Understanding Mesothelioma: The Impact of BAP1 and p16 in Accurate Diagnosis

Understanding Mesothelioma: The Impact of BAP1 and p16 in Accurate Diagnosis

ByHolly Zink

Mesothelioma is a rare and serious type of cancer that affects the lining of organs like the lungs and abdomen. It is caused by exposure to a harmful substance called asbestos, which is sometimes used in construction materials. Detecting mesothelioma can be tricky, and doctors often need special tests to be sure. A recent study looked into two important factors, called BAP1 and p16, to help diagnose mesothelioma more accurately. Redefining Mesothelioma Diagnosis Between 2019 and 2022, scientists studied 21 fluid samples from around the lungs and abdomen of people suspected to have mesothelioma. These samples were examined closely to find out if the BAP1 protein was missing and if the p16 gene had certain changes. These tests were important…

P16 Test May Improve Diagnostic Accuracy for Mesothelioma
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P16 Test May Improve Diagnostic Accuracy for Mesothelioma

ByAlex Strauss

Scientists in the UK say testing for a tumor suppressor protein called p16 can improve diagnostic accuracy for mesothelioma. It may also help predict which patients are likely to have the best treatment response. The p16 protein is encoded by the CDKN2A gene. Many people with mesothelioma are missing this gene.  Previous studies show a lack of p16 may be linked to lower cancer survival. Now, researchers in Manchester say it should be added to routine tests to improve prognostic and diagnostic accuracy for mesothelioma. The Challenge of Diagnostic Accuracy for Mesothelioma It is not easy to diagnose mesothelioma. There is no single test that can show if a person has this cancer. Diagnosis usually involves blood tests, imaging studies,…