Tag Archives: new mesothelioma drug

New Mesothelioma Drug Kills Cancer Stem Cells

test tube

Citing “significant enthusiasm within the mesothelioma community”, the manufacturers of a promising new mesothelioma drug say they have begun a major test of the drug in patients. Massachusetts-based Verastem, Inc. focuses on drugs that fight cancer by attacking the stem cells that give rise to them. Earlier this summer, the FDA granted orphan drug status to their stem cell inhibitor, defactinib, for the treatment of mesothelioma. The designation, which is reserved for drugs that fight the rarest of diseases, helps pave the way for testing and faster approval, depending on the results of clinical trials. “Development of a drug that preferentially kills cancer stem cells is a promising approach, as many standard-of-care treatments have been shown to either have no … Continue reading New Mesothelioma Drug Kills Cancer Stem Cells »

New Mesothelioma Drug Granted Special FDA Status

The Federal Drug Administration (FDA) has granted orphan drug status to a medication that may help boost the effectiveness of the standard cisplatin/pemetrexed chemotherapy combination for mesothelioma. CBP501, produced by the Japanese Drug company CanBas, is a novel synthetic peptide that seems to enhance the effectiveness of cisplatin by acting on multiple pathways that govern the lifecycle of cells and the natural repair of DNA damage. By modulating the production of a certain enzyme, it allows mesothelioma cells to become more susceptible to the damaging effects of platinum (cisplatin) build-up. At the same time, it prevents the cells from properly repairing themselves. The drug has also shown the ability to resensitize mesothelioma cells that have become resistant to cisplatin. The FDA’s … Continue reading New Mesothelioma Drug Granted Special FDA Status »