Mesothelioma Surgical Decisions: New Method May Make Them Easier

mesothelioma surgical decisions

Cancer researchers in India and the UK have come up with a method for making better mesothelioma surgical decisions. The group focused on peritoneal mesothelioma, the second most common form of asbestos cancer. Peritoneal mesothelioma affects the membrane around the abdominal organs. It can spread throughout the abdomen.  Some peritoneal mesothelioma patients get good results with cytoreductive surgery. But success depends on a number of factors such as how far cancer has spread and where mesothelioma tumors are located. The new decision-making tool reminds doctors of five important factors to consider when making mesothelioma surgical decisions for the best outcomes. It is based on the acronym PAUSE. Peritoneal Mesothelioma and the Promise of CRS/HIPEC Malignant mesothelioma is an especially aggressive … Continue reading Mesothelioma Surgical Decisions: New Method May Make Them Easier »

New Treatment for Malignant Mesothelioma Kills Cancer ‘From the Inside Out’

new treatment for malignant mesothelioma

The University of Vermont is about to start a first-in-human trial of a new kind of treatment for malignant mesothelioma.  The new approach involves a drug called RSO-021. The drug works differently from other cancer therapies. It blocks the ability of cancer cells to manage their own waste products. It’s developers say the new treatment for malignant mesothelioma aims to kill cancer cells from the inside out.  The concept for RSO-021 was first developed at the University of Vermont. Scientists at Wake Forest University School of Medicine and the UK biotech company RS Oncology have tested the drug in mice with promising results.  Human trials of RSO-021 will start soon in the UK. US patients will be recruited in 2022.  … Continue reading New Treatment for Malignant Mesothelioma Kills Cancer ‘From the Inside Out’ »

Drug Reation May Predict Mesothelioma Immunotherapy Results

mesothelioma immunotherapy results

Patients who have more serious reactions to the drug nivolumab tend to have better mesothelioma immunotherapy results than those who have little or no reaction.  That is the finding of a new study from Japan’s Tokushima University.  Researchers studied the cases of 11 patients treated with nivolumab between 2009 and 2021. They found that the patients who got the sickest from the drug had the best mesothelioma immunotherapy results.  The study’s authors say it’s even more reason to find ways to manage immunotherapy side effects. If patients can work through their worst reactions, more of them might survive mesothelioma.  Nivolumab in Mesothelioma Treatment Nivolumab is an immune checkpoint inhibitor sold under the brand name Opdivo. It is a type of … Continue reading Drug Reation May Predict Mesothelioma Immunotherapy Results »

Follow-Up Care for Mesothelioma: What Happens After Treatment?

follow-up care for mesothelioma

A new UK study on follow-up care for mesothelioma finds that patients need more continuity, timely information, and more input from their caregivers.  The study focused on three National Health Service facilities in the South of England. Two were secondary care hospitals and the third was a tertiary care center. A tertiary care center has special, high-level expertise in mesothelioma care.  Researchers talked to patients, nurses, caregivers, and members of practice groups called clinical commissioning groups. They used the feedback to develop the UK’s first set of best practices for follow-up care for mesothelioma. They now plan to share these best practices with clinicians across the country to improve after-care for all mesothelioma patients.  The Importance of Follow-Up Care for … Continue reading Follow-Up Care for Mesothelioma: What Happens After Treatment? »

Sensitizer Could Improve Radiotherapy for Pleural Mesothelioma

radiotherapy for pleural mesothelioma

A chemical compound that sensitizes cancer cells to radiation could help improve radiotherapy for pleural mesothelioma. Radiotherapy uses ionizing radiation to scramble the DNA of cancer cells. This makes it harder for cells to replicate and form new tumors.  But mesothelioma cells and other hard-to-treat cancers have ways of protecting themselves against radiation-induced DNA damage. The possibility of damaging healthy cells is another limiting factor in radiotherapy for pleural mesothelioma.  Now, a Japanese study of mice shows a new compound called SQAP can enhance the damage to cancer cells from radiation. The researchers are hopeful it could help keep mesothelioma tumors in check. The Challenge of Radiotherapy for Pleural Mesothelioma Malignant pleural mesothelioma is difficult to treat. This aggressive membrane … Continue reading Sensitizer Could Improve Radiotherapy for Pleural Mesothelioma »

Mesothelioma Histology Impacts Response to Chemotherapy

Response to chemotherapy

Response to chemotherapy for people with malignant mesothelioma may depend – at least in part – on the histology or subtype of their tumor. That is the finding of a new study from a team of Spanish doctors. The doctors analyzed the cases of 189 pleural mesothelioma patients treated at their hospital between 2002 and 2020.  Their study confirms what other studies have suggested: People with epithelioid tumors have better response to chemotherapy than those with non-epithelioid subtypes. These patients experienced both longer progression-free survival and longer overall survival.  Systemic Treatment for Pleural Mesothelioma The first chemotherapy drug for malignant pleural mesothelioma received FDA approval in 2004. Alimta was the only approved systemic (whole body) treatment for pleural mesothelioma until 2020.  … Continue reading Mesothelioma Histology Impacts Response to Chemotherapy »

Immunotherapy and Chemotherapy Shrink Peritoneal Mesothelioma Tumors: New Case Reports

immunotherapy and chemotherapy

Two new case reports appear to support the idea that immunotherapy and chemotherapy can work together to fight peritoneal mesothelioma.  The case reports appears in the newest issue of the Journal of Immunotherapy. It details the cases of two patients with malignant peritoneal mesothelioma – a lethal cancer of the lining of the abdomen.  Both patients relapsed on standard platinum-based chemotherapy. But adding an immune checkpoint inhibitor dramatically improved their results. In one case, a patient’s tumor nearly disappeared.  Doctors at New York’s Memorial Sloan Kettering Cancer Center say the cases suggest that immunotherapy and chemotherapy might offer an alternative for patients who have run out of options.  Alternative Treatments Needed for Peritoneal Mesothelioma About a fifth of patients who … Continue reading Immunotherapy and Chemotherapy Shrink Peritoneal Mesothelioma Tumors: New Case Reports »

New Mesothelioma Trial to Test Tri-Modal Approach

new mesothelioma trial

Enrollment is open for a new mesothelioma trial run by Memorial Sloan Kettering Cancer Center to test a three-prong approach to treatment.  Pleural mesothelioma is a lung-related cancer caused by asbestos. It is notoriously difficult to treat and highly aggressive.  The new mesothelioma trial aims to recruit 150 pleural mesothelioma patients. Patients will receive lung-sparing surgery and chemotherapy. Some will also receive intensity modulated radiation therapy (IMRT).  Researchers will test which group does better – those who only have surgery and chemotherapy or those who also have targeted radiation therapy. They plan to measure not only survival but also complications, quality of life, and how long it takes for the cancer to come back.  Tri-Modal Treatment to Fight Mesothelioma The … Continue reading New Mesothelioma Trial to Test Tri-Modal Approach »

Targeting Nerve Cells Might Offer New Way to Fight Mesothelioma, Other Cancers

targeting nerve cells

Israeli scientists may have found a new way to fight mesothelioma and other cancers from the inside out by targeting nerve cells.  Researchers at Technion – Israel Institute of Technology conducted the new study. It appears in the journal Science Advances.  Nerve cells called neurons help promote tumor growth. The team reasoned that targeting these tumor nerve cells with a damaging drug might slow cancer progression.  They tested the theory on triple-negative breast cancer tumors in mice. The tumors still grew but they grew much slower than the untreated tumors. The findings could have implications for other hard-to-treat cancers like malignant mesothelioma.  New Options Needed for Malignant Mesothelioma Malignant mesothelioma is one of the rarest and most treatment-resistant cancers. Many … Continue reading Targeting Nerve Cells Might Offer New Way to Fight Mesothelioma, Other Cancers »

Relapsed Mesothelioma Patients Live Longer on Opdivo in Phase 3 Trial

relapsed mesothelioma patients

A multi-center British study suggests that the cancer drug Opdivo (nivolumab) may be a solid second-line treatment option for relapsed mesothelioma patients.  The Phase-3 trial involved mesothelioma patients from 24 UK hospitals. All had an ECOG score of 0 or 1, meaning they were in reasonably good health overall.  All of the patients had first-line treatment with platinum-based chemotherapy. Then their cancer came back. There is no approved treatment for relapsed mesothelioma patients. So these patients enrolled in the nivolumab trial.  Although Opdivo is not a cure for mesothelioma, the results of the news trial show it could extend survival for the right patients.  How Does Opdivo Work? Nivolumab is sold under the brand name Opdivo. It is an immunotherapy … Continue reading Relapsed Mesothelioma Patients Live Longer on Opdivo in Phase 3 Trial »

Get your free copy of
“Surviving Mesothelioma” Today!