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Evening Primrose Extract: Targeting TYMS for Mesothelioma Treatment

Evening Primrose Extract: Targeting TYMS for Mesothelioma Treatment

Recent studies have provided exciting insights into how evening primrose extract interacts with TYMS. TYMS is a protein crucial in the development and progression of malignant pleural mesothelioma.

A special mixture derived from evening primrose seeds is showing great potential in reducing TYMS activity. This groundbreaking research is offering new hope to those affected by this aggressive form of cancer.

Understanding Malignant Pleural Mesothelioma

Malignant pleural mesothelioma is a type of cancer that is known for being tough to treat, especially in its advanced stages. Scientists have discovered that a key target for treatment is a protein called thymidylate synthase (TYMS).

This protein influences how mesothelioma responds to certain drugs. A natural extract from evening primrose seeds has shown promise. This extract is slowing down the growth and spread of mesothelioma cells.

Malignant pleural mesothelioma is a serious form of cancer. It often develops silently over many years without showing any symptoms. It is caused by exposure to a toxic mineral called asbestos. Mesothelioma is known for its low survival rate, with only 10% of patients surviving beyond five years after diagnosis. The standard treatment for mesothelioma is a combination of surgery, chemotherapy, and radiation.

The TYMS Protein and Evening Primrose Extract

One of the reasons mesothelioma is resistant to certain drugs is because of a protein called TYMS. TYMS tends to be overactive in this type of cancer. This overactivity has also been seen in other solid tumors. TYMS levels are closely linked with how aggressive the cancer cells become, and how much they spread.

Polyphenols are natural compounds found in plants. They are known for their cancer-fighting properties. Studies have shown that they can cause cancer cell death and slow down cancer cell growth. They also play a role in stopping the spread of cancer to other parts of the body.

Evening primrose extract is a special mixture of polyphenols made from the seeds of the evening primrose plant. Research has shown that this extract might help to treat cancer. It has been found to slow the spread of cancer cells and has even shown promise in reducing the growth of tumors.

Recent studies have provided exciting insights into how evening primrose extract affects TYMS. Scientists have discovered that this extract targets specific areas of the TYMS gene, effectively reducing its activity.

The research on evening primrose extract and its potential in treating mesothelioma is a significant step forward. By understanding how evening primrose extract interacts with TYMS and other cellular processes, scientists are finding new possibilities for better treatments. More research is needed, but this natural extract holds great promise in offering hope to those affected by mesothelioma.


Chmielewska-Kassassir M, Sobierajska K, Ciszewski WM, Kryczka J, Zieleniak A, Wozniak LA. Evening Primrose Extract Modulates TYMS Expression via SP1 Transcription Factor in Malignant Pleural Mesothelioma. Cancers (Basel). 2023;15(20):5003. Published 2023 Oct 16. doi:10.3390/cancers15205003. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605291/

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