of a new drug combination for relapsed mesothelioma. The drug is called bemcentinib. It blocks a protein encoded by the AXL gene. People with mesothelioma tend to overexpress this protein. Studies show that this extra AXL protein might help cancer cells hide from the immune system. It might also help them spread to other parts of the body.  In the new trial, patients with relapsed mesothelioma will get a combination of bemcentinib and Keytruda (pembrolizumab). Keytruda is an immunotherapy drug. Like bemcentinib, it helps make mesothelioma cells vulnerable to immune system attack.  Animal studies and tests in lung cancer patients show that bemcentinib may help immune … Continue reading First Patient Dosed in New Trial for Relapsed Mesothelioma »

Pleural Mesothelioma Rates Expected to Decline Just as Lung Cancer Deaths Have

pleural mesothelioma rates

A new report suggests that pleural mesothelioma rates will continue to decline worldwide over the next decade as many countries get wise to the dangers of asbestos. The report comes on the heels of another study showing dramatic declines in US lung cancer deaths.  The report on mesothelioma rates comes from market research website, Research and Markets. The company evaluated malignant pleural mesothelioma incidence in seven countries to come up with an 11-year forecast. According to the research, the US, UK, Japan, and four European countries can expect declining rates of asbestos cancer through 2030. Those who do receive a pleural mesothelioma diagnosis may benefit from some of the same drugs that are helping lung cancer patients survive. Lung Cancer … Continue reading Pleural Mesothelioma Rates Expected to Decline Just as Lung Cancer Deaths Have »

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