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Immunotherapy Drug: More May be Better for Advanced Mesothelioma

The same team of Italian researchers that first reported on the safety and efficacy of the immunotherapy drug tremelimumab for mesothelioma now say that giving more of the drug might be even more effective. Tremelimumab is a monoclonal antibody that acts on a particular downregulator of the immune system called cytotoxic T-lymphocyte antigen 4 (CTLA4). The goal of tremelimumab is to inhibit the immune system tolerance to tumors, which tends to allow them to grow unchecked. When CTLA4 is reactivated with a drug like tremelimumab, it regains its ability to attack tumors. Based on the results of their 2013 study that showed a 31% rate of disease control in patients with unresectable mesothelioma who were given tremelimumab, the team tested … Continue reading Immunotherapy Drug: More May be Better for Advanced Mesothelioma »