Korean Cancer Doctors Embrace PIPAC for Mesothelioma

PIPAC for mesothelioma

Five out of ten Korean oncologists surveyed feel positive about using an aerosolized chemotherapy system called PIPAC for mesothelioma and other types of cancer. PIPAC stands for pressurized intraperitoneal aerosol chemotherapy. The system turns liquid chemotherapy drugs into a spray that can be applied with a nebulizer. It was developed to treat surface malignancies like peritoneal mesothelioma that can be hard to treat with standard methods.  PIPAC can be used in conjunction with mesothelioma surgery or by itself as either a palliative or curative treatment.  The technology is still very new. Many doctors have never used it. But research conducted by the Seoul National University College of Medicine shows Korean doctors are ready to embrace it. How Spray-on Chemotherapy Works … Continue reading Korean Cancer Doctors Embrace PIPAC for Mesothelioma »

“Remodeling” Mesothelioma Cells May Improve Responsiveness to Immunotherapy

Responsiveness to immunotherapy

Italian researchers are experimenting with the idea of remodeling mesothelioma cells from the inside out to improve their responsiveness to immunotherapy. Malignant mesothelioma is highly resistant to standard cancer treatments. Immunotherapy is widely considered to be one of the most hopeful new approaches to this cancer. But this approach works better for some people than it does for others.  The difference may lie in the genes. Scientists at University Hospital of Siena believe that manipulating the gene expression of mesothelioma cells could be the key to bolstering responsiveness to immunotherapy.  Mesothelioma, Genetics, and Responsiveness to Immunotherapy Immunotherapy is a method of treating disease by using the body’s natural immune response. This can mean trying to attract more immune cells to … Continue reading “Remodeling” Mesothelioma Cells May Improve Responsiveness to Immunotherapy »

Could Phlebotomy Delay Development of Mesothelioma?

development of mesothelioma

New research from Japan suggests that removing some blood from the body might offer a way to delay the development of mesothelioma in people exposed to asbestos.  Nearly all cases of malignant mesothelioma occur in people with a history of asbestos exposure. Scientists know that asbestos causes mesothelioma. But they still do not know exactly how.  What is clear is that both iron and byproducts of metabolism called reactive oxygen species (ROS) appear to play a role. Blood removal or phlebotomy can temporarily reduce iron and ROS levels.  The new report from Yasumasa Okazaki, a pathologist with Japan’s Nagoya University Graduate School of Medicine, details how phlebotomy in asbestos-exposed mice delayed the development of mesothelioma. It offers hope that this … Continue reading Could Phlebotomy Delay Development of Mesothelioma? »

Asbestos Cement Roofing Poses an Ongoing Risk for Mesothelioma

asbestos cement roofing

Australian researchers have a warning for people in homes with asbestos cement roofing: Replace your roof or risk mesothelioma in the future.  Michael Kottek and Man Lee Yuen are with the Asbestos Diseases Research Institute in Sydney. They recently published a new report on the risk of mesothelioma from roof tiles made of asbestos.  Like all asbestos-containing products, asbestos cement roofing breaks down over time. Disintegrating or “friable” asbestos is the number one cause of deadly malignant mesothelioma worldwide.  Writing in the American Journal of Industrial Medicine, Kottek and Yuen say buildings with roofs made from asbestos pose an ongoing threat to occupants, even if the tiles are not disturbed.  Asbestos-Containing Products and Asbestos Cancer There was a time when … Continue reading Asbestos Cement Roofing Poses an Ongoing Risk for Mesothelioma »

Cancer Biomarker Test Could Detect Mesothelioma Earlier

cancer biomarker test

A new cancer biomarker test that promises to identify cancer in patients with “non-specific symptoms” could be the key to detecting mesothelioma earlier.  Malignant mesothelioma is a deadly cancer caused by asbestos. The early symptoms of mesothelioma are usually vague and similar to other conditions. As a result, mesothelioma is frequently diagnosed in a late stage. But a cancer biomarker test developed in the UK could change that. The test looks for small molecules called metabolites in the blood. Its developers say it has the potential to find cancer earlier than other blood-based cancer tests.  Non-Specific Symptoms Make Mesothelioma a Diagnostic Challenge Mesothelioma is a rare cancer. It is most common in people who worked or lived around asbestos in … Continue reading Cancer Biomarker Test Could Detect Mesothelioma Earlier »

Improve Mesothelioma Outcomes with a Fast-Mimicking Diet: Is it Possible?

Improve mesothelioma outcomes

New science from Italy suggests that it might eventually be possible to improve mesothelioma outcomes by severely restricting calories during cancer treatment.  The study appears in a recent version of the journal Cancer Discovery. Researchers with Italy’s FIRC Institute of Molecular Oncology (IFOM) in Milan tested a fast-mimicking diet in 101 cancer patients.  They concluded that restricting calories is a safe and feasible method for “reshaping metabolism” to impact tumor growth. If further studies confirm their findings, it could improve mesothelioma outcomes for thousands of patients. The Need for Better Mesothelioma Treatments Mesothelioma is a fast-growing and deadly type of cancer. Most people who receive a mesothelioma diagnosis do not live out the year. Malignant mesothelioma grows on the membranes … Continue reading Improve Mesothelioma Outcomes with a Fast-Mimicking Diet: Is it Possible? »

Patients Live Twice as Long with Less of this Biomarker for Pleural Mesothelioma

biomarker for pleural mesothelioma

An enzyme that helps mop up the products of cellular oxidation might also serve as a powerful biomarker for pleural mesothelioma. People with the lowest levels of this enzyme  survived longer with mesothelioma than those with higher levels. Glutathione peroxidase-1 (GPX-1) is an enzyme found in all cells. It helps keep toxins from building up inside cells. It also helps regulate certain cellular processes.   But there is also evidence that GPX-1 may play a role in the development of cancer. Researchers in Egypt recently discovered that pleural mesothelioma tumors have more GPX-1 than the healthy tissue around them. The less they have, the better the prognosis.  The findings suggest that GPX-1 could be a useful biomarker for pleural mesothelioma.  Mesothelioma … Continue reading Patients Live Twice as Long with Less of this Biomarker for Pleural Mesothelioma »

Genetic Mesothelioma Risk May Lead to Shorter Latency

genetic mesothelioma risk

A particular genetic risk for mesothelioma may be behind the few cases where cancer develops just a few years after asbestos exposure. That is the word from researchers at Australia’s Flinders University and the Asbestos Diseases Research Institute.  Latency is the time it takes after exposure to a cancer-causing agent for signs of cancer to show up. Malignant mesothelioma has one of the longest latency periods of any cancer. In most cases, it takes about 40 years for mesothelioma to develop. As a result, mesothelioma is rare in people under 65. But, in rare cases, mesothelioma develops earlier in life. These cases have sometimes been dismissed as being unrelated to asbestos. But in a new journal article, mesothelioma experts from … Continue reading Genetic Mesothelioma Risk May Lead to Shorter Latency »

Expert Says Malignant Mesothelioma Research ‘Turned a Corner’ in 2021

mesothelioma research

An internationally-known mesothelioma specialist says 2021 has been one of the best years yet for malignant mesothelioma research, giving patients and their families more reason than ever to be hopeful.  Hedy Lee Kindler, MD, is Director of the University of Chicago Medical Center’s Mesothelioma Program. In a commentary in JCO Oncology Practice, Dr. Kindler says the outlook for mesothelioma sufferers this year is “far brighter than it has been for a very long time.” Dr. Kindler points to several recent advances in malignant mesothelioma research and treatment as reasons for optimism. The FDA approved the second systemic therapy for mesothelioma in late 2020. This year saw five positive mesothelioma clinical trials.  Kindler says these advances suggest that the future may … Continue reading Expert Says Malignant Mesothelioma Research ‘Turned a Corner’ in 2021 »

Glucose Solution May Prevent Complication After Pleural Mesothelioma Surgery

pleural mesothelioma surgery

There is new evidence that a solution of hypertonic glucose can help correct persistent air leak –  a complication that sometimes occurs after major pleural mesothelioma surgery. Pleural mesothelioma affects the membrane that surrounds the lungs. Efforts to surgically separate a mesothelioma tumor from the surface of the lungs can damage the lungs.  When this damage causes air to seep out of the lungs into the chest cavity, it is an air leak. Some air leaks fix themselves within a few days. But when an air leak persists for more than 5 days, it can cause further complications and slow recovery after pleural mesothelioma surgery.  A team of thoracic oncologists in Milan, Italy say hypertonic glucose can help clear up … Continue reading Glucose Solution May Prevent Complication After Pleural Mesothelioma Surgery »

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