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Alcoholism Drug Suppresses Mesothelioma Tumors in Mice

A drug approved by the FDA for the treatment of alcoholism appears to have the potential to fight malignant pleural mesothelioma, an aggressive form of lung cancer that is often unresponsive to conventional therapies. Disulfiram (sold under the brand name Antabuse) blocks the processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase. Some studies have suggested that the drug’s ability to bind to copper, a mineral often elevated in the blood serum of cancer patients, may also give it anti-tumor properties and the ability to make cancer cells more susceptible to chemotherapy. In the new mesothelioma study, a team led by cancer researchers at Detroit’s Wayne State University School of Medicine administered copper complexed disulfiram (DSF-Cu) to mice with … Continue reading Alcoholism Drug Suppresses Mesothelioma Tumors in Mice »