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Leukemia Drug Fails Mesothelioma Trial

An oral leukemia medicine doctor’s had hoped might help certain mesothelioma patients won’t be moving on to the next level of clinical trials. Phase II drug trials use human subject to determine a drug’s safe dose and measure its effectiveness.  In Phase II trials of dasatinib, a drug currently used for leukemia patients that have failed other treatments,  mesothelioma researchers found the medicine had “no activity” and was too toxic to justify its use. Caused by exposure to asbestos, mesothelioma is challenging to treat and effective therapies are limited.  Because of dasatinib’s success as a second-line treatment for chronic myeloid leukemia, doctors reasoned that it might help patients with inoperable mesothelioma.  In the study to test this hypothesis, 46 mesothelioma patients were … Continue reading Leukemia Drug Fails Mesothelioma Trial »