Tag Archives: prognosis

Predicting Mesothelioma Survival with Routine Clinical Tests

predicting mesothelioma survival

UK researchers say predicting mesothelioma survival does not have to be complicated. Their new study shows routine doctor’s office tests may be just as accurate as more complex metrics. The study appears in the new issue of the BMJ Open Respiratory Research journal. It involved 100 patients with malignant mesothelioma over a four-year period.  The team compared treatment outcomes among these patients with their results on basic health tests. More often than not, these tests correctly predicted their prognosis. The researchers say simplifying the process of predicting mesothelioma survival could help doctors and patients make better treatment decisions.  Prognostic Indicators in Asbestos Cancer Malignant pleural mesothelioma is an uncommon but lethal form of membrane cancer. Patients who get it usually … Continue reading Predicting Mesothelioma Survival with Routine Clinical Tests »

High PD-L1 Levels Could Be Bad News for Mesothelioma Surgery Candidates

Yet another new study has found a link between PD-L1 levels and mesothelioma survival – this time in people slated to have surgery for malignant pleural mesothelioma.  PD-L1 stands for programmed cell death ligand 1. It is a protein expressed by some cancer cells that helps them avoid immune system attack.  Researchers at Baylor College of Medicine are the latest to show that higher PD-L1 levels may lead to a worse mesothelioma prognosis. Their study focused specifically on mesothelioma surgery candidates.  The results were published recently in the Annals of Thoracic Surgery.  PD-L1 Levels and Mesothelioma Prognosis Even healthy people express some amount of PD-L1. Its job is to suppress the part of the immune system that attacks foreign tissues. … Continue reading High PD-L1 Levels Could Be Bad News for Mesothelioma Surgery Candidates »

Age is a Factor in Mesothelioma Survival After Surgery

mesothelioma survival after surgery

Age appears to be one of the biggest predictors of mesothelioma survival after surgery. This holds true no matter which kind of surgery a patient has.  A new study from the University of Pennsylvania compared the outcomes of more than 2,000 mesothelioma surgery patients. They compared them by surgical type. They also compared their survival with that of people who did not have surgery. Mesothelioma survival after surgery was consistently longer for younger patients. The risk of death within a few months went up a little bit with each year of age. The news could help patients and doctors make better treatment decisions. Surgical Procedures for Mesothelioma Operating on mesothelioma patients is controversial. Mesothelioma tumors are irregularly shaped and difficult to … Continue reading Age is a Factor in Mesothelioma Survival After Surgery »

Liquid Biopsy for Early Stage Mesothelioma Diagnosis

liquid biopsy

Canadian researchers are exploring a liquid biopsy test that could lead to early diagnosis of malignant mesothelioma. The test is based on mesothelial precursor cells (MPC). The researchers say these cells – in combination with mesothelin and some kinds of stem cells – “could be implicated” in the development of mesothelioma.  A liquid biopsy detects cells in blood instead of tissue. The University of Toronto scientists think MPC in blood may be a new mesothelioma biomarker. If it proves to be true, this kind of biopsy might be able to identify mesothelioma patients even before they have symptoms. How Liquid Biopsy Works Patients with suspected mesothelioma may have many tests. Imaging scans and blood tests can help tell if a … Continue reading Liquid Biopsy for Early Stage Mesothelioma Diagnosis »

The Peritoneal Cancer Index in Mesothelioma Prognosis

peritoneal cancer index

The peritoneal cancer index is a valuable prognostic tool and should be considered in mesothelioma treatment planning. That is the word from a group of Finnish cancer researchers. They analyzed twelve years of data on peritoneal mesothelioma in their country. Mesothelioma patients with a higher peritoneal cancer index had a worse prognosis than those with a lower PCI. The group says cancer doctors ought to be including the PCI in their decision-making for people with peritoneal mesothelioma. What is the Peritoneal Cancer Index? Peritoneal mesothelioma makes up about a fifth of all mesothelioma cases. It grows on the peritoneum, a membrane that surrounds the abdominal organs. As cancer spreads, tumors can show up in other areas inside the peritoneal cavity.  … Continue reading The Peritoneal Cancer Index in Mesothelioma Prognosis »

The Best Biomarkers for Mesothelioma Diagnosis, Prognosis, & Monitoring

Best Biomarkers for Mesothelioma

What are the best biomarkers for mesothelioma? The answer is still Soluble Mesothelin-Related Proteins (SMRPs). That is the conclusion of a major review of medical literature by some of the world’s top mesothelioma experts. Dr. Harvey Pass of New York University’s Langone Medical Center and Dr. Michele Carbone of the University of Hawaii are among the authors on the new report.  They analyzed 20 years of research on the best biomarkers for mesothelioma. Several were valuable for mesothelioma prognosis. But SMRPs once again came out the winner for mesothelioma prognosis, diagnosis, and treatment monitoring.  How Do Biomarkers Work? A biomarker is any substance produced by the body that can act as a biological signpost. Proteins usually make the best biomarkers … Continue reading The Best Biomarkers for Mesothelioma Diagnosis, Prognosis, & Monitoring »

BAP1 Expression Not an Independent Factor in Mesothelioma Prognosis

BAP1 Expression and Mesothelioma Prognosis

A new report says the prognostic role of BAP1 expression in mesothelioma is not as cut-and-dried as some studies suggest. Italian researchers analyzed the cases of 698 patients with pleural mesothelioma. The group included 60 of their own patients and another 638 from other studies. Their analysis suggests that mesothelioma prognosis has more to do with subtype than with genetic BAP1 expression. They caution doctors not to put too much stock in a patient’s BAP1 status without also considering other factors. Genetic Alterations and Mesothelioma Survival Asbestos exposure is the primary cause of mesothelioma. But not everyone who is exposed to asbestos gets cancer. This may have to do with their genetic makeup. Certain genetic alterations may make a person … Continue reading BAP1 Expression Not an Independent Factor in Mesothelioma Prognosis »

Artificial Intelligence in Mesothelioma Diagnosis, Prognosis, and Treatment Planning

Artificial Intelligence

Two newly-published studies highlight some of the ways that artificial intelligence may help with the diagnosis and treatment of malignant mesothelioma.  The first study focuses on machine learning algorithms for mesothelioma diagnosis. Researchers used data from Turkey, which has a high rate of mesothelioma among families.  A separate study from New York’s Mount Sinai Medical Center demonstrates the role that artificial intelligence can play in planning mesothelioma radiotherapy. Both studies suggest that machine learning may be a valuable tool to help doctors tackle asbestos cancer.  How Does Machine Learning Work? Artificial intelligence refers to intelligence generated by a computer. Like people, computers have to “learn” before they can provide intelligent answers to medical questions.  In both of the new studies, … Continue reading Artificial Intelligence in Mesothelioma Diagnosis, Prognosis, and Treatment Planning »

Breast Cancer and Mesothelioma: Case Study Illustrates Diagnostic Challenge

breast cancer and mesothelioma

A newly published Croatian case illustrates how challenging it can sometimes be to distinguish between breast cancer and mesothelioma. The case involves a 61-year-old woman with what appeared to be breast cancer. Further study revealed that what the woman actually had was pleural mesothelioma. The mesothelioma had spread to her breast.  Breast cancer and mesothelioma cells look similar under the microscope. But they are very different. The authors of the new report caution doctors against the “pitfall” of mistaking one for the other.  Breast Metastasis is Rare Pleural mesothelioma occurs on the membrane that surrounds the lungs. It is rare for mesothelioma to spread to the breast. The most common place for mesothelioma cells to spread is the lungs.  Women … Continue reading Breast Cancer and Mesothelioma: Case Study Illustrates Diagnostic Challenge »

PD-L1 Expression and Mesothelioma Prognosis

PD-L1 expression and mesothelioma prognosis

The largest study yet on PD-L1 expression and mesothelioma prognosis shows that patients with more of this protein in their cells have poorer odds of survival. Programmed death ligand 1 (PD-L1) helps cancer cells evade immune system attack.  Other studies have suggested a link between PD-L1 expression and mesothelioma prognosis. But the new meta-analysis performed by two Chinese researchers appears to confirm it with an even bigger data set.  Understanding Mesothelioma Prognosis Malignant mesothelioma is an uncommon cancer that typically carries a poor prognosis. Many people diagnosed with mesothelioma lose their lives to the illness within a year.  But there are also many exceptions. Some mesothelioma survivors live for decades after a mesothelioma diagnosis. Australian Paul Kraus is an example. … Continue reading PD-L1 Expression and Mesothelioma Prognosis »