Researchers in England are testing a new cancer blood test that promises to reveal the presence of hard-to-find cancers like mesothelioma earlier. The country’s National Health Service will offer the test to 165,000 UK residents next year as part of a clinical trial. “Early detection, particularly for hard to treat conditions like ovarian and pancreatic cancer, has the potential to save many lives,” NHS England’s’ chief executive Simon Stevens told The Guardian newspaper. “This promising blood test could therefore be a gamechanger in cancer care, helping thousands more people to get successful treatment.” If the trial of the new cancer blood test is successful, it could be available to help detect mesothelioma within a few years. The Challenge of Identifying … Continue reading New Cancer Blood Test: Could it Find Early Mesothelioma?
Canadian researchers are exploring a liquid biopsy test that could lead to early diagnosis of malignant mesothelioma. The test is based on mesothelial precursor cells (MPC). The researchers say these cells – in combination with mesothelin and some kinds of stem cells – “could be implicated” in the development of mesothelioma. A liquid biopsy detects cells in blood instead of tissue. The University of Toronto scientists think MPC in blood may be a new mesothelioma biomarker. If it proves to be true, this kind of biopsy might be able to identify mesothelioma patients even before they have symptoms. How Liquid Biopsy Works Patients with suspected mesothelioma may have many tests. Imaging scans and blood tests can help tell if a … Continue reading Liquid Biopsy for Early Stage Mesothelioma Diagnosis
There is new evidence that a protein called Activin A could help predict response to chemotherapy in patients with malignant pleural mesothelioma. It may also make it easier for doctors to distinguish mesothelioma from benign lung tumors. Activin A influences many cellular processes. Among other things, it plays a role in cell proliferation, immune response, metabolism, and natural cell death. FInnish researchers say mesothelioma patients with higher levels of Activin A in their blood are more likely to suffer from cachexia. Cachexia is weakness and wasting of the body due to chronic illness. High expressors of Activin A are also less likely to have a good response to chemotherapy. Activin A and Mesothelioma Activin A is a member of the … Continue reading Response to Chemotherapy in Mesothelioma Patients: Could This Protein Predict It?
Mesothelioma patients and their doctors may have reason to be optimistic about a new lung cancer blood test. A random trial of more than 12,000 high-risk people in Scotland shows the EarlyCDT test combined with CT imaging can detect cancer early. Earlier diagnosis is likely to lead to longer survival of lung cancers like pleural mesothelioma. Researchers presented their findings on the new lung cancer blood test at a global conference this week in Spain. Largest Lung Cancer Trial As in the US, lung cancer is the biggest cancer killer in Scotland. Pleural mesothelioma is a form of lung cancer. Although it is rare, mesothelioma is more common in the UK than in other parts of the world. This is … Continue reading Lung Cancer Blood Test: Can it Find Early Mesothelioma?
Israeli researchers hope that a new kind of cancer blood test could help detect mesothelioma and other malignancies earlier. Earlier diagnosis could lead to longer mesothelioma survival. The blood test is based on the idea that immune system cells undergo metabolic changes when they fight a cancer like pleural mesothelioma. Different kinds of changes are associated with different kinds of cancers. The new cancer blood test detects these changes. Immune System Cells and Metabolism The immune system is the body’s primary way of defending itself against diseases like malignant mesothelioma. Metabolism refers to the way immune system cells expend energy to fight cancer. An Israeli company is developing the new cancer blood test. It focuses on the metabolism of immune … Continue reading New Cancer Blood Test Could Identify Early Mesothelioma
Italian researchers say it’s possible to monitor mesothelioma tumor progression with a simple blood test. They make their case in a Letter to the Editor in the latest edition of the Journal of Thoracic Oncology. The researchers say blood serum levels of the protein mesothelin correlate closely with tumor volume in malignant pleural mesothelioma patients. They are recommending that the blood test be used alongside CT to track mesothelioma tumor progression. The Importance of Monitoring Mesothelioma Tumor Progression Pleural mesothelioma is a rare cancer with a grim prognosis. Mesothelioma tumors tend to grow and spread quickly. Doctors have to carefully monitor mesothelioma tumor progression to tell if a treatment is working. Most mesothelioma patients have chemotherapy with Alimta (pemetrexed) and … Continue reading Mesothelioma Tumor Progression Can be Tracked With Blood Test
A discovery in Japan could lead to a more effective mesothelioma blood test for mesothelioma diagnosis. Japanese scientists say they have found a better way to detect mesothelioma cells in the blood. The scientists are experts in occupational health. Malignant mesothelioma is an occupational cancer because people can get it from working near asbestos. Mesothelioma diagnosis is challenging. But a powerful mesothelioma blood test could make it easier to find the asbestos cancer earlier. Treatment often works better when patients start it earlier. Circulating Tumor Cells in the Blood of Mesothelioma Patients No matter what kind of cancer a person has, their tumor releases some cells into the blood. Mesothelioma tumors are no exception. These circulating tumor cells (CTCs) are … Continue reading Japanese Discovery Could Lead to New Mesothelioma Blood Test
A team from the Center of Molecular Medicine in Bochum, Germany tested the blood of 43 male mesothelioma patients along with 52 control subjects that had been exposed to asbestos but hadn’t developed mesothelioma. Blood was analyzed for the presence of mesothelin, a protein that is the most common blood-based mesothelioma biomarker, and miR-103a-3p, a microRNA gene. When the team attempted to identify the mesothelioma patients by mesothelin levels alone, they were able to correctly identify 74% of the sick patients. At the same time, the mesothelin-only blood test correctly ruled out mesothelioma in 85% of the healthy control subjects. The micro RNA gene proved to be a more accurate identifier of mesothelioma. Using the microRNA gene as their only … Continue reading In Search of a Better Mesothelioma Blood Test
There is new evidence that a blood test for a biomarker called N-ERC/mesothelin could help identify mesothelioma earlier and improve outcomes in people at risk for the disease. Cancer researchers with Juntendo University in Tokyo released a study in 2008 suggesting that N-ERC/mesothelin, a soluble protein released by certain kinds of cancer cells, was “a very promising tumor marker for mesothelioma, especially epithelioid mesothelioma”. In their newest study, the same group attempted to test the value of the biomarker as a warning tool for closer monitoring in populations at high mesothelioma risk. The new study included construction workers who were part of a large-scale, 5-year screening of people known to be exposed to asbestos, the primary cause of mesothelioma. The … Continue reading Mesothelioma Blood Test May Save Lives through Earlier Diagnosis
An international team of researchers is studying the proteins found on the surface of cancer cells in an effort to improve mesothelioma diagnosis. The team, made up of scientists from the US, Switzerland, Italy and Chile, has just published their findings on a new kind of test to identify protein-derived mesothelioma biomarkers in blood serum. Mesothelioma is an aggressive cancer of the membranes around organs. Because the most common mesothelioma biomarker, mesothelin, is also overproduced by other kinds of cancer cells, it has only limited diagnostic value. A test to identify a set of proteins produced specifically by mesothelioma cells could greatly improve diagnostic accuracy. Led by Ferdinando Cerciello and Bernd Wollscheid of the Institute of Molecular Systems Biology in … Continue reading Mesothelioma Blood Test May Be Possible