Mesothelioma Chemotherapy Could Get a Boost from Altered Virus
An altered form of a virus that typically causes respiratory illness may help boost the effectiveness of chemotherapy for mesothelioma. In a study published in the Journal of Thoracic Oncology, researchers found that deleting a gene from adenoviruses made the drugs pemetrexed and cisplatin more cytotoxic to mesothelioma cells in the lab. In its unaltered state, the adenovirus is the virus most closely associated with respiratory problems, ranging from the common cold to pneumonia, croup and bronchitis. It can also cause gastroenteritis, cystitis, and conjunctivitis. However, when it is altered in the lab by removing a particular gene, it can become a powerful ally in the fight against hard-to-treat cancers like mesothelioma. In the latest study, researchers first deleted the E1B-55kD…